Anders Persson, PhD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
AddressLocation Required
Varies CA 00000
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division
    Collapse Awards and Honors
    University of California San Francisco2005Swedish Society of Medicine
    University of California San Francisco2005Swedish Brain Tumor Foundation
    University of California San Francisco2005  - 2006Swedish Society for Medical Research
    University of California San Francisco2008Sandler Postdoctoral Fellowship Award
    University of California San Francisco2008  - 2009American Brain Tumor Association Fellowship
    University of California San Francisco2010Hellman Family Foundation Early-Career Award
    University of California San Francisco2010American Brain Tumor Association Translational Award
    University of California San Francisco2011UCSF SPORE -Career Developmental Award
    University of California San Francisco2012American Cancer Society Individual Research Award
    University of California San Francisco2013  - 2015NBTS Oligodendroglioma Award
    Universiy of California San Francisco2014  - 2016NIH Exploratory/Developmental Award (R21)
    University of California San Francisco2015  - 2016UCSCF RAP Pilot Award in Basic and Clinical/Translational Sciences

    Collapse Overview 
    Collapse Overview
    Our research focus on understanding how oncogenic events can transform neural stem cells (NSCs) and oligodendrocyte progenitor cells (OPCs) into distinct types of childhood and adult gliomas. In addition, we have recently identified a previously unrecognized population of potential NSCs with tumorigenic capacity and regenerative potential. We are currently studying the regenerative potential of these cells during normal development and disease. In human gliomas, aggressive therapy leaves behind subpopulations of tumor cells displaying properties of NSCs or OPCs, suggesting a lineage-relationship between the cell of origin and therapy-resistant tumor cells. We and others have confirmed this relationship in genetically-engineered murine models (GEMM) of glioma. We use detailed knowledge about glial cells to identify the intrinsic and environmental components that impact glioma biology. We find that deregulation of NSC- and OPC-related microRNAs (miRNAs) regulate tumor biology in a glioma subtype-specific manner. Reintroduction of a single miRNA can turn glioblastoma (GBM) cells into neurons. We also study whether the cell of origin regulates response to ionizing radiation (IR) and the ability to regulate cell volume. Major goals: (i) Develop GEMM of glioma using relevant oncogenic events to identify the initial steps that transform NSCs and OPCs in a temporal and regional fashion. (ii) Identify drugable targets that drive stemness in glioma. (iii) Study the effect of IR and role of osmotic swelling on glioma biology.

    Identification of a novel NSC population
    We have established a team of collaborators to characterize the tumorigenic capacity potential of a novel NSC population. In addition, we study the regenerative potential using fate-mapping techniques during normal development and following traumatic brain injury (TBI). We also study cell genesis following stress, enriched environment, and exercise.

    Development of IDH1R132H, H3F3A, and PDGF-driven mutant glioma models
    Human gliomas displaying mutations in the isocitrate dehydrogenase 1/2 (IDH1/2) genes are diagnosed in young adults. In high-grade glioblastoma (GBM), H3F3A (K27) and H3F3A (G34) tumors are expressed in young children and adolescent patients, respectively. We are using retroviral (RCAS) transformation of cells expressing the TVA receptor to produce these tumors in mice.

    Targeting stemness in glioblastoma
    Pre-clinical experiments show that radiotherapy and treatment with temozolomide enrich for highly tumorigenic and stem-like tumor cells in human GBMs. We optimize IR regimens to better target these stem-like cells. Our laboratory use GEMMs and human GBM biopsies to study the mechanisms underlying treatment-resistance, including dormancy and epigenetic control of translation of genes. In particular, we identify small non-coding RNAs that regulate glioma biology.

    Osmotic swelling as a therapeutic target in cancer
    High pressure is a major obstacle for uptake in solid tumors, less is known how elevated interstitial fluid pressure impacts tumor biology. We find that high pressure drive tumor proliferation in solid cancers. In this NIH-supported project, we have identified a mechanism that blocks the ability of GBM cells to regulate cell volume, leading to massive apoptosis and reduced survival of xenografted mice. We currently test whether osmotic swelling regulates translational control of genes that drives GBM aggressiveness.

    Collapse Research 
    Collapse Research Activities and Funding
    Antisecretory factor as a novel therapeutic agent in human glioblastoma
    NIH R21NS088114May 1, 2014 - Apr 30, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kaushik S, Persson AI. Unlocking the Dangers of a Stiffening Brain. Neuron. 2018 Nov 21; 100(4):763-765. PMID: 30465758.
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    2. Chantzichristos D, Persson A, Miftaraj M, Eliasson B, Svensson AM, Johannsson G. Early Clinical Indicators of Addison's Disease in Adults with Type 1 Diabetes: a Nationwide, Observational, Cohort Study. J Clin Endocrinol Metab. 2018 Nov 21. PMID: 30476180.
      View in: PubMed
    3. Guan X, Hasan MN, Begum G, Kohanbash G, Carney KE, Pigott VM, Persson AI, Castro MG, Jia W, Sun D. Blockade of Na/H exchanger stimulates glioma tumor immunogenicity and enhances combinatorial TMZ and anti-PD-1 therapy. Cell Death Dis. 2018 Sep 27; 9(10):1010. PMID: 30262908.
      View in: PubMed
    4. Luks TL, McKnight TR, Jalbert LE, Williams A, Neill E, Lobo KA, Persson AI, Perry A, Phillips JJ, Molinaro AM, Chang SM, Nelson SJ. Relationship of In Vivo MR Parameters to Histopathological and Molecular Characteristics of Newly Diagnosed, Nonenhancing Lower-Grade Gliomas. Transl Oncol. 2018 Jun 05; 11(4):941-949. PMID: 29883968.
      View in: PubMed
    5. Coenen A, Kim YH, Kruk M, Tesche C, De Geer J, Kurata A, Lubbers ML, Daemen J, Itu L, Rapaka S, Sharma P, Schwemmer C, Persson A, Schoepf UJ, Kepka C, Hyun Yang D, Nieman K. Diagnostic Accuracy of a Machine-Learning Approach to Coronary Computed Tomographic Angiography-Based Fractional Flow Reserve: Result From the MACHINE Consortium. Circ Cardiovasc Imaging. 2018 Jun; 11(6):e007217. PMID: 29914866.
      View in: PubMed
    6. Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR, Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, Ghosh M, Tirosh I, Huillard E, Alvarez-Buylla A, Oldham MC, Persson AI, Weiss WA, Batchelor TT, Stemmer-Rachamimov A, Suvà ML, Phillips JJ, Aghi MK, Mehta S, Jain RK, Rowitch DH. A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment. Cancer Cell. 2018 May 14; 33(5):874-889.e7. PMID: 29681511.
      View in: PubMed
    7. Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips JJ, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI. Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma. Mol Cancer Res. 2018 Feb 05. PMID: 29431617.
      View in: PubMed
    8. Chantzichristos D, Persson A, Eliasson B, Miftaraj M, Franzén S, Svensson AM, Johannsson G. Incidence, prevalence and seasonal onset variation of Addison's disease among persons with type 1 diabetes mellitus: nationwide, matched cohort studies. Eur J Endocrinol. 2018 Jan; 178(1):115-122. PMID: 29066573.
      View in: PubMed
    9. Tran VM, Wade A, McKinney A, Chen K, Lindberg OR, Engler JR, Persson AI, Phillips JJ. Heparan Sulfate Glycosaminoglycans in Glioblastoma Promote Tumor Invasion. Mol Cancer Res. 2017 Nov; 15(11):1623-1633. PMID: 28778876.
      View in: PubMed
    10. Bull C, Cooper C, Lindahl V, Fitting S, Persson AI, Grandér R, Alborn AM, Björk-Eriksson T, Kuhn HG, Blomgren K. Exercise in Adulthood after Irradiation of the Juvenile Brain Ameliorates Long-Term Depletion of Oligodendroglial Cells. Radiat Res. 2017 10; 188(4):443-454. PMID: 28777696.
      View in: PubMed
    11. Jones C, Karajannis MA, Jones DTW, Kieran MW, Monje M, Baker SJ, Becher OJ, Cho YJ, Gupta N, Hawkins C, Hargrave D, Haas-Kogan DA, Jabado N, Li XN, Mueller S, Nicolaides T, Packer RJ, Persson AI, Phillips JJ, Simonds EF, Stafford JM, Tang Y, Pfister SM, Weiss WA. Pediatric high-grade glioma: biologically and clinically in need of new thinking. Neuro Oncol. 2017 02 01; 19(2):153-161. PMID: 27282398.
      View in: PubMed
    12. Chantzichristos D, Persson A, Eliasson B, Miftaraj M, Franzén S, Bergthorsdottir R, Gudbjörnsdottir S, Svensson AM, Johannsson G. Mortality in patients with diabetes mellitus and Addison's disease: a nationwide, matched, observational cohort study. Eur J Endocrinol. 2017 Jan; 176(1):31-39. PMID: 27928991.
      View in: PubMed
    13. Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM. Tissue mechanics promote IDH1-dependent HIF1a-tenascin C feedback to regulate glioblastoma aggression. Nat Cell Biol. 2016 Dec; 18(12):1336-1345. PMID: 27820599.
      View in: PubMed
    14. Rinkenbaugh AL, Cogswell PC, Calamini B, Dunn DE, Persson AI, Weiss WA, Lo DC, Baldwin AS. IKK/NF-?B signaling contributes to glioblastoma stem cell maintenance. Oncotarget. 2016 Oct 25; 7(43):69173-69187. PMID: 27732951.
      View in: PubMed
    15. Andersson M, Jägervall K, Eriksson P, Persson A, Granerus G, Wang C, Smedby Ö. How to measure renal artery stenosis--a retrospective comparison of morphological measurement approaches in relation to hemodynamic significance. BMC Med Imaging. 2015 Oct 12; 15:42. PMID: 26459634; PMCID: PMC4601150.
    16. Lau J, Ilkhanizadeh S, Wang S, Miroshnikova YA, Salvatierra NA, Wong RA, Schmidt C, Weaver VM, Weiss WA, Persson AI. STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma. Cancer Res. 2015 Oct 15; 75(20):4302-11. PMID: 26282165; PMCID: PMC4609277 [Available on 10/15/16].
    17. Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI. Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. Mol Cancer Ther. 2015 Feb; 14(2):419-28. PMID: 25522764; PMCID: PMC4326592.
    18. Swartling FJ, Cancer M, Frantz A, Weishaupt H, Persson AI. Deregulated proliferation and differentiation in brain tumors. Cell Tissue Res. 2015 Jan; 359(1):225-54. PMID: 25416506; PMCID: PMC4286433.
    19. Ilkanizadeh S, Lau J, Huang M, Foster DJ, Wong R, Frantz A, Wang S, Weiss WA, Persson AI. Glial progenitors as targets for transformation in glioma. Adv Cancer Res. 2014; 121:1-65. PMID: 24889528; PMCID: PMC4270964.
    20. Lidell ME, Betz MJ, Dahlqvist Leinhard O, Heglind M, Elander L, Slawik M, Mussack T, Nilsson D, Romu T, Nuutila P, Virtanen KA, Beuschlein F, Persson A, Borga M, Enerbäck S. Evidence for two types of brown adipose tissue in humans. Nat Med. 2013 May; 19(5):631-4. PMID: 23603813.
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    21. Shchors K, Persson AI, Rostker F, Tihan T, Lyubynska N, Li N, Swigart LB, Berger MS, Hanahan D, Weiss WA, Evan GI. Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):E1480-9. PMID: 23542378; PMCID: PMC3631679.
    22. Swartling FJ, Bolin S, Phillips JJ, Persson AI. Signals that regulate the oncogenic fate of neural stem cells and progenitors. Exp Neurol. 2014 Oct; 260:56-68. PMID: 23376224; PMCID: PMC3758390.
    23. Swartling FJ, Savov V, Persson AI, Chen J, Hackett CS, Northcott PA, Grimmer MR, Lau J, Chesler L, Perry A, Phillips JJ, Taylor MD, Weiss WA. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. Cancer Cell. 2012 May 15; 21(5):601-13. PMID: 22624711; PMCID: PMC3360885.
    24. Chanthery YH, Gustafson WC, Itsara M, Persson A, Hackett CS, Grimmer M, Charron E, Yakovenko S, Kim G, Matthay KK, Weiss WA. Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma. Sci Transl Med. 2012 Jan 04; 4(115):115ra3. PMID: 22218692; PMCID: PMC3402217.
    25. Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep 13; 20(3):328-40. PMID: 21907924; PMCID: PMC3297490.
    26. Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA. Non-stem cell origin for oligodendroglioma. Cancer Cell. 2010 Dec 14; 18(6):669-82. PMID: 21156288; PMCID: PMC3031116.
    27. Eriksson P, Mohammed AA, De Geer J, Kihlberg J, Persson A, Granerus G, Nyström F, Smedby Ö. Non-invasive investigations of potential renal artery stenosis in renal insufficiency. Nephrol Dial Transplant. 2010 Nov; 25(11):3607-14. PMID: 20488819.
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    28. Persson AI, Weiss WA. The side story of stem-like glioma cells. Cell Stem Cell. 2009 Mar 06; 4(3):191-2. PMID: 19265652.
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    29. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008 Jun 24; 6:14. PMID: 18577219; PMCID: PMC2443372.
    30. Larsson M, Persson A, Eriksson P, Kihlberg J, Smedby O. Renal artery stenosis: extracting quantitative parameters with a mathematical model fitted to magnetic resonance blood flow data. J Magn Reson Imaging. 2008 Jan; 27(1):140-7. PMID: 18050354.
      View in: PubMed
    31. Persson AI, Bull C, Eriksson PS. Requirement for Id1 in opioid-induced oligodendrogenesis in cultured adult rat hippocampal progenitors. Eur J Neurosci. 2006 May; 23(9):2277-88. PMID: 16706836.
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    32. Zarnegar P, Persson AI, Ming Y, Terenius L. Opioid-induced regulation of gene expression in PC12 cells stably transfected with mu-opioid receptor. Neurosci Lett. 2006 Apr 03; 396(3):197-201. PMID: 16377088.
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    33. Persson AI, Thorlin T, Eriksson PS. Comparison of immunoblotted delta opioid receptor proteins expressed in the adult rat brain and their regulation by growth hormone. Neurosci Res. 2005 May; 52(1):1-9. PMID: 15811547.
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    34. Naylor AS, Persson AI, Eriksson PS, Jonsdottir IH, Thorlin T. Extended voluntary running inhibits exercise-induced adult hippocampal progenitor proliferation in the spontaneously hypertensive rat. J Neurophysiol. 2005 May; 93(5):2406-14. PMID: 15615829.
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    35. Dahl A, Eriksson PS, Davidsson P, Persson AI, Ekman R, Westman-Brinkmalm A. Demonstration of multiple novel glycoforms of the stem cell survival factor CCg. J Neurosci Res. 2004 Jul 01; 77(1):9-14. PMID: 15197734.
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    36. Persson AI, Naylor AS, Jonsdottir IH, Nyberg F, Eriksson PS, Thorlin T. Differential regulation of hippocampal progenitor proliferation by opioid receptor antagonists in running and non-running spontaneously hypertensive rats. Eur J Neurosci. 2004 Apr; 19(7):1847-55. PMID: 15078558.
      View in: PubMed
    37. Persson AI, Thorlin T, Bull C, Eriksson PS. Opioid-induced proliferation through the MAPK pathway in cultures of adult hippocampal progenitors. Mol Cell Neurosci. 2003 Jul; 23(3):360-72. PMID: 12837621.
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    38. Persson AI, Thorlin T, Bull C, Zarnegar P, Ekman R, Terenius L, Eriksson PS. Mu- and delta-opioid receptor antagonists decrease proliferation and increase neurogenesis in cultures of rat adult hippocampal progenitors. Eur J Neurosci. 2003 Mar; 17(6):1159-72. PMID: 12670304.
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    39. Persson AI, Aberg ND, Oscarsson J, Isaksson OG, Rönnbäck L, Frick F, Sonesson C, Eriksson PS. Expression of delta opioid receptor mRNA and protein in the rat cerebral cortex and cerebellum is decreased by growth hormone. J Neurosci Res. 2003 Feb 15; 71(4):496-503. PMID: 12548705.
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    40. Paulson L, Martin P, Persson A, Nilsson CL, Ljung E, Westman-Brinkmalm A, Eriksson PS, Blennow K, Davidsson P. Comparative genome- and proteome analysis of cerebral cortex from MK-801-treated rats. J Neurosci Res. 2003 Feb 15; 71(4):526-33. PMID: 12548708.
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    41. Dahl A, Eriksson PS, Persson AI, Karlsson G, Davidsson P, Ekman R, Westman-Brinkmalm A. Proteome analysis of conditioned medium from cultured adult hippocampal progenitors. Rapid Commun Mass Spectrom. 2003; 17(19):2195-202. PMID: 14515317.
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    42. Persson PA, Thorlin T, Rönnbäck L, Hansson E, Eriksson PS. Differential expression of delta opioid receptors and mRNA in proliferating astrocytes during the cell cycle. J Neurosci Res. 2000 Aug 15; 61(4):371-5. PMID: 10931523.
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    43. Thorlin T, Anders P, Persson I, Eriksson PS, Rönnbäck L, Hansson E. Astrocyte beta1-adrenergic receptor immunoreactivity and agonist induced increases in [Ca2+]i: differential results indicative of a modified membrane receptor. Life Sci. 2000 Aug 04; 67(11):1285-96. PMID: 10972197.
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    44. Thorlin T, Persson PA, Eriksson PS, Hansson E, Rönnbäck L. Delta-opioid receptor immunoreactivity on astrocytes is upregulated during mitosis. Glia. 1999 Feb 15; 25(4):370-8. PMID: 10028919.
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    45. Thorlin T, Eriksson PS, Persson PA, Aberg ND, Hansson E, Rönnbäck L. Delta-opioid receptors on astroglial cells in primary culture: mobilization of intracellular free calcium via a pertussis sensitive G protein. Neuropharmacology. 1998; 37(3):299-311. PMID: 9681928.
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