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Aparna Bhaduri, PhD

Title(s)Postdoctoral Scholar, Regeneration Medicine
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Rice University, Houston, TXB.S./B.A.05/2010Biochemistry and Cell Biology; Political Science
    Stanford University, Stanford, CAPh.D.06/2016Cancer Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Understanding Brain Development Through the Lens of Metabolism
    NIH/NINDS K99NS111731Jun 1, 2019 - May 31, 2021
    Role: Principal Investigator
    Using Single-Cell RNA Sequencing to Characterize Regional Differences in Cortical Development
    NIH/NINDS F32NS103266Aug 1, 2017 - Jul 31, 2019
    Role: Principal Investigator
    SMRT-2 in Epidermal Neoplasia
    NIH/NCI F31CA180408Jul 1, 2013 - Jun 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cadwell CR, Bhaduri A, Mostajo-Radji MA, Keefe MG, Nowakowski TJ. Development and Arealization of the Cerebral Cortex. Neuron. 2019 Sep 25; 103(6):980-1004. PMID: 31557462.
      View in: PubMed
    2. Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, Vistnes S, Stockley JH, Young A, Steindel M, Tung B, Goyal N, Bhaduri A, Mayer S, Engler JB, Bayraktar OA, Franklin RJM, Haeussler M, Reynolds R, Schafer DP, Friese MA, Shiow LR, Kriegstein AR, Rowitch DH. Neuronal vulnerability and multilineage diversity in multiple sclerosis. Nature. 2019 Sep; 573(7772):75-82. PMID: 31316211.
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    3. Velmeshev D, Schirmer L, Jung D, Haeussler M, Perez Y, Mayer S, Bhaduri A, Goyal N, Rowitch DH, Kriegstein AR. Single-cell genomics identifies cell type-specific molecular changes in autism. Science. 2019 05 17; 364(6441):685-689. PMID: 31097668.
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    4. A. Ji, A. Rubin, D. Reynolds, M. Guo, A. Bhaduri, B. George, S. Hollmig, S. Aasi, P. Khavari. 136 Dissecting intratumoral heterogeneity and microenvironment interactions in SCC through single-cell RNA-sequencing. Journal of Investigative Dermatology. 2019 May 1; 139(5):s24.
      View in: Publisher Site
    5. Mayer S, Chen J, Velmeshev D, Mayer A, Eze UC, Bhaduri A, Cunha CE, Jung D, Arjun A, Li E, Alvarado B, Wang S, Lovegren N, Gonzales ML, Szpankowski L, Leyrat A, West JAA, Panagiotakos G, Alvarez-Buylla A, Paredes MF, Nowakowski TJ, Pollen AA, Kriegstein AR. Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex. Neuron. 2019 Apr 03; 102(1):143-158.e7. PMID: 30770253.
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    6. Pollen AA, Bhaduri A, Andrews MG, Nowakowski TJ, Meyerson OS, Mostajo-Radji MA, Di Lullo E, Alvarado B, Bedolli M, Dougherty ML, Fiddes IT, Kronenberg ZN, Shuga J, Leyrat AA, West JA, Bershteyn M, Lowe CB, Pavlovic BJ, Salama SR, Haussler D, Eichler EE, Kriegstein AR. Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution. Cell. 2019 Feb 07; 176(4):743-756.e17. PMID: 30735633.
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    7. Miller DJ, Bhaduri A, Sestan N, Kriegstein A. Shared and derived features of cellular diversity in the human cerebral cortex. Curr Opin Neurobiol. 2019 Jun; 56:117-124. PMID: 30677551.
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    8. Adorjan I, Tyler T, Bhaduri A, Demharter S, Finszter CK, Bako M, Sebok OM, Nowakowski TJ, Khodosevich K, Møllgård K, Kriegstein AR, Shi L, Hoerder-Suabedissen A, Ansorge O, Molnár Z. Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing. J Anat. 2019 Sep; 235(3):543-554. PMID: 30644551.
      View in: PubMed
    9. Kovalski JR, Bhaduri A, Zehnder AM, Neela PH, Che Y, Wozniak GG, Khavari PA. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. Mol Cell. 2019 02 21; 73(4):830-844.e12. PMID: 30639242.
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    10. Soeren Mueller, Aparna Bhaduri, Elizabeth DiLullo, Garima Yagnik, Daniel Lim, Manish Aghi, Arnold Kriegstein, Aaron Diaz. STEM-06. A DRAFT SINGLE-CELL ATLAS OF HUMAN GLIOBLASTOMA REVEALS SPATIAL AND DIFFERENTIATION GRADIENTS OF STEM-LIKE CELLS. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi244-vi245.
      View in: Publisher Site
    11. Bhaduri A, Nowakowski TJ. Single-cell sequencing paints diverse pictures of the brain. Nature. 2018 11; 563(7729):38-39. PMID: 30382219.
      View in: PubMed
    12. Bhaduri A, Nowakowski TJ, Pollen AA, Kriegstein AR. Identification of cell types in a mouse brain single-cell atlas using low sampling coverage. BMC Biol. 2018 10 11; 16(1):113. PMID: 30309354.
      View in: PubMed
    13. Fiddes IT, Lodewijk GA, Mooring M, Bosworth CM, Ewing AD, Mantalas GL, Novak AM, van den Bout A, Bishara A, Rosenkrantz JL, Lorig-Roach R, Field AR, Haeussler M, Russo L, Bhaduri A, Nowakowski TJ, Pollen AA, Dougherty ML, Nuttle X, Addor MC, Zwolinski S, Katzman S, Kriegstein A, Eichler EE, Salama SR, Jacobs FMJ, Haussler D. Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis. Cell. 2018 05 31; 173(6):1356-1369.e22. PMID: 29856954.
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    14. V. Lopez-Pajares, A. Bhaduri, O. Garcia, A. Guerrero, G. Gowrishankar, Y. Che, A. Sanchez, L. Boxer, S. Gambhir, P. Khavari. 727 Metabolomic analysis reveals an essential role for glucose in epidermal differentiation. Journal of Investigative Dermatology. 2018 May 1; 138(5):s123.
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    15. Nagy A, Bhaduri A, Shahmarvand N, Shahryari J, Zehnder JL, Warnke RA, Mughal T, Ali S, Ohgami RS. Next-generation sequencing of idiopathic multicentric and unicentric Castleman disease and follicular dendritic cell sarcomas. Blood Adv. 2018 03 13; 2(5):481-491. PMID: 29496669.
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    16. Lee CS, Mah A, Aros CJ, Lopez-Pajares V, Bhaduri A, Webster DE, Kretz M, Khavari PA. Cancer-Associated Long Noncoding RNA SMRT-2 Controls Epidermal Differentiation. J Invest Dermatol. 2018 06; 138(6):1445-1449. PMID: 29360484.
      View in: PubMed
    17. Müller S, Kohanbash G, Liu SJ, Alvarado B, Carrera D, Bhaduri A, Watchmaker PB, Yagnik G, Di Lullo E, Malatesta M, Amankulor NM, Kriegstein AR, Lim DA, Aghi M, Okada H, Diaz A. Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment. Genome Biol. 2017 Dec 20; 18(1):234. PMID: 29262845.
      View in: PubMed
    18. Nowakowski TJ, Bhaduri A, Pollen AA, Alvarado B, Mostajo-Radji MA, Di Lullo E, Haeussler M, Sandoval-Espinosa C, Liu SJ, Velmeshev D, Ounadjela JR, Shuga J, Wang X, Lim DA, West JA, Leyrat AA, Kent WJ, Kriegstein AR. Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex. Science. 2017 12 08; 358(6368):1318-1323. PMID: 29217575.
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    19. E. Rios, A. Bhaduri, Z. Siprashvili, B. Zarnegar, P.A. Khavari. 121 The SNORD86 small non-coding RNA binds and regulates Rac1. Journal of Investigative Dermatology. 2017 May 1; 137(5):s21.
      View in: Publisher Site
    20. Ozawa MG, Bhaduri A, Chisholm KM, Baker SA, Ma L, Zehnder JL, Luna-Fineman S, Link MP, Merker JD, Arber DA, Ohgami RS. A study of the mutational landscape of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma. Mod Pathol. 2016 10; 29(10):1212-20. PMID: 27338637.
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    21. Siprashvili Z, Webster DE, Johnston D, Shenoy RM, Ungewickell AJ, Bhaduri A, Flockhart R, Zarnegar BJ, Che Y, Meschi F, Puglisi JD, Khavari PA. The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer. Nat Genet. 2016 Jan; 48(1):53-8. PMID: 26595770.
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    22. Bhaduri A, Ungewickell A, Boxer LD, Lopez-Pajares V, Zarnegar BJ, Khavari PA. Network Analysis Identifies Mitochondrial Regulation of Epidermal Differentiation by MPZL3 and FDXR. Dev Cell. 2015 Nov 23; 35(4):444-57. PMID: 26609959.
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    23. Ungewickell A, Bhaduri A, Rios E, Reuter J, Lee CS, Mah A, Zehnder A, Ohgami R, Kulkarni S, Armstrong R, Weng WK, Gratzinger D, Tavallaee M, Rook A, Snyder M, Kim Y, Khavari PA. Genomic analysis of mycosis fungoides and Sézary syndrome identifies recurrent alterations in TNFR2. Nat Genet. 2015 Sep; 47(9):1056-60. PMID: 26258847.
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    24. Lee CS, Bhaduri A, Mah A, Johnson WL, Ungewickell A, Aros CJ, Nguyen CB, Rios EJ, Siprashvili Z, Straight A, Kim J, Aasi SZ, Khavari PA. Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma. Nat Genet. 2014 Oct; 46(10):1060-2. PMID: 25194279.
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    25. Noderer WL, Flockhart RJ, Bhaduri A, Diaz de Arce AJ, Zhang J, Khavari PA, Wang CL. Quantitative analysis of mammalian translation initiation sites by FACS-seq. Mol Syst Biol. 2014 Aug 28; 10:748. PMID: 25170020.
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    26. Lee CS, Ungewickell A, Bhaduri A, Qu K, Webster DE, Armstrong R, Weng WK, Aros CJ, Mah A, Chen RO, Lin M, Sundram U, Chang HY, Kretz M, Kim YH, Khavari PA. Transcriptome sequencing in Sezary syndrome identifies Sezary cell and mycosis fungoides-associated lncRNAs and novel transcripts. Blood. 2012 Oct 18; 120(16):3288-97. PMID: 22936659.
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    27. Bhaduri A, Qu K, Lee CS, Ungewickell A, Khavari PA. Rapid identification of non-human sequences in high-throughput sequencing datasets. Bioinformatics. 2012 Apr 15; 28(8):1174-5. PMID: 22377895.
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    28. Morlacchi P, Wilson WK, Xiong Q, Bhaduri A, Sttivend D, Kolesnikova MD, Matsuda SP. Product profile of PEN3: the last unexamined oxidosqualene cyclase in Arabidopsis thaliana. Org Lett. 2009 Jun 18; 11(12):2627-30. PMID: 19445469.
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