Anita Sil, MD, PhD

Title(s)Professor, Microbiology and Immunology
SchoolSchool of Medicine
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    Other Positions
    Title(s)Howard Hughes Investigator

    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.1998 Medicine
    University of California, San FranciscoPh.D.1996 Graduate Division (Biochemistry)

    Collapse Research 
    Collapse Research Activities and Funding
    Evolutionary multispecies transcriptomics to reveal genes that govern fungal spore germination and pathogenesis
    NIH/NIAID R01AI146584May 16, 2019 - Apr 30, 2024
    Role: Co-Principal Investigator
    Using Genetics and Genomics to Dissect Coccidioides Spherulation
    NIH/NIAID R21AI144855Feb 1, 2019 - Jan 31, 2021
    Role: Principal Investigator
    Elucidating the mechanism of macrophage death during infection with the AIDS-associated opportunistic pathogen Histoplasma capsulatum
    NIH/NIAID R01AI136735Jul 10, 2018 - Jun 30, 2022
    Role: Principal Investigator
    Proteomics Analysis of Host-Pathogen Interactions in Histoplasma
    NIH/NIAID R21AI122064Dec 15, 2015 - Nov 30, 2017
    Role: Principal Investigator
    Natural products from a human-asssociated fungal pathogen
    NIH/NIAID R21AI101722Jul 1, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Molecular dissection of Histoplasma-induced host-cell death
    NIH/NIAID R01AI093640Apr 15, 2012 - Mar 31, 2016
    Role: Principal Investigator
    Pacific Southwest RCE for Biodefense &Emerging Infectious Diseases Research
    NIH/NIAID U54AI065359May 20, 2005 - Apr 30, 2014
    Role: Co-Investigator
    Gene circuits that control morphology in Histoplasma
    NIH/NIAID R01AI066224May 15, 2005 - Apr 30, 2020
    Role: Principal Investigator
    Intracellular pathogens and innate immunity
    NIH P01AI063302Sep 30, 2004 - Jun 30, 2021
    Role: Co-Investigator

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    Collapse Global Health
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. English BC, Van Prooyen N, Örd T, Örd T, Sil A. The transcription factor CHOP, an effector of the integrated stress response, is required for host sensitivity to the fungal intracellular pathogen Histoplasma capsulatum. PLoS Pathog. 2017 Sep; 13(9):e1006589. PMID: 28953979.
      View in: PubMed
    2. Van Prooyen N, Henderson CA, Hocking Murray D, Sil A. CD103+ Conventional Dendritic Cells Are Critical for TLR7/9-Dependent Host Defense against Histoplasma capsulatum, an Endemic Fungal Pathogen of Humans. PLoS Pathog. 2016 07; 12(7):e1005749. PMID: 27459510.
      View in: PubMed
    3. Isaac DT, Berkes CA, English BC, Murray DH, Lee YN, Coady A, Sil A. Macrophage cell death and transcriptional response are actively triggered by the fungal virulence factor Cbp1 during H. capsulatum infection. Mol Microbiol. 2015 Dec; 98(5):910-929. PMID: 26288377; PMCID: PMC5002445 [Available on 12/01/16].
    4. Gilmore SA, Voorhies M, Gebhart D, Sil A. Genome-Wide Reprogramming of Transcript Architecture by Temperature Specifies the Developmental States of the Human Pathogen Histoplasma. PLoS Genet. 2015 Jul; 11(7):e1005395. PMID: 26177267; PMCID: PMC4503680.
    5. Coady A, Sil A. MyD88-dependent signaling drives host survival and early cytokine production during Histoplasma capsulatum infection. Infect Immun. 2015 Apr; 83(4):1265-75. PMID: 25583527; PMCID: PMC4363404.
    6. Sil A, Andrianopoulos A. Thermally Dimorphic Human Fungal Pathogens--Polyphyletic Pathogens with a Convergent Pathogenicity Trait. Cold Spring Harb Perspect Med. 2014 Nov 10; 5(8):a019794. PMID: 25384771.
      View in: PubMed
    7. Gilmore SA, Naseem S, Konopka JB, Sil A. N-acetylglucosamine (GlcNAc) triggers a rapid, temperature-responsive morphogenetic program in thermally dimorphic fungi. PLoS Genet. 2013; 9(9):e1003799. PMID: 24068964; PMCID: PMC3778022.
    8. Beyhan S, Gutierrez M, Voorhies M, Sil A. A temperature-responsive network links cell shape and virulence traits in a primary fungal pathogen. PLoS Biol. 2013 Jul; 11(7):e1001614. PMID: 23935449; PMCID: PMC3720256.
    9. Inglis DO, Voorhies M, Hocking Murray DR, Sil A. Comparative transcriptomics of infectious spores from the fungal pathogen Histoplasma capsulatum reveals a core set of transcripts that specify infectious and pathogenic states. Eukaryot Cell. 2013 Jun; 12(6):828-52. PMID: 23563482; PMCID: PMC3675998.
    10. Isaac DT, Coady A, Van Prooyen N, Sil A. The 3-hydroxy-methylglutaryl coenzyme A lyase HCL1 is required for macrophage colonization by human fungal pathogen Histoplasma capsulatum. Infect Immun. 2013 Feb; 81(2):411-20. PMID: 23184522; PMCID: PMC3553812.
    11. Muhammed M, Feldmesser M, Shubitz LF, Lionakis MS, Sil A, Wang Y, Glavis-Bloom J, Lewis RE, Galgiani JN, Casadevall A, Kontoyiannis DP, Mylonakis E. Mouse models for the study of fungal pneumonia: a collection of detailed experimental protocols for the study of Coccidioides, Cryptococcus, Fusarium, Histoplasma and combined infection due to Aspergillus-Rhizopus. Virulence. 2012 May 01; 3(3):329-38. PMID: 22546902; PMCID: PMC3442846.
    12. Hwang LH, Seth E, Gilmore SA, Sil A. SRE1 regulates iron-dependent and -independent pathways in the fungal pathogen Histoplasma capsulatum. Eukaryot Cell. 2012 Jan; 11(1):16-25. PMID: 22117028; PMCID: PMC3255934.
    13. Cain CW, Lohse MB, Homann OR, Sil A, Johnson AD. A conserved transcriptional regulator governs fungal morphology in widely diverged species. Genetics. 2012 Feb; 190(2):511-21. PMID: 22095082; PMCID: PMC3276625.
    14. Voorhies M, Foo CK, Sil A. Experimental annotation of the human pathogen Histoplasma capsulatum transcribed regions using high-resolution tiling arrays. BMC Microbiol. 2011 Sep 29; 11:216. PMID: 21958208; PMCID: PMC3207942.
    15. Inglis DO, Berkes CA, Hocking Murray DR, Sil A. Conidia but not yeast cells of the fungal pathogen Histoplasma capsulatum trigger a type I interferon innate immune response in murine macrophages. Infect Immun. 2010 Sep; 78(9):3871-82. PMID: 20605974; PMCID: PMC2937464.
    16. Webster RH, Sil A. Conserved factors Ryp2 and Ryp3 control cell morphology and infectious spore formation in the fungal pathogen Histoplasma capsulatum. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14573-8. PMID: 18791067; PMCID: PMC2567189.
    17. Hwang LH, Mayfield JA, Rine J, Sil A. Histoplasma requires SID1, a member of an iron-regulated siderophore gene cluster, for host colonization. PLoS Pathog. 2008 Apr 11; 4(4):e1000044. PMID: 18404210; PMCID: PMC2275787.
    18. Nguyen VQ, Sil A. Temperature-induced switch to the pathogenic yeast form of Histoplasma capsulatum requires Ryp1, a conserved transcriptional regulator. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4880-5. PMID: 18339808; PMCID: PMC2290814.
    19. Fraser JA, Stajich JE, Tarcha EJ, Cole GT, Inglis DO, Sil A, Heitman J. Evolution of the mating type locus: insights gained from the dimorphic primary fungal pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii. Eukaryot Cell. 2007 Apr; 6(4):622-9. PMID: 17337636; PMCID: PMC1865663.
    20. Gebhart D, Bahrami AK, Sil A. Identification of a copper-inducible promoter for use in ectopic expression in the fungal pathogen Histoplasma capsulatum. Eukaryot Cell. 2006 Jun; 5(6):935-44. PMID: 16757741; PMCID: PMC1489277.
    21. Nittler MP, Hocking-Murray D, Foo CK, Sil A. Identification of Histoplasma capsulatum transcripts induced in response to reactive nitrogen species. Mol Biol Cell. 2005 Oct; 16(10):4792-813. PMID: 16030248.
      View in: PubMed
    22. Hwang L, Hocking-Murray D, Bahrami AK, Andersson M, Rine J, Sil A. Identifying phase-specific genes in the fungal pathogen Histoplasma capsulatum using a genomic shotgun microarray. Mol Biol Cell. 2003 Jun; 14(6):2314-26. PMID: 12808032.
      View in: PubMed
    23. Sil AK, Xin P, Hopper JE. Vectors allowing amplified expression of the Saccharomyces cerevisiae Gal3p-Gal80p-Gal4p transcription switch: applications to galactose-regulated high-level production of proteins. Protein Expr Purif. 2000 Mar; 18(2):202-12. PMID: 10686151.
      View in: PubMed
    24. Sil AK, Alam S, Xin P, Ma L, Morgan M, Lebo CM, Woods MP, Hopper JE. The Gal3p-Gal80p-Gal4p transcription switch of yeast: Gal3p destabilizes the Gal80p-Gal4p complex in response to galactose and ATP. Mol Cell Biol. 1999 Nov; 19(11):7828-40. PMID: 10523671; PMCID: PMC84853.
    25. Takizawa PA, Sil A, Swedlow JR, Herskowitz I, Vale RD. Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast. Nature. 1997 Sep 04; 389(6646):90-3. PMID: 9288973.
      View in: PubMed
    26. Sil A, Herskowitz I. Identification of asymmetrically localized determinant, Ash1p, required for lineage-specific transcription of the yeast HO gene. Cell. 1996 Mar 08; 84(5):711-22. PMID: 8625409.
      View in: PubMed
    27. Kruger W, Peterson CL, Sil A, Coburn C, Arents G, Moudrianakis EN, Herskowitz I. Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription. Genes Dev. 1995 Nov 15; 9(22):2770-9. PMID: 7590252.
      View in: PubMed
    28. Pryciak PM, Sil A, Varmus HE. Retroviral integration into minichromosomes in vitro. EMBO J. 1992 Jan; 11(1):291-303. PMID: 1310932; PMCID: PMC556450.