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Alexander Monto, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
AddressVAMC
San Francisco CA 94121
Phone415-221-4810 ext. 2958
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    University of California, San FranciscoResidency School of Medicine

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    Dr. Monto is a hepatologist and gastroenterologist, a Professor of Clinical Medicine at the University of California, San Francisco, and Director of the Liver Clinic at the San Francisco Veterans Affairs Medical Center. He is also a member of the U.C.S.F. Gastroenterology Faculty Practice on the Moffitt-Long campus. He received his M.D. from Columbia University College of Physicians and Surgeons in New York City, completed his residency in internal medicine at Columbia Presbyterian Medical Center in New York and Massachusetts General Hospital in Boston, MA, and his fellowship in gastroenterology at U.C.S.F.

    He has been involved with the national VA Hepatitis C program since its inception in 2001, helping to organize many national conferences about hepatitis C and liver disease management. He has contributed to VA management recommendations related to hepatitis C, cirrhosis, and liver cancer during that time. He has been a co-author on more than 50 peer-reviewed publications related to liver disease, most of which focus on either hepatitis C disease pathogenesis or liver cancer. He studies how liver disease and cancer are influenced by clinical factors like alcohol use, obesity, HIV, and hepatitis C therapy.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hepatitis C Virus Cure in Human Immunodeficiency Virus Coinfection Dampens Inflammation and Improves Cognition Through Multiple Mechanisms. J Infect Dis. 2020 Jul 06; 222(3):396-406. Sun B, Abadjian L, Monto A, Freasier H, Pulliam L. PMID: 32157304.
      View in: PubMed   Mentions: 1     Fields:    
    2. Ombitasvir/paritaprevir/ritonavir and dasabuvir±ribavirin for chronic HCV infection in US veterans with psychiatric disorders. J Med Virol. 2019 Dec 12. Fuchs M, Monto A, Bräu N, Charafeddine M, Schmidt W, Kozal M, Naggie S, Cheung R, Schnell G, Yu Y, Richards K, Mullally V, Cohen DE, Toro D. PMID: 31829433.
      View in: PubMed   Mentions:    Fields:    
    3. Preoperative Treatment of Hepatitis C Is Associated With Lower Prosthetic Joint Infection Rates in US Veterans. J Arthroplasty. 2019 Jul; 34(7S):S319-S326.e1. Bendich I, Takemoto S, Patterson JT, Monto A, Barber TC, Kuo AC. PMID: 30930157.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Screening for Hepatocellular Carcinoma to Improve Cancer-Related Mortality: Looking Behind When We Should Be Looking Ahead. Gastroenterology. 2019 03; 156(4):1215-1217. Mehta N, Monto A, Yao FY. PMID: 30543796.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    5. Evaluation of an abbreviated screening MRI protocol for patients at risk for hepatocellular carcinoma. Abdom Radiol (NY). 2018 07; 43(7):1627-1633. Lee JY, Huo EJ, Weinstein S, Santos C, Monto A, Corvera CU, Yee J, Hope TA. PMID: 29018942.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    6. Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success. J Immunol. 2018 02 01; 200(3):1124-1132. Méndez-Lagares G, Lu D, Chen C, Terrault N, Segal MR, Khalili M, Monto A, Shen H, Manos MM, Lanier LL, Ryan JC, McCune JM, Hartigan-O'Connor DJ. PMID: 29263212.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Change in Liver Imaging Reporting and Data System Characterization of Focal Liver Lesions Using Gadoxetate Disodium Magnetic Resonance Imaging Compared With Contrast-Enhanced Computed Tomography. J Comput Assist Tomogr. 2017 May/Jun; 41(3):376-381. Hope TA, Aslam R, Weinstein S, Yeh BM, Corvera CU, Monto A, Yee J. PMID: 27801693.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Identifying Drug-Induced Liver Illness (DILI) with Computerized Information Extraction: No More Dilly-Dallying. Dig Dis Sci. 2017 03; 62(3):564-566. Shen H, Monto A. PMID: 27943016.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Multiple arterial phase MRI of arterial hypervascular hepatic lesions: improved arterial phase capture and lesion enhancement. Abdom Radiol (NY). 2017 03; 42(3):870-876. Ikram NS, Yee J, Weinstein S, Yeh BM, Corvera CU, Monto A, Hope TA. PMID: 27770162.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Genetic Variation in the IL-6 and HLA-DQB1 Genes Is Associated with Spontaneous Clearance of Hepatitis C Virus Infection. J Immunol Res. 2016; 2016:6530436. Waldron PR, Belitskaya-Lévy I, Chary A, Won J, Winters M, Monto A, Ryan J, Lazzeroni LC, Holodniy M. PMID: 27340680.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    11. Variation in Treatment Priorities for Chronic Hepatitis C: A Latent Class Analysis. Patient. 2016 06; 9(3):241-9. Fraenkel L, Lim J, Garcia-Tsao G, Reyna V, Monto A, Bridges JF. PMID: 26518200.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    12. Efficacy of Sofosbuvir Plus Ribavirin in Veterans With Hepatitis C Virus Genotype 2 Infection, Compensated Cirrhosis, and Multiple Comorbidities. Clin Gastroenterol Hepatol. 2017 02; 15(2):282-288. Ho SB, Monto A, Peyton A, Kaplan DE, Byrne S, Moon S, Copans A, Rossaro L, Roy A, Le H, Dvory-Sobol H, Zhu Y, Brainard DM, Guyer W, Shaikh O, Fuchs M, Morgan TR. PMID: 27237429.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsCTClinical Trials
    13. Improved Survival Among all Interferon-a-Treated Patients in HCV-002, a Veterans Affairs Hepatitis C Cohort of 2211 Patients, Despite Increased Cirrhosis Among Nonresponders. Dig Dis Sci. 2016 06; 61(6):1744-56. Cozen ML, Ryan JC, Shen H, Cheung R, Kaplan DE, Pocha C, Brau N, Aytaman A, Schmidt WN, Pedrosa M, Anand BS, Chang KM, Morgan T, Monto A. PMID: 27059981.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Examining Hepatitis C Virus Treatment Preference Heterogeneity Using Segmentation Analysis: Treat Now or Defer? J Clin Gastroenterol. 2016 Mar; 50(3):252-7. Fraenkel L, Lim J, Garcia-Tsao G, Reyna V, Monto A. PMID: 26166145.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Commentary: treatment of hepatitis C-related cirrhosis in the era of direct-acting anti-virals - authors' reply. Aliment Pharmacol Ther. 2014 Jun; 39(12):1428. Saxena V, Monto A, Terrault N. PMID: 24849150.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Esophageal varices on computed tomography and subsequent variceal hemorrhage. Abdom Imaging. 2014 Apr; 39(2):251-6. Somsouk M, To'o K, Ali M, Vittinghoff E, Yeh BM, Yee J, Monto A, Inadomi JM, Aslam R. PMID: 24366107.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. Telaprevir or boceprevir triple therapy in patients with chronic hepatitis C and varying severity of cirrhosis. Aliment Pharmacol Ther. 2014 May; 39(10):1213-24. Saxena V, Manos MM, Yee HS, Catalli L, Wayne E, Murphy RC, Shvachko VA, Pauly MP, Chua J, Monto A, Terrault NA. PMID: 24654657.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    18. Expanded use of aggressive therapies improves survival in early and intermediate hepatocellular carcinoma. HPB (Oxford). 2014 Aug; 16(8):758-67. Ho EY, Cozen ML, Shen H, Lerrigo R, Trimble E, Ryan JC, Corvera CU, Monto A. PMID: 24467780.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. Contrast-enhanced CT quantification of the hepatic fractional extracellular space: correlation with diffuse liver disease severity. AJR Am J Roentgenol. 2013 Dec; 201(6):1204-10. Zissen MH, Wang ZJ, Yee J, Aslam R, Monto A, Yeh BM. PMID: 24261358.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    20. Nonresponse to interferon-a based treatment for chronic hepatitis C infection is associated with increased hazard of cirrhosis. PLoS One. 2013; 8(4):e61568. Cozen ML, Ryan JC, Shen H, Lerrigo R, Yee RM, Sheen E, Wu R, Monto A. PMID: 23637856.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    21. Monocyte activation in HIV/HCV coinfection correlates with cognitive impairment. PLoS One. 2013; 8(2):e55776. Rempel H, Sun B, Calosing C, Abadjian L, Monto A, Pulliam L. PMID: 23437063.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    22. Impaired lymphocyte reactivity measured by immune function testing in untransplanted patients with cirrhosis. Clin Vaccine Immunol. 2013 Apr; 20(4):526-9. Yee RM, Lehil MS, Rongey C, Shen H, Cozen ML, Monto A, Ryan JC. PMID: 23389930.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    23. Differential cognitive impairment in HCV coinfected men with controlled HIV compared to HCV monoinfection. J Acquir Immune Defic Syndr. 2013 Feb 01; 62(2):190-6. Sun B, Abadjian L, Rempel H, Monto A, Pulliam L. PMID: 23187938.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    24. Is IL28B genotype associated with more than one aspect of viral clearance? Hepatology. 2012 Dec; 56(6):2414-6. Monto A, Ryan J. PMID: 23212777.
      View in: PubMed   Mentions: 1     Fields:    
    25. Update on the management and treatment of hepatitis C virus infection: recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program Office. Am J Gastroenterol. 2012 May; 107(5):669-89; quiz 690. Yee HS, Chang MF, Pocha C, Lim J, Ross D, Morgan TR, Monto A. PMID: 22525303.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    26. Role of retroviral restriction factors in the interferon-a-mediated suppression of HIV-1 in vivo. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3035-40. Pillai SK, Abdel-Mohsen M, Guatelli J, Skasko M, Monto A, Fujimoto K, Yukl S, Greene WC, Kovari H, Rauch A, Fellay J, Battegay M, Hirschel B, Witteck A, Bernasconi E, Ledergerber B, Günthard HF, Wong JK. PMID: 22315404.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    27. Multi-center evaluation of the Abbott RealTime HCV assay for monitoring patients undergoing antiviral therapy for chronic hepatitis C. J Clin Virol. 2011 Oct; 52(2):133-7. Vermehren J, Yu ML, Monto A, Yao JD, Anderson C, Bertuzis R, Schneider G, Sarrazin C. PMID: 21803650.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    28. Retreatment of hepatitis C with consensus interferon and ribavirin after nonresponse or relapse to pegylated interferon and ribavirin: a national VA clinical practice study. Dig Dis Sci. 2011 Aug; 56(8):2439-48. Yee HS, Currie SL, Tortorice K, Cozen M, Shen H, Chapman S, Cunningham F, Monto A. PMID: 21633833.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Progression of biopsy-measured liver fibrosis in untreated patients with hepatitis C infection: non-Markov multistate model analysis. PLoS One. 2011; 6(5):e20104. Bacchetti P, Boylan R, Astemborski J, Shen H, Mehta SH, Thomas DL, Terrault NA, Monto A. PMID: 21637766.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    30. The human fetal immune response to hepatitis C virus exposure in utero. J Infect Dis. 2011 Jan 15; 203(2):196-206. Babik JM, Cohan D, Monto A, Hartigan-O'Connor DJ, McCune JM. PMID: 21288819.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    31. Evaluation of a new, rapid test for detecting HCV infection, suitable for use with blood or oral fluid. J Virol Methods. 2011 Mar; 172(1-2):27-31. Lee SR, Kardos KW, Schiff E, Berne CA, Mounzer K, Banks AT, Tatum HA, Friel TJ, Demicco MP, Lee WM, Eder SE, Monto A, Yearwood GD, Guillon GB, Kurtz LA, Fischl M, Unangst JL, Kriebel L, Feiss G, Roehler M. PMID: 21182871.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    32. Periprocedural complications by Child-Pugh class in patients undergoing transcatheter arterial embolization or chemoembolization to treat unresectable hepatocellular carcinoma at a VA medical center. Am J Surg. 2010 Nov; 200(5):659-64. Russell JS, Sawhney R, Monto A, Nanavati S, Davoren JB, Aslam R, Corvera CU. PMID: 21056149.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Non-Markov multistate modeling using time-varying covariates, with application to progression of liver fibrosis due to hepatitis C following liver transplant. Int J Biostat. 2010 Feb 20; 6(1):Article 7. Bacchetti P, Boylan RD, Terrault NA, Monto A, Berenguer M. PMID: 20305705.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. Lessons from HIV therapy applied to viral hepatitis therapy: summary of a workshop. Am J Gastroenterol. 2010 May; 105(5):989-1004; quiz 988, 1005. Monto A, Schooley RT, Lai JC, Sulkowski MS, Chung RT, Pawlotsky JM, McHutchison JG, Jacobson IM. PMID: 20087331.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    35. Cost-effectiveness of hepatitis A vaccination for individuals with chronic hepatitis C. Vaccine. 2010 Feb 17; 28(7):1726-31. Chapko MK, Yee HS, Monto A, Dominitz JA. PMID: 20044051.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    36. Association of hepatitis C virus seropositivity with inflammatory markers and heart failure in persons with coronary heart disease: data from the Heart and Soul study. J Card Fail. 2009 Jun; 15(5):451-6. Tsui JI, Whooley MA, Monto A, Seal K, Tien PC, Shlipak M. PMID: 19477406.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    37. Hepatocellular carcinoma after sustained virologic response in hepatitis C patients without cirrhosis on a pretreatment liver biopsy. Eur J Gastroenterol Hepatol. 2009 Feb; 21(2):225-9. Sewell JL, Stick KM, Monto A. PMID: 19212213.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    38. Efficacy and safety of peginterferon alfa-2a/ribavirin in methadone maintenance patients: randomized comparison of direct observed therapy and self-administration. Am J Gastroenterol. 2008 Nov; 103(11):2757-65. Bonkovsky HL, Tice AD, Yapp RG, Bodenheimer HC, Monto A, Rossi SJ, Sulkowski MS. PMID: 18684176.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    39. Liver disease in injection drug users with hepatitis C, with and without HIV coinfection. J Addict Dis. 2008; 27(2):49-59. Monto A, Currie S, Wright TL. PMID: 18681191.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    40. Implementation of a multidisciplinary treatment team for hepatocellular cancer at a Veterans Affairs Medical Center improves survival. HPB (Oxford). 2008; 10(6):405-11. Chang TT, Sawhney R, Monto A, Davoren JB, Kirkland JG, Stewart L, Corvera CU. PMID: 19088925.
      View in: PubMed   Mentions: 16     Fields:    
    41. A prospective study to examine persistent HCV reinfection in injection drug users who have previously cleared the virus. Drug Alcohol Depend. 2008 Jan 11; 93(1-2):148-54. Currie SL, Ryan JC, Tracy D, Wright TL, George S, McQuaid R, Kim M, Shen H, Monto A. PMID: 17977668.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    42. The association of human immunodeficiency virus infection with spontaneously resolved hepatitis C virus infection and level of viremia among injection drug users. Dig Dis Sci. 2007 Dec; 52(12):3423-30. Seal KH, Monto A, Dove L, Shen H, Vittinghoff E, Tracy D, Miller E, Lau E, Wright TL. PMID: 17443407.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    43. Contributions to hepatic fibrosis in HIV-HCV coinfected and HCV monoinfected patients. Am J Gastroenterol. 2006 Jul; 101(7):1509-15. Monto A, Kakar S, Dove LM, Bostrom A, Miller EL, Wright TL. PMID: 16863554.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    44. Natural history of patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplantation. Am J Transplant. 2006 Jul; 6(7):1600-8. Hui CK, Lau E, Monto A, Kim M, Luk JM, Poon RT, Leung N, Lo CM, Fan ST, Lau GK, Wright TL. PMID: 16827860.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    45. Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C. Gastroenterology. 2006 May; 130(6):1679-87. Huang H, Shiffman ML, Cheung RC, Layden TJ, Friedman S, Abar OT, Yee L, Chokkalingam AP, Schrodi SJ, Chan J, Catanese JJ, Leong DU, Ross D, Hu X, Monto A, McAllister LB, Broder S, White T, Sninsky JJ, Wright TL. PMID: 16697732.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    46. Viral evolution of hepatitis C in injection drug users. J Viral Hepat. 2005 Nov; 12(6):574-83. Dove L, Phung Y, Bzowej N, Kim M, Monto A, Wright TL. PMID: 16255758.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    47. Fibrosis progression in chronic hepatitis C patients with occult hepatitis B co-infection. J Clin Virol. 2006 Feb; 35(2):185-92. Hui CK, Lau E, Wu H, Monto A, Kim M, Luk JM, Lau GK, Wright TL. PMID: 16103008.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    48. Hepatic steatosis in HIV/hepatitis C coinfection: prevalence and significance compared with hepatitis C monoinfection. Hepatology. 2005 Aug; 42(2):310-6. Monto A, Dove LM, Bostrom A, Kakar S, Tien PC, Wright TL. PMID: 16025515.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    49. Risks of a range of alcohol intake on hepatitis C-related fibrosis. Hepatology. 2004 Mar; 39(3):826-34. Monto A, Patel K, Bostrom A, Pianko S, Pockros P, McHutchison JG, Wright TL. PMID: 14999703.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    50. Outcomes of interferon alpha and ribavirin treatment for chronic hepatitis C in patients with normal serum aminotransaminases. Gut. 2003 Nov; 52(11):1644-8. Hui CK, Monto A, Belaye T, Lau E, Wright TL. PMID: 14570736.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    51. Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcohol. Hepatology. 2002 Sep; 36(3):729-36. Monto A, Alonzo J, Watson JJ, Grunfeld C, Wright TL. PMID: 12198667.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    52. Hepatitis C and steatosis. Semin Gastrointest Dis. 2002 Jan; 13(1):40-6. Monto A. PMID: 11944633.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    53. The epidemiology and prevention of hepatocellular carcinoma. Semin Oncol. 2001 Oct; 28(5):441-9. Monto A, Wright TL. PMID: 11685737.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    54. Mutations in the NS5A region do not predict interferon-responsiveness in american patients infected with genotype 1b hepatitis C virus. J Med Virol. 1999 Aug; 58(4):353-8. Chung RT, Monto A, Dienstag JL, Kaplan LM. PMID: 10421401.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
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