Amy Weeks, PhD

TitlePostdoctoral Scholar
InstitutionUniversity of California San Francisco
DepartmentPharmaceutical Chemistry
Address1700 4th Street
San Francisco CA 94158
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    1. Weeks AM, Wang N, Pelton JG, Chang MCY. Entropy drives selective fluorine recognition in the fluoroacetyl-CoA thioesterase from Streptomyces cattleya. Proc Natl Acad Sci U S A. 2018 Mar 06; 115(10):E2193-E2201. PMID: 29453276.
      View in: PubMed
    2. Weeks AM, Wells JA. Engineering peptide ligase specificity by proteomic identification of ligation sites. Nat Chem Biol. 2018 Jan; 14(1):50-57. PMID: 29155430.
      View in: PubMed
    3. Lin S, Yang X, Jia S, Weeks AM, Hornsby M, Lee PS, Nichiporuk RV, Iavarone AT, Wells JA, Toste FD, Chang CJ. Redox-based reagents for chemoselective methionine bioconjugation. Science. 2017 02 10; 355(6325):597-602. PMID: 28183972.
      View in: PubMed
    4. Weeks, AM, Keddie, NS, Wadoux, RD, O'Hagan, D, Chang, MC.Molecular recognition of fluorine impacts substrate selectivity in the fluoroacetyl-CoA thioesterase FlK. Biochemistry. 2014; 53(12):2053-2063.
    5. Weeks AM, Chang MC. Catalytic control of enzymatic fluorine specificity. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19667-72. PMID: 23150553; PMCID: PMC3511759.
    6. Bond-Watts BB, Weeks AM, Chang MC. Biochemical and structural characterization of the trans-enoyl-CoA reductase from Treponema denticola. Biochemistry. 2012 Aug 28; 51(34):6827-37. PMID: 22906002.
      View in: PubMed
    7. Walker MC, Wen M, Weeks AM, Chang MC. Temporal and fluoride control of secondary metabolism regulates cellular organofluorine biosynthesis. ACS Chem Biol. 2012 Sep 21; 7(9):1576-85. PMID: 22769062.
      View in: PubMed
    8. Weeks AM, Chang MC. Constructing de novo biosynthetic pathways for chemical synthesis inside living cells. Biochemistry. 2011 Jun 21; 50(24):5404-18. PMID: 21591680; PMCID: PMC3768262.
    9. Weeks AM, Coyle SM, Jinek M, Doudna JA, Chang MC. Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. Biochemistry. 2010 Nov 02; 49(43):9269-79. PMID: 20836570; PMCID: PMC3461317.
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