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Amnon Sharir, PhD, DVM

Title(s)Assistant Professor, Orofacial Sciences
SchoolSchool of Dentistry
Phone415-476-4720
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    Collapse Research 
    Collapse Research Activities and Funding
    Incisor stem cell dynamics in homeostasis and repair
    NIH/NIDCR K08DE026219Aug 1, 2016 - Aug 31, 2021
    Role: Principal Investigator
    The Role of RAS/MAPK Signaling in Alveolar Process Development
    NIH/NIDCR F32DE023702Sep 1, 2013 - Aug 31, 2016
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sharir A, Marangoni P, Zilionis R, Wan M, Wald T, Hu JK, Kawaguchi K, Castillo-Azofeifa D, Epstein L, Harrington K, Pagella P, Mitsiadis T, Siebel CW, Klein AM, Klein OD. A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage. Nat Cell Biol. 2019 09; 21(9):1102-1112. PMID: 31481792.
      View in: PubMed
    2. Ransom RC, Carter AC, Salhotra A, Leavitt T, Marecic O, Murphy MP, Lopez ML, Wei Y, Marshall CD, Shen EZ, Jones RE, Sharir A, Klein OD, Chan CKF, Wan DC, Chang HY, Longaker MT. Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration. Nature. 2018 11; 563(7732):514-521. PMID: 30356216.
      View in: PubMed
    3. Ching ST, Infante CR, Du W, Sharir A, Park S, Menke DB, Klein OD. Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a. Hum Mol Genet. 2018 01 01; 27(1):107-119. PMID: 29126155.
      View in: PubMed
    4. Sharir A, Klein OD. Watching a deep dive: Live imaging provides lessons about tooth invagination. J Cell Biol. 2016 09 12; 214(6):645-7. PMID: 27621361.
      View in: PubMed
    5. Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM. Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome. J Neurosci. 2016 Jan 06; 36(1):142-52. PMID: 26740656.
      View in: PubMed
    6. Stern T, Aviram R, Rot C, Galili T, Sharir A, Kalish Achrai N, Keller Y, Shahar R, Zelzer E. Isometric Scaling in Developing Long Bones Is Achieved by an Optimal Epiphyseal Growth Balance. PLoS Biol. 2015 Aug; 13(8):e1002212. PMID: 26241802.
      View in: PubMed
    7. Tapaltsyan V, Eronen JT, Lawing AM, Sharir A, Janis C, Jernvall J, Klein OD. Continuously growing rodent molars result from a predictable quantitative evolutionary change over 50 million years. Cell Rep. 2015 May 05; 11(5):673-80. PMID: 25921530.
      View in: PubMed
    8. Bauer O, Sharir A, Kimura A, Hantisteanu S, Takeda S, Groner Y. Loss of osteoblast Runx3 produces severe congenital osteopenia. Mol Cell Biol. 2015 Apr; 35(7):1097-109. PMID: 25605327.
      View in: PubMed
    9. Goodwin AF, Tidyman WE, Jheon AH, Sharir A, Zheng X, Charles C, Fagin JA, McMahon M, Diekwisch TG, Ganss B, Rauen KA, Klein OD. Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation. Hum Mol Genet. 2014 Feb 01; 23(3):682-92. PMID: 24057668.
      View in: PubMed
    10. Blitz E, Sharir A, Akiyama H, Zelzer E. Tendon-bone attachment unit is formed modularly by a distinct pool of Scx- and Sox9-positive progenitors. Development. 2013 Jul; 140(13):2680-90. PMID: 23720048.
      View in: PubMed
    11. Sharir A, Milgram J, Dubnov-Raz G, Zelzer E, Shahar R. A temporary decrease in mineral density in perinatal mouse long bones. Bone. 2013 Jan; 52(1):197-205. PMID: 23044045.
      View in: PubMed
    12. Sharir A, Stern T, Rot C, Shahar R, Zelzer E. Muscle force regulates bone shaping for optimal load-bearing capacity during embryogenesis. Development. 2011 Aug; 138(15):3247-59. PMID: 21750035.
      View in: PubMed
    13. Sharir A, Israeli D, Milgram J, Currey JD, Monsonego-Ornan E, Shahar R. The canine baculum: the structure and mechanical properties of an unusual bone. J Struct Biol. 2011 Sep; 175(3):451-6. PMID: 21708270.
      View in: PubMed
    14. Sharir A, Ramniceanu G, Brumfeld V. High resolution 3D imaging of ex-vivo biological samples by micro CT. J Vis Exp. 2011 Jun 21; (52). PMID: 21712803.
      View in: PubMed
    15. Sharir A, Zelzer E. Tendon homeostasis: the right pull. Curr Biol. 2011 Jun 21; 21(12):R472-4. PMID: 21683902.
      View in: PubMed
    16. Mahamid J, Sharir A, Gur D, Zelzer E, Addadi L, Weiner S. Bone mineralization proceeds through intracellular calcium phosphate loaded vesicles: a cryo-electron microscopy study. J Struct Biol. 2011 Jun; 174(3):527-35. PMID: 21440636.
      View in: PubMed
    17. Lyashenko N, Weissenböck M, Sharir A, Erben RG, Minami Y, Hartmann C. Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded. Dev Dyn. 2010 Aug; 239(8):2266-77. PMID: 20593419.
      View in: PubMed
    18. Vandoorne K, Magland J, Plaks V, Sharir A, Zelzer E, Wehrli F, Hemmings BA, Harmelin A, Neeman M. Bone vascularization and trabecular bone formation are mediated by PKB alpha/Akt1 in a gene-dosage-dependent manner: in vivo and ex vivo MRI. Magn Reson Med. 2010 Jul; 64(1):54-64. PMID: 20572141.
      View in: PubMed
    19. Blitz E, Viukov S, Sharir A, Shwartz Y, Galloway JL, Pryce BA, Johnson RL, Tabin CJ, Schweitzer R, Zelzer E. Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell. 2009 Dec; 17(6):861-73. PMID: 20059955.
      View in: PubMed
    20. Vicki Plaks, Elina Berkovitz, Katrien Vandoorne, Amnon Sharir, Elazar Zelzer, Felix W. Wehrli, Nava Dekel, Brian A. Hemmings, Michal Neeman, Alon Harmelin. Vascular function and growth is differentially regulated by fetal and placental PKBalpha/Akt1 in a gene dosage dependent manner: Non-invasive dynamic contrast enhanced MRI. Developmental Biology. 2009 Jul 1; 331(2):499.
      View in: Publisher Site
    21. Kahn J, Shwartz Y, Blitz E, Krief S, Sharir A, Breitel DA, Rattenbach R, Relaix F, Maire P, Rountree RB, Kingsley DM, Zelzer E. Muscle contraction is necessary to maintain joint progenitor cell fate. Dev Cell. 2009 May; 16(5):734-43. PMID: 19460349.
      View in: PubMed
    22. Chattah NL, Sharir A, Weiner S, Shahar R. Determining the elastic modulus of mouse cortical bone using electronic speckle pattern interferometry (ESPI) and micro computed tomography: a new approach for characterizing small-bone material properties. Bone. 2009 Jul; 45(1):84-90. PMID: 19332167.
      View in: PubMed
    23. Shipov A, Sharir A, Zelzer E, Milgram J, Monsonego-Ornan E, Shahar R. The influence of severe prolonged exercise restriction on the mechanical and structural properties of bone in an avian model. Vet J. 2010 Feb; 183(2):153-60. PMID: 19135394.
      View in: PubMed
    24. Shivtiel S, Kollet O, Lapid K, Schajnovitz A, Goichberg P, Kalinkovich A, Shezen E, Tesio M, Netzer N, Petit I, Sharir A, Lapidot T. CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules. J Exp Med. 2008 Sep 29; 205(10):2381-95. PMID: 18779349.
      View in: PubMed
    25. Mahamid J, Sharir A, Addadi L, Weiner S. Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12748-53. PMID: 18753619.
      View in: PubMed
    26. Reich A, Sharir A, Zelzer E, Hacker L, Monsonego-Ornan E, Shahar R. The effect of weight loading and subsequent release from loading on the postnatal skeleton. Bone. 2008 Oct; 43(4):766-74. PMID: 18619566.
      View in: PubMed
    27. Barak MM, Sharir A, Shahar R. Optical metrology methods for mechanical testing of whole bones. Vet J. 2009 Apr; 180(1):7-14. PMID: 18291692.
      View in: PubMed
    28. Sharir A, Barak MM, Shahar R. Whole bone mechanics and mechanical testing. Vet J. 2008 Jul; 177(1):8-17. PMID: 17986396.
      View in: PubMed
    29. Amarilio R, Viukov SV, Sharir A, Eshkar-Oren I, Johnson RS, Zelzer E. HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development. 2007 Nov; 134(21):3917-28. PMID: 17913788.
      View in: PubMed
    30. Sharir A, Milgram J, Shahar R. Structural and functional anatomy of the neck musculature of the dog (Canis familiaris). J Anat. 2006 Mar; 208(3):331-51. PMID: 16533316.
      View in: PubMed