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Streptococcus pyogenes infects human endometrium by limiting the innate immune response. J Clin Invest. 2021 02 15; 131(4).
Weckel A, Guilbert T, Lambert C, Plainvert C, Goffinet F, Poyart C, Méhats C, Fouet A. PMID: 33320843.
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Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature. Cell Rep Med. 2020 Nov 17; 1(8):100132.
Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC. PMID: 33294857.
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Permissive Fatty Acid Incorporation Promotes Staphylococcal Adaptation to FASII Antibiotics in Host Environments. Cell Rep. 2019 12 17; 29(12):3974-3982.e4.
Kénanian G, Morvan C, Weckel A, Pathania A, Anba-Mondoloni J, Halpern D, Gaillard M, Solgadi A, Dupont L, Henry C, Poyart C, Fouet A, Lamberet G, Gloux K, Gruss A. PMID: 31851927.
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7 Fields:
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AnimalsCells
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Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria. Cell Host Microbe. 2019 12 11; 26(6):795-809.e5.
Leech JM, Dhariwala MO, Lowe MM, Chu K, Merana GR, Cornuot C, Weckel A, Ma JM, Leitner EG, Gonzalez JR, Vasquez KS, Diep BA, Scharschmidt TC. PMID: 31784259.
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13 Fields:
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AnimalsCells
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MAIT cells are imprinted by the microbiota in early life and promote tissue repair. Science. 2019 10 25; 366(6464).
Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y. PMID: 31649166.
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HumansAnimalsCells
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Streptococcus pyogenes infects human endometrium by limiting its immune response. bioRxiv. 2019 Jul 25; 713875.
Antonin Weckel, Thomas Guilbert, Clara Lambert, Céline Plainvert, François Goffinet, Claire Poyart, Céline Méhats, Agnès Fouet. .
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The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus. Front Immunol. 2019; 10:1230.
Ermert D, Laabei M, Weckel A, Mörgelin M, Lundqvist M, Björck L, Ram S, Linse S, Blom AM. PMID: 31214187.
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2 Fields:
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HumansCells
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Permissive Fatty Acid Incorporation in Host Environments Promotes Staphylococcal Adaptation to FASII Antibiotics. bioRxiv. 2019 May 13; 635698.
Gérald Kénanian, Claire Morvan, Antonin Weckel, Amit Pathania, Jamila Anba-Mondoloni, David Halpern, Audrey Solgadi, Laetitia Dupont, Céline Henry, Claire Poyart, Agnès Fouet, Gilles Lamberet, Karine Gloux, Alexandra Gruss. .
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C4BP-mediated complement evasion in streptococcal infections: How the good guys turn bad. Molecular Immunology. 2018 Oct 1; 102:146.
Antonin Weckel, Michal Magda, Matthias Mörgelin, Jutamas Shaughnessy, Martin Lundqvist, Peter Rice, Lars Björck, Sara Linse, Sanjay Ram, Anna Blom, David Ermert. .
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The N-terminal domain of the R28 protein promotes emm28 group A Streptococcus adhesion to host cells via direct binding to three integrins. J Biol Chem. 2018 10 12; 293(41):16006-16018.
Weckel A, Ahamada D, Bellais S, Méhats C, Plainvert C, Longo M, Poyart C, Fouet A. PMID: 30150299.
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6 Fields:
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HumansCells
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Human IgG Increases Virulence of Streptococcus pyogenes through Complement Evasion. J Immunol. 2018 05 15; 200(10):3495-3505.
Ermert D, Weckel A, Magda M, Mörgelin M, Shaughnessy J, Rice PA, Björck L, Ram S, Blom AM. PMID: 29626087.
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6 Fields:
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HumansAnimalsCells
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A new complement evasion strategy: How S. pyogenes exploits IgGs to recruit more C4BP. Molecular Immunology. 2017 Sep 1; 89:155.
David Ermert, A. Weckel, M. Magda, J. Shaughnessy, J. Kaplan, M. Mörgelin, L. Björck, P.A. Rice, S. Ram, A.M. Blom. .
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Complete Genome Sequence of Streptococcus pyogenes emm28 Clinical Isolate M28PF1, Responsible for a Puerperal Fever. Genome Announc. 2015 Jul 16; 3(4).
Longo M, De Jode M, Plainvert C, Weckel A, Hua A, Château A, Glaser P, Poyart C, Fouet A. PMID: 26184934.
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Investigating how the highly virulent Streptococcus pyogenes AP1 strain binds and interacts with human C4BP to evade complement attack. Molecular Immunology. 2013 Dec 1; 56(3):312.
D. Ermert, A. Weckel, I.-M. Frick, L. Björck, A. Blom. .
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Binding of complement inhibitor C4b-binding protein to a highly virulent Streptococcus pyogenes M1 strain is mediated by protein H and enhances adhesion to and invasion of endothelial cells. J Biol Chem. 2013 Nov 08; 288(45):32172-32183.
Ermert D, Weckel A, Agarwal V, Frick IM, Björck L, Blom AM. PMID: 24064215.
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15 Fields:
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HumansCellsCTClinical Trials