Bhairavi Tolani, PhD

Title(s)Assistant Professor, Surgery
SchoolSchool of Medicine
Address2340 Sutter Street, #N222
San Francisco CA 94115
Phone--
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    Collapse Biography 
    Collapse Education and Training
    University of Southern CaliforniaPh.D.2013Molecular Biology
    Hood CollegeM.S.2007Biomedical Sciences
    Hood CollegeB.A.2004Biochemistry
    Collapse Awards and Honors
    University of Southern California2010"Best Poster" at Biology Interdepartmental Graduate Symposium
    The National Cancer Institute2004"Outstanding Poster Presentation" at the Spring Research Festival
    UC Davis2014Keller Entrepreneurship Fellow
    UCSF2019Hellman Fellows Fund
    UCSF2019UCSF RAP Pilot Award

    Collapse Overview 
    Collapse Overview
    Bhairavi Tolani, Ph.D. provides research mentorship and supervision to surgical residents in UCSF's program as well as visiting thoracic surgeons, technicians and high school students. Dr. Tolani's research is focused on developing targeted therapies, small molecule inhibitors and biologics, for lung cancer.

    Over the past 13 years, Dr. Tolani's cancer research experience has been diverse including breast cancer, ovarian cancer, cervical cancer, lung cancer and hematological malignancies spanning academia, industry and the National Institutes of Health. Prior to graduate school, she worked at 3 biotechnology companies [Invitrogen Life Technologies, Lonza, & Digene (Qiagen)] for 3 years. While at Digene, she contributed to the development of a test to detect cervical cancer in women. Concurrently she earned her M.S. in Biomedical Sciences while conducting her thesis research on cancer stem cells and the Hedgehog pathway in breast cancer at the National Cancer Institute.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Pancreatic Cancer and Autophagy
    UCSF RAP Pilot Award Jul 1, 2019 - Jun 30, 2020
    Role: Principal Investigator
    Autophagy Inhibition as a Therapeutic Strategy in Pancreatic Cancers
    Hellman Family Awards for Early Career Faculty Jul 1, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice. Nat Biotechnol. 2022 Jul 25. Tolani B, Celli A, Yao Y, Tan YZ, Fetter R, Liem CR, de Smith AJ, Vasanthakumar T, Bisignano P, Cotton AD, Seiple IB, Rubinstein JL, Jost M, Weissman JS. PMID: 35879364.
      View in: PubMed   Mentions: 4     Fields:    
    2. The pleiotropic functions of autophagy in metastasis. J Cell Sci. 2021 01 22; 134(2). Marsh T, Tolani B, Debnath J. PMID: 33483365; PMCID: PMC7847272.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    3. High-Throughput Screening: today's biochemical and cell-based approaches. Drug Discov Today. 2020 10; 25(10):1807-1821. Blay V, Tolani B, Ho SP, Arkin MR. PMID: 32801051.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    4. Differential gene expression identifies KRT7 and MUC1 as potential metastasis-specific targets in sarcoma. Cancer Manag Res. 2019; 11:8209-8218. Jiang L, Tolani B, Yeh CC, Fan Y, Reza JA, Horvai AE, Xia E, Kratz JR, Jablons DM, Mann MJ. PMID: 31686913; PMCID: PMC6751227.
      View in: PubMed   Mentions: 3  
    5. A review of soft-tissue sarcomas: translation of biological advances into treatment measures. Cancer Manag Res. 2018; 10:1089-1114. Hoang NT, Acevedo LA, Mann MJ, Tolani B. PMID: 29785138; PMCID: PMC5955018.
      View in: PubMed   Mentions: 40  
    6. Preclinical characterization of therapeutic antibodies targeted at the carboxy-terminus of Sonic hedgehog. Oncotarget. 2018 03 06; 9(18):14311-14323. Tolani B, Hoang NT, Acevedo LA, Giroux Leprieur E, Li H, He B, Jablons DM. PMID: 29581846; PMCID: PMC5865672.
      View in: PubMed   Mentions: 6     Fields:    
    7. Heterogeneous Contributing Factors in MPM Disease Development and Progression: Biological Advances and Clinical Implications. Int J Mol Sci. 2018 Jan 13; 19(1). Tolani B, Acevedo LA, Hoang NT, He B. PMID: 29342862; PMCID: PMC5796186.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    8. Review of the clinical applications and technological advances of circulating tumor DNA in cancer monitoring. Ther Clin Risk Manag. 2017; 13:1363-1374. Chang Y, Tolani B, Nie X, Zhi X, Hu M, He B. PMID: 29066904; PMCID: PMC5644666.
      View in: PubMed   Mentions: 33  
    9. Membrane-bound full-length Sonic Hedgehog identifies cancer stem cells in human non-small cell lung cancer. Oncotarget. 2017 11 28; 8(61):103744-103757. Giroux Leprieur E, Tolani B, Li H, Leguay F, Hoang NT, Acevedo LA, Jin JQ, Tseng HH, Yue D, Kim IJ, Wislez M, Wang C, Jablons DM, He B. PMID: 29262597; PMCID: PMC5732763.
      View in: PubMed   Mentions: 16     Fields:    
    10. Gli promotes epithelial-mesenchymal transition in human lung adenocarcinomas. Oncotarget. 2016 Dec 06; 7(49):80415-80425. Li H, Yue D, Jin JQ, Woodard GA, Tolani B, Luh TM, Giroux-Leprieur E, Mo M, Chen Z, Che J, Zhang Z, Zhou Y, Wang L, Hao X, Jablons D, Wang C, He B. PMID: 27533453; PMCID: PMC5348330.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    11. EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas. PLoS One. 2015; 10(7):e0132134. Yue D, Li H, Che J, Zhang Y, Tolani B, Mo M, Zhang H, Zheng Q, Yang Y, Cheng R, Jin JQ, Luh TW, Yang C, Tseng HH, Giroux-Leprieur E, Woodard GA, Hao X, Wang C, Jablons DM, He B. PMID: 26132438; PMCID: PMC4488446.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    12. Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors. Oncogene. 2016 Apr 07; 35(14):1797-810. Gopalakrishnan R, Matta H, Tolani B, Triche T, Chaudhary PM. PMID: 26119939; PMCID: PMC4486341.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    13. Measurement of genome-wide DNA methylation predicts survival benefits from chemotherapy in non-small cell lung cancer. J Cancer Res Clin Oncol. 2015 May; 141(5):901-8. Mo ML, Ma J, Chen Z, Wei B, Li H, Zhou Y, Shi H, Tolani B, Jin JQ, Tseng HH, Shen D, Zhan Y, Li J, Jablons DM, Zhang RQ, Guo Y, He B, Zhou HM. PMID: 25367137.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. NEMO is essential for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP K13-induced gene expression and protection against death receptor-induced cell death, and its N-terminal 251 residues are sufficient for this process. J Virol. 2014 Jun; 88(11):6345-54. Tolani B, Matta H, Gopalakrishnan R, Punj V, Chaudhary PM. PMID: 24672029; PMCID: PMC4093867.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    15. Targeting Myc in KSHV-associated primary effusion lymphoma with BET bromodomain inhibitors. Oncogene. 2014 May 29; 33(22):2928-37. Tolani B, Gopalakrishnan R, Punj V, Matta H, Chaudhary PM. PMID: 23792448; PMCID: PMC4892892.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    16. Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor-induced growth arrest and apoptosis through NF-κB activation. J Virol. 2013 Feb; 87(4):2242-52. Graham C, Matta H, Yang Y, Yi H, Suo Y, Tolani B, Chaudhary PM. PMID: 23236068; PMCID: PMC3571451.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    17. Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-κB pathway independent of TRAF6, TAK1 and LUBAC. PLoS One. 2012; 7(5):e36601. Matta H, Gopalakrishnan R, Graham C, Tolani B, Khanna A, Yi H, Suo Y, Chaudhary PM. PMID: 22590573; PMCID: PMC3348130.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
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