Anna Orr, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    The J. David Gladstone InstitutesStaff Scientist2016Gladstone Institute of Neurological Disease
    The J. David Gladstone InstitutesResearch Scientist2014Gladstone Institute of Neurological Disease
    The J. David Gladstone Institutes and UCSFPostdoctoral fellow2013Gladstone Institute of Neurological Disease and the Department of Neurology
    Emory University, Atlanta, GAPh.D.2008Neuroscience Graduate Program
    Allegheny College, Meadville, PAB.S.2002Neuroscience, Psychology (Magna cum laude)
    Collapse Awards and Honors
    The J. David Gladstone Institutes2015Alan Kaganov Scholar
    Alzheimer's Disease Research Center, UCSF2015Resource Allocation Program Pilot Grant for Junior Investigators
    National Institute on Aging (NIA/NIH)2014K99 Pathway to Independence Career Award
    National Institute on Aging (NIA/NIH)2011F32 National Research Service Award
    National Institute of Neurological Disorders and Stroke (NINDS/NIH)2006F31 National Research Service Award
    Society for Neuroscience2013Postdoctoral Fellow Travel Award
    Society for Neuroscience2005Graduate Student Travel Award

    Collapse Overview 
    Collapse Overview
    Our goal is to understand the roles of glial cells in CNS health and disease. In particular, we investigate how receptor signaling in astrocytes and microglia affects cognitive function and neurodegeneration. Insights gained from our exploratory and preclinical studies are used to better understand the causes of disease and help develop new therapies for neurological disorders.

    Dr. Orr received her bachelor’s degree in Neuroscience and Psychology from Allegheny College in 2002 and earned her Ph.D. in Neuroscience from Emory University in 2008. She completed postdoctoral training at the Gladstone Institute of Neurological Disease in 2013. Her research has been supported by the National Institutes of Health, the Alzheimer’s Disease Research Center at UCSF, and the Alan Kaganov Scholarship. She is a recipient of the K99/R00 Pathway to Independence Career Award from the National Institute on Aging and currently a Staff Scientist at the Gladstone Institute of Neurological Disease and Assistant Adjunct Professor at UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    Roles of Astrocytic G Protein-Coupled Signaling in Memory
    NIH/NIA R00AG048222Jul 15, 2017 - Mar 31, 2020
    Role: Principal Investigator
    Roles of Astrocytic G Protein-Coupled Signaling in Memory
    NIH/NIA K99AG048222Sep 1, 2014 - Apr 30, 2016
    Role: Principal Investigator
    Astrocytic A2A Receptors: Novel Roles and Mechanisms in Alzheimers Disease
    NIH/NIA F32AG039220Sep 1, 2011 - Aug 31, 2014
    Role: Principal Investigator
    Role of Protease-Activated Receptor-2 in Reactive Glia
    NIH/NINDS F31NS054515Jul 1, 2006 - Jun 30, 2008
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Orr AG, Lo I, Schumacher H, Ho K, Gill M, Guo W, Kim DH, Knox A, Saito T, Saido TC, Simms J, Toddes C, Wang X, Yu GQ, Mucke L. Istradefylline reduces memory deficits in aging mice with amyloid pathology. Neurobiol Dis. 2018 Feb; 110:29-36. PMID: 29100987.
      View in: PubMed
    2. Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. Nat Neurosci. 2015 Mar; 18(3):423-34. PMID: 25622143.
      View in: PubMed
    3. Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu GQ, Palop JJ, Mucke L. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):E2895-903. PMID: 22869752; PMCID: PMC3479491.
    4. Cissé M, Halabisky B, Harris J, Devidze N, Dubal DB, Sun B, Orr A, Lotz G, Kim DH, Hamto P, Ho K, Yu GQ, Mucke L. Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Nature. 2011 Jan 06; 469(7328):47-52. PMID: 21113149; PMCID: PMC3030448.
    5. Mullasseril P, Hansen KB, Vance KM, Ogden KK, Yuan H, Kurtkaya NL, Santangelo R, Orr AG, Le P, Vellano KM, Liotta DC, Traynelis SF. A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nat Commun. 2010 Oct 05; 1:90. PMID: 20981015; PMCID: PMC3113701.
    6. Hansen KB, Mullasseril P, Dawit S, Kurtkaya NL, Yuan H, Vance KM, Orr AG, Kvist T, Ogden KK, Le P, Vellano KM, Lewis I, Kurtkaya S, Du Y, Qui M, Murphy TJ, Snyder JP, Bräuner-Osborne H, Traynelis SF. Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists. J Pharmacol Exp Ther. 2010 Jun; 333(3):650-62. PMID: 20197375; PMCID: PMC2879924.
    7. Gyoneva S, Orr AG, Traynelis SF. Differential regulation of microglial motility by ATP/ADP and adenosine. Parkinsonism Relat Disord. 2009 Dec; 15 Suppl 3:S195-9. PMID: 20082989.
      View in: PubMed
    8. Orr AG, Sharma A, Binder NB, Miller AH, Pearce BD. Interleukin-1 mediates long-term hippocampal dentate granule cell loss following postnatal viral infection. J Mol Neurosci. 2010 May; 41(1):89-96. PMID: 19774496.
      View in: PubMed
    9. Orr AG, Orr AL, Li XJ, Gross RE, Traynelis SF. Adenosine A(2A) receptor mediates microglial process retraction. Nat Neurosci. 2009 Jul; 12(7):872-8. PMID: 19525944; PMCID: PMC2712729.
    10. Mannaioni G, Orr AG, Hamill CE, Yuan H, Pedone KH, McCoy KL, Berlinguer Palmini R, Junge CE, Lee CJ, Yepes M, Hepler JR, Traynelis SF. Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1. J Biol Chem. 2008 Jul 18; 283(29):20600-11. PMID: 18474593; PMCID: PMC2459301.
    11. Nicole O, Goldshmidt A, Hamill CE, Sorensen SD, Sastre A, Lyuboslavsky P, Hepler JR, McKeon RJ, Traynelis SF. Activation of protease-activated receptor-1 triggers astrogliosis after brain injury. J Neurosci. 2005 Apr 27; 25(17):4319-29. PMID: 15858058.
      View in: PubMed
    12. Hamill CE, Goldshmidt A, Nicole O, McKeon RJ, Brat DJ, Traynelis SF. Special lecture: glial reactivity after damage: implications for scar formation and neuronal recovery. Clin Neurosurg. 2005; 52:29-44. PMID: 16626052.
      View in: PubMed