Axel Bethke, PhD

TitleResearch Associate
InstitutionUniversity of California San Francisco
DepartmentCellular Molecular Pharmacology
Address600 16th St
San Francisco CA 94158
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    1. Bethke A, Schroeder FC. Endogenous NHR ligands: metabolomics to the rescue. Aging (Albany NY). 2014 Jul; 6(7):522-3. PMID: 24973567; PMCID: PMC4153620.
    2. Mahanti P, Bose N, Bethke A, Judkins JC, Wollam J, Dumas KJ, Zimmerman AM, Campbell SL, Hu PJ, Antebi A, Schroeder FC. Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan. Cell Metab. 2014 Jan 07; 19(1):73-83. PMID: 24411940; PMCID: PMC3924769.
    3. Ludewig AH, Izrayelit Y, Park D, Malik RU, Zimmermann A, Mahanti P, Fox BW, Bethke A, Doering F, Riddle DL, Schroeder FC. Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5522-7. PMID: 23509272; PMCID: PMC3619363.
    4. Park D, O'Doherty I, Somvanshi RK, Bethke A, Schroeder FC, Kumar U, Riddle DL. Interaction of structure-specific and promiscuous G-protein-coupled receptors mediates small-molecule signaling in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):9917-22. PMID: 22665789; PMCID: PMC3382479.
    5. Bethke A, Fielenbach N, Wang Z, Mangelsdorf DJ, Antebi A. Nuclear hormone receptor regulation of microRNAs controls developmental progression. Science. 2009 Apr 03; 324(5923):95-8. PMID: 19342589; PMCID: PMC2757405.
    6. Giroux S, Bethke A, Fielenbach N, Antebi A, Corey EJ. Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A. Org Lett. 2008 Aug 21; 10(16):3643-5. PMID: 18642835; PMCID: PMC2659505.
    7. Ewering C, Brämer CO, Bruland N, Bethke A, Steinbüchel A. Occurrence and expression of tricarboxylate synthases in Ralstonia eutropha. Appl Microbiol Biotechnol. 2006 Jun; 71(1):80-9. PMID: 16133321.
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    8. Ludewig AH, Kober-Eisermann C, Weitzel C, Bethke A, Neubert K, Gerisch B, Hutter H, Antebi A. A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging. Genes Dev. 2004 Sep 01; 18(17):2120-33. PMID: 15314028; PMCID: PMC515290.
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