Alexandra Nelson, MD, PhD

Title(s)Associate Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone--
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


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    Striatal Mechanisms of Levodopa-Induced Dyskinesia
    NIH R01NS101354Jul 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Optogenetic dissection of striatal circuits in a mouse model of human dystonia
    NIH K08NS081001Sep 1, 2012 - Nov 30, 2017
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Therapeutic deep brain stimulation disrupts movement-related subthalamic nucleus activity in Parkinsonian mice. Elife. 2022 Jul 04; 11. Schor JS, Gonzalez Montalvo I, Spratt PWE, Brakaj RJ, Stansil JA, Twedell EL, Bender KJ, Nelson AB. PMID: 35786442.
      View in: PubMed   Mentions:    Fields:    
    2. Striatal Indirect Pathway Dysfunction Underlies Motor Deficits in a Mouse Model of Paroxysmal Dyskinesia. J Neurosci. 2022 03 30; 42(13):2835-2848. Nelson AB, Girasole AE, Lee HY, Ptácek LJ, Kreitzer AC. PMID: 35165171; PMCID: PMC8973425.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning. Proc Natl Acad Sci U S A. 2021 09 14; 118(37). Schonewille M, Girasole AE, Rostaing P, Mailhes-Hamon C, Ayon A, Nelson AB, Triller A, Casado M, De Zeeuw CI, Bouvier G. PMID: 34507990; PMCID: PMC8449340.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    4. Frontostriatal Projections Regulate Innate Avoidance Behavior. J Neurosci. 2021 06 23; 41(25):5487-5501. Loewke AC, Minerva AR, Nelson AB, Kreitzer AC, Gunaydin LA. PMID: 34001628; PMCID: PMC8221601.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    5. Directly to the Point: Dopamine Persistently Enhances Excitability of Direct Pathway Striatal Neurons. Neuron. 2020 04 22; 106(2):201-203. McGregor MM, Nelson AB. PMID: 32325053.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. A diagnostic ceiling for exome sequencing in cerebellar ataxia and related neurological disorders. Hum Mutat. 2020 02; 41(2):487-501. Ngo KJ, Rexach JE, Lee H, Petty LE, Perlman S, Valera JM, Deignan JL, Mao Y, Aker M, Posey JE, Jhangiani SN, Coban-Akdemir ZH, Boerwinkle E, Muzny D, Nelson AB, Hassin-Baer S, Poke G, Neas K, Geschwind MD, Grody WW, Gibbs R, Geschwind DH, Lupski JR, Below JE, Nelson SF, Fogel BL. PMID: 31692161; PMCID: PMC7182470.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    7. Functionally Distinct Connectivity of Developmentally Targeted Striosome Neurons. Cell Rep. 2019 11 05; 29(6):1419-1428.e5. McGregor MM, McKinsey GL, Girasole AE, Bair-Marshall CJ, Rubenstein JLR, Nelson AB. PMID: 31693884; PMCID: PMC6866662.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    8. Multiple stimulation parameters influence efficacy of deep brain stimulation in parkinsonian mice. J Clin Invest. 2019 06 13; 129(9):3833-3838. Schor JS, Nelson AB. PMID: 31194696; PMCID: PMC6715414.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    9. Circuit Mechanisms of Parkinson's Disease. Neuron. 2019 03 20; 101(6):1042-1056. McGregor MM, Nelson AB. PMID: 30897356.
      View in: PubMed   Mentions: 79     Fields:    Translation:Humans
    10. Aberrant Striatal Activity in Parkinsonism and Levodopa-Induced Dyskinesia. Cell Rep. 2018 06 19; 23(12):3438-3446.e5. Ryan MB, Bair-Marshall C, Nelson AB. PMID: 29924988; PMCID: PMC6407866.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    11. Expanding the global prevalence of spinocerebellar ataxia type 42. Neurol Genet. 2018 Jun; 4(3):e232. Ngo K, Aker M, Petty LE, Chen J, Cavalcanti F, Nelson AB, Hassin-Baer S, Geschwind MD, Perlman S, Italiano D, Laganà A, Cavallaro S, Coppola G, Below JE, Fogel BL. PMID: 29629410; PMCID: PMC5886831.
      View in: PubMed   Mentions: 8  
    12. A Subpopulation of Striatal Neurons Mediates Levodopa-Induced Dyskinesia. Neuron. 2018 02 21; 97(4):787-795.e6. Girasole AE, Lum MY, Nathaniel D, Bair-Marshall CJ, Guenthner CJ, Luo L, Kreitzer AC, Nelson AB. PMID: 29398356; PMCID: PMC6233726.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    13. 500 Fronto-Striatal Modulation of Anxiety-Like Behaviors. Biological Psychiatry. 2017 May 1; 81(10):s203. Gunaydin GL, Nelson NA, Kreitzer KA. .
      View in: Publisher Site   Mentions:
    14. BK Channels Are Required for Multisensory Plasticity in the Oculomotor System. Neuron. 2017 Jan 04; 93(1):211-220. Nelson AB, Faulstich M, Moghadam S, Onori K, Meredith A, du Lac S. PMID: 27989457; PMCID: PMC5575767.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    15. Parkinsonism Driven by Antipsychotics Originates from Dopaminergic Control of Striatal Cholinergic Interneurons. Neuron. 2016 07 06; 91(1):67-78. Kharkwal G, Brami-Cherrier K, Lizardi-Ortiz JE, Nelson AB, Ramos M, Del Barrio D, Sulzer D, Kreitzer AC, Borrelli E. PMID: 27387649; PMCID: PMC4939839.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    16. Pearls & Oy-sters: Episodic ataxia type 2: Case report and review of the literature. Neurology. 2016 06 07; 86(23):e239-41. Guterman EL, Yurgionas B, Nelson AB. PMID: 27272039; PMCID: PMC4898315.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    17. Bridging the Gap: Muscarinic M4 Receptors Promote Striatal Plasticity in Health and Disease. Neuron. 2015 Nov 18; 88(4):621-3. Girasole AE, Nelson AB. PMID: 26590337.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    18. Probing striatal microcircuitry to understand the functional role of cholinergic interneurons. Mov Disord. 2015 Sep; 30(10):1306-18. Girasole AE, Nelson AB. PMID: 26227561; PMCID: PMC5942899.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    19. Striatal cholinergic neurotransmission requires VGLUT3. J Neurosci. 2014 Jun 25; 34(26):8772-7. Nelson AB, Bussert TG, Kreitzer AC, Seal RP. PMID: 24966377; PMCID: PMC4069355.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    20. Striatal cholinergic interneurons Drive GABA release from dopamine terminals. Neuron. 2014 Apr 02; 82(1):63-70. Nelson AB, Hammack N, Yang CF, Shah NM, Seal RP, Kreitzer AC. PMID: 24613418; PMCID: PMC3976769.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    21. Reassessing models of basal ganglia function and dysfunction. Annu Rev Neurosci. 2014; 37:117-35. Nelson AB, Kreitzer AC. PMID: 25032493; PMCID: PMC4416475.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimals
    22. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol. 2013 Sep 01; 70(9):1158-66. Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L. PMID: 23835471; PMCID: PMC4013391.
      View in: PubMed   Mentions: 230     Fields:    Translation:Humans
    23. Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. PLoS One. 2012; 7(7):e40555. Andrews-Zwilling Y, Gillespie AK, Kravitz AV, Nelson AB, Devidze N, Lo I, Yoon SY, Bien-Ly N, Ring K, Zwilling D, Potter GB, Rubenstein JL, Kreitzer AC, Huang Y. PMID: 22792368; PMCID: PMC3390383.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    24. A comparison of striatal-dependent behaviors in wild-type and hemizygous Drd1a and Drd2 BAC transgenic mice. J Neurosci. 2012 Jul 04; 32(27):9119-23. Nelson AB, Hang GB, Grueter BA, Pascoli V, Luscher C, Malenka RC, Kreitzer AC. PMID: 22764221; PMCID: PMC3420343.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    25. Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. Alzheimer's & Dementia. 2012 Jul 1; 8(4):s747. Andrews-Zwilling AY, Gillespie GA, Kravitz KA, Nelson NA, Devidze DN, Lo LI, Yoon YS, Bien-Ly BN, Ring RK, Zwilling ZD, Potter PG, Rubenstein RJ, Kreitzer KA, Huang HY. .
      View in: Publisher Site   Mentions:
    26. Distinct roles of GABAergic interneurons in the regulation of striatal output pathways. J Neurosci. 2010 Feb 10; 30(6):2223-34. Gittis AH, Nelson AB, Thwin MT, Palop JJ, Kreitzer AC. PMID: 20147549; PMCID: PMC2836801.
      View in: PubMed   Mentions: 190     Fields:    Translation:AnimalsCells
    27. Speech-activated myoclonus masquerading as stuttering. Neurology. 2009 Jun 02; 72(22):1964. Gelfand JM, Nelson AB, Fross RD, Glass GA. PMID: 19487657.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons. Neuron. 2005 May 19; 46(4):623-31. Nelson AB, Gittis AH, du Lac S. PMID: 15944130.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    29. Long-lasting increases in intrinsic excitability triggered by inhibition. Neuron. 2003 Oct 30; 40(3):609-20. Nelson AB, Krispel CM, Sekirnjak C, du Lac S. PMID: 14642283.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    30. Regulation of firing response gain by calcium-dependent mechanisms in vestibular nucleus neurons. J Neurophysiol. 2002 Apr; 87(4):2031-42. Smith MR, Nelson AB, Du Lac S. PMID: 11929921.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
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