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Andrew Brack, PhD

Title(s)Associate Professor, Orthopaedic Surgery
SchoolSchool of Medicine
Address35 Medical Center Way
San Francisco CA 94143
Phone415-476-3979
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    Originally from Liverpool, England, Andrew graduated with a PhD in Molecular Biology and Biophysics from King’s College London. He did two postdoctoral fellowships, the first with Simon Hughes at King’s College London and the second with Tom Rando at Stanford University. Andrew started his own lab at the Center for Regenerative Medicine, MGH, Harvard University in 2008. In 2015 he moved to UCSF to begin the next phase of his lab's journey.

    Brack Lab's is focused on understanding the cellullar communication between the muscle stem cell and its environment to identify strategies that improve skeletal muscle regeneration and ameliorate sarcopenia.

    Quiescence and self-renewal
    Maintenance and reacquisition of quiescence are defining features of adult stem cells. We are studying the intrinsic and extrinsic factors that control quiescence and how they impinge on self-renewal and differentiation potential during muscle homeostasis, injury response and aging. Using a muscle stem cell specific mutant we demonstrated that Sprouty1 (Spry1), an RTK signaling inhibitor, is required for the reestablishment of quiescence in proliferating stem cells. We are presently identifying intrinsic and niche-derived signals that promote and retain stem cell potential.

    Stem cell niche
    The stem cell niche as originally conceptualized refers to the microenvironment that maintains ‘stemness’. The niche is a protector of stem cell number and function restraining proliferation and differentiation of stem cells and maintaining a quiescent phenotype. The satellite cell niche may be composed of different cell types. We are presently identifying the cell types and the essential signaling elements that compose the niche to retain stemness after injury and are deregulated during aging.

    Satellite cell heterogeneity
    It is apparent that adult stem cell populations are heterogeneous. Using a marker of proliferative history, based on retention of a fluorescent marker, we recently demonstrated that the adult satellite cell pool is composed of subsets of cells that are slowly dividing during ontogeny. Label retaining cells possess the properties of stem cells; in contrast, satellite cell subsets that diluted label functioned as progenitors. During aging a subset of functional label retaining cells are preserved. Current projects are deciphering whether heterogeneity is due to extrinsic influences, such as discrete niches, or cell intrinsic regulation, such as epigenetic and metabolic status.

    Aging
    Aging is associated with a progressive decline in many tissues throughout the body. Skeletal muscle is no exception. We are studying the mechanisms that lead to a loss of stem cell number and function during aging.

    Brack Lab's Full Address is:
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    Department of Orthopaedic Surgery
    University of California, San Francisco
    35 Medical Center Way Box 0669
    San Francisco, CA 94143

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    Niche Regulation of Muscle Stem Cells
    NIH/NIAMS R01AR076252Aug 1, 2019 - May 31, 2024
    Role: Principal Investigator
    Single cell activation dynamics as a predictor and regulator of aged MuSC dysfunction.
    NIH/NIA R21AG063416Feb 1, 2019 - Jan 31, 2021
    Role: Principal Investigator
    Muscle Satellite Cell Pool During Aging
    NIH/NIAMS R01AR060868Aug 1, 2015 - Jul 31, 2016
    Role: Principal Investigator
    Quiescence of Muscle Stem Cells During Growth and Repair
    NIH/NIAMS R01AR061002Apr 1, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Muscle stem cell heterogeneity
    NIH/NIAMS R56AR060868Sep 21, 2011 - Aug 31, 2019
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Aging induces aberrant state transition kinetics in murine muscle stem cells. Development. 2020 May 05; 147(9). Kimmel JC, Hwang AB, Scaramozza A, Marshall WF, Brack AS. PMID: 32198156.
      View in: PubMed   Mentions:    Fields:    
    2. Functionally heterogeneous human satellite cells identified by single cell RNA sequencing. Elife. 2020 Apr 01; 9. Barruet E, Garcia SM, Striedinger K, Wu J, Lee S, Byrnes L, Wong A, Xuefeng S, Tamaki S, Brack AS, Pomerantz JH. PMID: 32234209.
      View in: PubMed   Mentions: 4     Fields:    
    3. Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells. Cell Stem Cell. 2019 11 07; 25(5):654-665.e4. Eliazer S, Muncie JM, Christensen J, Sun X, D'Urso RS, Weaver VM, Brack AS. PMID: 31495781.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    4. Deep convolutional and recurrent neural networks for cell motility discrimination and prediction. IEEE/ACM Trans Comput Biol Bioinform. 2019 Jun 27. Kimmel J, Brack A, Marshall W. PMID: 31251191.
      View in: PubMed   Mentions:    Fields:    
    5. Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress. Cell Stem Cell. 2019 06 06; 24(6):944-957.e5. Scaramozza A, Park D, Kollu S, Beerman I, Sun X, Rossi DJ, Lin CP, Scadden DT, Crist C, Brack AS. PMID: 31006621.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. Thermal stress induces glycolytic beige fat formation via a myogenic state. Nature. 2019 01; 565(7738):180-185. Chen Y, Ikeda K, Yoneshiro T, Scaramozza A, Tajima K, Wang Q, Kim K, Shinoda K, Sponton CH, Brown Z, Brack A, Kajimura S. PMID: 30568302.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    7. Inferring cell state by quantitative motility analysis reveals a dynamic state system and broken detailed balance. PLoS Comput Biol. 2018 01; 14(1):e1005927. Kimmel JC, Chang AY, Brack AS, Marshall WF. PMID: 29338005.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. Muscle Stem Cells and Aging. Curr Top Dev Biol. 2018; 126:299-322. Hwang AB, Brack AS. PMID: 29305003.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    9. Stem cells: Cause and consequence in aged-muscle decline. Nature. 2016 12 15; 540(7633):349-350. Eliazer S, Brack AS. PMID: 27919069.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects? Circ Res. 2016 Apr 01; 118(7):1143-50; discussion 1150. Harper SC, Brack A, MacDonnell S, Franti M, Olwin BB, Bailey BA, Rudnicki MA, Houser SR. PMID: 27034276.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    11. The ins and outs of muscle stem cell aging. Skelet Muscle. 2016; 6:1. Brack AS, Muñoz-Cánoves P. PMID: 26783424.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    12. Lost in Translation: Preserving Satellite Cell Function with Global Translational Control. Cell Stem Cell. 2016 Jan 07; 18(1):5-7. Eliazer S, Brack AS. PMID: 26748748.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration. Cell Metab. 2015 Jul 07; 22(1):164-74. Egerman MA, Cadena SM, Gilbert JA, Meyer A, Nelson HN, Swalley SE, Mallozzi C, Jacobi C, Jennings LL, Clay I, Laurent G, Ma S, Brachat S, Lach-Trifilieff E, Shavlakadze T, Trendelenburg AU, Brack AS, Glass DJ. PMID: 26001423.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    14. The Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells. Stem Cell Reports. 2015 Jun 09; 4(6):1061-74. Kollu S, Abou-Khalil R, Shen C, Brack AS. PMID: 25960061.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    15. Pax7 is back. Skelet Muscle. 2014; 4(1):24. Brack AS. PMID: 25546147.
      View in: PubMed   Mentions: 5     Fields:    
    16. Lineage of origin in rhabdomyosarcoma informs pharmacological response. Genes Dev. 2014 Jul 15; 28(14):1578-91. Abraham J, Nuñez-Álvarez Y, Hettmer S, Carrió E, Chen HI, Nishijo K, Huang ET, Prajapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA, Goros MW, Michalek JE, Meltzer PS, Langenau DM, LeGallo RD, Mansoor A, Chen Y, Suelves M, Rubin BP, Keller C. PMID: 25030697.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    17. Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state. Development. 2014 Apr; 141(8):1649-59. Chakkalakal JV, Christensen J, Xiang W, Tierney MT, Boscolo FS, Sacco A, Brack AS. PMID: 24715455.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    18. Cellular mechanisms of somatic stem cell aging. Curr Top Dev Biol. 2014; 107:405-38. Jung Y, Brack AS. PMID: 24439814.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    19. ISSCR 2013: back to Bean Town. Stem Cell Reports. 2013; 1(6):479-85. Brack AS, Hochedlinger K. PMID: 25847520.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    20. Ageing of the heart reversed by youthful systemic factors! EMBO J. 2013 Aug 14; 32(16):2189-90. Brack AS. PMID: 23860129.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    21. An HMGA2-IGF2BP2 Axis Regulates Myoblast Proliferation and Myogenesis. Developmental Cell. 2013 Jan 1; 24(1):112. Zhizhong Li, Jason A. Gilbert, Yunyu Zhang, Minsi Zhang, Qiong Qiu, Krishnan Ramanujan, Tea Shavlakadze, John K. Eash, Annarita Scaramozza, Matthew M. Goddeeris, David G. Kirsch, Kevin P. Campbell, Andrew S. Brack, David J. Glass. .
      View in: Publisher Site   Mentions:
    22. An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis. Dev Cell. 2012 Dec 11; 23(6):1176-88. Li Z, Gilbert JA, Zhang Y, Zhang M, Qiu Q, Ramanujan K, Shavlakadze T, Eash JK, Scaramozza A, Goddeeris MM, Kirsch DG, Campbell KP, Brack AS, Glass DJ. PMID: 23177649.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    23. The aged niche disrupts muscle stem cell quiescence. Nature. 2012 Oct 18; 490(7420):355-60. Chakkalakal JV, Jones KM, Basson MA, Brack AS. PMID: 23023126.
      View in: PubMed   Mentions: 215     Fields:    Translation:AnimalsCells
    24. Tissue-specific stem cells: lessons from the skeletal muscle satellite cell. Cell Stem Cell. 2012 May 04; 10(5):504-14. Brack AS, Rando TA. PMID: 22560074.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    25. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell. 2010 Nov 05; 7(5):618-30. Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A, Daley GQ, Brack AS, Collins JJ, Cowan C, Schlaeger TM, Rossi DJ. PMID: 20888316.
      View in: PubMed   Mentions: 862     Fields:    Translation:HumansCells
    26. Muscle stem cells and reversible quiescence: the role of sprouty. Cell Cycle. 2010 Jul 01; 9(13):2575-80. Abou-Khalil R, Brack AS. PMID: 20581433.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    27. Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration. Cell Stem Cell. 2010 Feb 05; 6(2):117-29. Shea KL, Xiang W, LaPorta VS, Licht JD, Keller C, Basson MA, Brack AS. PMID: 20144785.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    28. BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration. Dev Biol. 2009 Nov 01; 335(1):93-105. Brack AS, Murphy-Seiler F, Hanifi J, Deka J, Eyckerman S, Keller C, Aguet M, Rando TA. PMID: 19699733.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    29. Adult muscle stem cells avoid death and Paxes. Cell Stem Cell. 2009 Aug 07; 5(2):132-4. Brack A. PMID: 19664985.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    30. MyoD- and nerve-dependent maintenance of MyoD expression in mature muscle fibres acts through the DRR/PRR element. BMC Dev Biol. 2008 Jan 23; 8:5. Chargé SB, Brack AS, Bayol SA, Hughes SM. PMID: 18215268.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    31. A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis. Cell Stem Cell. 2008 Jan 10; 2(1):50-9. Brack AS, Conboy IM, Conboy MJ, Shen J, Rando TA. PMID: 18371421.
      View in: PubMed   Mentions: 219     Fields:    Translation:HumansAnimalsCells
    32. Age-Dependent Changes in Skeletal MuscleRegeneration. Skeletal Muscle Repair and Regeneration. 2008 Jan 1; 3:359-374. Andrew S. Brack, Thomas A. Rando. .
      View in: Publisher Site   Mentions:
    33. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science. 2007 Aug 10; 317(5839):807-10. Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, Keller C, Rando TA. PMID: 17690295.
      View in: PubMed   Mentions: 495     Fields:    Translation:AnimalsCells
    34. Intrinsic changes and extrinsic influences of myogenic stem cell function during aging. Stem Cell Rev. 2007; 3(3):226-37. Brack AS, Rando TA. PMID: 17917136.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    35. Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy. J Cell Sci. 2005 Oct 15; 118(Pt 20):4813-21. Brack AS, Bildsoe H, Hughes SM. PMID: 16219688.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    36. Muscle hypertrophy induced by the Ski protein: cyto-architecture and ultrastructure. Acta Physiol Scand. 2005 Oct; 185(2):141-9. Bruusgaard JC, Brack AS, Hughes SM, Gundersen K. PMID: 16168008.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    37. Bifunctional rhodamine probes of Myosin regulatory light chain orientation in relaxed skeletal muscle fibers. Biophys J. 2004 Apr; 86(4):2329-41. Brack AS, Brandmeier BD, Ferguson RE, Criddle S, Dale RE, Irving M. PMID: 15041671.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    38. In situ orientations of protein domains: troponin C in skeletal muscle fibers. Mol Cell. 2003 Apr; 11(4):865-74. Ferguson RE, Sun YB, Mercier P, Brack AS, Sykes BD, Corrie JE, Trentham DR, Irving M. PMID: 12718873.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    39. Aging-related satellite cell differentiation defect occurs prematurely after Ski-induced muscle hypertrophy. Am J Physiol Cell Physiol. 2002 Oct; 283(4):C1228-41. Chargé SB, Brack AS, Hughes SM. PMID: 12225986.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    40. Tissue-destructive macrophages in giant cell arteritis. Circ Res. 1999 May 14; 84(9):1050-8. Rittner HL, Kaiser M, Brack A, Szweda LI, Goronzy JJ, Weyand CM. PMID: 10325242.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
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