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Barbara Malynn, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentMedicine
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-502-9406
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    FUNCTION OF N-MYC PROTEIN IN LYMPHOCYTE DIFFERENTIATION
    NIH/NCI R29CA061009Jul 1, 1993 - Jun 30, 1999
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Aki A, Nagasaki M, Malynn B, Ma A, Kagari T. Hypomorphic A20 expression confers susceptibility to psoriasis. PLoS One. 2017; 12(6):e0180481. PMID: 28658319.
      View in: PubMed
    2. Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn B, Ma A. The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Immunity. 2017 Mar 21; 46(3):405-420. PMID: 28314591.
      View in: PubMed
    3. Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn B, Zamvil SS, Ma A. Erratum: The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol. 2015 Jul; 16(7):785. PMID: 26086145; PMCID: PMC4881846.
    4. Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn B, Zamvil SS, Ma A. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol. 2015 Jun; 16(6):618-27. PMID: 25939025; PMCID: PMC4439357.
    5. Duong BH, Onizawa M, Oses-Prieto JA, Advincula R, Burlingame A, Malynn B, Ma A. A20 restricts ubiquitination of pro-interleukin-1ß protein complexes and suppresses NLRP3 inflammasome activity. Immunity. 2015 Jan 20; 42(1):55-67. PMID: 25607459; PMCID: PMC4302274.
    6. Callahan JA, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn B, Ma A. Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. J Immunol. 2013 Jul 15; 191(2):535-9. PMID: 23785118; PMCID: PMC3702626.
    7. Shao L, Oshima S, Duong B, Advincula R, Barrera J, Malynn B, Ma A. A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis. PLoS One. 2013; 8(5):e62223. PMID: 23671587; PMCID: PMC3645994.
    8. Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, Agelidis A, Shifrin N, Advincula R, Barrera J, Malynn B, Wu H, Ma A. Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. Immunity. 2013 May 23; 38(5):896-905. PMID: 23602765; PMCID: PMC3665706.
    9. Ma A, Malynn B. A20: linking a complex regulator of ubiquitylation to immunity and human disease. Nat Rev Immunol. 2012 Nov; 12(11):774-85. PMID: 23059429; PMCID: PMC3582397.
    10. Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn B, Reizis B, DeFranco A, Criswell LA, Nakamura MC, Ma A. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol. 2011 Oct 23; 12(12):1184-93. PMID: 22019834; PMCID: PMC3419270.
    11. Malynn B, Ma A. Ubiquitin makes its mark on immune regulation. Immunity. 2010 Dec 14; 33(6):843-52. PMID: 21168777; PMCID: PMC3030984.
    12. Tavares RM, Turer EE, Liu CL, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn B, Ma A. The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity. 2010 Aug 27; 33(2):181-91. PMID: 20705491; PMCID: PMC2931361.
    13. Mortier E, Advincula R, Kim L, Chmura S, Barrera J, Reizis B, Malynn B, Ma A. Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets. Immunity. 2009 Nov 20; 31(5):811-22. PMID: 19913445.
      View in: PubMed
    14. Malynn B, Ma A. A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme. J Exp Med. 2009 May 11; 206(5):977-80. PMID: 19380636; PMCID: PMC2715039.
    15. Oshima S, Turer EE, Callahan JA, Chai S, Advincula R, Barrera J, Shifrin N, Lee B, Benedict Yen TS, Yen B, Woo T, Malynn B, Ma A. ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Nature. 2009 Feb 12; 457(7231):906-9. PMID: 19060883; PMCID: PMC2642523.
    16. Hitotsumatsu O, Ahmad RC, Tavares R, Wang M, Philpott D, Turer EE, Lee BL, Shiffin N, Advincula R, Malynn B, Werts C, Ma A. The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity. 2008 Mar; 28(3):381-90. PMID: 18342009; PMCID: PMC3606373.
    17. Turer EE, Tavares RM, Mortier E, Hitotsumatsu O, Advincula R, Lee B, Shifrin N, Malynn B, Ma A. Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20. J Exp Med. 2008 Feb 18; 205(2):451-64. PMID: 18268035; PMCID: PMC2271029.
    18. Takeuchi O, Fisher J, Suh H, Harada H, Malynn B, Korsmeyer SJ. Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11272-7. PMID: 16055554; PMCID: PMC1183578.
    19. Malynn B, Shaw AC, Young F, Stewart V, Alt FW. Truncated immunoglobulin Dmu causes incomplete developmental progression of RAG-deficient pro-B cells. Mol Immunol. 2002 Jan; 38(7):547-56. PMID: 11750656.
      View in: PubMed
    20. Ranger AM, Malynn B, Korsmeyer SJ. Mouse models of cell death. Nat Genet. 2001 Jun; 28(2):113-8. PMID: 11381252.
      View in: PubMed
    21. de Alboran IM, O'Hagan RC, Gärtner F, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA, Alt FW. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity. 2001 Jan; 14(1):45-55. PMID: 11163229.
      View in: PubMed
    22. Sleckman BP, Khan WN, Xu W, Bassing CH, Malynn B, Copeland NG, Bardon CG, Breit TM, Davidson L, Oltz EM, Jenkins NA, Berman JE, Alt FW. Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene. Mol Cell Biol. 2000 Jun; 20(12):4405-10. PMID: 10825203; PMCID: PMC85807.
    23. Malynn B, de Alboran IM, O'Hagan RC, Bronson R, Davidson L, DePinho RA, Alt FW. N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev. 2000 Jun 01; 14(11):1390-9. PMID: 10837031; PMCID: PMC316670.
    24. Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn B, Bryans M, Zhu C, Chaudhuri J, Davidson L, Ferrini R, Stamato T, Orkin SH, Greenberg ME, Alt FW. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 1998 Dec 23; 95(7):891-902. PMID: 9875844.
      View in: PubMed
    25. Malynn B, Demengeot J, Stewart V, Charron J, Alt FW. Generation of normal lymphocytes derived from N-myc-deficient embryonic stem cells. Int Immunol. 1995 Oct; 7(10):1637-47. PMID: 8562509.
      View in: PubMed
    26. Khan WN, Alt FW, Gerstein RM, Malynn B, Larsson I, Rathbun G, Davidson L, Müller S, Kantor AB, Herzenberg LA. Defective B cell development and function in Btk-deficient mice. Immunity. 1995 Sep; 3(3):283-99. PMID: 7552994.
      View in: PubMed
    27. Charron J, Malynn B, Fisher P, Stewart V, Jeannotte L, Goff SP, Robertson EJ, Alt FW. Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev. 1992 Dec; 6(12A):2248-57. PMID: 1459450.
      View in: PubMed
    28. Ferrier P, Covey LR, Li SC, Suh H, Malynn B, Blackwell TK, Morrow MA, Alt FW. Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice. J Exp Med. 1990 Jun 01; 171(6):1909-18. PMID: 2112584; PMCID: PMC2187946.
    29. Charron J, Malynn B, Robertson EJ, Goff SP, Alt FW. High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination. Mol Cell Biol. 1990 Apr; 10(4):1799-804. PMID: 2181287; PMCID: PMC362289.
    30. Malynn B, Yancopoulos GD, Barth JE, Bona CA, Alt FW. Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice. J Exp Med. 1990 Mar 01; 171(3):843-59. PMID: 2261012; PMCID: PMC2187788.
    31. Blackwell TK, Malynn B, Pollock RR, Ferrier P, Covey LR, Fulop GM, Phillips RA, Yancopoulos GD, Alt FW. Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. EMBO J. 1989 Mar; 8(3):735-42. PMID: 2785917; PMCID: PMC400869.
    32. Blackwell TK, Ferrier P, Malynn B, Pollock RR, Covey LR, Suh HY, Heinke LB, Fulop GM, Phillips RA, Yancopoulos GD. The effect of the scid mutation on mechanism and control of immunoglobulin heavy and light chain gene rearrangement. Curr Top Microbiol Immunol. 1989; 152:85-94. PMID: 2805801.
      View in: PubMed
    33. Malynn B, Blackwell TK, Fulop GM, Rathbun GA, Furley AJ, Ferrier P, Heinke LB, Phillips RA, Yancopoulos GD, Alt FW. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell. 1988 Aug 12; 54(4):453-60. PMID: 3135938.
      View in: PubMed
    34. Yancopoulos GD, Malynn B, Alt FW. Developmentally regulated and strain-specific expression of murine VH gene families. J Exp Med. 1988 Jul 01; 168(1):417-35. PMID: 3135366; PMCID: PMC2188955.
    35. Alt FW, Ferrier P, Malynn B, Lutzker S, Rothman P, Berman J, Blackwell K, Mellis S, Pollock R, Furley A. Control of recombination events during lymphocyte differentiation. Heavy chain variable region gene assembly and heavy chain class switching. Ann N Y Acad Sci. 1988; 546:9-24. PMID: 3150262.
      View in: PubMed
    36. Malynn B, Berman JE, Yancopoulos GD, Bona CA, Alt FW. Expression of the immunoglobulin heavy-chain variable gene repertoire. Curr Top Microbiol Immunol. 1987; 135:75-94. PMID: 3107914.
      View in: PubMed
    37. Berman JE, Malynn B, Blackwell TK, Alt FW. Regulation fo immunoglobulin variable region gene assembly: development of the primary antibody repertoire. Bioessays. 1986 Nov; 5(5):197-203. PMID: 3545193.
      View in: PubMed
    38. Malynn B, Romeo DT, Wortis HH. Antigen-specific B cells efficiently present low doses of antigen for induction of T cell proliferation. J Immunol. 1985 Aug; 135(2):980-8. PMID: 2409164.
      View in: PubMed
    39. Malynn B, Wortis HH. Role of antigen-specific B cells in the induction of SRBC-specific T cell proliferation. J Immunol. 1984 May; 132(5):2253-8. PMID: 6201538.
      View in: PubMed
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