Andy Chang, PhD
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Title(s) | Assistant Professor, Cardiovascular Research Inst |
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School | School of Medicine |
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Address | 555 Mission Bay Blvd South San Francisco CA 94158
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Phone | 415-476-5544 |
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vCard | Download vCard |
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Biography Harvard University | A.B. | 2000 | Biochemical Sciences | University of California, San Francisco | Ph.D. | 2006 | Cell Biology (Tetrad) | The Rockefeller University | Postdoc | 2008 | Neuroscience | Stanford University School of Medicine | Postdoc | 2016 | Biochemistry |
Harvard University | 2000 | | A.B., magna cum laude in Biochemical Sciences | National Science Foundation | 2001
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| 2004 | Graduate Research Fellowship | NHLBI | 2008
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| 2011 | K12 Career Development Program | Helen Hay Whitney Foundation | 2009
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| 2012 | Postdoctoral Fellowship |
Overview To maintain optimal oxygen delivery to tissues, there is constant regulation of respiratory and cardiovascular systems by mechanisms that act on different time scales. On a fast time scale, a small chemosensory organ called the carotid body senses decreases in blood oxygen to increase breathing within seconds. The carotid body can also regulate cardiovascular function acutely, and carotid body hyperactivity contributes to disease progression in hypertension, heart failure, and metabolic syndrome. Using the mouse as our primary model, we aim to identify the molecular mechanisms that mediate the carotid body’s ability to detect changes in blood oxygen as well as other metabolic signals, such as carbon dioxide and acid. One long term goal is to apply this knowledge to manipulating carotid body activity in the treatment of cardiovascular disease and metabolic syndrome.
Research ORNG Applications Bibliographic
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Chang et al. reply. Nature. 2018 09; 561(7724):E41.
Chang AJ, Kim NS, Hireed H, de Arce AD, Ortega FE, Riegler J, Madison DV, Krasnow MA. PMID: 30258152.
View in: PubMed Mentions: 1 Fields:
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Acute oxygen sensing by the carotid body: from mitochondria to plasma membrane. J Appl Physiol (1985). 2017 Nov 01; 123(5):1335-1343.
Chang AJ. PMID: 28819004.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Rodents and humans are able to detect the odour of L-Lactate. PLoS One. 2017; 12(5):e0178478.
PMID: 28542639.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimalsCells
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Oxygen regulation of breathing through an olfactory receptor activated by lactate. Nature. 2015 Nov 12; 527(7577):240-4.
PMID: 26560302.
View in: PubMed Mentions: 51 Fields: Translation: HumansAnimalsCells
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Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases. Neuron. 2009 Mar 26; 61(6):865-79.
Zimmer M, Gray JM, Pokala N, Chang AJ, Karow DS, Marletta MA, Hudson ML, Morton DB, Chronis N, Bargmann CI. PMID: 19323996.
View in: PubMed Mentions: 100 Fields: Translation: AnimalsCells
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Hypoxia and the HIF-1 transcriptional pathway reorganize a neuronal circuit for oxygen-dependent behavior in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2008 May 20; 105(20):7321-6.
Chang AJ, Bargmann CI. PMID: 18477695.
View in: PubMed Mentions: 40 Fields: Translation: AnimalsCells
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A distributed chemosensory circuit for oxygen preference in C. elegans. PLoS Biol. 2006 Sep; 4(9):e274.
Chang AJ, Chronis N, Karow DS, Marletta MA, Bargmann CI. PMID: 16903785.
View in: PubMed Mentions: 92 Fields: Translation: AnimalsCells
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Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature. 2004 Jul 15; 430(6997):317-22.
Gray JM, Karow DS, Lu H, Chang AJ, Chang JS, Ellis RE, Marletta MA, Bargmann CI. PMID: 15220933.
View in: PubMed Mentions: 218 Fields: Translation: AnimalsCells
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Regulation of Easter activity is required for shaping the Dorsal gradient in the Drosophila embryo. Development. 2002 Dec; 129(24):5635-45.
Chang AJ, Morisato D. PMID: 12421704.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Year | Publications |
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2002 | 1 | 2004 | 1 | 2006 | 1 | 2008 | 1 | 2009 | 1 | 2015 | 1 | 2017 | 2 | 2018 | 1 |
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