Audrey O'Neill, PhD

TitlePostdoc Employee
SchoolUCSF School of Dentistry
DepartmentCell and Tissue Biology
Address513 Parnassus Ave
San Francisco CA 94143
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    Collapse Overview
    Cell and organismal biologist with 15 years of experience in signal transduction and mouse models of disease, with skills in:
    -animal handling, surgery, and drug administration
    -mouse models of genetic disease
    -microscopy and live imaging
    -protein biochemistry and molecular biology
    -written and oral communication.

    Collapse Research 
    Collapse Research Activities and Funding
    Eph signaling through RhoGTPase in cell segregation and craniofacial disease
    NIH/NIDCR F32DE024370Apr 1, 2014 - Apr 30, 2017
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Niethamer TK, Larson AR, O'Neill A, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO. EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells. Stem Cell Reports. 2017 Mar 14; 8(3):529-537. PMID: 28238796.
      View in: PubMed
    2. O'Neill A, Kindberg AA, Niethamer TK, Larson AR, Ho HH, Greenberg ME, Bush JO. Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. J Cell Biol. 2016 Oct 24; 215(2):217-229. PMID: 27810913.
      View in: PubMed
    3. Lewis AE, Vasudevan HN, O'Neill A, Soriano P, Bush JO. The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Dev Biol. 2013 Jul 15; 379(2):229-34. PMID: 23648512; PMCID: PMC3804302.
    4. O'Neill A, Niederst MJ, Newton AC. Suppression of survival signalling pathways by the phosphatase PHLPP. FEBS J. 2013 Jan; 280(2):572-83. PMID: 22340730; PMCID: PMC3770140.
    5. Abrahamsen H, O'Neill A, Kannan N, Kruse N, Taylor SS, Jennings PA, Newton AC. Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. J Biol Chem. 2012 Apr 13; 287(16):13262-78. PMID: 22318721; PMCID: PMC3339987.
    6. O'Neill A, Gallegos LL, Justilien V, Garcia EL, Leitges M, Fields AP, Hall RA, Newton AC. Protein kinase Ca promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1). J Biol Chem. 2011 Dec 16; 286(50):43559-68. PMID: 22027822; PMCID: PMC3234831.
    7. Chen M, Pratt CP, Zeeman ME, Schultz N, Taylor BS, O'Neill A, Castillo-Martin M, Nowak DG, Naguib A, Grace DM, Murn J, Navin N, Atwal GS, Sander C, Gerald WL, Cordon-Cardo C, Newton AC, Carver BS, Trotman LC. Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell. 2011 Aug 16; 20(2):173-86. PMID: 21840483; PMCID: PMC3176728.
    8. Patterson SJ, Han JM, Garcia R, Assi K, Gao T, O'Neill A, Newton AC, Levings MK. Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. J Immunol. 2011 May 15; 186(10):5533-7. PMID: 21498666; PMCID: PMC4015973.
    9. Xu Q, Fitzsimmons B, Steinauer J, O'Neill A, Newton AC, Hua XY, Yaksh TL. Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia. J Neurosci. 2011 Feb 09; 31(6):2113-24. PMID: 21307248; PMCID: PMC3097059.
    10. Masubuchi S, Gao T, O'Neill A, Eckel-Mahan K, Newton AC, Sassone-Corsi P. Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1642-7. PMID: 20080691; PMCID: PMC2824391.
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