Andrew Yang, PhD

Photo of Andrew Yang, PhD
Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
Address35 Medical Center Way, #1038
San Francisco CA 94143
ORCID ORCID Icon0000-0002-6756-4746 Additional info
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    Collapse Overview 
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    Our lab studies the molecular logic of crosstalk between the brain and body. We develop new approaches to decode the meaning, mechanisms, and therapeutic relevance of unexpected protein and immune cell communication across brain barriers. By deciphering the general principles by which the periphery communicates with the brain, we will understand and rationally modulate key intercellular pathways to confer greater resilience against brain aging and neurodegeneration.

    Collapse Biography 
    Collapse education and training
    Stanford University, Stanford, CAPhDBioengineering
    MIT, Cambridge, MABSMechanical Engineering, Materials Science

    Collapse Research 
    Collapse research activities and funding
    Vascular-immune mechanisms of cerebral amyloid angiopathy and Alzheimer's pathology
    NIH RF1NS139975Sep 19, 2024 - Aug 31, 2027
    Role: Principal Investigator
    Molecular tools to decipher communication across the blood-brain barrier
    NIH DP5OD033381Sep 14, 2022 - Aug 31, 2027
    Role: Principal Investigator
    Understanding how human brain vascular cells mediate genetic risk for Alzheimer's disease
    NIH R03AG079029Aug 1, 2022 - Jul 31, 2024
    Role: Principal Investigator
    Elucidating microvascular contributions to cognitive impairment at single-cell resolution
    NIH R01NS128909Jul 1, 2022 - Jun 30, 2028
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Spatial atlas of the human brain vasculature reveals specialized cell ensembles. Cell. 2026 Jul 31. Wang JC, Sanchez D, Arul S, Gülsuyu B, Gopinadhan A, Mukhtar T, Kim J, Andrews JP, Alonso Cee Williams M, Jung Y, Hashimoto ML, Kim CN, Bhalla S, Ewing-Crystal NA, Bernabei JM, Letchuman V, Haddad AF, Hemphill K, Weinsheimer SM, Kim H, Narsinh KH, Cooke DL, Cadwell CR, Wälchli T, Elahi FM, Yang AC, He P, Chang EF, Molofsky AB, Winkler EA. PMID: 42537647.
      View in: PubMed   Mentions:    Fields:    
    2. Cerebrovascular vulnerability and fibrosis in human brain aneurysms. Nat Neurosci. 2026 Aug; 29(8):1814-1825. Wang JC, Kim CN, Bhalla S, Scherschinski L, Gopinadhan A, Arul S, Sanchez D, Schriber TD, Apolonio ACM, Gülsuyu B, Öztürk MM, Andrews JP, Kim J, Jahromi BR, Niemelä M, Lehecka M, Poddar A, Wälchli T, Catapano JS, Sen RD, Levitt MR, Cooke DL, Narsinh K, Jha RM, Hashimoto T, Oh SP, Huang EJ, Chang EF, Lim DA, Abla AA, Yang AC, Nowakowski TJ, Lawton MT, Winkler EA. PMID: 42271045; PMCID: PMC13433319.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease. Cell. 2026 Apr 30; 189(9):2648-2662.e19. Garg A, Blume SY, Huynh H, Barrios AM, Karabulut OO, Zhao Q, Midha AD, Turner AW, Resnick BV, Chen X, Agrawal A, Kim J, Chen L, Ran Q, Ryan AM, Larson RC, Negahban M, Nelson SCK, Yang AC, Traglia M, Thomas R, Sun R, Paredes M, Corces MR, Lin H, Jain IH. PMID: 41747729; PMCID: PMC13008479.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Liver exerkine reverses aging- and Alzheimer's-related memory loss via vasculature. Cell. 2026 Mar 05; 189(5):1499-1516.e25. Bieri G, Pratt KJB, Fuseya Y, Aghayev T, Sucharov J, Horowitz AM, Philp AR, Fonseca-Valencia K, Chu R, Phan M, Remesal L, Wang SJ, Yang AC, Casaletto KB, Villeda SA. PMID: 41713415; PMCID: PMC13070421.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    5. Therapeutic targeting of neuroimmune mechanisms in neurodegeneration. Nat Rev Drug Discov. 2026 May; 25(5):390-405. Monroe KM, Hong S, Lewcock JW, Yang AC. PMID: 41699298.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Beyond blood pressure: Angiotensin II drives early brain injury. Neuron. 2026 Feb 04; 114(3):375-377. Reid MM, Yang AC. PMID: 41643637.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Ageing promotes microglial accumulation of slow-degrading synaptic proteins. Nature. 2026 Feb; 650(8103):930-941. Guldner IH, Wagner VP, Moran-Losada P, Shi SM, Golub SW, Hevler JF, Chen K, Meese BT, Ghoochani A, Pulido E, Oh HS, Le Guen Y, Lu N, Wong PS, To NS, Garceau D, Guo Z, Luo J, Bertozzi CR, Lundberg E, Abu-Remaileh M, Sasner M, Keller A, Yang AC, Cheung TH, Wyss-Coray T. PMID: 41565824; PMCID: PMC12935553.
      View in: PubMed   Mentions: 3     Fields:    
    8. Resolving the mysteries of brain clearance and immune surveillance. Neuron. 2025 Dec 03; 113(23):3908-3923. Kipnis J, Benveniste H, Eichmann A, Thomas JL, Reich DS, Lewis LD, Tsai LH, Drieu A, Bakker ENTP, Kelley DH, Lundgaard I, Mestre H, Zott B, Eide PK, van Osch MJP, van Veluw SJ, Iliff J, Yang AC, Santambrogio L, Da Mesquita S, Daneman R, Rustenhoven J, Goldman SA, Nedergaard M. PMID: 41289996; PMCID: PMC12757055.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    9. Human brain vascular multi-omics elucidates disease-risk associations. Neuron. 2025 Oct 01; 113(19):3143-3161.e5. Reid MM, Menon S, Liu H, Zhou H, Hu Z, Frerich S, Ding B, Oveisgharan S, Zhang Z, Nelson S, Apolonio A, Bennett DA, Dichgans M, Pollard KS, Corces MR, Yang AC. PMID: 40730185; PMCID: PMC12321221.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Single-Cell Analysis in Cerebrovascular Research: Primed for Breakthroughs and Clinical Impact. Stroke. 2025 Apr; 56(4):1082-1091. Albertson AJ, Winkler EA, Yang AC, Buckwalter MS, Dingman AL, Fan H, Herson PS, McCullough LD, Perez-Pinzon MA, Sansing LH, Sun D, Alkayed NJ. PMID: 39772596; PMCID: PMC11932790.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    11. A protocol for collection and infusion of cerebrospinal fluid in mice. STAR Protoc. 2023 03 17; 4(1):102015. Kaur A, Shuken S, Yang AC, Iram T. PMID: 36638015; PMCID: PMC9852694.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    12. Postmortem Human Dura Mater Cells Exhibit Phenotypic, Transcriptomic and Genetic Abnormalities that Impact their Use for Disease Modeling. Stem Cell Rev Rep. 2022 12; 18(8):3050-3065. Argouarch AR, Schultz N, Yang AC, Jang Y, Garcia K, Cosme CG, Corrales CI, Nana AL, Karydas AM, Spina S, Grinberg LT, Miller B, Wyss-Coray T, Abyzov A, Goodarzi H, Seeley WW, Kao AW. PMID: 35809166; PMCID: PMC9622518.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. A human brain vascular atlas reveals diverse mediators of Alzheimer's risk. Nature. 2022 03; 603(7903):885-892. Yang AC, Vest RT, Kern F, Lee DP, Agam M, Maat CA, Losada PM, Chen MB, Schaum N, Khoury N, Toland A, Calcuttawala K, Shin H, Pálovics R, Shin A, Wang EY, Luo J, Gate D, Schulz-Schaeffer WJ, Chu P, Siegenthaler JA, McNerney MW, Keller A, Wyss-Coray T. PMID: 35165441; PMCID: PMC9635042.
      View in: PubMed   Mentions: 461     Fields:    Translation:HumansAnimalsCells
    14. Exercise plasma boosts memory and dampens brain inflammation via clusterin. Nature. 2021 12; 600(7889):494-499. De Miguel Z, Khoury N, Betley MJ, Lehallier B, Willoughby D, Olsson N, Yang AC, Hahn O, Lu N, Vest RT, Bonanno LN, Yerra L, Zhang L, Saw NL, Fairchild JK, Lee D, Zhang H, McAlpine PL, Contrepois K, Shamloo M, Elias JE, Rando TA, Wyss-Coray T. PMID: 34880498; PMCID: PMC9721468.
      View in: PubMed   Mentions: 232     Fields:    Translation:HumansAnimalsCells
    15. Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics. Am J Hum Genet. 2021 12 02; 108(12):2336-2353. He Z, Le Guen Y, Liu L, Lee J, Ma S, Yang AC, Liu X, Rutledge J, Losada PM, Song B, Belloy ME, Butler RR, Longo FM, Tang H, Mormino EC, Wyss-Coray T, Greicius MD, Ionita-Laza I. PMID: 34767756; PMCID: PMC8715147.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    16. CD4+ T cells contribute to neurodegeneration in Lewy body dementia. Science. 2021 Nov 12; 374(6569):868-874. Gate D, Tapp E, Leventhal O, Shahid M, Nonninger TJ, Yang AC, Strempfl K, Unger MS, Fehlmann T, Oh H, Channappa D, Henderson VW, Keller A, Aigner L, Galasko DR, Davis MM, Poston KL, Wyss-Coray T. PMID: 34648304; PMCID: PMC9122025.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    17. Dysregulation of brain and choroid plexus cell types in severe COVID-19. Nature. 2021 07; 595(7868):565-571. Yang AC, Kern F, Losada PM, Agam MR, Maat CA, Schmartz GP, Fehlmann T, Stein JA, Schaum N, Lee DP, Calcuttawala K, Vest RT, Berdnik D, Lu N, Hahn O, Gate D, McNerney MW, Channappa D, Cobos I, Ludwig N, Schulz-Schaeffer WJ, Keller A, Wyss-Coray T. PMID: 34153974; PMCID: PMC8400927.
      View in: PubMed   Mentions: 358     Fields:    Translation:HumansCells
    18. Cell type-selective secretome profiling in vivo. Nat Chem Biol. 2021 03; 17(3):326-334. Wei W, Riley NM, Yang AC, Kim JT, Terrell SM, Li VL, Garcia-Contreras M, Bertozzi CR, Long JZ. PMID: 33199915; PMCID: PMC7904581.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    19. Physiological blood-brain transport is impaired with age by a shift in transcytosis. Nature. 2020 07; 583(7816):425-430. Yang AC, Stevens MY, Chen MB, Lee DP, Stähli D, Gate D, Contrepois K, Chen W, Iram T, Zhang L, Vest RT, Chaney A, Lehallier B, Olsson N, du Bois H, Hsieh R, Cropper HC, Berdnik D, Li L, Wang EY, Traber GM, Bertozzi CR, Luo J, Snyder MP, Elias JE, Quake SR, James ML, Wyss-Coray T. PMID: 32612231; PMCID: PMC8331074.
      View in: PubMed   Mentions: 261     Fields:    Translation:HumansAnimalsCells
    20. Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues. Cell Rep. 2020 03 31; 30(13):4418-4432.e4. Chen MB, Yang AC, Yousef H, Lee D, Chen W, Schaum N, Lehallier B, Quake SR, Wyss-Coray T. PMID: 32234477; PMCID: PMC7292569.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    21. Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease. Nature. 2020 01; 577(7790):399-404. Gate D, Saligrama N, Leventhal O, Yang AC, Unger MS, Middeldorp J, Chen K, Lehallier B, Channappa D, De Los Santos MB, McBride A, Pluvinage J, Elahi F, Tam GK, Kim Y, Greicius M, Wagner AD, Aigner L, Galasko DR, Davis MM, Wyss-Coray T. PMID: 31915375; PMCID: PMC7445078.
      View in: PubMed   Mentions: 555     Fields:    Translation:HumansCells
    22. Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis. Cell. 2019 10 03; 179(2):459-469.e9. Yehl K, Lemire S, Yang AC, Ando H, Mimee M, Torres MT, de la Fuente-Nunez C, Lu TK. PMID: 31585083; PMCID: PMC6924272.
      View in: PubMed   Mentions: 218     Fields:    Translation:AnimalsCells
    23. Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. Nat Med. 2019 06; 25(6):988-1000. Yousef H, Czupalla CJ, Lee D, Chen MB, Burke AN, Zera KA, Zandstra J, Berber E, Lehallier B, Mathur V, Nair RV, Bonanno LN, Yang AC, Peterson T, Hadeiba H, Merkel T, Körbelin J, Schwaninger M, Buckwalter MS, Quake SR, Butcher EC, Wyss-Coray T. PMID: 31086348; PMCID: PMC6642642.
      View in: PubMed   Mentions: 245     Fields:    Translation:HumansAnimalsCells
    24. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature. 2019 04; 568(7751):187-192. Pluvinage JV, Haney MS, Smith BAH, Sun J, Iram T, Bonanno L, Li L, Lee DP, Morgens DW, Yang AC, Shuken SR, Gate D, Scott M, Khatri P, Luo J, Bertozzi CR, Bassik MC, Wyss-Coray T. PMID: 30944478; PMCID: PMC6574119.
      View in: PubMed   Mentions: 225     Fields:    Translation:AnimalsCells
    25. Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics. J Am Chem Soc. 2018 06 13; 140(23):7046-7051. Yang AC, du Bois H, Olsson N, Gate D, Lehallier B, Berdnik D, Brewer KD, Bertozzi CR, Elias JE, Wyss-Coray T. PMID: 29775058; PMCID: PMC6598694.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
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