Anthony Sebastian, MD

InstitutionUniversity of California San Francisco
Address505 Parnassus Avenue
San Francisco CA 94117
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco Residency School of Medicine
    University of California, San FranciscoM.D.1965 School of Medicine
    Collapse Awards and Honors
    UCSFChampion of Diversity Award
    American Society of Nephology2002The Belding H. Scribner Award
    UCSF Medical School Class of 19652016The Anthony & Patricia Sebastian Endowed Scholarship

    Collapse Overview 
    Collapse Overview

    University of California, Los Angeles, B.S (Chemistry) -1960
    University of California, San Francisco, M.D. - 1965
    University of California, San Francisco, Internship & Residency, Medicine - 1966-1968
    University of California, San Francisco, Nephrology Fellowship, - 1968-1972


    Collapse Research 
    Collapse Research Activities and Funding
    NIH/NIDDK R01DK053172Mar 15, 1998 - Feb 29, 2000
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Sebastian A, Cordain L, Frassetto L, Banerjee T, Morris RC. Postulating the major environmental condition resulting in the expression of essential hypertension and its associated cardiovascular diseases: Dietary imprudence in daily selection of foods in respect of their potassium and sodium content resulting in oxidative stress-induced dysfunction of the vascular endothelium, vascular smooth muscle, and perivascular tissues. Med Hypotheses. 2018 Oct; 119:110-119. PMID: 30122481.
      View in: PubMed
    2. Frassetto L, Banerjee T, Powe N, Sebastian A. Acid Balance, Dietary Acid Load, and Bone Effects-A Controversial Subject. Nutrients. 2018 Apr 21; 10(4). PMID: 29690515.
      View in: PubMed
    3. Sebastian A, Frassetto LA. A neglected requirement for optimizing treatment of age-related osteoporosis: Replenishing the skeleton's base reservoir with net base-producing diets. Med Hypotheses. 2016 Jun; 91:103-108. PMID: 27142156.
      View in: PubMed
    4. Morris RC, Schmidlin O, Sebastian A, Tanaka M, Kurtz TW. Vasodysfunction That Involves Renal Vasodysfunction, Not Abnormally Increased Renal Retention of Sodium, Accounts for the Initiation of Salt-Induced Hypertension. Circulation. 2016 Mar 01; 133(9):881-93. PMID: 26927006; PMCID: PMC4778403 [Available on 03/01/17].
    5. Morris RC, Schmidlin O, Sebastian A, Tanaka M, Kurtz TW. Response to Hall. Circulation. 2016 Mar 01; 133(9):907. PMID: 27358993.
      View in: PubMed
    6. Raphael KL, Murphy RA, Shlipak MG, Satterfield S, Huston HK, Sebastian A, Sellmeyer DE, Patel KV, Newman AB, Sarnak MJ, Ix JH, Fried LF. Bicarbonate Concentration, Acid-Base Status, and Mortality in the Health, Aging, and Body Composition Study. Clin J Am Soc Nephrol. 2016 Feb 05; 11(2):308-16. PMID: 26769766; PMCID: PMC4741040 [Available on 02/05/17].
    7. Kalani L Raphael, Rachel A Murphy, Michael G Shlipak, Suzanne Satterfield, Hunter K Huston, Anthony Sebastian, Deborah E Sellmeyer, Kushang V Patel, Anne B Newman, Mark J Sarnak, Joachim H Ix, Linda F Fried .Bicarbonate concentration, acid-base status, and mortality in the health, aging, and body composition study. Clinical Journal of the American Society of Nephrology, CJN.06200615. 2016.
    8. Frassetto LA, Sebastian A. Commentary to accompany the paper entitled 'nutritional disturbance in acid-base balance and osteoporosis: a hypothesis that disregards the essential homeostatic role of the kidney', by Jean-Philippe Bonjour. Br J Nutr. 2013 Dec 14; 110(11):1935-7. PMID: 23769203.
      View in: PubMed
    9. Park-Sigal J, Don BR, Porzig A, Recker R, Griswold V, Sebastian A, Duh QY, Portale AA, Shoback D, Schambelan M. Severe hypercalcemic hyperparathyroidism developing in a patient with hyperaldosteronism and renal resistance to parathyroid hormone. J Bone Miner Res. 2013 Mar; 28(3):700-8. PMID: 23074096.
      View in: PubMed
    10. Moseley KF, Weaver CM, Appel L, Sebastian A, Sellmeyer DE. Potassium citrate supplementation results in sustained improvement in calcium balance in older men and women. J Bone Miner Res. 2013 Mar; 28(3):497-504. PMID: 22991267; PMCID: PMC3578058.
    11. Frassetto LA, Hardcastle AC, Sebastian A, Aucott L, Fraser WD, Reid DM, Macdonald HM. No evidence that the skeletal non-response to potassium alkali supplements in healthy postmenopausal women depends on blood pressure or sodium chloride intake. Eur J Clin Nutr. 2012 Dec; 66(12):1315-22. PMID: 23093337.
      View in: PubMed
    12. Frassetto LA, Sebastian A. How metabolic acidosis and oxidative stress alone and interacting may increase the risk of fracture in diabetic subjects. Med Hypotheses. 2012 Aug; 79(2):189-92. PMID: 22583559.
      View in: PubMed
    13. Schmidlin O, Forman A, Leone A, Sebastian A, Morris RC. Salt sensitivity in blacks: evidence that the initial pressor effect of NaCl involves inhibition of vasodilatation by asymmetrical dimethylarginine. Hypertension. 2011 Sep; 58(3):380-5. PMID: 21788605.
      View in: PubMed
    14. Ströhle A, Hahn A, Sebastian A. Latitude, local ecology, and hunter-gatherer dietary acid load: implications from evolutionary ecology. Am J Clin Nutr. 2010 Oct; 92(4):940-5. PMID: 20702605.
      View in: PubMed
    15. Schmidlin O, Tanaka M, Sebastian A, Morris RC. Selective chloride loading is pressor in the stroke-prone spontaneously hypertensive rat despite hydrochlorothiazide-induced natriuresis. J Hypertens. 2010 Jan; 28(1):87-94. PMID: 19851120; PMCID: PMC2927202.
    16. Ströhle A, Hahn A, Sebastian A. Estimation of the diet-dependent net acid load in 229 worldwide historically studied hunter-gatherer societies. Am J Clin Nutr. 2010 Feb; 91(2):406-12. PMID: 20042527.
      View in: PubMed
    17. Frassetto LA, Schloetter M, Mietus-Synder M, Morris RC, Sebastian A. Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet. Eur J Clin Nutr. 2009 Aug; 63(8):947-55. PMID: 19209185.
      View in: PubMed
    18. Frassetto LA, Morris RC, Sellmeyer DE, Sebastian A. Adverse effects of sodium chloride on bone in the aging human population resulting from habitual consumption of typical American diets. J Nutr. 2008 Feb; 138(2):419S-422S. PMID: 18203914.
      View in: PubMed
    19. Schmidlin O, Forman A, Sebastian A, Morris RC. Sodium-selective salt sensitivity: its occurrence in blacks. Hypertension. 2007 Dec; 50(6):1085-92. PMID: 17938378; PMCID: PMC2765787.
    20. Frassetto LA, Lanham-New SA, Macdonald HM, Remer T, Sebastian A, Tucker KL, Tylavsky FA. Standardizing terminology for estimating the diet-dependent net acid load to the metabolic system. J Nutr. 2007 Jun; 137(6):1491-2. PMID: 17513412.
      View in: PubMed
    21. Frassetto LA, Morris RC, Sebastian A. Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet. Am J Physiol Renal Physiol. 2007 Aug; 293(2):F521-5. PMID: 17522265.
      View in: PubMed
    22. Sebastian A, Frassetto LA, Sellmeyer DE, Morris RC. The evolution-informed optimal dietary potassium intake of human beings greatly exceeds current and recommended intakes. Semin Nephrol. 2006 Nov; 26(6):447-53. PMID: 17275582.
      View in: PubMed
    23. Morris RC, Schmidlin O, Frassetto LA, Sebastian A. Relationship and interaction between sodium and potassium. J Am Coll Nutr. 2006 Jun; 25(3 Suppl):262S-270S. PMID: 16772638.
      View in: PubMed
    24. Sebastian A. Protein consumption as an important predictor of lower-limb bone mass in elderly women. Am J Clin Nutr. 2005 Dec; 82(6):1355-6; author reply 1356. PMID: 16332672.
      View in: PubMed
    25. Sebastian A. Dietary protein content and the diet's net acid load: opposing effects on bone health. Am J Clin Nutr. 2005 Nov; 82(5):921-2. PMID: 16280420.
      View in: PubMed
    26. Sebastian A. Isoflavones, protein, and bone. Am J Clin Nutr. 2005 Apr; 81(4):733-5. PMID: 15817845.
      View in: PubMed
    27. Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, O'Keefe JH, Brand-Miller J. Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr. 2005 Feb; 81(2):341-54. PMID: 15699220.
      View in: PubMed
    28. Frassetto L, Morris RC, Sebastian A. Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women. J Clin Endocrinol Metab. 2005 Feb; 90(2):831-4. PMID: 15572425.
      View in: PubMed
    29. Sebastian A. Low versus high meat diets: effects on calcium metabolism. J Nutr. 2003 Oct; 133(10):3237-8; author reply 3240. PMID: 14519817.
      View in: PubMed
    30. Sebastian A, Frassetto LA, Sellmeyer DE, Merriam RL, Morris RC. Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors. Am J Clin Nutr. 2002 Dec; 76(6):1308-16. PMID: 12450898.
      View in: PubMed
    31. Morris RC, Sebastian A. Alkali therapy in renal tubular acidosis: who needs it? J Am Soc Nephrol. 2002 Aug; 13(8):2186-8. PMID: 12138154.
      View in: PubMed
    32. Sellmeyer DE, Schloetter M, Sebastian A. Potassium citrate prevents increased urine calcium excretion and bone resorption induced by a high sodium chloride diet. J Clin Endocrinol Metab. 2002 May; 87(5):2008-12. PMID: 11994333.
      View in: PubMed