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Alina Guna, PhD

Photo of Alina Guna, PhD
Title(s)Assistant Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th Street, #N312E
San Francisco CA 94158
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    Collapse Biography 
    Collapse education and training
    University of Cambridge, Cambridge, UKPhD07/2018Cell Biology
    University of Toronto, Toronto, CanadaBSc07/2014Neuroscience

    Collapse Overview 
    Collapse overview
    The Guna lab focuses on how proteins get made in human cells. We use a combination of functional genomics and biochemistry to understand the molecular mechanisms that govern protein homeostasis in various organelles and across cell types.
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Monitoring alpha-helical membrane protein insertion into the outer mitochondrial membrane in mammalian cells. Methods Enzymol. 2024; 707:63-99. Hazu M, Guna A, Stevens TA, Voorhees RM. PMID: 39488394.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins. Mol Cell. 2024 Sep 05; 84(17):3302-3319.e11. Page KR, Nguyen VN, Pleiner T, Tomaleri GP, Wang ML, Guna A, Hazu M, Wang TY, Chou TF, Voorhees RM. PMID: 39173640.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    3. Author Correction: Macromolecular condensation buffers intracellular water potential. Nature. 2024 Apr; 628(8009):E4. Watson JL, Seinkmane E, Styles CT, Mihut A, Krüger LK, McNally KE, Planelles-Herrero VJ, Dudek M, McCall PM, Barbiero S, Vanden Oever M, Peak-Chew SY, Porebski BT, Zeng A, Rzechorzek NM, Wong DCS, Beale AD, Stangherlin A, Riggi M, Iwasa J, Morf J, Miliotis C, Guna A, Inglis AJ, Brugués J, Voorhees RM, Chambers JE, Meng QJ, O'Neill JS, Edgar RS, Derivery E. PMID: 38589575; PMCID: PMC11041646.
      View in: PubMed   Mentions:    Fields:    
    4. Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology. Mol Cell. 2024 Mar 21; 84(6):1101-1119.e9. Muthukumar G, Stevens TA, Inglis AJ, Esantsi TK, Saunders RA, Schulte F, Voorhees RM, Guna A, Weissman JS. PMID: 38428433.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    5. Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins. bioRxiv. 2023 Nov 29. Page KR, Nguyen VN, Pleiner T, Tomaleri GP, Wang ML, Guna A, Wang TY, Chou TF, Voorhees RM. PMID: 38076791; PMCID: PMC10705394.
      View in: PubMed   Mentions:
    6. A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens. BMC Genomics. 2023 Oct 30; 24(1):651. Guna A, Page KR, Replogle JM, Esantsi TK, Wang ML, Weissman JS, Voorhees RM. PMID: 37904134; PMCID: PMC10614335.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    7. Macromolecular condensation buffers intracellular water potential. Nature. 2023 11; 623(7988):842-852. Watson JL, Seinkmane E, Styles CT, Mihut A, Krüger LK, McNally KE, Planelles-Herrero VJ, Dudek M, McCall PM, Barbiero S, Vanden Oever M, Peak-Chew SY, Porebski BT, Zeng A, Rzechorzek NM, Wong DCS, Beale AD, Stangherlin A, Riggi M, Iwasa J, Morf J, Miliotis C, Guna A, Inglis AJ, Brugués J, Voorhees RM, Chambers JE, Meng QJ, O'Neill JS, Edgar RS, Derivery E. PMID: 37853127; PMCID: PMC10665201.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    8. Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology. bioRxiv. 2023 Aug 17. Muthukumar G, Stevens TA, Inglis AJ, Esantsi TK, Saunders RA, Schulte F, Voorhees RM, Guna A, Weissman JS. PMID: 37645817; PMCID: PMC10462106.
      View in: PubMed   Mentions:
    9. A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens. bioRxiv. 2023 Aug 14. Guna A, Page KR, Replogle JM, Esantsi TK, Wang ML, Weissman JS, Voorhees RM. PMID: 36711738; PMCID: PMC9882262.
      View in: PubMed   Mentions:
    10. Coupled protein quality control during nonsense-mediated mRNA decay. J Cell Sci. 2023 05 15; 136(10). Inglis AJ, Guna A, Gálvez-Merchán Á, Pal A, Esantsi TK, Keys HR, Frenkel EM, Oania R, Weissman JS, Voorhees RM. PMID: 37218462; PMCID: PMC10234110.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    11. A genome-wide optical pooled screen reveals regulators of cellular antiviral responses. Proc Natl Acad Sci U S A. 2023 04 18; 120(16):e2210623120. Carlson RJ, Leiken MD, Guna A, Hacohen N, Blainey PC. PMID: 37043539; PMCID: PMC10120039.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    12. A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum. Cold Spring Harb Perspect Biol. 2023 03 01; 15(3). Guna A, Hazu M, Pinton Tomaleri G, Voorhees RM. PMID: 36041783; PMCID: PMC9979854.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    13. Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors. Elife. 2022 12 28; 11. Replogle JM, Bonnar JL, Pogson AN, Liem CR, Maier NK, Ding Y, Russell BJ, Wang X, Leng K, Guna A, Norman TM, Pak RA, Ramos DM, Ward ME, Gilbert LA, Kampmann M, Weissman JS, Jost M. PMID: 36576240; PMCID: PMC9829409.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    14. MTCH2 is a mitochondrial outer membrane protein insertase. Science. 2022 10 21; 378(6617):317-322. Guna A, Stevens TA, Inglis AJ, Replogle JM, Esantsi TK, Muthukumar G, Shaffer KCL, Wang ML, Pogson AN, Jones JJ, Lomenick B, Chou TF, Weissman JS, Voorhees RM. PMID: 36264797; PMCID: PMC9674023.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    15. Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq. Cell. 2022 07 07; 185(14):2559-2575.e28. Replogle JM, Saunders RA, Pogson AN, Hussmann JA, Lenail A, Guna A, Mascibroda L, Wagner EJ, Adelman K, Lithwick-Yanai G, Iremadze N, Oberstrass F, Lipson D, Bonnar JL, Jost M, Norman TM, Weissman JS. PMID: 35688146; PMCID: PMC9380471.
      View in: PubMed   Mentions: 261     Fields:    
    16. Publisher Correction: Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology. Nat Commun. 2021 Nov 24; 12(1):6988. Stangherlin A, Watson JL, Wong DCS, Barbiero S, Zeng A, Seinkmane E, Chew SP, Beale AD, Hayter EA, Guna A, Inglis AJ, Putker M, Bartolami E, Matile S, Lequeux N, Pons T, Day J, van Ooijen G, Voorhees RM, Bechtold DA, Derivery E, Edgar RS, Newham P, O'Neill JS. PMID: 34819501; PMCID: PMC8613194.
      View in: PubMed   Mentions: 4     Fields:    
    17. Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology. Nat Commun. 2021 10 15; 12(1):6035. Stangherlin A, Watson JL, Wong DCS, Barbiero S, Zeng A, Seinkmane E, Chew SP, Beale AD, Hayter EA, Guna A, Inglis AJ, Putker M, Bartolami E, Matile S, Lequeux N, Pons T, Day J, van Ooijen G, Voorhees RM, Bechtold DA, Derivery E, Edgar RS, Newham P, O'Neill JS. PMID: 34654800; PMCID: PMC8520019.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    18. WNK1 is an assembly factor for the human ER membrane protein complex. Mol Cell. 2021 07 01; 81(13):2693-2704.e12. Pleiner T, Hazu M, Tomaleri GP, Januszyk K, Oania RS, Sweredoski MJ, Moradian A, Guna A, Voorhees RM. PMID: 33964204; PMCID: PMC8254792.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    19. Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex. Cell Rep. 2020 03 17; 30(11):3691-3698.e5. Inglis AJ, Page KR, Guna A, Voorhees RM. PMID: 32187542; PMCID: PMC7147533.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    20. EMC Is Required to Initiate Accurate Membrane Protein Topogenesis. Cell. 2018 11 29; 175(6):1507-1519.e16. Chitwood PJ, Juszkiewicz S, Guna A, Shao S, Hegde RS. PMID: 30415835; PMCID: PMC6269167.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    21. Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control. Curr Biol. 2018 04 23; 28(8):R498-R511. Guna A, Hegde RS. PMID: 29689233.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    22. Elucidating the diagnostic odyssey of 22q11.2 deletion syndrome. Am J Med Genet A. 2018 04; 176(4):936-944. Palmer LD, Butcher NJ, Boot E, Hodgkinson KA, Heung T, Chow EWC, Guna A, Crowley TB, Zackai E, McDonald-McGinn DM, Bassett AS. PMID: 29575622; PMCID: PMC5873609.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    23. The ER membrane protein complex is a transmembrane domain insertase. Science. 2018 01 26; 359(6374):470-473. Guna A, Volkmar N, Christianson JC, Hegde RS. PMID: 29242231; PMCID: PMC5788257.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansCells
    24. Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms. J Neurodev Disord. 2015; 7(1):18. Guna A, Butcher NJ, Bassett AS. PMID: 26137170; PMCID: PMC4487986.
      View in: PubMed   Mentions: 67     Fields:    
    25. Response to clozapine in a clinically identifiable subtype of schizophrenia. Br J Psychiatry. 2015 Jun; 206(6):484-91. Butcher NJ, Fung WL, Fitzpatrick L, Guna A, Andrade DM, Lang AE, Chow EW, Bassett AS. PMID: 25745132; PMCID: PMC4459828.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
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