Ashish Raj, PhD
Biography Cornell University, Ithaca, NY | PhD | 05/2005 | Electrical and Computer Engineering | University of Auckland, Auckland, New Zealand | BE | 12/1998 | Electrical Engineering |
Overview I have more than 15 years experience in computer vision, signal processing, graph theory, medical imaging and informatics. I have had continuous and successive experiences in forming and leading research teams comprising of basic and clinical scientists in executing NIH-funded research projects. I have published more than 70 peer reviewed papers ranging from microwave engineering, superconductivity, image/signal processing, vision, graph theory and neuroscience, and two US patents. I have attracted several NIH grants, on graph algorithms for accelerated MRI, theoretical neuroscience and network modeling of dementia and Parkinson’s.
The defining characteristic of my work has been inter-disciplinarity: finding innovative ways to apply computation and algorithms to biomedical applications. My group was an early adopter of mathematical models of brain connectivity networks, a subject that marries computer science with neuroradiology. I have deep interest in the graph properties of brain networks, and how they are altered in neurological disorders like epilepsy, dementia, movement disorders, traumatic brain injury and stroke. A recent project on dementia modeling was selected by the NIH for the prestigious EUREKA award that supports highly innovative but risky research, and another by the BRAIN Initiative. My team has developed novel image reconstruction algorithms for fast MRI, motion correction for MR angiography, and new methods in tractography, Q-ball imaging, brain connectivity networks and computational neurology.
My research program is now perfectly poised to help bring the fields of neurology and radiology into the era of personalized, precision medicine, using mathematical modeling and data science.
Research ORNG Applications Bibliographic
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Algebraic relationship between the structural network's Laplacian and functional network's adjacency matrix is preserved in temporal lobe epilepsy subjects. Neuroimage. 2020 Dec 30; 228:117705.
Abdelnour F, Dayan M, Devinsky O, Thesen T, Raj A. PMID: 33385550.
View in: PubMed Mentions: Fields: Translation: Humans
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Molecular Imaging of Striatal Dopaminergic Neuronal Loss and the Neurovascular Unit in Parkinson Disease. Front Neurosci. 2020; 14:528809.
Ivanidze J, Skafida M, Pandya S, Patel D, Osborne JR, Raj A, Gupta A, Henchcliffe C, Dyke JP. PMID: 33071729.
View in: PubMed Mentions:
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A dictionary-based graph-cut algorithm for MRI reconstruction. NMR Biomed. 2020 Dec; 33(12):e4344.
Xu J, Pannetier N, Raj A. PMID: 32618082.
View in: PubMed Mentions: Fields:
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Origins of atrophy in Parkinson linked to early onset and local transcription patterns. Brain Commun. 2020; 2(2):fcaa065.
Maia PD, Pandya S, Freeze B, Torok J, Gupta A, Zeighami Y, Raj A. PMID: 32954322.
View in: PubMed Mentions:
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Network mediation of pathology pattern in sporadic Creutzfeldt-Jakob disease. Brain Commun. 2020; 2(1):fcaa060.
Freeze B, Maia P, Pandya S, Raj A. PMID: 32954308.
View in: PubMed Mentions:
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Spectral graph theory of brain oscillations. Hum Brain Mapp. 2020 Aug 01; 41(11):2980-2998.
Raj A, Cai C, Xie X, Palacios E, Owen J, Mukherjee P, Nagarajan S. PMID: 32202027.
View in: PubMed Mentions: 1 Fields:
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Stereotaxic Diffusion Tensor Imaging White Matter Atlas for the in vivo Domestic Feline Brain. Front Neuroanat. 2020; 14:1.
Johnson PJ, Pascalau R, Luh WM, Raj A, Cerda-Gonzalez S, Barry EF. PMID: 32116572.
View in: PubMed Mentions:
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Dynamical Role of Pivotal Brain Regions in Parkinson Symptomatology Uncovered with Deep Learning. Brain Sci. 2020 Jan 30; 10(2).
Nguyen AA, Maia PD, Gao X, F Damasceno P, Raj A. PMID: 32019067.
View in: PubMed Mentions:
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Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation. Neurobiol Dis. 2020 02; 134:104623.
Mezias C, Rey N, Brundin P, Raj A. PMID: 31628991.
View in: PubMed Mentions: 8 Fields:
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Regional transcriptional architecture of Parkinson's disease pathogenesis and network spread. Brain. 2019 10 01; 142(10):3072-3085.
Freeze B, Pandya S, Zeighami Y, Raj A. PMID: 31359041.
View in: PubMed Mentions: 4 Fields: Translation: HumansCells
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Longitudinal increases in structural connectome segregation and functional connectome integration are associated with better recovery after mild TBI. Hum Brain Mapp. 2019 10 15; 40(15):4441-4456.
Kuceyeski AF, Jamison KW, Owen JP, Raj A, Mukherjee P. PMID: 31294921.
View in: PubMed Mentions: 4 Fields: Translation: Humans
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Slow-gamma frequencies are optimally guarded against effects of neurodegenerative diseases and traumatic brain injuries. J Comput Neurosci. 2019 08; 47(1):1-16.
Maia PD, Raj A, Kutz JN. PMID: 31165337.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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Editorial: Network Spread Models of Neurodegenerative Diseases. Front Neurol. 2018; 9:1159.
Raj A, Iturria-Medina Y. PMID: 30671020.
View in: PubMed Mentions:
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Normal diffusivity of the domestic feline brain. J Comp Neurol. 2019 04 01; 527(5):1012-1023.
Barry EF, Cerda-Gonzalez S, Luh WM, Daws RE, Raj A, Johnson PJ. PMID: 30298687.
View in: PubMed Mentions: Fields: Translation: Animals
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Models of Network Spread and Network Degeneration in Brain Disorders. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 09; 3(9):788-797.
Raj A, Powell F. PMID: 30170711.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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A method for inferring regional origins of neurodegeneration. Brain. 2018 03 01; 141(3):863-876.
Torok J, Maia PD, Powell F, Pandya S, Raj A. PMID: 29409009.
View in: PubMed Mentions: 8 Fields: Translation: HumansCells
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Functional brain connectivity is predictable from anatomic network's Laplacian eigen-structure. Neuroimage. 2018 05 15; 172:728-739.
Abdelnour F, Dayan M, Devinsky O, Thesen T, Raj A. PMID: 29454104.
View in: PubMed Mentions: 6 Fields: Translation: Humans
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Regional expression of genes mediating trans-synaptic alpha-synuclein transfer predicts regional atrophy in Parkinson disease. Neuroimage Clin. 2018; 18:456-466.
Freeze B, Acosta D, Pandya S, Zhao Y, Raj A. PMID: 29868450.
View in: PubMed Mentions: 6 Fields: Translation: Humans
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Regional vulnerability in Alzheimer's disease: The role of cell-autonomous and transneuronal processes. Alzheimers Dement. 2018 06; 14(6):797-810.
Acosta D, Powell F, Zhao Y, Raj A. PMID: 29306583.
View in: PubMed Mentions: 2 Fields: Translation: Humans
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Preserved Structural Network Organization Mediates Pathology Spread in Alzheimer's Disease Spectrum Despite Loss of White Matter Tract Integrity. J Alzheimers Dis. 2018; 65(3):747-764.
Powell F, Tosun D, Sadeghi R, Weiner M, Raj A. PMID: 29578480.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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Predictive Model of Spread of Progressive Supranuclear Palsy Using Directional Network Diffusion. Front Neurol. 2017; 8:692.
Pandya S, Mezias C, Raj A. PMID: 29312121.
View in: PubMed Mentions:
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Analysis of Amyloid-ß Pathology Spread in Mouse Models Suggests Spread Is Driven by Spatial Proximity, Not Connectivity. Front Neurol. 2017; 8:653.
Mezias C, Raj A. PMID: 29326640.
View in: PubMed Mentions:
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Age-Related Changes in Topological Degradation of White Matter Networks and Gene Expression in Chronic Schizophrenia. Brain Connect. 2017 11; 7(9):574-589.
Powell F, LoCastro E, Acosta D, Ahmed M, O'Donoghue S, Forde N, Cannon D, Scanlon C, Rao T, McDonald C, Raj A. PMID: 28946750.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Mature Hippocampal Neurons Require LIS1 for Synaptic Integrity: Implications for Cognition. Biol Psychiatry. 2018 03 15; 83(6):518-529.
Sudarov A, Zhang XJ, Braunstein L, LoCastro E, Singh S, Taniguchi Y, Raj A, Shi SH, Moore H, Ross ME. PMID: 29150182.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Connectivity, not region-intrinsic properties, predicts regional vulnerability to progressive tau pathology in mouse models of disease. Acta Neuropathol Commun. 2017 08 14; 5(1):61.
Mezias C, LoCastro E, Xia C, Raj A. PMID: 28807028.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Brain network eigenmodes provide a robust and compact representation of the structural connectome in health and disease. PLoS Comput Biol. 2017 Jun; 13(6):e1005550.
Wang MB, Owen JP, Mukherjee P, Raj A. PMID: 28640803.
View in: PubMed Mentions: 4 Fields: Translation: Humans
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MRI Analysis of White Matter Myelin Water Content in Multiple Sclerosis: A Novel Approach Applied to Finding Correlates of Cortical Thinning. Front Neurosci. 2017; 11:284.
Dayan M, Hurtado Rúa SM, Monohan E, Fujimoto K, Pandya S, LoCastro EM, Vartanian T, Nguyen TD, Raj A, Gauthier SA. PMID: 28603479.
View in: PubMed Mentions:
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The Brain's Structural Connectome Mediates the Relationship between Regional Neuroimaging Biomarkers in Alzheimer's Disease. J Alzheimers Dis. 2017; 55(4):1639-1657.
Pandya S, Kuceyeski A, Raj A, . PMID: 27911289.
View in: PubMed Mentions: 5 Fields: Translation: Humans
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Network Analysis on Predicting Mean Diffusivity Change at Group Level in Temporal Lobe Epilepsy. Brain Connect. 2016 10; 6(8):607-620.
Abdelnour F, Raj A, Devinsky O, Thesen T. PMID: 27405726.
View in: PubMed Mentions: 1 Fields:
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Diffuse reduction of cerebral grey matter volumes in Erdheim-Chester disease. Orphanet J Rare Dis. 2016 08 02; 11(1):109.
Diamond EL, Hatzoglou V, Patel S, Abdel-Wahab O, Rampal R, Hyman DM, Holodny AI, Raj A. PMID: 27484739.
View in: PubMed Mentions: 4 Fields: Translation: Humans
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Structural connectome disruption at baseline predicts 6-months post-stroke outcome. Hum Brain Mapp. 2016 07; 37(7):2587-601.
Kuceyeski A, Navi BB, Kamel H, Raj A, Relkin N, Toglia J, Iadecola C, O'Dell M. PMID: 27016287.
View in: PubMed Mentions: 13 Fields: Translation: Humans
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Profilometry: A new statistical framework for the characterization of white matter pathways, with application to multiple sclerosis. Hum Brain Mapp. 2016 Mar; 37(3):989-1004.
Dayan M, Monohan E, Pandya S, Kuceyeski A, Nguyen TD, Raj A, Gauthier SA. PMID: 26667008.
View in: PubMed Mentions: 4 Fields: Translation: Humans
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Relating Cortical Atrophy in Temporal Lobe Epilepsy with Graph Diffusion-Based Network Models. PLoS Comput Biol. 2015 Oct; 11(10):e1004564.
Abdelnour F, Mueller S, Raj A. PMID: 26513579.
View in: PubMed Mentions: 5 Fields: Translation: Humans
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Measuring longitudinal myelin water fraction in new multiple sclerosis lesions. Neuroimage Clin. 2015; 9:369-75.
Vargas WS, Monohan E, Pandya S, Raj A, Vartanian T, Nguyen TD, Hurtado Rúa SM, Gauthier SA. PMID: 26594620.
View in: PubMed Mentions: 13 Fields: Translation: HumansCells
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Feasibility and reproducibility of whole brain myelin water mapping in 4 minutes using fast acquisition with spiral trajectory and adiabatic T2prep (FAST-T2) at 3T. Magn Reson Med. 2016 08; 76(2):456-65.
Nguyen TD, Deh K, Monohan E, Pandya S, Spincemaille P, Raj A, Wang Y, Gauthier SA. PMID: 26331978.
View in: PubMed Mentions: 11 Fields: Translation: HumansCells
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Exploring the brain's structural connectome: A quantitative stroke lesion-dysfunction mapping study. Hum Brain Mapp. 2015 Jun; 36(6):2147-60.
Kuceyeski A, Navi BB, Kamel H, Relkin N, Villanueva M, Raj A, Toglia J, O'Dell M, Iadecola C. PMID: 25655204.
View in: PubMed Mentions: 9 Fields: Translation: Humans
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Network Diffusion Model of Progression Predicts Longitudinal Patterns of Atrophy and Metabolism in Alzheimer's Disease. Cell Rep. 2015 Jan 20; 10(3):359-369.
Raj A, LoCastro E, Kuceyeski A, Tosun D, Relkin N, Weiner M, . PMID: 25600871.
View in: PubMed Mentions: 41 Fields:
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Simultaneous phase unwrapping and removal of chemical shift (SPURS) using graph cuts: application in quantitative susceptibility mapping. IEEE Trans Med Imaging. 2015 Feb; 34(2):531-40.
Dong J, Liu T, Chen F, Zhou D, Dimov A, Raj A, Cheng Q, Spincemaille P, Wang Y. PMID: 25312917.
View in: PubMed Mentions: 18 Fields: Translation: Humans
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Widespread white matter degeneration preceding the onset of dementia. Alzheimers Dement. 2015 May; 11(5):485-493.e2.
Maier-Hein KH, Westin CF, Shenton ME, Weiner MW, Raj A, Thomann P, Kikinis R, Stieltjes B, Pasternak O. PMID: 25035154.
View in: PubMed Mentions: 20 Fields: Translation: HumansCells
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Multi-compartment T2 relaxometry using a spatially constrained multi-Gaussian model. PLoS One. 2014; 9(6):e98391.
Raj A, Pandya S, Shen X, LoCastro E, Nguyen TD, Gauthier SA. PMID: 24896833.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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Spatial patterns of genome-wide expression profiles reflect anatomic and fiber connectivity architecture of healthy human brain. Hum Brain Mapp. 2014 Aug; 35(8):4204-18.
Goel P, Kuceyeski A, LoCastro E, Raj A. PMID: 24677576.
View in: PubMed Mentions: 12 Fields: Translation: Humans
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Predicting future brain tissue loss from white matter connectivity disruption in ischemic stroke. Stroke. 2014 Mar; 45(3):717-22.
Kuceyeski A, Kamel H, Navi BB, Raj A, Iadecola C. PMID: 24523041.
View in: PubMed Mentions: 15 Fields: Translation: Humans
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Network diffusion accurately models the relationship between structural and functional brain connectivity networks. Neuroimage. 2014 Apr 15; 90:335-47.
Abdelnour F, Voss HU, Raj A. PMID: 24384152.
View in: PubMed Mentions: 42 Fields: Translation: Humans
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Discriminative random field segmentation of lung nodules in CT studies. Comput Math Methods Med. 2013; 2013:683216.
Liu B, Raj A. PMID: 24592283.
View in: PubMed Mentions: Fields: Translation: Humans
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The Network Modification (NeMo) Tool: elucidating the effect of white matter integrity changes on cortical and subcortical structural connectivity. Brain Connect. 2013; 3(5):451-63.
Kuceyeski A, Maruta J, Relkin N, Raj A. PMID: 23855491.
View in: PubMed Mentions: 19 Fields: Translation: Humans
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Robust myelin quantitative imaging from multi-echo T2 MRI using edge preserving spatial priors. Med Image Comput Comput Assist Interv. 2013; 16(Pt 1):622-30.
Shen X, Nguyen TD, Gauthier SA, Raj A. PMID: 24505719.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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Loss in connectivity among regions of the brain reward system in alcohol dependence. Hum Brain Mapp. 2013 Dec; 34(12):3129-42.
Kuceyeski A, Meyerhoff DJ, Durazzo TC, Raj A. PMID: 22815206.
View in: PubMed Mentions: 9 Fields: Translation: Humans
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Statistics of weighted brain networks reveal hierarchical organization and Gaussian degree distribution. PLoS One. 2012; 7(6):e35029.
Ivkovic M, Kuceyeski A, Raj A. PMID: 22761649.
View in: PubMed Mentions: 8 Fields: Translation: Humans
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A network diffusion model of disease progression in dementia. Neuron. 2012 Mar 22; 73(6):1204-15.
Raj A, Kuceyeski A, Weiner M. PMID: 22445347.
View in: PubMed Mentions: 185 Fields: Translation: Humans
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Linking white matter integrity loss to associated cortical regions using structural connectivity information in Alzheimer's disease and fronto-temporal dementia: the Loss in Connectivity (LoCo) score. Neuroimage. 2012 Jul 16; 61(4):1311-23.
Kuceyeski A, Zhang Y, Raj A. PMID: 22484307.
View in: PubMed Mentions: 10 Fields: Translation: HumansCells
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Bayesian algorithm using spatial priors for multiexponential T2 relaxometry from multiecho spin echo MRI. Magn Reson Med. 2012 Nov; 68(5):1536-43.
Kumar D, Nguyen TD, Gauthier SA, Raj A. PMID: 22266707.
View in: PubMed Mentions: 20 Fields: Translation: HumansCells
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T2 prep three-dimensional spiral imaging with efficient whole brain coverage for myelin water quantification at 1.5 tesla. Magn Reson Med. 2012 Mar; 67(3):614-21.
Nguyen TD, Wisnieff C, Cooper MA, Kumar D, Raj A, Spincemaille P, Wang Y, Vartanian T, Gauthier SA. PMID: 22344579.
View in: PubMed Mentions: 19 Fields: Translation: HumansCells
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The wiring economy principle: connectivity determines anatomy in the human brain. PLoS One. 2011; 6(9):e14832.
Raj A, Chen YH. PMID: 21915250.
View in: PubMed Mentions: 26 Fields: Translation: Humans
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A pilot study of quantitative MRI measurements of ventricular volume and cortical atrophy for the differential diagnosis of normal pressure hydrocephalus. Neurol Res Int. 2012; 2012:718150.
Moore DW, Kovanlikaya I, Heier LA, Raj A, Huang C, Chu KW, Relkin NR. PMID: 21860791.
View in: PubMed Mentions:
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The generation and validation of white matter connectivity importance maps. Neuroimage. 2011 Sep 01; 58(1):109-21.
Kuceyeski A, Maruta J, Niogi SN, Ghajar J, Raj A. PMID: 21722739.
View in: PubMed Mentions: 18 Fields: Translation: Humans
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A fast Edge-preserving Bayesian reconstruction method for Parallel Imaging applications in cardiac MRI. Magn Reson Med. 2011 Jan; 65(1):184-9.
Singh G, Raj A, Kressler B, Nguyen TD, Spincemaille P, Zabih R, Wang Y. PMID: 20939095.
View in: PubMed Mentions: Fields: Translation: Humans
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Spatial HARDI: improved visualization of complex white matter architecture with Bayesian spatial regularization. Neuroimage. 2011 Jan 01; 54(1):396-409.
Raj A, Hess C, Mukherjee P. PMID: 20670684.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
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Visualization and segmentation of liver tumors using dynamic contrast MRI. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:6985-9.
Raj A, Juluru K. PMID: 19964723.
View in: PubMed Mentions:
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A maximum likelihood approach to parallel imaging with coil sensitivity noise. IEEE Trans Med Imaging. 2007 Aug; 26(8):1046-57.
Raj A, Wang Y, Zabih R. PMID: 17695125.
View in: PubMed Mentions: Fields: Translation: Humans
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Fast and stable bayesian image expansion using sparse edge priors. IEEE Trans Image Process. 2007 Apr; 16(4):1073-84.
Raj A, Thakur K. PMID: 17405438.
View in: PubMed Mentions: Fields:
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Bayesian parallel imaging with edge-preserving priors. Magn Reson Med. 2007 Jan; 57(1):8-21.
Raj A, Singh G, Zabih R, Kressler B, Wang Y, Schuff N, Weiner M. PMID: 17195165.
View in: PubMed Mentions: 11 Fields: Translation: Humans
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Automatic algorithm for correcting motion artifacts in time-resolved two-dimensional magnetic resonance angiography using convex projections. Magn Reson Med. 2006 Mar; 55(3):649-58.
Raj A, Zhang H, Prince MR, Wang Y, Zabih R. PMID: 16463347.
View in: PubMed Mentions: 2 Fields: Translation: Humans
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Statistical aspects of parallel imaging reconstruction. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:377-80.
Raj A, Kressler B, Singh G, Zabih R, Wang Y. PMID: 17946826.
View in: PubMed Mentions: Fields: Translation: Humans
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Improved signal-to-noise ratio in parallel coronary artery magnetic resonance angiography using graph cuts based Bayesian reconstruction. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:703-6.
Singh G, Nguyen T, Kressler B, Spincemaille P, Raj A, Zabih R, Wang Y. PMID: 17946852.
View in: PubMed Mentions: Fields: Translation: Humans
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Year | Publications |
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2006 | 3 | 2007 | 3 | 2009 | 1 | 2010 | 1 | 2011 | 4 | 2012 | 6 | 2013 | 4 | 2014 | 5 | 2015 | 6 | 2016 | 3 | 2017 | 8 | 2018 | 7 | 2019 | 5 | 2020 | 8 |
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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