Ana Ruiz-Saenz, PhD

Title(s)Associate Specialist, Medicine
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Autonomous University of MadridPh.D.2011Molecular Biology
    Collapse Awards and Honors
    UCSF Postdoc Research Symposium  - 2016Best talk award
    UCSF Breast Oncology Program Scientific Retreat  - 2015Best poster award
    Ramon Areces Foundation2013  - 2015Ramon Areces Fellowship
    EMBO  - 2009EMBO Short-Term Fellowship
    Spanish Ministry of Science and Innovation2007  - 2011Ph.D. Fellowship (FPI)

    Collapse Research 
    Collapse Research Activities and Funding
    Postdoctoral fellowship - Novel insights into the deregulation of Src kinases in human cancers
    Fundacion Ramon Areces Oct 1, 2013 - Oct 1, 2015

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse In The News
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Spassov DS, Ruiz-Saenz A, Piple A, Moasser MM. A Dimerization Function in the Intrinsically Disordered N-Terminal Region of Src. Cell Rep. 2018 Oct 09; 25(2):449-463.e4. PMID: 30304684.
      View in: PubMed
    2. Ruiz-Saenz A, Dreyer C, Campbell MR, Steri V, Gulizia N, Moasser MM. HER2 Amplification in Tumors Activates PI3K/Akt Signaling Independent of HER3. Cancer Res. 2018 Jul 01; 78(13):3645-3658. PMID: 29760043.
      View in: PubMed
    3. Ruiz-Saenz A, Moasser MM. Targeting HER2 by Combination Therapies. J Clin Oncol. 2018 Mar 10; 36(8):808-811. PMID: 29381433.
      View in: PubMed
    4. Rangel L, Lospitao E, Ruiz-Sáenz A, Alonso MA, Correas I. Alternative polyadenylation in a family of paralogous EPB41 genes generates protein 4.1 diversity. RNA Biol. 2017 02; 14(2):236-244. PMID: 27981895.
      View in: PubMed
    5. Campbell MR, Zhang H, Ziaee S, Ruiz-Saenz A, Gulizia N, Oeffinger J, Amin DN, Ahuja D, Moasser MM, Park CC. Effective treatment of HER2-amplified breast cancer by targeting HER3 and ß1 integrin. Breast Cancer Res Treat. 2016 Feb; 155(3):431-40. PMID: 26860947; PMCID: PMC4767608 [Available on 02/09/17].
    6. Amin DN, Ruiz-Saenz A, Gulizia N, Moasser MM. Chemical probing of HER2-amplified cancer cells identifies TORC2 as a particularly effective secondary target for combination with lapatinib. Oncotarget. 2015 Dec 01; 6(38):41123-33. PMID: 26516700.
      View in: PubMed
    7. Ana Ruiz-Saenz, Manbir Sandhu, Yazmin Carrasco, Rebecca L. Maglathlin, Jack Taunton, and Mark M. Moasser.Abstract 2635: Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum. 2015.
    8. Ruiz-Saenz A, Sandhu M, Carrasco Y, Maglathlin RL, Taunton J, Moasser MM. Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum. Oncogene. 2015 Oct 08; 34(41):5288-94. PMID: 25619841; PMCID: PMC4515412.
    9. Ruiz-Saenz A, van Haren J, Sayas CL, Rangel L, Demmers J, Millán J, Alonso MA, Galjart N, Correas I. Protein 4.1R binds to CLASP2 and regulates dynamics, organization and attachment of microtubules to the cell cortex. J Cell Sci. 2013 Oct 15; 126(Pt 20):4589-601. PMID: 23943871.
      View in: PubMed
    10. Aranda JF, Reglero-Real N, Marcos-Ramiro B, Ruiz-Sáenz A, Fernández-Martín L, Bernabé-Rubio M, Kremer L, Ridley AJ, Correas I, Alonso MA, Millán J. MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression. Mol Biol Cell. 2013 Feb; 24(4):483-94. PMID: 23264465; PMCID: PMC3571871.
    11. Andrés-Delgado L, Antón OM, Bartolini F, Ruiz-Sáenz A, Correas I, Gundersen GG, Alonso MA. INF2 promotes the formation of detyrosinated microtubules necessary for centrosome reorientation in T cells. J Cell Biol. 2012 Sep 17; 198(6):1025-37. PMID: 22986496; PMCID: PMC3444772.
    12. Ruiz-Sáenz A, Kremer L, Alonso MA, Millán J, Correas I. Protein 4.1R regulates cell migration and IQGAP1 recruitment to the leading edge. J Cell Sci. 2011 Aug 01; 124(Pt 15):2529-38. PMID: 21750196.
      View in: PubMed
    13. Aranda JF, Reglero-Real N, Kremer L, Marcos-Ramiro B, Ruiz-Sáenz A, Calvo M, Enrich C, Correas I, Millán J, Alonso MA. MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration. Mol Biol Cell. 2011 Apr 15; 22(8):1252-62. PMID: 21325632; PMCID: PMC3078064.