Alexander Marson, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE, #508
San Francisco CA 94143
Phone415-734-4861
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    Collapse Biography 
    Collapse Education and Training
    Harvard CollegeA.B. 2001Biology
    University of Cambridge, UKM.Phil2003Biological Sciences
    Massachusetts Institute of Technology (MIT)Ph.D.2008Biology
    Harvard Medical SchoolM.D.2010Medicine
    Collapse Awards and Honors
    2016American Society of Clinical Investigation (ASCI) Young Physician-Scientist Award
    2016Burroughs Wellcome Foundation Career Award for Medical Scientists
    2016NIDA/NIH Avenir New Innovator Award
    2016Parker Institute for Cancer Immunotherapy, Project Member
    2017Chan Zuckerberg Biohub Investigator
    2019Elected Member of American Society of Clinical Investigators (ASCI)
    2019CRI Lloyd J. Old STAR Career Award
    2022Elected Member of Association of American Physicians (AAP)

    Collapse Overview 
    Collapse Overview
    Our lab's goal is to understand the genetic circuits that control human immune cell function in health and disease. We have begun to identify how genetic risk variants for autoimmune diseases disrupt immune cell circuits (Farh and Marson et al., Nature 2015; Simeonov et al., Nature, 2017), and how pathogenic circuits may be targeted with novel therapeutics (Xiao et al., Immunity 2014). My lab has developed new tools for efficient CRISPR genome engineering in primary human T cells (Schumann et al., PNAS 2015; Roth et al., Nature 2018; Nguyen et al. Nature Biotech 2020). Now we are pursuing a comprehensive strategy to test how coding and non-coding genetic variation control essential programs in the human immune system (Simeonov et al. Nature, 2017; Shifrut et al., Cell 2018; Roth et al., Cell 2020; Cortez et al., Nature 2020; Schumann et al., Nature Immunology 2020). Genome engineered human T cells hold great potential for the next generation of cell-based therapies for cancer, autoimmunity and infectious diseases.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Inherited T cell defects: Diagnosis, Mechanisms and Treatments
    NIH P01AI138962Sep 8, 2020 - Aug 31, 2025
    Role: Principal Investigator
    Functional Molecular Investigation of Inflammatory Bowel Disease (IBD) Risk Variants
    NIH R01DK119979Sep 18, 2018 - May 31, 2022
    Role: Principal Investigator
    Functional Interrogation of Non-Coding Type 1 Diabetes Risk Variants in Human Immune Cells and Beta Cells
    NIH DP3DK111914Sep 30, 2016 - May 31, 2021
    Role: Principal Investigator
    Functional Testing of Host Genes that control HIV Latency in Primary Immune Cells
    NIH DP2DA042423Jun 1, 2016 - May 31, 2021
    Role: Principal Investigator

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Antigen-Specific T Cell Receptor Discovery for Treating Progressive Multifocal Leukoencephalopathy. bioRxiv. 2024 Nov 04. Gupta S, Martinov T, Thelen A, Sunahara M, Mureli S, Vazquez A, Gerdts J, Dandekar R, Cortese I, Fouassier C, Schanzer E, Urnov FD, Marson A, Shy BR, Greenberg PD, Wilson MR. PMID: 39574748; PMCID: PMC11580961.
      View in: PubMed   Mentions:
    2. Method of moments framework for differential expression analysis of single-cell RNA sequencing data. Cell. 2024 Oct 31; 187(22):6393-6410.e16. Kim MC, Gate R, Lee DS, Tolopko A, Lu A, Gordon E, Shifrut E, Garcia-Nieto PE, Marson A, Ntranos V, Ye CJ. PMID: 39454576.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Gene regulatory network inference from CRISPR perturbations in primary CD4+ T cells elucidates the genomic basis of immune disease. Cell Genom. 2024 Oct 10; 100671. Weinstock JS, Arce MM, Freimer JW, Ota M, Marson A, Battle A, Pritchard JK. PMID: 39395408.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Phenotypic profiling of human induced regulatory T cells at early differentiation: insights into distinct immunosuppressive potential. Cell Mol Life Sci. 2024 Sep 12; 81(1):399. Kattelus R, Starskaia I, Lindén M, Batkulwar K, Pietilä S, Moulder R, Marson A, Rasool O, Suomi T, Elo LL, Lahesmaa R, Buchacher T. PMID: 39264416; PMCID: PMC11393232.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Deciphering regulation of FOXP3 expression in human conventional T cells. bioRxiv. 2024 Sep 02. Umhoefer JM, Arce MM, Dajani R, Belk JA, Mowery CT, Nguyen V, Gowen BG, Simeonov DR, Curie GL, Corn JE, Chang HY, Marson A. PMID: 39282425; PMCID: PMC11398386.
      View in: PubMed   Mentions:
    6. NKp30 and NKG2D contribute to natural killer recognition of HIV-infected cells. bioRxiv. 2024 Jun 27. Zhao NQ, Pi R, Nguyen DN, Ranganath T, Seiler C, Holmes S, Marson A, Blish CA. PMID: 38979175; PMCID: PMC11230221.
      View in: PubMed   Mentions:
    7. A model for accurate quantification of CRISPR effects in pooled FACS screens. bioRxiv. 2024 Jun 18. Pimentel H, Freimer JW, Arce MM, Garrido CM, Marson A, Pritchard JK. PMID: 38948774; PMCID: PMC11213010.
      View in: PubMed   Mentions:
    8. Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells. Nat Genet. 2024 Jun; 56(6):1156-1167. Mowery CT, Freimer JW, Chen Z, Casaní-Galdón S, Umhoefer JM, Arce MM, Gjoni K, Daniel B, Sandor K, Gowen BG, Nguyen V, Simeonov DR, Garrido CM, Curie GL, Schmidt R, Steinhart Z, Satpathy AT, Pollard KS, Corn JE, Bernstein BE, Ye CJ, Marson A. PMID: 38811842; PMCID: PMC11176074.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4+ regulatory T cells by regulating IL2RA. Proc Natl Acad Sci U S A. 2024 Jun 04; 121(23):e2315363121. Andrabi SBA, Kalim UU, Palani S, Khan MM, Khan MH, Fagersund J, Orpana J, Paulin N, Batkulwar K, Junttila S, Buchacher T, Grönroos T, Toikka L, Ammunet T, Sen P, Orešic M, Kumpulainen V, Tuomisto JEE, Sinha R, Marson A, Rasool O, Elo LL, Lahesmaa R. PMID: 38805281; PMCID: PMC11161746.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. A proximal enhancer regulates RORA expression during early human Th17 cell differentiation. Clin Immunol. 2024 Jul; 264:110261. Kalim UU, Biradar R, Junttila S, Khan MM, Tripathi S, Khan MH, Smolander J, Kanduri K, Envall T, Laiho A, Marson A, Rasool O, Elo LL, Lahesmaa R. PMID: 38788884.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Bidirectional epigenetic editing reveals hierarchies in gene regulation. Nat Biotechnol. 2024 May 17. Pacalin NM, Steinhart Z, Shi Q, Belk JA, Dorovskyi D, Kraft K, Parker KR, Shy BR, Marson A, Chang HY. PMID: 38760566.
      View in: PubMed   Mentions: 2     Fields:    
    12. Publisher Correction: Advancing T cell-based cancer therapy with single-cell technologies. Nat Med. 2024 May; 30(5):1505. Bucktrout SL, Banovich NE, Butterfield LH, Cimen-Bozkus C, Giles JR, Good Z, Goodman D, Jonsson VD, Lareau C, Marson A, Maurer DM, Munson PV, Stubbington M, Taylor S, Cutchin A. PMID: 38317023.
      View in: PubMed   Mentions:    Fields:    
    13. Improving prime editing with an endogenous small RNA-binding protein. Nature. 2024 Apr; 628(8008):639-647. Yan J, Oyler-Castrillo P, Ravisankar P, Ward CC, Levesque S, Jing Y, Simpson D, Zhao A, Li H, Yan W, Goudy L, Schmidt R, Solley SC, Gilbert LA, Chan MM, Bauer DE, Marson A, Parsons LR, Adamson B. PMID: 38570691; PMCID: PMC11023932.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    14. CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells. mBio. 2024 Apr 10; 15(4):e0222223. Rathore U, Haas P, Easwar Kumar V, Hiatt J, Haas KM, Bouhaddou M, Swaney DL, Stevenson E, Zuliani-Alvarez L, McGregor MJ, Turner-Groth A, Ochieng' Olwal C, Bediako Y, Braberg H, Soucheray M, Ott M, Eckhardt M, Hultquist JF, Marson A, Kaake RM, Krogan NJ. PMID: 38411080; PMCID: PMC11005436.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    15. Ultra-high efficiency T cell reprogramming at multiple loci with SEED-Selection. bioRxiv. 2024 Feb 07. Chang CR, Vykunta VS, Goodman DB, Muldoon JJ, Nyberg WA, Liu C, Allain V, Rothrock A, Wang CH, Marson A, Shy BR, Eyquem J. PMID: 38370809; PMCID: PMC10871224.
      View in: PubMed   Mentions:
    16. The lncRNA Malat1 inhibits miR-15/16 to enhance cytotoxic T cell activation and memory cell formation. Elife. 2023 Dec 21; 12. Wheeler BD, Gagnon JD, Zhu WS, Muñoz-Sandoval P, Wong SK, Simeonov DS, Li Z, DeBarge R, Spitzer MH, Marson A, Ansel KM. PMID: 38127070; PMCID: PMC10735224.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    17. Base-editing mutagenesis maps alleles to tune human T cell functions. Nature. 2024 Jan; 625(7996):805-812. Schmidt R, Ward CC, Dajani R, Armour-Garb Z, Ota M, Allain V, Hernandez R, Layeghi M, Xing G, Goudy L, Dorovskyi D, Wang C, Chen YY, Ye CJ, Shy BR, Gilbert LA, Eyquem J, Pritchard JK, Dodgson SE, Marson A. PMID: 38093011; PMCID: PMC11065414.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    18. Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein. iScience. 2024 Jan 19; 27(1):108693. Bevacqua RJ, Zhao W, Merheb E, Kim SH, Marson A, Gloyn AL, Kim SK. PMID: 38205242; PMCID: PMC10777115.
      View in: PubMed   Mentions: 1  
    19. PIM kinases regulate early human Th17 cell differentiation. Cell Rep. 2023 12 26; 42(12):113469. Buchacher T, Shetty A, Koskela SA, Smolander J, Kaukonen R, Sousa AGG, Junttila S, Laiho A, Rundquist O, Lönnberg T, Marson A, Rasool O, Elo LL, Lahesmaa R. PMID: 38039135; PMCID: PMC10765319.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    20. Gene regulatory network inference from CRISPR perturbations in primary CD4+ T cells elucidates the genomic basis of immune disease. bioRxiv. 2023 Oct 24. Weinstock JS, Arce MM, Freimer JW, Ota M, Marson A, Battle A, Pritchard JK. PMID: 37745614; PMCID: PMC10516010.
      View in: PubMed   Mentions:
    21. HIC1 interacts with FOXP3 multi protein complex: Novel pleiotropic mechanisms to regulate human regulatory T cell differentiation and function. Immunol Lett. 2023 11; 263:123-132. Andrabi SBA, Batkulwar K, Bhosale SD, Moulder R, Khan MH, Buchacher T, Khan MM, Arnkil I, Rasool O, Marson A, Kalim UU, Lahesmaa R. PMID: 37838026.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    22. Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein. bioRxiv. 2023 Sep 17. Bevacqua RJ, Zhao W, Merheb E, Kim SH, Marson A, Gloyn AL, Kim SK. PMID: 37745551; PMCID: PMC10516051.
      View in: PubMed   Mentions:
    23. Modular pooled discovery of synthetic knockin sequences to program durable cell therapies. Cell. 2023 09 14; 186(19):4216-4234.e33. Blaeschke F, Chen YY, Apathy R, Daniel B, Chen AY, Chen PA, Sandor K, Zhang W, Li Z, Mowery CT, Yamamoto TN, Nyberg WA, To A, Yu R, Bueno R, Kim MC, Schmidt R, Goodman DB, Feuchtinger T, Eyquem J, Jimmie Ye C, Carnevale J, Satpathy AT, Shifrut E, Roth TL, Marson A. PMID: 37714135; PMCID: PMC10508323.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    24. CRISPR screens decode cancer cell pathways that trigger γδ T cell detection. Nature. 2023 Sep; 621(7977):188-195. Mamedov MR, Vedova S, Freimer JW, Sahu AD, Ramesh A, Arce MM, Meringa AD, Ota M, Chen PA, Hanspers K, Nguyen VQ, Takeshima KA, Rios AC, Pritchard JK, Kuball J, Sebestyen Z, Adams EJ, Marson A. PMID: 37648854; PMCID: PMC11003766.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    25. The lncRNA Malat1 Inhibits miR-15/16 to Enhance Cytotoxic T Cell Activation and Memory Cell Formation. bioRxiv. 2023 Jul 29. Wheeler BD, Gagnon JD, Zhu WS, Muñoz-Sandoval P, Wong SK, Simeonov DR, Li Z, Debarge R, Spitzer MH, Marson A, Ansel KM. PMID: 37547023; PMCID: PMC10401941.
      View in: PubMed   Mentions:
    26. Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes autoimmune disease risk. bioRxiv. 2023 Jun 18. Simeonov DR, Park K, Cortez JT, Young A, Li Z, Nguyen V, Umhoefer J, Indart AC, Woo JM, Anderson MS, Tsang JS, Germain RN, Wong HS, Marson A. PMID: 37503101; PMCID: PMC10370162.
      View in: PubMed   Mentions:
    27. Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes. Nat Biomed Eng. 2023 05; 7(5):647-660. Foss DV, Muldoon JJ, Nguyen DN, Carr D, Sahu SU, Hunsinger JM, Wyman SK, Krishnappa N, Mendonsa R, Schanzer EV, Shy BR, Vykunta VS, Allain V, Li Z, Marson A, Eyquem J, Wilson RC. PMID: 37147433; PMCID: PMC10129304.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    28. Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signaling. bioRxiv. 2023 Mar 15. Lee J, Robinson ME, Sun R, Kume K, Ma N, Cosgun KN, Chan LN, Leveille E, Geng H, Vykunta VS, Shy BR, Marson A, Katz S, Chen J, Paietta E, Meffre E, Vaidehi N, Müschen M. PMID: 36993276; PMCID: PMC10054997.
      View in: PubMed   Mentions:
    29. A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function. Nat Immunol. 2023 04; 24(4):676-689. Lo WL, Kuhlmann M, Rizzuto G, Ekiz HA, Kolawole EM, Revelo MP, Andargachew R, Li Z, Tsai YL, Marson A, Evavold BD, Zehn D, Weiss A. PMID: 36914891; PMCID: PMC10063449.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    30. Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies. Sci Transl Med. 2022 11 09; 14(670):eabm1463. Goodman DB, Azimi CS, Kearns K, Talbot A, Garakani K, Garcia J, Patel N, Hwang B, Lee D, Park E, Vykunta VS, Shy BR, Ye CJ, Eyquem J, Marson A, Bluestone JA, Roybal KT. PMID: 36350984; PMCID: PMC9939256.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    31. Advancing T cell-based cancer therapy with single-cell technologies. Nat Med. 2022 09; 28(9):1761-1764. Bucktrout SL, Banovich NE, Butterfield LH, Cimen-Bozkus C, Giles JR, Good Z, Goodman D, Jonsson VD, Lareau C, Marson A, Maurer DM, Munson PV, Stubbington M, Taylor S, Cutchin A. PMID: 36127419.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    32. High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails. Nat Biotechnol. 2023 04; 41(4):521-531. Shy BR, Vykunta VS, Ha A, Talbot A, Roth TL, Nguyen DN, Pfeifer WG, Chen YY, Blaeschke F, Shifrut E, Vedova S, Mamedov MR, Chung JJ, Li H, Yu R, Wu D, Wolf J, Martin TG, Castro CE, Ye L, Esensten JH, Eyquem J, Marson A. PMID: 36008610; PMCID: PMC10065198.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    33. RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Nature. 2022 09; 609(7925):174-182. Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibañez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A. PMID: 36002574; PMCID: PMC9433322.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    34. A single-cell transcriptional gradient in human cutaneous memory T cells restricts Th17/Tc17 identity. Cell Rep Med. 2022 08 16; 3(8):100715. Cook CP, Taylor M, Liu Y, Schmidt R, Sedgewick A, Kim E, Hailer A, North JP, Harirchian P, Wang H, Kashem SW, Shou Y, McCalmont TC, Benz SC, Choi J, Purdom E, Marson A, Ramos SBV, Cheng JB, Cho RJ. PMID: 35977472; PMCID: PMC9418858.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    35. Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks. Nat Genet. 2022 08; 54(8):1133-1144. Freimer JW, Shaked O, Naqvi S, Sinnott-Armstrong N, Kathiria A, Garrido CM, Chen AF, Cortez JT, Greenleaf WJ, Pritchard JK, Marson A. PMID: 35817986; PMCID: PMC10035359.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    36. Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence. Cancer Cell. 2022 07 11; 40(7):768-786.e7. Belk JA, Yao W, Ly N, Freitas KA, Chen YT, Shi Q, Valencia AM, Shifrut E, Kale N, Yost KE, Duffy CV, Daniel B, Hwee MA, Miao Z, Ashworth A, Mackall CL, Marson A, Carnevale J, Vardhana SA, Satpathy AT. PMID: 35750052; PMCID: PMC9949532.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    37. Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling. Cell Rep. 2022 04 12; 39(2):110690. Johnson JR, Crosby DC, Hultquist JF, Kurland AP, Adhikary P, Li D, Marlett J, Swann J, Hüttenhain R, Verschueren E, Johnson TL, Newton BW, Shales M, Simon VA, Beltrao P, Frankel AD, Marson A, Cox JS, Fregoso OI, Young JAT, Krogan NJ. PMID: 35417684; PMCID: PMC9429972.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    38. A functional map of HIV-host interactions in primary human T cells. Nat Commun. 2022 04 01; 13(1):1752. Hiatt J, Hultquist JF, McGregor MJ, Bouhaddou M, Leenay RT, Simons LM, Young JM, Haas P, Roth TL, Tobin V, Wojcechowskyj JA, Woo JM, Rathore U, Cavero DA, Shifrut E, Nguyen TT, Haas KM, Malik HS, Doudna JA, May AP, Marson A, Krogan NJ. PMID: 35365639; PMCID: PMC8976027.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    39. Obesity alters pathology and treatment response in inflammatory disease. Nature. 2022 04; 604(7905):337-342. Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, Cohen JN, Sturgill JL, Crotty Alexander LE, Suh JM, Liddle C, Atkins AR, Yu RT, Downes M, Liu S, Nikolajczyk BS, Lee IK, Guttman-Yassky E, Ansel KM, Woodruff PG, Fahy JV, Sheppard D, Gallo RL, Ye CJ, Evans RM, Zheng Y, Marson A. PMID: 35355021; PMCID: PMC9165753.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    40. Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage. J Clin Invest. 2022 03 01; 132(5). Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG. PMID: 35077396; PMCID: PMC8884902.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    41. Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression. Mol Cell Proteomics. 2022 04; 21(4):100217. Byrnes JR, Weeks AM, Shifrut E, Carnevale J, Kirkemo L, Ashworth A, Marson A, Wells JA. PMID: 35217172; PMCID: PMC9006863.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    42. CRISPR-Cas9-mediated nuclear transport and genomic integration of nanostructured genes in human primary cells. Nucleic Acids Res. 2022 02 22; 50(3):1256-1268. Lin-Shiao E, Pfeifer WG, Shy BR, Saffari Doost M, Chen E, Vykunta VS, Hamilton JR, Stahl EC, Lopez DM, Sandoval Espinoza CR, Deyanov AE, Lew RJ, Poirer MG, Marson A, Castro CE, Doudna JA. PMID: 35104875; PMCID: PMC8860605.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    43. CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells. Science. 2022 02 11; 375(6581):eabi5965. Liu D, Duan L, Rodda LB, Lu E, Xu Y, An J, Qiu L, Liu F, Looney MR, Yang Z, Allen CDC, Li Z, Marson A, Cyster JG. PMID: 35143305; PMCID: PMC9310086.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    44. CRISPR activation and interference screens decode stimulation responses in primary human T cells. Science. 2022 02 04; 375(6580):eabj4008. Schmidt R, Steinhart Z, Layeghi M, Freimer JW, Bueno R, Nguyen VQ, Blaeschke F, Ye CJ, Marson A. PMID: 35113687; PMCID: PMC9307090.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    45. ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8+ T Cell Effector and Memory Responses. J Immunol. 2022 03 01; 208(5):1155-1169. Sin JH, Kashyap S, Acenas D, Cortez JT, Lee J, Marson A, Matloubian M, Waterfield MR. PMID: 35110421; PMCID: PMC8881383.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    46. Robust T cell activation requires an eIF3-driven burst in T cell receptor translation. Elife. 2021 12 31; 10. De Silva D, Ferguson L, Chin GH, Smith BE, Apathy RA, Roth TL, Blaeschke F, Kudla M, Marson A, Ingolia NT, Cate JH. PMID: 34970966; PMCID: PMC8758144.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    47. PICS2: next-generation fine mapping via probabilistic identification of causal SNPs. Bioinformatics. 2021 09 29; 37(18):3004-3007. Taylor KE, Ansel KM, Marson A, Criswell LA, Farh KK. PMID: 33624747; PMCID: PMC8528038.
      View in: PubMed   Mentions: 17     Fields:    
    48. Genome editing to define the function of risk loci and variants in rheumatic disease. Nat Rev Rheumatol. 2021 08; 17(8):462-474. Baglaenko Y, Macfarlane D, Marson A, Nigrovic PA, Raychaudhuri S. PMID: 34188205; PMCID: PMC10782829.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    49. Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione. Sci Immunol. 2021 06 04; 6(60). Gallman AE, Wolfreys FD, Nguyen DN, Sandy M, Xu Y, An J, Li Z, Marson A, Lu E, Cyster JG. PMID: 34088745; PMCID: PMC8458272.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    50. Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering. Cell Rep. 2021 06 01; 35(9):109207. Hamilton JR, Tsuchida CA, Nguyen DN, Shy BR, McGarrigle ER, Sandoval Espinoza CR, Carr D, Blaeschke F, Marson A, Doudna JA. PMID: 34077734; PMCID: PMC8236216.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
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    100. Generation of knock-in primary human T cells using Cas9 ribonucleoproteins. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10437-42. Schumann K, Lin S, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone JA, Doudna JA, Marson A. PMID: 26216948; PMCID: PMC4547290.
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    101. Genetic basis of autoimmunity. J Clin Invest. 2015 Jun; 125(6):2234-41. Marson A, Housley WJ, Hafler DA. PMID: 26030227; PMCID: PMC4497748.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimals
    102. The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation. Immunity. 2015 Feb 17; 42(2):227-238. DuPage M, Chopra G, Quiros J, Rosenthal WL, Morar MM, Holohan D, Zhang R, Turka L, Marson A, Bluestone JA. PMID: 25680271; PMCID: PMC4347854.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    103. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature. 2015 Feb 19; 518(7539):337-43. Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE. PMID: 25363779; PMCID: PMC4336207.
      View in: PubMed   Mentions: 968     Fields:    Translation:HumansCells
    104. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest. 2014 Jun; 124(6):2513-22. Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA. PMID: 24812667; PMCID: PMC4089462.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    105. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 2014 Apr 17; 40(4):477-89. Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK. PMID: 24745332; PMCID: PMC4066874.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    106. Successful medical management of a Nocardia farcinica multiloculated pontine abscess. BMJ Case Rep. 2013 Dec 05; 2013. Chow FC, Marson A, Liu C. PMID: 24311420; PMCID: PMC3863074.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    107. Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature. 2010 Jan 21; 463(7279):374-8. Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P. PMID: 20090754; PMCID: PMC2943587.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    108. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell. 2008 Aug 08; 134(3):521-33. Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, Hannett N, Sharp PA, Bartel DP, Jaenisch R, Young RA. PMID: 18692474; PMCID: PMC2586071.
      View in: PubMed   Mentions: 795     Fields:    Translation:AnimalsCells
    109. Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell. 2008 Aug 07; 3(2):132-5. Marson A, Foreman R, Chevalier B, Bilodeau S, Kahn M, Young RA, Jaenisch R. PMID: 18682236; PMCID: PMC3235673.
      View in: PubMed   Mentions: 194     Fields:    Translation:HumansAnimalsCells
    110. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature. 2007 Feb 22; 445(7130):931-5. Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von Boehmer H, Young RA. PMID: 17237765; PMCID: PMC3008159.
      View in: PubMed   Mentions: 335     Fields:    Translation:AnimalsCells
    111. PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein. Nat Struct Mol Biol. 2004 Nov; 11(11):1114-21. Daniels MJ, Marson A, Venkitaraman AR. PMID: 15467728.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
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