Barbara Malynn, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB, #1075
San Francisco CA 94117
Phone415-502-9406
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    Collapse Biography 
    Collapse Education and Training
    Tufts Sackler School of Biomedical Sciences, Boston, MAPhD
    Columbia College of Physicians & Surgeons, NY, NYPostdoctoral

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Sa1536: TISSUE SPECIFIC PATHOGENIC CD4 T CELLS DRIVE ENTEROCOLITIS IN MICE EXPRESSING MUTATIONS IN A20’S ZF7 MOTIF. Gastroenterology. 2022 May 1; 162(7):s-405. Stibor SD, Sun SX, Bowman BC, Sun SY, Razani RB, Kim KM, Advincula AR, Achacoso AP, Malynn MB, Ye YC, Ma MA. .
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    2. Tu1517: MICROBIAL SIGNALS, MYD88, AND LYMPHOTOXIN DRIVE TNFINDEPENDENT DEATH OF A20 AND ABIN-1 DEFICIENT EPITHELIUM. Gastroenterology. 2022 May 1; 162(7):s-995. Rusu RI, Mennillo ME, Bain BJ, Li LZ, Sun SX, Ly LK, Rosli RY, Naser NM, Wang WZ, Advincula AR, Achacoso AP, Shao SL, Razani RB, Klein KO, Marson MA, Turnbaugh TJ, Turnbaugh TP, Malynn MB, Ma MA, Kattah KM. .
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    3. Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage. J Clin Invest. 2022 03 01; 132(5). Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG. PMID: 35077396; PMCID: PMC8884902.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    4. Preserving immune homeostasis with A20. Adv Immunol. 2020; 148:1-48. Razani B, Malynn BA, Ma A. PMID: 33190732.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    5. Editorial: Modulating Cytokines as Treatment for Autoimmune Diseases and Cancer. Front Immunol. 2020; 11:608636. Mortier E, Ma A, Malynn BA, Neurath MF. PMID: 33178231; PMCID: PMC7593236.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    6. Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis-like disease and inflammation. Nat Immunol. 2020 04; 21(4):422-433. Razani B, Whang MI, Kim FS, Nakamura MC, Sun X, Advincula R, Turnbaugh JA, Pendse M, Tanbun P, Achacoso P, Turnbaugh PJ, Malynn BA, Ma A. PMID: 32205880; PMCID: PMC7195210.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    7. A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis. PLoS One. 2019; 14(7):e0218999. Talpin A, Kattah MG, Advincula R, Fadrosh D, Lynch K, LaMere B, Fujimura KE, Nagalingam NA, Malynn BA, Lynch SV, Ma A. PMID: 31295268; PMCID: PMC6622485.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. 474 Binding of ubiquitin by A20 restricts psoriatic skin and joint disease. Journal of Investigative Dermatology. 2019 May 1; 139(5):s81. Razani RB, Whang WM, Advincula AR, Oses OJ, Burlingame BA, Malynn MB, Ma MA. .
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    9. A20: A multifunctional tool for regulating immunity and preventing disease. Cell Immunol. 2019 06; 340:103914. Malynn BA, Ma A. PMID: 31030956; PMCID: PMC6584049.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    10. OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination. J Biol Chem. 2018 11 23; 293(47):18285-18295. Pasupala N, Morrow ME, Que LT, Malynn BA, Ma A, Wolberger C. PMID: 30282802; PMCID: PMC6254341.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    11. A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival. J Exp Med. 2018 07 02; 215(7):1839-1852. Kattah MG, Shao L, Rosli YY, Shimizu H, Whang MI, Advincula R, Achacoso P, Shah S, Duong BH, Onizawa M, Tanbun P, Malynn BA, Ma A. PMID: 29930103; PMCID: PMC6028510.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    12. Ubiquitin-Modifying Enzymes and Regulation of the Inflammasome. J Mol Biol. 2017 11 10; 429(22):3471-3485. Kattah MG, Malynn BA, Ma A. PMID: 29031697; PMCID: PMC5675782.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    13. Hypomorphic A20 expression confers susceptibility to psoriasis. PLoS One. 2017; 12(6):e0180481. Aki A, Nagasaki M, Malynn BA, Ma A, Kagari T. PMID: 28658319; PMCID: PMC5489224.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    14. The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Immunity. 2017 03 21; 46(3):405-420. Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A. PMID: 28314591; PMCID: PMC5400745.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    15. P-285 A20 and ABIN-1 Cooperate to Preserve Intestinal Epithelial Homeostasis. Inflammatory Bowel Diseases. 2017 Feb 1; 23(&NA;):s92. Kattah KM, Shao SL, Rosli RY, Whang WM, Advincula AR, Malynn MB, Ma MA. .
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    16. 245 A20 and ABIN-1 Cooperate to Restrict Intestinal Epithelial Cell Death and Maintain Mucosal Immune Homeostasis. Gastroenterology. 2016 Apr 1; 150(4):s59. Shao SL, Kattah KM, Whang WM, Duong DB, Onizawa OM, Abbasi AS, Rosli RY, Callahan CJ, Pendse PM, Barrera BJ, Glazier GA, Advincula AR, Malynn MB, Ma MA. .
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    17. Erratum: The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol. 2015 Jul; 16(7):785. Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A. PMID: 26086145; PMCID: PMC4881846.
      View in: PubMed   Mentions: 2     Fields:    
    18. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol. 2015 Jun; 16(6):618-27. Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A. PMID: 25939025; PMCID: PMC4439357.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimalsCells
    19. A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity. Immunity. 2015 Jan 20; 42(1):55-67. Duong BH, Onizawa M, Oses-Prieto JA, Advincula R, Burlingame A, Malynn BA, Ma A. PMID: 25607459; PMCID: PMC4302274.
      View in: PubMed   Mentions: 143     Fields:    Translation:AnimalsCells
    20. Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. J Immunol. 2013 Jul 15; 191(2):535-9. Callahan JA, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A. PMID: 23785118; PMCID: PMC3702626.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    21. A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis. PLoS One. 2013; 8(5):e62223. Shao L, Oshima S, Duong B, Advincula R, Barrera J, Malynn BA, Ma A. PMID: 23671587; PMCID: PMC3645994.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    22. 823 A20 Restricts Canonical Wnt Signaling in Intestinal Epithelial Cells and Suppresses Colon Carcinogenesis. Gastroenterology. 2013 May 1; 144(5):s-144. Shao SL, Oshima OS, Duong DB, Advincula AR, Barrera BJ, Malynn MB, I. IA. .
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    23. Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. Immunity. 2013 May 23; 38(5):896-905. Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, Agelidis A, Shifrin N, Advincula R, Barrera J, Malynn BA, Wu H, Ma A. PMID: 23602765; PMCID: PMC3665706.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    24. A20: linking a complex regulator of ubiquitylation to immunity and human disease. Nat Rev Immunol. 2012 Nov; 12(11):774-85. Ma A, Malynn BA. PMID: 23059429; PMCID: PMC3582397.
      View in: PubMed   Mentions: 244     Fields:    Translation:HumansAnimalsCells
    25. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol. 2011 Oct 23; 12(12):1184-93. Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, Reizis B, DeFranco A, Criswell LA, Nakamura MC, Ma A. PMID: 22019834; PMCID: PMC3419270.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    26. Ubiquitin makes its mark on immune regulation. Immunity. 2010 Dec 14; 33(6):843-52. Malynn BA, Ma A. PMID: 21168777; PMCID: PMC3030984.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    27. A20 Tumor Suppressor Deletion and BCL6 Oncogene Activation Cooperate In Deregulating B Cell Differentiation In Vivo. Blood. 2010 Nov 19; 116(21):148-148. Mandelbaum MJ, Shen SQ, Tang TH, Mo MT, Malynn MB, Ma MA, Dalla-Favera DR, Pasqualucci PL. .
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    28. The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity. 2010 Aug 27; 33(2):181-91. Tavares RM, Turer EE, Liu CL, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn BA, Ma A. PMID: 20705491; PMCID: PMC2931361.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    29. Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets. Immunity. 2009 Nov 20; 31(5):811-22. Mortier E, Advincula R, Kim L, Chmura S, Barrera J, Reizis B, Malynn BA, Ma A. PMID: 19913445.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    30. A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme. The Journal of Cell Biology. 2009 May 4; 185(3):i3-i3. Malynn MB, Ma MA. .
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    31. A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme. J Exp Med. 2009 May 11; 206(5):977-80. Malynn BA, Ma A. PMID: 19380636; PMCID: PMC2715039.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    32. Erratum: ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Nature. 2009 Mar 1; 458(7237):538-538. Oshima OS, Turer TE, Callahan CJ, Chai CS, Advincula AR, Barrera BJ, Shifrin SN, Lee LB, Yen YT, Woo WT, Malynn MB, Ma MA. .
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    33. ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Nature. 2009 Feb 12; 457(7231):906-9. Oshima S, Turer EE, Callahan JA, Chai S, Advincula R, Barrera J, Shifrin N, Lee B, Benedict Yen TS, Yen B, Woo T, Malynn BA, Ma A. PMID: 19060883; PMCID: PMC2642523.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    34. The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity. 2008 Mar; 28(3):381-90. Hitotsumatsu O, Ahmad RC, Tavares R, Wang M, Philpott D, Turer EE, Lee BL, Shiffin N, Advincula R, Malynn BA, Werts C, Ma A. PMID: 18342009; PMCID: PMC3606373.
      View in: PubMed   Mentions: 184     Fields:    Translation:AnimalsCells
    35. Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20. J Exp Med. 2008 Feb 18; 205(2):451-64. Turer EE, Tavares RM, Mortier E, Hitotsumatsu O, Advincula R, Lee B, Shifrin N, Malynn BA, Ma A. PMID: 18268035; PMCID: PMC2271029.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    36. Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11272-7. Takeuchi O, Fisher J, Suh H, Harada H, Malynn BA, Korsmeyer SJ. PMID: 16055554; PMCID: PMC1183578.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    37. Truncated immunoglobulin Dmu causes incomplete developmental progression of RAG-deficient pro-B cells. Mol Immunol. 2002 Jan; 38(7):547-56. Malynn BA, Shaw AC, Young F, Stewart V, Alt FW. PMID: 11750656.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    38. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity. 2001 Jan; 14(1):45-55. de Alboran IM, O'Hagan RC, Gärtner F, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA, Alt FW. PMID: 11163229.
      View in: PubMed   Mentions: 194     Fields:    Translation:AnimalsCells
    39. N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev. 2000 Jun 01; 14(11):1390-9. Malynn BA, de Alboran IM, O'Hagan RC, Bronson R, Davidson L, DePinho RA, Alt FW. PMID: 10837031; PMCID: PMC316670.
      View in: PubMed   Mentions: 165     Fields:    Translation:AnimalsCells
    40. Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene. Mol Cell Biol. 2000 Jun; 20(12):4405-10. Sleckman BP, Khan WN, Xu W, Bassing CH, Malynn BA, Copeland NG, Bardon CG, Breit TM, Davidson L, Oltz EM, Jenkins NA, Berman JE, Alt FW. PMID: 10825203; PMCID: PMC85807.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    41. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 1998 Dec 23; 95(7):891-902. Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn BA, Bryans M, Zhu C, Chaudhuri J, Davidson L, Ferrini R, Stamato T, Orkin SH, Greenberg ME, Alt FW. PMID: 9875844.
      View in: PubMed   Mentions: 238     Fields:    Translation:AnimalsCells
    42. Generation of normal lymphocytes derived from N-myc-deficient embryonic stem cells. Int Immunol. 1995 Oct; 7(10):1637-47. Malynn BA, Demengeot J, Stewart V, Charron J, Alt FW. PMID: 8562509.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    43. Defective B cell development and function in Btk-deficient mice. Immunity. 1995 Sep; 3(3):283-99. Khan WN, Alt FW, Gerstein RM, Malynn BA, Larsson I, Rathbun G, Davidson L, Müller S, Kantor AB, Herzenberg LA, et al. PMID: 7552994.
      View in: PubMed   Mentions: 229     Fields:    Translation:HumansAnimalsCells
    44. Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev. 1992 Dec; 6(12A):2248-57. Charron J, Malynn BA, Fisher P, Stewart V, Jeannotte L, Goff SP, Robertson EJ, Alt FW. PMID: 1459450.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    45. Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice. J Exp Med. 1990 Jun 01; 171(6):1909-18. Ferrier P, Covey LR, Li SC, Suh H, Malynn BA, Blackwell TK, Morrow MA, Alt FW. PMID: 2112584; PMCID: PMC2187946.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    46. High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination. Mol Cell Biol. 1990 Apr; 10(4):1799-804. Charron J, Malynn BA, Robertson EJ, Goff SP, Alt FW. PMID: 2181287; PMCID: PMC362289.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    47. High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination. Molecular and Cellular Biology. 1990 Apr 1; 10(4):1799-1804. Charron CJ, Malynn MB, Robertson RE, Goff GS, Alt AF. .
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    48. High-Frequency Disruption of the N-myc Gene in Embryonic Stem and Pre-B Cell Lines by Homologous Recombination. Molecular and Cellular Biology. 1990 Apr 1; 10(4):1799-1804. Charron CJ, Malynn MB, Robertson RE, Goff GS, Alt AF. .
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    49. Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice. J Exp Med. 1990 Mar 01; 171(3):843-59. Malynn BA, Yancopoulos GD, Barth JE, Bona CA, Alt FW. PMID: 2261012; PMCID: PMC2187788.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    50. Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. EMBO J. 1989 Mar; 8(3):735-42. Blackwell TK, Malynn BA, Pollock RR, Ferrier P, Covey LR, Fulop GM, Phillips RA, Yancopoulos GD, Alt FW. PMID: 2785917; PMCID: PMC400869.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    51. The effect of the scid mutation on mechanism and control of immunoglobulin heavy and light chain gene rearrangement. Curr Top Microbiol Immunol. 1989; 152:85-94. Blackwell TK, Ferrier P, Malynn BA, Pollock RR, Covey LR, Suh HY, Heinke LB, Fulop GM, Phillips RA, Yancopoulos GD, et al. PMID: 2805801.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    52. B Cell Differentiation: Development of Antibody Repertoires. Progress in Immunology. 1989 Jan 1; 351-360. Alt AF, Rathbun RG, Berman BJ, Malynn MB, Morrow MM, Logtenberg LT, Yancopoulos YG. .
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    53. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell. 1988 Aug 12; 54(4):453-60. Malynn BA, Blackwell TK, Fulop GM, Rathbun GA, Furley AJ, Ferrier P, Heinke LB, Phillips RA, Yancopoulos GD, Alt FW. PMID: 3135938.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    54. Developmentally regulated and strain-specific expression of murine VH gene families. J Exp Med. 1988 Jul 01; 168(1):417-35. Yancopoulos GD, Malynn BA, Alt FW. PMID: 3135366; PMCID: PMC2188955.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    55. Control of recombination events during lymphocyte differentiation. Heavy chain variable region gene assembly and heavy chain class switching. Ann N Y Acad Sci. 1988; 546:9-24. Alt FW, Ferrier P, Malynn B, Lutzker S, Rothman P, Berman J, Blackwell K, Mellis S, Pollock R, Furley A, et al. PMID: 3150262.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    56. Expression of the immunoglobulin heavy-chain variable gene repertoire. Curr Top Microbiol Immunol. 1987; 135:75-94. Malynn BA, Berman JE, Yancopoulos GD, Bona CA, Alt FW. PMID: 3107914.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    57. Regulation fo immunoglobulin variable region gene assembly: development of the primary antibody repertoire. Bioessays. 1986 Nov; 5(5):197-203. Berman JE, Malynn BA, Blackwell TK, Alt FW. PMID: 3545193.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    58. Antigen-specific B cells efficiently present low doses of antigen for induction of T cell proliferation. J Immunol. 1985 Aug; 135(2):980-8. Malynn BA, Romeo DT, Wortis HH. PMID: 2409164.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    59. Role of antigen-specific B cells in the induction of SRBC-specific T cell proliferation. J Immunol. 1984 May; 132(5):2253-8. Malynn BA, Wortis HH. PMID: 6201538.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells