Anna Bakardjiev, MD

TitleAssociate Professor
InstitutionUniversity of California San Francisco
Address513 Parnassus Ave
San Francisco CA 94143
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Medizzinsche Hochschule Hannover, Hannover, GermanyM.D.12/1995Medicine
    University of California, San Francisco, San Francisco, CAResidency 06/2000Pediatrics
    Benioff Children's Hospital, Oakland, Oakland, CAFellowship06/2003Infectious Diseases

    Collapse Overview 
    Collapse Overview
    Anna Bakardjiev MD is Associate Professor of Pediatrics, Division of Infectious Diseases and Global Health, and a member of the Microbial Pathogenesis and Host Defense program at UCSF. She is an active member of the graduate program in biomedical sciences, the director of the molecular medicine program in pediatrics, and co-director of the molecular medicine pathway for the school of medicine. Her laboratory studies host-pathogen interactions at the maternal-fetal interface with a particular focus on the pathogenesis of listeriosis. Listeria monocytogenes is a bacterial pathogen that causes febrile gastroenteritis in healthy non-pregnant adults and children. In pregnant women and immunocompromised adults L. monocytogenes can cause disseminated disease with high mortality. Infection during pregnancy leads to preterm labor, stillbirth and severe neonatal disease. The research in the Bakardjiev lab combines techniques of microbial genetics with primary human cells and tissues and relevant animal models to investigate the key processes of microbial dissemination, intracellular survival and growth, and host defenses at the maternal-fetal interface.

    Collapse Research 
    Collapse Research Activities and Funding
    Role of Host Cells in Invasive Listeriosis
    NIH/NIAID R01AI084928Jul 1, 2010 - Jun 30, 2020
    Role: Principal Investigator
    Vertical transmission of Listeria monocytogenes
    NIH/NIAID K08AI064951Apr 1, 2005 - Sep 30, 2008
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Faralla C, Bastounis EE, Ortega FE, Light SH, Rizzuto G, Nocadello S, Anderson WF, Robbins JR, Theriot JA, Bakardjiev A. Listeria monocytogenes InlP interacts with afadin and facilitates basement membrane crossing. PLoS Pathog. 2018 May 30; 14(5):e1007094. PMID: 29847585.
      View in: PubMed
    2. Lowe DE, Robbins JR, Bakardjiev A. Animal and human tissue models of vertical Listeria monocytogenes transmission and implications for other pregnancy-associated infections. Infect Immun. 2018 Feb 26. PMID: 29483290.
      View in: PubMed
    3. Rizzuto G, Tagliani E, Manandhar P, Erlebacher A, Bakardjiev A. Limited Colonization Undermined by Inadequate Early Immune Responses Defines the Dynamics of Decidual Listeriosis. Infect Immun. 2017 08; 85(8). PMID: 28507070.
      View in: PubMed
    4. Faralla C, Rizzuto GA, Lowe DE, Kim B, Cooke C, Shiow LR, Bakardjiev A. InlP, a New Virulence Factor with Strong Placental Tropism. Infect Immun. 2016 Dec; 84(12):3584-3596. PMID: 27736782.
      View in: PubMed
    5. Rizzuto GA, Kapidzic M, Gormley M, Bakardjiev A. Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface. J Vis Exp. 2016 07 21; (113). PMID: 27500727.
      View in: PubMed
    6. Vigliani MB, Bakardjiev A. Intracellular Organisms as Placental Invaders. Fetal Matern Med Rev. 2014 Nov; 25(3-4):332-338. PMID: 27695204.
      View in: PubMed
    7. Bakardjiev A. Immunology: Stillbirth prevented by signal blockade. Nature. 2015 Apr 30; 520(7549):627-8. PMID: 25925473.
      View in: PubMed
    8. Vigliani MB, Bakardjiev A. First trimester typhoid Fever with vertical transmission of salmonella typhi, an intracellular organism. Case Rep Med. 2013; 2013:973297. PMID: 24459469; PMCID: PMC3891435.
    9. Zeldovich VB, Clausen CH, Bradford E, Fletcher DA, Maltepe E, Robbins JR, Bakardjiev A. Placental syncytium forms a biophysical barrier against pathogen invasion. PLoS Pathog. 2013; 9(12):e1003821. PMID: 24348256; PMCID: PMC3861541.
    10. Zeldovich VB, Bakardjiev A. Host defense and tolerance: unique challenges in the placenta. PLoS Pathog. 2012; 8(8):e1002804. PMID: 22912572; PMCID: PMC3415450.
    11. Wasilewski M, Semenzato M, Rafelski SM, Robbins J, Bakardjiev A, Scorrano L. Optic atrophy 1-dependent mitochondrial remodeling controls steroidogenesis in trophoblasts. Curr Biol. 2012 Jul 10; 22(13):1228-34. PMID: 22658590; PMCID: PMC3396839.
    12. Robbins JR, Bakardjiev A. Pathogens and the placental fortress. Curr Opin Microbiol. 2012 Feb; 15(1):36-43. PMID: 22169833; PMCID: PMC3265690.
    13. Melton-Witt JA, Rafelski SM, Portnoy DA, Bakardjiev A. Oral infection with signature-tagged Listeria monocytogenes reveals organ-specific growth and dissemination routes in guinea pigs. Infect Immun. 2012 Feb; 80(2):720-32. PMID: 22083714; PMCID: PMC3264322.
    14. Robbins JR, Zeldovich VB, Poukchanski A, Boothroyd JC, Bakardjiev A. Tissue barriers of the human placenta to infection with Toxoplasma gondii. Infect Immun. 2012 Jan; 80(1):418-28. PMID: 22083708; PMCID: PMC3255695.
    15. Zeldovich VB, Robbins JR, Kapidzic M, Lauer P, Bakardjiev A. Invasive extravillous trophoblasts restrict intracellular growth and spread of Listeria monocytogenes. PLoS Pathog. 2011 Mar; 7(3):e1002005. PMID: 21408203; PMCID: PMC3048367.
    16. Maltepe E, Bakardjiev A, Fisher SJ. The placenta: transcriptional, epigenetic, and physiological integration during development. J Clin Invest. 2010 Apr; 120(4):1016-25. PMID: 20364099; PMCID: PMC2846055.
    17. Robbins JR, Skrzypczynska KM, Zeldovich VB, Kapidzic M, Bakardjiev A. Placental syncytiotrophoblast constitutes a major barrier to vertical transmission of Listeria monocytogenes. PLoS Pathog. 2010 Jan 22; 6(1):e1000732. PMID: 20107601; PMCID: PMC2809766.
    18. Bakardjiev A, Theriot JA, Portnoy DA. Listeria monocytogenes traffics from maternal organs to the placenta and back. PLoS Pathog. 2006 Jun; 2(6):e66. PMID: 16846254; PMCID: PMC1483233.
    19. Bakardjiev A, Stacy BA, Portnoy DA. Growth of Listeria monocytogenes in the guinea pig placenta and role of cell-to-cell spread in fetal infection. J Infect Dis. 2005 Jun 01; 191(11):1889-97. PMID: 15871123.
      View in: PubMed
    20. Bakardjiev A, Stacy BA, Fisher SJ, Portnoy DA. Listeriosis in the pregnant guinea pig: a model of vertical transmission. Infect Immun. 2004 Jan; 72(1):489-97. PMID: 14688130; PMCID: PMC343973.