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Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup. Immunity. 2023 Mar 29.
Weckel A, Dhariwala MO, Ly K, Tran VM, Ojewumi OT, Riggs JB, Gonzalez JR, Dwyer LR, Okoro JN, Leech JM, Bacino MS, Cho GD, Merana G, Anandasabapathy N, Kumamoto Y, Scharschmidt TC. PMID: 37028427.
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A Novel CovS Variant Harbored by a Colonization Strain Reduces Streptococcus pyogenes Virulence. J Bacteriol. 2023 Mar 15; e0003923.
Plainvert C, Rosinski-Chupin I, Weckel A, Lambert C, Touak G, Sauvage E, Poyart C, Glaser P, Fouet A. PMID: 36920220.
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AnimalsCells
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FLG Deficiency in Mice Alters the Early-Life CD4+ T-Cell Response to Skin Commensal Bacteria. J Invest Dermatol. 2023 May; 143(5):790-800.e12.
Gonzalez JR, Celli A, Weckel A, Dhariwala MO, Merana GR, Ojewumi OT, Okoro J, Dwyer LR, Tran VM, Meyer JM, Mauro TM, Scharschmidt TC. PMID: 36496196.
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AnimalsCells
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Intestinal inflammation alters the antigen-specific immune response to a skin commensal. Cell Rep. 2022 05 31; 39(9):110891.
Merana GR, Dwyer LR, Dhariwala MO, Weckel A, Gonzalez JR, Okoro JN, Cohen JN, Tamaki CM, Han J, Tasoff P, Palacios-Calderon Y, Ha CWY, Lynch SV, Segre JA, Kong HH, Kattah MG, Ma A, Scharschmidt TC. PMID: 35649365; PMCID: PMC9248974.
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1 Fields:
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AnimalsCells
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Streptococcus pyogenes infects human endometrium by limiting the innate immune response. J Clin Invest. 2021 02 15; 131(4).
Weckel A, Guilbert T, Lambert C, Plainvert C, Goffinet F, Poyart C, Méhats C, Fouet A. PMID: 33320843; PMCID: PMC7880408.
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3 Fields:
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HumansCells
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Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature. Cell Rep Med. 2020 11 17; 1(8):100132.
Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC. PMID: 33294857; PMCID: PMC7691438.
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10 Fields:
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HumansCells
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Permissive Fatty Acid Incorporation Promotes Staphylococcal Adaptation to FASII Antibiotics in Host Environments. Cell Rep. 2019 12 17; 29(12):3974-3982.e4.
Kénanian G, Morvan C, Weckel A, Pathania A, Anba-Mondoloni J, Halpern D, Gaillard M, Solgadi A, Dupont L, Henry C, Poyart C, Fouet A, Lamberet G, Gloux K, Gruss A. PMID: 31851927.
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13 Fields:
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AnimalsCells
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Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria. Cell Host Microbe. 2019 12 11; 26(6):795-809.e5.
Leech JM, Dhariwala MO, Lowe MM, Chu K, Merana GR, Cornuot C, Weckel A, Ma JM, Leitner EG, Gonzalez JR, Vasquez KS, Diep BA, Scharschmidt TC. PMID: 31784259; PMCID: PMC6989301.
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29 Fields:
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AnimalsCells
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MAIT cells are imprinted by the microbiota in early life and promote tissue repair. Science. 2019 10 25; 366(6464).
Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y. PMID: 31649166; PMCID: PMC7603427.
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153 Fields:
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HumansAnimalsCells
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Streptococcus pyogenes infects human endometrium by limiting its immune response. bioRxiv. 2019 Jul 25; 713875.
Weckel WA, Guilbert GT, Lambert LC, Plainvert PC, Goffinet GF, Poyart PC, Méhats MC, Fouet FA. .
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The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus. Front Immunol. 2019; 10:1230.
Ermert D, Laabei M, Weckel A, Mörgelin M, Lundqvist M, Björck L, Ram S, Linse S, Blom AM. PMID: 31214187; PMCID: PMC6557989.
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5 Fields:
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HumansCells
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Permissive Fatty Acid Incorporation in Host Environments Promotes Staphylococcal Adaptation to FASII Antibiotics. bioRxiv. 2019 May 13; 635698.
Kénanian KG, Morvan MC, Weckel WA, Pathania PA, Anba-Mondoloni AJ, Halpern HD, Solgadi SA, Dupont DL, Henry HC, Poyart PC, Fouet FA, Lamberet LG, Gloux GK, Gruss GA. .
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C4BP-mediated complement evasion in streptococcal infections: How the good guys turn bad. Molecular Immunology. 2018 Oct 1; 102:146.
Weckel WA, Magda MM, Mörgelin MM, Shaughnessy SJ, Lundqvist LM, Rice RP, Björck BL, Linse LS, Ram RS, Blom BA, Ermert ED. .
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The N-terminal domain of the R28 protein promotes emm28 group A Streptococcus adhesion to host cells via direct binding to three integrins. J Biol Chem. 2018 10 12; 293(41):16006-16018.
Weckel A, Ahamada D, Bellais S, Méhats C, Plainvert C, Longo M, Poyart C, Fouet A. PMID: 30150299; PMCID: PMC6187617.
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11 Fields:
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HumansCells
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Human IgG Increases Virulence of Streptococcus pyogenes through Complement Evasion. J Immunol. 2018 05 15; 200(10):3495-3505.
Ermert D, Weckel A, Magda M, Mörgelin M, Shaughnessy J, Rice PA, Björck L, Ram S, Blom AM. PMID: 29626087; PMCID: PMC6028238.
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11 Fields:
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HumansAnimalsCells
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A new complement evasion strategy: How S. pyogenes exploits IgGs to recruit more C4BP. Molecular Immunology. 2017 Sep 1; 89:155.
Ermert ED, Weckel WA, Magda MM, Shaughnessy SJ, Kaplan KJ, Mörgelin MM, Björck BL, Rice RP, Ram RS, Blom BA. .
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Complete Genome Sequence of Streptococcus pyogenes emm28 Clinical Isolate M28PF1, Responsible for a Puerperal Fever. Genome Announc. 2015 Jul 16; 3(4).
Longo M, De Jode M, Plainvert C, Weckel A, Hua A, Château A, Glaser P, Poyart C, Fouet A. PMID: 26184934; PMCID: PMC4505122.
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6
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Investigating how the highly virulent Streptococcus pyogenes AP1 strain binds and interacts with human C4BP to evade complement attack. Molecular Immunology. 2013 Dec 1; 56(3):312.
Ermert ED, Weckel WA, Frick FI, Björck BL, Blom BA. .
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Binding of complement inhibitor C4b-binding protein to a highly virulent Streptococcus pyogenes M1 strain is mediated by protein H and enhances adhesion to and invasion of endothelial cells. J Biol Chem. 2013 Nov 08; 288(45):32172-32183.
Ermert D, Weckel A, Agarwal V, Frick IM, Björck L, Blom AM. PMID: 24064215; PMCID: PMC3820857.
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22 Fields:
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HumansCellsCTClinical Trials