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Andrew Goddard, MD

Title(s)Professor, Dean's Office
SchoolSchool of Medicine
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    Andrew Goddard M.D.
    Professor, UCSF

    Dr. Goddard completed his undergraduate and medical degrees at the University of Melbourne in Australia. He completed his residency at Mount Sinai Medical Center and a postdoctoral fellowship at Yale University. Dr. Goddard is board certified in Psychiatry.

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    GABA NEURONAL DYSFUNCTION IN PANIC DISORDER
    NIH/NIMH R01MH058657Aug 15, 1999 - Jul 31, 2001
    Role: Principal Investigator
    NEURONAL INTERACTIONS IN THE SRI TREATMENT OF PANIC
    NIH/NIMH K08MH001322Sep 30, 1996 - Apr 30, 2001
    Role: Principal Investigator
    MODULATION BY 5-HT OF NE FUNCTION IN PANIC DISORDER
    NIH/NIMH R03MH050641Apr 1, 1993 - Mar 31, 1995
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Krystal AD, Pizzagalli DA, Mathew SJ, Sanacora G, Keefe R, Song A, Calabrese J, Goddard A, Goodman W, Lisanby SH, Smoski M, Weiner R, Iosifescu D, Nurnberger J, Szabo S, Murrough J, Shekhar A, Potter W. The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development. Nat Rev Drug Discov. 2018 12 28; 18(1):82-84. PMID: 30591715.
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    2. Goddard AW. Morbid Anxiety: Identification and Treatment. Focus (Am Psychiatr Publ). 2017 Apr; 15(2):136-143. PMID: 31975846.
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    3. Goddard AW. Anxiety Across the Lifespan. Focus (Am Psychiatr Publ). 2017 Apr; 15(2):135. PMID: 31975845.
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    4. Andrew W. Goddard. Morbid Anxiety: Identification and Treatment. FOCUS The Journal of Lifelong Learning in Psychiatry. 2017 Apr 1; 15(2):136-143.
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    5. Andrew W. Goddard. Anxiety Across the Lifespan. FOCUS The Journal of Lifelong Learning in Psychiatry. 2017 Apr 1; 15(2):135-135.
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    6. Andrew W. Goddard. The Neurobiology of Panic: A Chronic Stress Disorder. Chronic Stress. 2017 Jan 1; 1:2470547017736038.
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    7. Goddard AW, Schwartz K, Hendrix K, Aalsma MC, Slaven J, Hancock EF, Lambert D, Downs S, Rosenman M. Trends in Use and Cost of Second-Generation Antipsychotics Among Children and Teens in Indiana Medicaid, 2004-2012. Psychiatr Serv. 2016 09 01; 67(9):1030-4. PMID: 27181731.
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    8. Goddard AW. Cortical and subcortical gamma amino acid butyric acid deficits in anxiety and stress disorders: Clinical implications. World J Psychiatry. 2016 Mar 22; 6(1):43-53. PMID: 27014597.
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    9. Goddard AW, Mahmud W, Medlock C, Shin YW, Shekhar A. A controlled trial of quetiapine XR coadministration treatment of SSRI-resistant panic disorder. Ann Gen Psychiatry. 2015; 14:26. PMID: 26379759.
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    10. Storch EA, Goddard AW, Grant JE, De Nadai AS, Goodman WK, Mutch PJ, Medlock C, Odlaug B, McDougle CJ, Murphy TK. Double-blind, placebo-controlled, pilot trial of paliperidone augmentation in serotonin reuptake inhibitor-resistant obsessive-compulsive disorder. J Clin Psychiatry. 2013 Jun; 74(6):e527-32. PMID: 23842022.
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    11. Shin YW, Dzemidzic M, Jo HJ, Long Z, Medlock C, Dydak U, Goddard AW. Increased resting-state functional connectivity between the anterior cingulate cortex and the precuneus in panic disorder: resting-state connectivity in panic disorder. J Affect Disord. 2013 Sep 25; 150(3):1091-5. PMID: 23688914.
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    12. Long Z, Medlock C, Dzemidzic M, Shin YW, Goddard AW, Dydak U. Decreased GABA levels in anterior cingulate cortex/medial prefrontal cortex in panic disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 01; 44:131-5. PMID: 23391588.
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    13. Wilson JR, Kumar R, Goddard A, Liddington M, Carter L, Russell J, Chumas PD. Recurrent ossifying fibroma of the sphenoid bone 26 years after primary surgical excision; a case report and review of the literature. Acta Neurochir (Wien). 2013 Mar; 155(3):549-51. PMID: 23192835.
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    14. Rascati KL, Richards KM, Ott CA, Goddard AW, Stafkey-Mailey D, Alvir J, Sanders KN, Mychaskiw M. Adherence, persistence of use, and costs associated with second-generation antipsychotics for bipolar disorder. Psychiatr Serv. 2011 Sep; 62(9):1032-40. PMID: 21885581.
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    15. Karen L. Rascati, Kristin M. Richards, Carol A. Ott, Andrew W. Goddard, Dana Stafkey-Mailey, Jose Alvir, Kafi N. Sanders, Marko Mychaskiw. Adherence, Persistence of Use, and Costs Associated With Second-Generation Antipsychotics for Bipolar Disorder. Psychiatric Services. 2011 Sep 1; 62(9):1032-1040.
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    16. Philip G. Janicak, Natalie C. Dattilo, Rachel C. Manos, Eric A. Storch, Andrew W. Goddard. D-Cycloserine Augmentation of Cognitive-Behavioral Therapy for the Treatment of Anxiety Disorders. Psychopharm Review. 2011 Aug 1; 46(8):49-56.
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    17. D Stafkey-Mailey, K Richards, K Rascati, CA Ott, A Goddard, J Alvir, K Sanders, MA Mychaskiw. PMH13 COSTS ASSOCIATED WITH ANTIPSYCHOTIC MEDICATIONS FOR PATIENTS WITH A BIPOLAR DIAGNOSIS AT CLINICALLY RECOMMENDED DOSES. Value in Health. 2010 Nov 1; 13(7):a447.
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    18. EK Richards, K Rascati, CA Ott, A Goddard, D Stafkey-Mailey, J Alvir, K Sanders, MA Mychaskiw. PMH30 COSTS ASSOCIATED WITH ANTIPSYCHOTIC MEDICATIONS AT CLINICALLY RECOMMENDED DOSES BASED ON MEDICAID CLAIMS DATA FROM EIGHT STATES. Value in Health. 2010 May 1; 13(3):a109.
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    19. Coric V, Feldman HH, Oren DA, Shekhar A, Pultz J, Dockens RC, Wu X, Gentile KA, Huang SP, Emison E, Delmonte T, D'Souza BB, Zimbroff DL, Grebb JA, Goddard AW, Stock EG. Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder. Depress Anxiety. 2010 May; 27(5):417-25. PMID: 20455246.
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    20. Goddard AW, Ball SG, Martinez J, Robinson MJ, Yang CR, Russell JM, Shekhar A. Current perspectives of the roles of the central norepinephrine system in anxiety and depression. Depress Anxiety. 2010 Apr; 27(4):339-50. PMID: 19960531.
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    21. Stein M, Steckler T, Lightfoot JD, Hay E, Goddard AW. Pharmacologic treatment of panic disorder. Curr Top Behav Neurosci. 2010; 2:469-85. PMID: 21309122.
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    22. Johnson PL, Truitt W, Fitz SD, Minick PE, Dietrich A, Sanghani S, Träskman-Bendz L, Goddard AW, Brundin L, Shekhar A. A key role for orexin in panic anxiety. Nat Med. 2010 Jan; 16(1):111-5. PMID: 20037593.
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    23. Brian L. Odlaug, Waqar Mahmud, Andrew Goddard, Jon E. Grant. Anxiety Disorders. Young Adult Mental Health. 2009 Sep 1; 231-254.
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    24. C.K. Haas, A. Shekhar, A.W. Goddard. Anxiety: Drug Therapy. Encyclopedia of Neuroscience. 2009 Jan 1; (Annals of the New York Academy of Sciences9852003):499-508.
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    25. Goddard AW, Shekhar A, Whiteman AF, McDougle CJ. Serotoninergic mechanisms in the treatment of obsessive-compulsive disorder. Drug Discov Today. 2008 Apr; 13(7-8):325-32. PMID: 18405845.
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    26. Kaabi B, Gelernter J, Woods SW, Goddard A, Page GP, Elston RC. Genome scan for loci predisposing to anxiety disorders using a novel multivariate approach: strong evidence for a chromosome 4 risk locus. Am J Hum Genet. 2006 Apr; 78(4):543-53. PMID: 16532386.
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    27. Ball SG, Kuhn A, Wall D, Shekhar A, Goddard AW. Selective serotonin reuptake inhibitor treatment for generalized anxiety disorder: a double-blind, prospective comparison between paroxetine and sertraline. J Clin Psychiatry. 2005 Jan; 66(1):94-9. PMID: 15669894.
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    28. Goddard AW, Mason GF, Appel M, Rothman DL, Gueorguieva R, Behar KL, Krystal JH. Impaired GABA neuronal response to acute benzodiazepine administration in panic disorder. Am J Psychiatry. 2004 Dec; 161(12):2186-93. PMID: 15569888.
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    29. Gelernter J, Liu X, Hesselbrock V, Page GP, Goddard A, Zhang H. Results of a genomewide linkage scan: support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 01; 128B(1):94-101. PMID: 15211640.
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    30. Goddard AW, Mason GF, Rothman DL, Behar KL, Petroff OA, Krystal JH. Family psychopathology and magnitude of reductions in occipital cortex GABA levels in panic disorder. Neuropsychopharmacology. 2004 Mar; 29(3):639-40. PMID: 14973435.
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    31. Ball S, Goddard A, Shekhar A. Evaluating and treating anxiety disorders in medical settings. J Postgrad Med. 2002 Oct-Dec; 48(4):317-21. PMID: 12571395.
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    32. Krystal JH, Sanacora G, Blumberg H, Anand A, Charney DS, Marek G, Epperson CN, Goddard A, Mason GF. Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Mol Psychiatry. 2002; 7 Suppl 1:S71-80. PMID: 11986998.
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    33. Gelernter J, Bonvicini K, Page G, Woods SW, Goddard AW, Kruger S, Pauls DL, Goodson S. Linkage genome scan for loci predisposing to panic disorder or agoraphobia. Am J Med Genet. 2001 Aug 08; 105(6):548-57. PMID: 11496373.
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    34. Asnis GM, Hameedi FA, Goddard AW, Potkin SG, Black D, Jameel M, Desagani K, Woods SW. Fluvoxamine in the treatment of panic disorder: a multi-center, double-blind, placebo-controlled study in outpatients. Psychiatry Res. 2001 Aug 05; 103(1):1-14. PMID: 11472786.
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    35. Goddard AW, Brouette T, Almai A, Jetty P, Woods SW, Charney D. Early coadministration of clonazepam with sertraline for panic disorder. Arch Gen Psychiatry. 2001 Jul; 58(7):681-6. PMID: 11448376.
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    36. Goddard AW, Mason GF, Almai A, Rothman DL, Behar KL, Petroff OA, Charney DS, Krystal JH. Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy. Arch Gen Psychiatry. 2001 Jun; 58(6):556-61. PMID: 11386984.
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    37. Krystal JH, D'Souza DC, Sanacora G, Goddard AW, Charney DS. Current perspectives on the pathophysiology of schizophrenia, depression, and anxiety disorders. Med Clin North Am. 2001 May; 85(3):559-77. PMID: 11349473.
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    38. Pollack MH, Zaninelli R, Goddard A, McCafferty JP, Bellew KM, Burnham DB, Iyengar MK. Paroxetine in the treatment of generalized anxiety disorder: results of a placebo-controlled, flexible-dosage trial. J Clin Psychiatry. 2001 May; 62(5):350-7. PMID: 11411817.
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    39. Jetty PV, Charney DS, Goddard AW. Neurobiology of generalized anxiety disorder. Psychiatr Clin North Am. 2001 Mar; 24(1):75-97. PMID: 11225510.
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    40. Guo S, Yamaguchi Y, Schilbach S, Wada T, Lee J, Goddard A, French D, Handa H, Rosenthal A. A regulator of transcriptional elongation controls vertebrate neuronal development. Nature. 2000 Nov 16; 408(6810):366-9. PMID: 11099044.
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    41. Powell J, Bray J, Roberts H, Goddard A, Smith E. Goal negotiation with older people in three day care settings. Health Soc Care Community. 2000 Nov; 8(6):380-389. PMID: 11560708.
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    42. Yan M, Wang LC, Hymowitz SG, Schilbach S, Lee J, Goddard A, de Vos AM, Gao WQ, Dixit VM. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science. 2000 Oct 20; 290(5491):523-7. PMID: 11039935.
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    43. Vythilingam M, Anderson ER, Goddard A, Woods SW, Staib LH, Charney DS, Bremner JD. Temporal lobe volume in panic disorder--a quantitative magnetic resonance imaging study. Psychiatry Res. 2000 Aug 28; 99(2):75-82. PMID: 10963983.
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    44. G. Sanacora, G.F. Mason, D.L. Rothman, C.N. Epperson, A.W. Goddard, J.H. Krystal. 305. Reduced cortical GABA in depression is not due to decreased gray matter. Biological Psychiatry. 2000 Apr 1; 47(8):s92.
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    45. G.F. Mason, G. Sanacora, A. Anand, C.N. Epperson, A.W. Goddard, D.L. Rothman, D.S. Charney, J.H. Krystal. 304. Cortical GABA reduced in unipolar but not bipolar depression. Biological Psychiatry. 2000 Apr 1; 47(8):s92.
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    46. Bremner JD, Innis RB, White T, Fujita M, Silbersweig D, Goddard AW, Staib L, Stern E, Cappiello A, Woods S, Baldwin R, Charney DS. SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biol Psychiatry. 2000 Jan 15; 47(2):96-106. PMID: 10664825.
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    47. Stone DM, Murone M, Luoh S, Ye W, Armanini MP, Gurney A, Phillips H, Brush J, Goddard A, de Sauvage FJ, Rosenthal A. Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. J Cell Sci. 1999 Dec; 112 ( Pt 23):4437-48. PMID: 10564661.
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    48. Guo S, Brush J, Teraoka H, Goddard A, Wilson SW, Mullins MC, Rosenthal A. Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein soulless/Phox2a. Neuron. 1999 Nov; 24(3):555-66. PMID: 10595509.
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    49. Xie MH, Holcomb I, Deuel B, Dowd P, Huang A, Vagts A, Foster J, Liang J, Brush J, Gu Q, Hillan K, Goddard A, Gurney AL. FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. Cytokine. 1999 Oct; 11(10):729-35. PMID: 10525310.
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    50. Goddard AW, Woods SW, Money R, Pande AC, Charney DS, Goodman WK, Heninger GR, Price LH. Effects of the CCK(B) antagonist CI-988 on responses to mCPP in generalized anxiety disorder. Psychiatry Res. 1999 Mar 22; 85(3):225-40. PMID: 10333376.
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    51. Grilo CM, Money R, Barlow DH, Goddard AW, Gorman JM, Hofmann SG, Papp LA, Shear MK, Woods SW. Pretreatment patient factors predicting attrition from a multicenter randomized controlled treatment study for panic disorder. Compr Psychiatry. 1998 Nov-Dec; 39(6):323-32. PMID: 9829138.
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    52. Woods SW, Sholomskas DE, Shear MK, Gorman JM, Barlow DH, Goddard AW, Cohen J. Efficient allocation of patients to treatment cells in clinical trials with more than two treatment conditions. Am J Psychiatry. 1998 Oct; 155(10):1446-8. PMID: 9766781.
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    53. Yang RB, Mark MR, Gray A, Huang A, Xie MH, Zhang M, Goddard A, Wood WI, Gurney AL, Godowski PJ. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature. 1998 Sep 17; 395(6699):284-8. PMID: 9751057.
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    54. G. Sanacora, A.W. Goddard, R. Gil, D.C. D'Souza, W. Abi-Saab, O.A.C. Petroff, R. Mattson, G. Mason, K.L. Behar, J. Ciarcia, R. Berman, D.S. Charney, D. Rothman, J.H. Krystal. 24. Quantification of cortical GABA levels in neuropsychiatric patients. Biological Psychiatry. 1998 Apr 1; 43(8):s8.
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    55. Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A, Rosenthal A, Epstein EH, de Sauvage FJ. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature. 1998 Jan 01; 391(6662):90-2. PMID: 9422511.
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    56. Goddard AW, Charney DS. SSRIs in the treatment of panic disorder. Depress Anxiety. 1998; 8 Suppl 1:114-20. PMID: 9809223.
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    57. Hynes M, Stone DM, Dowd M, Pitts-Meek S, Goddard A, Gurney A, Rosenthal A. Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron. 1997 Jul; 19(1):15-26. PMID: 9247260.
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    58. Klein RD, Sherman D, Ho WH, Stone D, Bennett GL, Moffat B, Vandlen R, Simmons L, Gu Q, Hongo JA, Devaux B, Poulsen K, Armanini M, Nozaki C, Asai N, Goddard A, Phillips H, Henderson CE, Takahashi M, Rosenthal A. A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Nature. 1997 Jun 12; 387(6634):717-21. PMID: 9192898.
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    59. Goddard AW, Charney DS. Toward an integrated neurobiology of panic disorder. J Clin Psychiatry. 1997; 58 Suppl 2:4-11; discussion 11-2. PMID: 9078988.
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    60. Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL, Scott MP, Pennica D, Goddard A, Phillips H, Noll M, Hooper JE, de Sauvage F, Rosenthal A. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature. 1996 Nov 14; 384(6605):129-34. PMID: 8906787.
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    61. Goddard AW, Narayan M, Woods SW, Germine M, Kramer GL, Davis LL, Petty F. Plasma levels of gamma-aminobutyric acid and panic disorder. Psychiatry Res. 1996 Jul 31; 63(2-3):223-5. PMID: 8878319.
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    62. Klein RD, Gu Q, Goddard A, Rosenthal A. Selection for genes encoding secreted proteins and receptors. Proc Natl Acad Sci U S A. 1996 Jul 09; 93(14):7108-13. PMID: 8692953.
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    63. Treanor JJ, Goodman L, de Sauvage F, Stone DM, Poulsen KT, Beck CD, Gray C, Armanini MP, Pollock RA, Hefti F, Phillips HS, Goddard A, Moore MW, Buj-Bello A, Davies AM, Asai N, Takahashi M, Vandlen R, Henderson CE, Rosenthal A. Characterization of a multicomponent receptor for GDNF. Nature. 1996 Jul 04; 382(6586):80-3. PMID: 8657309.
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    64. Yang M, Luoh SM, Goddard A, Reilly D, Henzel W, Bass S. The bglX gene located at 47.8 min on the Escherichia coli chromosome encodes a periplasmic beta-glucosidase. Microbiology. 1996 Jul; 142 ( Pt 7):1659-65. PMID: 8757730.
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    65. Goddard AW, Charney DS, Germine M, Woods SW, Heninger GR, Krystal JH, Goodman WK, Price LH. Effects of tryptophan depletion on responses to yohimbine in healthy human subjects. Biol Psychiatry. 1995 Jul 15; 38(2):74-85. PMID: 7578653.
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    66. Goddard AW, Sholomskas DE, Walton KE, Augeri FM, Charney DS, Heninger GR, Goodman WK, Price LH. Effects of tryptophan depletion in panic disorder. Biol Psychiatry. 1994 Dec 01; 36(11):775-7. PMID: 7858076.
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    67. Germine M, Goddard AW, Sholomskas DE, Woods SW, Charney DS, Heninger GR. Response to meta-chlorophenylpiperazine in panic disorder patients and healthy subjects: influence of reduction in intravenous dosage. Psychiatry Res. 1994 Nov; 54(2):115-33. PMID: 7761547.
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    68. Mark MR, Scadden DT, Wang Z, Gu Q, Goddard A, Godowski PJ. rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain. J Biol Chem. 1994 Apr 08; 269(14):10720-8. PMID: 7511603.
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    69. Grillon C, Ameli R, Goddard A, Woods SW, Davis M. Baseline and fear-potentiated startle in panic disorder patients. Biol Psychiatry. 1994 Apr 01; 35(7):431-9. PMID: 8018793.
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    70. Goddard AW, Woods SW, Sholomskas DE, Goodman WK, Charney DS, Heninger GR. Effects of the serotonin reuptake inhibitor fluvoxamine on yohimbine-induced anxiety in panic disorder. Psychiatry Res. 1993 Aug; 48(2):119-33. PMID: 8416022.
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    71. Zoghbi SS, Baldwin RM, Seibyl JP, al-Tikriti MS, Zea-Ponce Y, Laruelle M, Sybirska EH, Woods SW, Goddard AW, Malison RT. Pharmacokinetics of the SPECT benzodiazepine receptor radioligand [123I]iomazenil in human and non-human primates. Int J Rad Appl Instrum B. 1992 Nov; 19(8):881-8. PMID: 1330992.
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    72. Seibyl JP, Woods SW, Zoghbi SS, Baldwin RM, Dey HM, Goddard AW, Zea-Ponce Y, Zubal G, Germine M, Smith EO. Dynamic SPECT imaging of dopamine D2 receptors in human subjects with iodine-123-IBZM. J Nucl Med. 1992 Nov; 33(11):1964-71. PMID: 1432157.
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    73. Germine M, Goddard AW, Woods SW, Charney DS, Heninger GR. Anger and anxiety responses to m-chlorophenylpiperazine in generalized anxiety disorder. Biol Psychiatry. 1992 Sep 01; 32(5):457-61. PMID: 1486151.
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    74. Woods SW, Seibyl JP, Goddard AW, Dey HM, Zoghbi SS, Germine M, Baldwin RM, Smith EO, Charney DS, Heninger GR. Dynamic SPECT imaging after injection of the benzodiazepine receptor ligand [123I]iomazenil in healthy human subjects. Psychiatry Res. 1992 Aug; 45(2):67-77. PMID: 1336860.
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