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Andrew Leavitt, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentLaboratory Medicine
Address513 Parnassus Ave, Med Sci
San Francisco CA 94122
Phone415-353-9364
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1991 Medicine (Cancer Research Institute)
    Harvard UniversityM.D.1984School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Structure Biology and Targeted Drug Design for AIDS
    NIH/NIGMS P01GM056531Sep 1, 1997 - Aug 31, 2007
    Role: Co-Investigator
    TRANSFUSION BIOLOGY AND MEDICINE
    NIH/NHLBI P50HL054476Feb 1, 1996 - Dec 31, 2006
    Role: Co-Investigator
    RETROVIRAL INTEGRATION
    NIH/NIAID R01AI036899Mar 1, 1994 - Feb 28, 1998
    Role: Principal Investigator
    DEVELOPMENT OF NEW APPROACHES TO INHIBIT GROWTH OF HIV
    NIH/NIAID U01AI027205Sep 1, 1988 - Nov 30, 1994
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt A, Passegué E, Looney MR. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 04 06; 544(7648):105-109. PMID: 28329764.
      View in: PubMed
    2. Sakurai K, Zhao S, Takatoh J, Rodriguez E, Lu J, Leavitt A, Fu M, Han BX, Wang F. Capturing and Manipulating Activated Neuronal Ensembles with CANE Delineates a Hypothalamic Social-Fear Circuit. Neuron. 2016 Nov 23; 92(4):739-753. PMID: 27974160.
      View in: PubMed
    3. Buckner TW, Leavitt A, Ragni M, Kempton CL, Eyster ME, Cuker A, Lentz SR, Ducore J, Leissinger C, Wang M, Key NS. Prospective, multicenter study of postoperative deep-vein thrombosis in patients with haemophilia undergoing major orthopaedic surgery. Thromb Haemost. 2016 Jul 04; 116(1):42-9. PMID: 27009484.
      View in: PubMed
    4. Pietras EM, Reynaud D, Kang YA, Carlin D, Calero-Nieto FJ, Leavitt A, Stuart JM, Göttgens B, Passegué E. Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions. Cell Stem Cell. 2015 Jul 02; 17(1):35-46. PMID: 26095048; PMCID: PMC4542150.
    5. Low E, Tessler R, Hauer KE, Leavitt A, Miller B, Maa J. The Surgical Clerkship and Medical Student Performance in a Standardized Patient Case of Acute Cholecystitis. J Surg Educ. 2015 Sep-Oct; 72(5):1045-51. PMID: 26089162.
      View in: PubMed
    6. Roubinian NH, Leavitt A. Shedding a little light on posttransfusion purpura. Transfusion. 2015 Feb; 55(2):232-4. PMID: 25683186.
      View in: PubMed
    7. Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA. Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Lancet Respir Med. 2015 Jan; 3(1):24-32. PMID: 25529339; PMCID: PMC4297579.
    8. Mannis GN, Logan AC, Leavitt A, Yanada M, Hwang J, Olin RL, Damon LE, Andreadis C, Ai WZ, Gaensler KM, Greene CC, Gupta NK, Kaplan LD, Mahindra A, Miyazaki Y, Naoe T, Ohtake S, Sayre PH, Smith CC, Venstrom JM, Wolf JL, Caballero L, Emi N, Martin TG. Delayed hematopoietic recovery after auto-SCT in patients receiving arsenic trioxide-based therapy for acute promyelocytic leukemia: a multi-center analysis. Bone Marrow Transplant. 2015 Jan; 50(1):40-4. PMID: 25243620.
      View in: PubMed
    9. Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt A, McKenna DH, Thompson BT, Matthay MA. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care. 2014; 4:22. PMID: 25593740; PMCID: PMC4273700.
    10. Kamata T, Dankort D, Kang J, Giblett S, Pritchard CA, McMahon M, Leavitt A. Hematopoietic expression of oncogenic BRAF promotes aberrant growth of monocyte-lineage cells resistant to PLX4720. Mol Cancer Res. 2013 Dec; 11(12):1530-41. PMID: 24152792; PMCID: PMC3869667.
    11. Jacquot C, Moayeri M, Kim B, Shugarts S, Lynch KL, Leavitt A. Prolonged ceftriaxone-induced immune thrombocytopenia due to impaired drug clearance: a case report. Transfusion. 2013 Nov; 53(11):2715-21. PMID: 23451879.
      View in: PubMed
    12. Choi YS, Patena W, Leavitt A, McManus MT. Widespread RNA 3'-end oligouridylation in mammals. RNA. 2012 Mar; 18(3):394-401. PMID: 22291204; PMCID: PMC3285928.
    13. Bu W, Chen J, Morrison GD, Huang S, Creighton CJ, Huang J, Chamness GC, Hilsenbeck SG, Roop DR, Leavitt A, Li Y. Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer. Oncogene. 2011 Oct 27; 30(43):4399-409. PMID: 21532625; PMCID: PMC3156856.
    14. Leavitt A. A vote for scientists as politicians. Science. 2011 Feb 25; 331(6020):1010. PMID: 21350149.
      View in: PubMed
    15. Leavitt A. Are there more tricks in the bag for treating thrombocytopenia? J Clin Invest. 2010 Nov; 120(11):3807-10. PMID: 20972327; PMCID: PMC2965007.
    16. King FW, Ritner C, Liszewski W, Kwan HC, Pedersen A, Leavitt A, Bernstein HS. Subpopulations of human embryonic stem cells with distinct tissue-specific fates can be selected from pluripotent cultures. Stem Cells Dev. 2009 Dec; 18(10):1441-50. PMID: 19254177; PMCID: PMC2939715.
    17. Alian A, Griner SL, Chiang V, Tsiang M, Jones G, Birkus G, Geleziunas R, Leavitt A, Stroud RM. Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs. Proc Natl Acad Sci U S A. 2009 May 19; 106(20):8192-7. PMID: 19416821; PMCID: PMC2688900.
    18. Nicholas CR, Gaur M, Wang S, Pera RA, Leavitt A. A method for single-cell sorting and expansion of genetically modified human embryonic stem cells. Stem Cells Dev. 2007 Feb; 16(1):109-17. PMID: 17348809.
      View in: PubMed
    19. Gaur M, Kamata T, Wang S, Moran B, Shattil SJ, Leavitt A. Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function. J Thromb Haemost. 2006 Feb; 4(2):436-42. PMID: 16420577.
      View in: PubMed
    20. Watson SP, Bahou WF, Fitzgerald D, Ouwehand W, Rao AK, Leavitt A. Mapping the platelet proteome: a report of the ISTH Platelet Physiology Subcommittee. J Thromb Haemost. 2005 Sep; 3(9):2098-101. PMID: 16102118.
      View in: PubMed
    21. Kamata T, Kang J, Lee TH, Wojnowski L, Pritchard CA, Leavitt A. A critical function for B-Raf at multiple stages of myelopoiesis. Blood. 2005 Aug 01; 106(3):833-40. PMID: 15784729; PMCID: PMC1895151.
    22. Kerrigan SW, Gaur M, Murphy RP, Shattil SJ, Leavitt A. Caspase-12: a developmental link between G-protein-coupled receptors and integrin alphaIIbbeta3 activation. Blood. 2004 Sep 01; 104(5):1327-34. PMID: 15059849.
      View in: PubMed
    23. Gaur M, Murphy GJ, Frampton J, Leavitt A. Using retroviruses to express genes in primary megakaryocyte lineage cells. Methods Mol Biol. 2004; 273:381-96. PMID: 15308813.
      View in: PubMed
    24. Kamata T, Pritchard CA, Leavitt A. Raf-1 is not required for megakaryocytopoiesis or TPO-induced ERK phosphorylation. Blood. 2004 Apr 01; 103(7):2568-70. PMID: 14576068.
      View in: PubMed
    25. Murphy GJ, Göttgens B, Vegiopoulos A, Sanchez MJ, Leavitt A, Watson SP, Green AR, Frampton J. Manipulation of mouse hematopoietic progenitors by specific retroviral infection. J Biol Chem. 2003 Oct 31; 278(44):43556-63. PMID: 12928443.
      View in: PubMed
    26. Eto K, Murphy R, Kerrigan SW, Bertoni A, Stuhlmann H, Nakano T, Leavitt A, Shattil SJ. Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12819-24. PMID: 12239348; PMCID: PMC130543.
    27. Shattil SJ, Leavitt A. All in the family: primary megakaryocytes for studies of platelet alphaIIbbeta3 signaling. Thromb Haemost. 2001 Jul; 86(1):259-65. PMID: 11487014.
      View in: PubMed
    28. Gaur M, Murphy GJ, deSauvage FJ, Leavitt A. Characterization of Mpl mutants using primary megakaryocyte-lineage cells from mpl(-/-) mice: a new system for Mpl structure-function studies. Blood. 2001 Mar 15; 97(6):1653-61. PMID: 11238104.
      View in: PubMed
    29. Chen JC, Krucinski J, Miercke LJ, Finer-Moore JS, Tang AH, Leavitt A, Stroud RM. Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8233-8. PMID: 10890912; PMCID: PMC26930.
    30. Shiraga M, Ritchie A, Aidoudi S, Baron V, Wilcox D, White G, Ybarrondo B, Murphy G, Leavitt A, Shattil S. Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling. J Cell Biol. 1999 Dec 27; 147(7):1419-30. PMID: 10613901; PMCID: PMC2174239.
    31. Murphy GJ, Leavitt A. A model for studying megakaryocyte development and biology. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3065-70. PMID: 10077637; PMCID: PMC15895.
    32. Gaur M, Leavitt A. Mutations in the human immunodeficiency virus type 1 integrase D,D(35)E motif do not eliminate provirus formation. J Virol. 1998 Jun; 72(6):4678-85. PMID: 9573231; PMCID: PMC109991.
    33. Mychaliska GB, Muench MO, Rice HE, Leavitt A, Cruz J, Harrison MR. The biology and ethics of banking fetal liver hematopoietic stem cells for in utero transplantation. J Pediatr Surg. 1998 Feb; 33(2):394-9. PMID: 9498425.
      View in: PubMed
    34. Fletcher TM, Soares MA, McPhearson S, Hui H, Wiskerchen M, Muesing MA, Shaw GM, Leavitt A, Boeke JD, Hahn BH. Complementation of integrase function in HIV-1 virions. EMBO J. 1997 Aug 15; 16(16):5123-38. PMID: 9305653; PMCID: PMC1170146.
    35. Gelb AB, Leavitt A. Crossmatch-compatible platelets improve corrected count increments in patients who are refractory to randomly selected platelets. Transfusion. 1997 Jun; 37(6):624-30. PMID: 9191823.
      View in: PubMed
    36. Brady KA, Cowan MJ, Leavitt A. Circulating red cells usually remain of host origin after bone marrow transplantation for severe combined immunodeficiency. Transfusion. 1996 Apr; 36(4):314-7. PMID: 8623130.
      View in: PubMed
    37. Leavitt A, Robles G, Alesandro N, Varmus HE. Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection. J Virol. 1996 Feb; 70(2):721-8. PMID: 8551608; PMCID: PMC189872.
    38. Delos SE, Cripe TP, Leavitt A, Greisman H, Garcea RL. Expression of the polyomavirus minor capsid proteins VP2 and VP3 in Escherichia coli: in vitro interactions with recombinant VP1 capsomeres. J Virol. 1995 Dec; 69(12):7734-42. PMID: 7494283; PMCID: PMC189715.
    39. Leavitt A, Shiue L, Varmus HE. Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro. J Biol Chem. 1993 Jan 25; 268(3):2113-9. PMID: 8420982.
      View in: PubMed
    40. Leavitt A, Rose RB, Varmus HE. Both substrate and target oligonucleotide sequences affect in vitro integration mediated by human immunodeficiency virus type 1 integrase protein produced in Saccharomyces cerevisiae. J Virol. 1992 Apr; 66(4):2359-68. PMID: 1548767; PMCID: PMC289031.
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