Andrew Ambrose, PhD

Title(s)Postdoctoral Scholar, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Function, Therapeutic Potential, and Inhibition of Hsp70 Chaperones. J Med Chem. 2021 06 10; 64(11):7060-7082. Ambrose AJ, Chapman E. PMID: 34009983.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Functional Differences between E. coli and ESKAPE Pathogen GroES/GroEL. mBio. 2021 01 12; 12(1). Sivinski J, Ambrose AJ, Panfilenko I, Zerio CJ, Machulis JM, Mollasalehi N, Kaneko LK, Stevens M, Ray AM, Park Y, Wu C, Hoang QQ, Johnson SM, Chapman E. PMID: 33436430.
      View in: PubMed   Mentions:    Fields:    
    3. An Isoform-Selective PTP1B Inhibitor Derived from Nitrogen-Atom Augmentation of Radicicol. Biochemistry. 2019 07 30; 58(30):3225-3231. Shi T, Wijeratne EMK, Solano C, Ambrose AJ, Ross AB, Norwood C, Orido CK, Grigoryan T, Tillotson J, Kang M, Luo G, Keegan BM, Hu W, Blagg BSJ, Zhang DD, Gunatilaka AAL, Chapman E. PMID: 31298844.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78. Bioorg Med Chem Lett. 2019 07 15; 29(14):1689-1693. Ambrose AJ, Zerio CJ, Sivinski J, Schmidlin CJ, Shi T, Ross AB, Widrick KJ, Johnson SM, Zhang DD, Chapman E. PMID: 31129054.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. A one-step, atom economical synthesis of thieno[2,3-d]pyrimidin-4-amine derivatives via a four-component reaction. European J Org Chem. 2019 Jun 02; 20(2):3269-3272. Shi T, Zerio CJ, Sivinski J, Ambrose AJ, Moore KT, Buckley T, Kaneko L, Zhang M, Zhang DD, Chapman E. PMID: 31857792.
      View in: PubMed   Mentions:
    6. One-Step Synthesis of Thieno[2,3-d]pyrimidin-4(3H)-ones via a Catalytic Four-Component Reaction of Ketones, Ethyl Cyanoacetate, S8 and Formamide. ACS Sustain Chem Eng. 2019 Jan 07; 7(1):1524-1528. Shi T, Kaneko L, Sandino M, Busse R, Zhang M, Mason D, Machulis J, Ambrose AJ, Zhang DD, Chapman E. PMID: 31754553.
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    7. Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus. J Med Chem. 2018 12 13; 61(23):10651-10664. Kunkle T, Abdeen S, Salim N, Ray AM, Stevens M, Ambrose AJ, Victorino J, Park Y, Hoang QQ, Chapman E, Johnson SM. PMID: 30392371.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    8. A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B). ACS Chem Biol. 2018 10 19; 13(10):3000-3010. François-Moutal L, Jahanbakhsh S, Nelson ADL, Ray D, Scott DD, Hennefarth MR, Moutal A, Perez-Miller S, Ambrose AJ, Al-Shamari A, Coursodon P, Meechoovet B, Reiman R, Lyons E, Beilstein M, Chapman E, Morris QD, Van Keuren-Jensen K, Hughes TR, Khanna R, Koehler C, Jen J, Gokhale V, Khanna M. PMID: 30141626.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA). J Med Chem. 2018 08 23; 61(16):7345-7357. Abdeen S, Kunkle T, Salim N, Ray AM, Mammadova N, Summers C, Stevens M, Ambrose AJ, Park Y, Schultz PG, Horwich AL, Hoang QQ, Chapman E, Johnson SM. PMID: 30060666.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    10. Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity. Clin Cancer Res. 2018 09 01; 24(17):4256-4270. Peters TL, Tillotson J, Yeomans AM, Wilmore S, Lemm E, Jiménez-Romero C, Amador LA, Li L, Amin AD, Pongtornpipat P, Zerio CJ, Ambrose AJ, Paine-Murrieta G, Greninger P, Vega F, Benes CH, Packham G, Rodríguez AD, Chapman E, Schatz JH. PMID: 29844128.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    11. Increased O-GlcNAcylation of SNAP29 Drives Arsenic-Induced Autophagic Dysfunction. Mol Cell Biol. 2018 06 01; 38(11). Dodson M, Liu P, Jiang T, Ambrose AJ, Luo G, Rojo de la Vega M, Cholanians AB, Wong PK, Chapman E, Zhang DD. PMID: 29507186.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    12. ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A. Bioorg Med Chem Lett. 2017 09 01; 27(17):4082-4085. Tillotson J, Kedzior M, Guimarães L, Ross AB, Peters TL, Ambrose AJ, Schmidlin CJ, Zhang DD, Costa-Lotufo LV, Rodríguez AD, Schatz JH, Chapman E. PMID: 28757063.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    13. Arsenic Compromises Both p97 and Proteasome Functions. Chem Res Toxicol. 2017 07 17; 30(7):1508-1514. Tillotson J, Zerio CJ, Harder B, Ambrose AJ, Jung KS, Kang M, Zhang DD, Chapman E. PMID: 28636814.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    14. Ritterostatin GN 1N , a Cephalostatin-Ritterazine Bis-steroidal Pyrazine Hybrid, Selectively Targets GRP78. Chembiochem. 2017 03 16; 18(6):506-510. Ambrose AJ, Santos EA, Jimenez PC, Rocha DD, Wilke DV, Beuzer P, Axelrod J, Kumar Kanduluru A, Fuchs PL, Cang H, Costa-Lotufo LV, Chapman E, La Clair JJ. PMID: 28074539.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    15. GroEL/ES inhibitors as potential antibiotics. Bioorg Med Chem Lett. 2016 07 01; 26(13):3127-3134. Abdeen S, Salim N, Mammadova N, Summers CM, Frankson R, Ambrose AJ, Anderson GG, Schultz PG, Horwich AL, Chapman E, Johnson SM. PMID: 27184767.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    16. The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (-)-Chlorizidine A Targets Proteins within the Glycolytic Pathway. Chembiochem. 2015 Sep 21; 16(14):2002-6. Álvarez-Micó X, Rocha DD, Guimarães LA, Ambrose A, Chapman E, Costa-Lotufo LV, La Clair JJ, Fenical W. PMID: 26267855.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    17. Unfolded DapA forms aggregates when diluted into free solution, confounding comparison with folding by the GroEL/GroES chaperonin system. FEBS Lett. 2015 Feb 13; 589(4):497-499. Ambrose A, Fenton W, Mason DJ, Chapman E, Horwich AL. PMID: 25601566.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    18. Identification of pyrazine-based TrkA inhibitors: design, synthesis, evaluation, and computational modeling studies. Medchemcomm. 2014 Oct 01; 5(10):1507-1514. Frett B, McConnell N, Wang Y, Xu Z, Ambrose A, Li HY. PMID: 26843921.
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