Audrey Hendley, PhD

Title(s)Associate Specialist, Surgery
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE, #550
San Francisco CA 94143
ORCID ORCID Icon0000-0003-0289-2092 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Johns Hopkins Univeristy School of MedicinePh.D. Human Genetics and Molecular Biology2016McKusick/Nathans Institute of Genetic Medicine
    University of South Carolina AikenB.S. Biology (Major), Chemistry (Minor)2009Department of Biology and Geology
    Collapse Awards and Honors
    American Pancreatic Association Annual Meeting2017APA Young Investigator Award
    American Pancreatic Association Annual Meeting2015Women in Pancreas travel award
    Gordon Research Conference on Pancreatic Diseases2015Travel Award
    University of South Carolina Aiken2009Outstanding Senior Student
    University of South Carolina Aiken2009Biology Student of the Year
    University of South Carolina2008Magellan Research Scholarship

    Collapse Overview 
    Collapse Overview
    As an Associate Specialist in the Surgery department at UCSF, my focus rests predominantly on the intersection of genetics and molecular biology particularly in relation to pancreatic diseases. Having received a B.S. in Biology from the University of South Carolina Aiken, I pursued a PhD in Human Genetics and Molecular Biology at Johns Hopkins University School of Medicine. My work, both as a researcher and principal investigator, has centered around exploring ceramide signaling, pancreatic cancer initiation, and the potential of genetic insights in combatting cancer. This has resulted in numerous research contributions and recognition in the form of awards, signifying a career marked by a deep-rooted interest in advancing our understanding of pancreatic cancer biology.

    Collapse Research 
    Collapse Research Activities and Funding
    Examination of ceramide signaling in the crosstalk between pancreatic cancer cells and the tumor microenvironment
    NIH F32CA221114Dec 1, 2017 - Nov 30, 2020
    Role: Principal Investigator
    Understanding sphingolipid metabolism in pancreatic cancer initiation, progression, and chemotherapeutics
    Hirshberg Foundation for Pancreatic Cancer Research Seed GrantNov 18, 2016 - Nov 30, 2017
    Role: Principal Investigator
    Molecular and Cellular Mechanisms in Cancer
    NIH T32CA108462Sep 1, 2004 - Aug 31, 2025
    Role: Trainee
    Predoctoral Training Program in Human Genetics
    NIH T32GM007814Jul 1, 1980 - Jun 30, 2022
    Role: Trainee

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Abstract A046: nSMase2-generated ceramide promotes PDA aggression through exosome reprogramming of the stroma. Cancer Research. 2024 Jan 16; 84(2_Supplement):a046-a046. Hendley HA, Urano UA, Peng PX, Ashe AS, Phu PT, Ng NM, Kerper KN, Berrios BD, Lee LJ, Jin JD, Jang JG, Gbenedio GO, Roose RJ, Yeh YJ, Gallinger GS, Biankin BA, Ntranos NV, Chang CD, Dawson DD, Kim KG, Weaver WV, Raffai RR, Hebrok HM. .
      View in: Publisher Site   Mentions:
    2. Abstract C051: Ceramide signaling regulates PDA aggression through exosome reprogramming of the stroma. Cancer Research. 2022 Nov 15; 82(22_Supplement):c051-c051. Hendley HA, Urano UA, Peng PX, Ashe AS, Kerper KN, Phu PT, Ng NM, Giacometti GS, Berrios BD, Jang JG, Yeh YJ, Gallinger GS, Chang CD, Biankin BA, Weaver WV, Kim KG, Dawson DD, Raffai RR, Hebrok HM. .
      View in: Publisher Site   Mentions:
    3. Abstract PR-008: Kdm6 demethylases are critical regulators of pancreatic cancer initiation, progression and subtype specification. Cancer Research. 2021 Nov 15; 81(22_Supplement):pr-008-pr-008. Leonhardt LL, Li LL, Berrios BD, Ashe AS, Hendley HA, Kim KG, Hebrok HM. .
      View in: Publisher Site   Mentions:
    4. Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree. Elife. 2021 05 19; 10. Hendley AM, Rao AA, Leonhardt L, Ashe S, Smith JA, Giacometti S, Peng XL, Jiang H, Berrios DI, Pawlak M, Li LY, Lee J, Collisson EA, Anderson MS, Fragiadakis GK, Yeh JJ, Ye CJ, Kim GE, Weaver VM, Hebrok M. PMID: 34009124; PMCID: PMC8184217.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    5. Abstract C20: Smpd3 augments chemotherapy and thwarts PDA progression. Cancer Research. 2019 Dec 13; 79(24_Supplement):c20-c20. Hendley HA, Urano UA, Kerper KN, Duong DP, Bailey BP, Chang CD, Biankin BA, Dawson DD, Kim KG, Raffai RR, Hebrok HM. .
      View in: Publisher Site   Mentions:
    6. Abstract PR03: Mutant p53 promotes adenocarcinoma in pancreatic ductal cells. Early Detection. 2016 Dec 15; pr03-pr03. Polireddy PK, Hendley HA, Pruski PM, Lafaro LK, Younes YM, Maitra MA, McAllister MF, Iacobuzio-Donahue IC, Dar DW, Bynon BJ, Leach LS, Bailey BJ. .
      View in: Publisher Site   Mentions:
    7. p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia. Cancer Res. 2016 06 01; 76(11):3351-63. Hendley AM, Wang YJ, Polireddy K, Alsina J, Ahmed I, Lafaro KJ, Zhang H, Roy N, Savidge SG, Cao Y, Hebrok M, Maitra A, Reynolds AB, Goggins M, Younes M, Iacobuzio-Donahue CA, Leach SD, Bailey JM. PMID: 27032419; PMCID: PMC4891257.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    8. Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions. Gastroenterology. 2016 Apr; 150(4):918-30.e13. Choi E, Hendley AM, Bailey JM, Leach SD, Goldenring JR. PMID: 26677984; PMCID: PMC4808451.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    9. p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells. Oncogene. 2016 08 11; 35(32):4282-8. Bailey JM, Hendley AM, Lafaro KJ, Pruski MA, Jones NC, Alsina J, Younes M, Maitra A, McAllister F, Iacobuzio-Donahue CA, Leach SD. PMID: 26592447.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    10. New insights into plasticity of pancreatic cancer: cancer to acinar cell reprogramming by the basic helix-loop-helix transcription factor E47. Pancreas. 2015 Jul; 44(5):683-5. Bailey JM, Hendley AM, Maitra A. PMID: 26061556.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    11. Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics. Regad T, Sayers TJ, Rees RC, editors. Chapter 11, Stem Cells and Pancreatic Cancer. 2015; 213-229. Hendley AM, Bailey, JM. View Publication.
    12. p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas. Dev Biol. 2015 Mar 01; 399(1):41-53. Hendley AM, Provost E, Bailey JM, Wang YJ, Cleveland MH, Blake D, Bittman RW, Roeser JC, Maitra A, Reynolds AB, Leach SD. PMID: 25523391; PMCID: PMC4868343.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    13. Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia. PLoS One. 2014; 9(11):e113127. Wang YJ, McAllister F, Bailey JM, Scott SG, Hendley AM, Leach SD, Ghosh B. PMID: 25405615; PMCID: PMC4236134.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
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