Bob Farese, MD

Title(s)PROFESSOR IN RESIDENCE - FY, Business Service Ctr
SchoolChancellor/EVC/FAS
Address1650 Owens St
San Francisco CA 94107
Phone415-734-2000
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Overview 
    Collapse Overview
    EDUCATION
    University of Florida, Gainesville, FL, B.S., 1981 (Chemistry)
    Vanderbilt Medical School, Nashville, TN, M.D., 1985


    POSTDOCTORAL TRAINING
    Internship And Residency
    1985–1988 Internal Medicine, University of Colorado Affiliated Hospitals, Denver, CO
    1988–1989 Chief Resident, Internal Medicine, University of Colorado Affiliated Hospitals,
    Denver, CO

    FELLOWSHIPS
    1989–1992 Endocrinology, Diabetes, and Metabolism, UCSF
    1990–1992 Postdoctoral Fellow, Gladstone Institute of Cardiovascular Disease

    Collapse Research 
    Collapse Research Activities and Funding
    2014 Lipoprotein Metabolism Gordon Research Conference and Gordon Research Semina
    NIH R13HL123268Jun 10, 2014 - May 31, 2015
    Role: Principal Investigator
    Physiology of Lipid Droplets and Triglyceride Storage
    NIH R01DK101579May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    The Mechanisms of Lipid Droplet Formation and Regulation
    NIH R01GM099844Mar 1, 2012 - Nov 30, 2015
    Role: Principal Investigator
    Role of DGAT in Triacyglycerol Metabolism
    NIH R56DK056084Sep 30, 2010 - Aug 31, 2011
    Role: Principal Investigator
    Enhancing Progranulin Expression - a Therapy for Frontotemporal Dementia
    NIH RC1NS068697Sep 30, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Functional Analysis of MGAT Enzymes
    NIH R01DK077233Aug 1, 2007 - Oct 31, 2011
    Role: Principal Investigator
    Identification of Genes that Regulate Cellular Lipid Storage
    NIH R21DK078254Apr 20, 2007 - Mar 31, 2009
    Role: Principal Investigator
    New Approaches to Dementia Heterogeneity
    NIH P50AG023501Apr 1, 2004 - Mar 31, 2019
    Role: Co-Investigator
    Triglyceride Synthesis and Lipotoxicity
    NIH R01DK065599Apr 15, 2003 - Mar 31, 2007
    Role: Principal Investigator
    Role of DGAT in Triacyglycerol Metabolism
    NIH R01DK056084May 1, 2000 - Jul 31, 2015
    Role: Principal Investigator
    Investigation of ACAT Functions Using Knockout
    NIH R01HL057170Feb 1, 1997 - Jan 31, 2008
    Role: Principal Investigator
    LIPOPROTEIN STRUCTURE/FUNCTION IN CHOLESTEROL METABOLISM
    NIH P01HL041633Feb 1, 1989 - Jan 31, 2005
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Correction: Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. J Biol Chem. 2024 Nov 30; 300(12):107975. Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Ott M. PMID: 39616949.
      View in: PubMed   Mentions:
    2. PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes. Cell. 2024 Oct 15. Singh S, Dransfeld UE, Ambaw YA, Lopez-Scarim J, Farese RV, Walther TC. PMID: 39423811.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Carboxy-terminal blockade of sortilin binding enhances progranulin gene therapy, a potential treatment for frontotemporal dementia. bioRxiv. 2024 Sep 16. Kashyap SN, Fox SN, Wilson KI, Murchison CF, Ambaw YA, Walther TC, Farese RV, Arrant AE, Roberson ED. PMID: 39345608; PMCID: PMC11430072.
      View in: PubMed   Mentions:
    4. PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes. bioRxiv. 2024 Mar 21. Singh S, Dransfeld U, Ambaw Y, Lopez-Scarim J, Farese RV, Walther TC. PMID: 38562702; PMCID: PMC10983895.
      View in: PubMed   Mentions:
    5. Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity. Elife. 2023 10 02; 12. Chitraju C, Fischer AW, Ambaw YA, Wang K, Yuan B, Hui S, Walther TC, Farese RV. PMID: 37782317; PMCID: PMC10545428.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    6. The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets. Nat Cell Biol. 2023 08; 25(8):1101-1110. Chung J, Park J, Lai ZW, Lambert TJ, Richards RC, Zhang J, Walther TC, Farese RV. PMID: 37443287; PMCID: PMC10415183.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    7. The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification. Nat Commun. 2023 06 14; 14(1):3533. Wang K, Lee CW, Sui X, Kim S, Wang S, Higgs AB, Baublis AJ, Voth GA, Liao M, Walther TC, Farese RV. PMID: 37316513; PMCID: PMC10267149.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    8. Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun. 2023 05 29; 14(1):3100. Sui X, Wang K, Song K, Xu C, Song J, Lee CW, Liao M, Farese RV, Walther TC. PMID: 37248213; PMCID: PMC10227072.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    9. Structure and function of lipid droplet assembly complexes. Curr Opin Struct Biol. 2023 06; 80:102606. Walther TC, Kim S, Arlt H, Voth GA, Farese RV. PMID: 37150040; PMCID: PMC10853036.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    10. Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum. Cold Spring Harb Perspect Biol. 2023 05 02; 15(5). Farese RV, Walther TC. PMID: 36096640; PMCID: PMC10153804.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    11. Fitm2 is required for ER homeostasis and normal function of murine liver. J Biol Chem. 2023 03; 299(3):103022. Bond LM, Ibrahim A, Lai ZW, Walzem RL, Bronson RT, Ilkayeva OR, Walther TC, Farese RV. PMID: 36805337; PMCID: PMC10027564.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Nat Commun. 2022 10 07; 13(1):5924. Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV. PMID: 36207292; PMCID: PMC9546883.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    13. Identification of two pathways mediating protein targeting from ER to lipid droplets. Nat Cell Biol. 2022 09; 24(9):1364-1377. Song J, Mizrak A, Lee CW, Cicconet M, Lai ZW, Tang WC, Lu CH, Mohr SE, Farese RV, Walther TC. PMID: 36050470; PMCID: PMC9481466.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    14. Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane. Elife. 2022 05 18; 11. Kim S, Chung J, Arlt H, Pak AJ, Farese RV, Walther TC, Voth GA. PMID: 35583926; PMCID: PMC9122495.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    15. Seipin forms a flexible cage at lipid droplet formation sites. Nat Struct Mol Biol. 2022 03; 29(3):194-202. Arlt H, Sui X, Folger B, Adams C, Chen X, Remme R, Hamprecht FA, DiMaio F, Liao M, Goodman JM, Farese RV, Walther TC. PMID: 35210614; PMCID: PMC8930772.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    16. The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology. Dev Cell. 2022 02 07; 57(3):387-397.e4. Mejhert N, Gabriel KR, Frendo-Cumbo S, Krahmer N, Song J, Kuruvilla L, Chitraju C, Boland S, Jang DK, von Grotthuss M, Costanzo MC, Rydén M, Olzmann JA, Flannick J, Burtt NP, Farese RV, Walther TC. PMID: 35134345; PMCID: PMC9129885.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    17. Key Factors Governing Initial Stages of Lipid Droplet Formation. J Phys Chem B. 2022 01 20; 126(2):453-462. Kim S, Li C, Farese RV, Walther TC, Voth GA. PMID: 34990551; PMCID: PMC8922452.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    18. Publisher Correction: An open-access volume electron microscopy atlas of whole cells and tissues. Nature. 2021 Nov; 599(7885):E5. Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF. PMID: 34732896.
      View in: PubMed   Mentions:    Fields:    
    19. An open-access volume electron microscopy atlas of whole cells and tissues. Nature. 2021 11; 599(7883):147-151. Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF. PMID: 34616045; PMCID: PMC9004664.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    20. The CYTOLD and ERTOLD pathways for lipid droplet-protein targeting. Trends Biochem Sci. 2022 01; 47(1):39-51. Olarte MJ, Swanson JMJ, Walther TC, Farese RV. PMID: 34583871; PMCID: PMC8688270.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    21. Conditional targeting of phosphatidylserine decarboxylase to lipid droplets. Biol Open. 2021 03 03; 10(3). Kumar S, Chitraju C, Farese RV, Walther TC, Burd CG. PMID: 33593792; PMCID: PMC7938800.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    22. Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin-resistant forms of obesity and type 2 diabetes mellitus. MedComm (2020). 2021 Mar; 2(1):3-16. Sajan MP, Hansen BC, Acevedo-Duncan M, Kindy MS, Cooper DR, Farese RV. PMID: 34766133; PMCID: PMC8491214.
      View in: PubMed   Mentions: 4  
    23. The power of two: lessons from a scientific partnership. J Clin Invest. 2021 01 19; 131(2). Farese RV, Walther TC. PMID: 33463550; PMCID: PMC7810469.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Control of β-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-λ/ι and Nuclear Factor κ-B. Curr Alzheimer Res. 2021; 18(12):941-955. Sajan MP, Leitges M, Park C, Diamond DM, Wu J, Hansen BC, Duncan MA, Apostolatos CA, Apostolatos AH, Kindy M, Farese RV. PMID: 34951366.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    25. A Systematic Protein Turnover Map for Decoding Protein Degradation. Cell Rep. 2020 11 10; 33(6):108378. Christiano R, Arlt H, Kabatnik S, Mejhert N, Lai ZW, Farese RV, Walther TC. PMID: 33176155; PMCID: PMC7745259.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    26. Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis. Cell Rep. 2020 11 03; 33(5):108348. Chitraju C, Fischer AW, Farese RV, Walther TC. PMID: 33147469; PMCID: PMC7696656.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    27. FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. J Cell Biol. 2020 10 05; 219(10). Becuwe M, Bond LM, Pinto AFM, Boland S, Mejhert N, Elliott SD, Cicconet M, Graham MM, Liu XN, Ilkayeva O, Saghatelian A, Walther TC, Farese RV. PMID: 32915949; PMCID: PMC7659722.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    28. Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature. 2020 12; 588(7838):459-465. Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ. PMID: 32866962; PMCID: PMC7746606.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    29. Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting. Dev Cell. 2020 08 24; 54(4):471-487.e7. Olarte MJ, Kim S, Sharp ME, Swanson JMJ, Farese RV, Walther TC. PMID: 32730754; PMCID: PMC7696655.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    30. Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature. 2020 05; 581(7808):323-328. Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV. PMID: 32433611; PMCID: PMC7398557.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    31. Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration. Proc Natl Acad Sci U S A. 2020 05 12; 117(19):10565-10574. Petit CS, Lee JJ, Boland S, Swarup S, Christiano R, Lai ZW, Mejhert N, Elliott SD, McFall D, Haque S, Huang EJ, Bronson RT, Harper JW, Farese RV, Walther TC. PMID: 32345721; PMCID: PMC7229683.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    32. Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression. Mol Cell. 2020 03 19; 77(6):1251-1264.e9. Mejhert N, Kuruvilla L, Gabriel KR, Elliott SD, Guie MA, Wang H, Lai ZW, Lane EA, Christiano R, Danial NN, Farese RV, Walther TC. PMID: 32023484; PMCID: PMC7397554.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    33. LDAF1 and Seipin Form a Lipid Droplet Assembly Complex. Dev Cell. 2019 12 02; 51(5):551-563.e7. Chung J, Wu X, Lambert TJ, Lai ZW, Walther TC, Farese RV. PMID: 31708432; PMCID: PMC7235935.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    34. Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics. Dev Cell. 2019 09 09; 50(5):530-532. Walther TC, Farese RV. PMID: 31505174; PMCID: PMC7397519.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    35. Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice. Hepatology. 2019 12; 70(6):1972-1985. Gluchowski NL, Gabriel KR, Chitraju C, Bronson RT, Mejhert N, Boland S, Wang K, Lai ZW, Farese RV, Walther TC. PMID: 31081165; PMCID: PMC6893913.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    36. The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes. J Lipid Res. 2019 06; 60(6):1112-1120. Chitraju C, Walther TC, Farese RV. PMID: 30936184; PMCID: PMC6547635.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    37. Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids. Mol Cell. 2019 04 04; 74(1):32-44.e8. Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV. PMID: 30846318; PMCID: PMC7696670.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    38. Atypical PKC: therapeutic target for Alzheimer's? Aging (Albany NY). 2018 12 20; 11(1):13-14. Farese RV, Sajan MP. PMID: 30573704; PMCID: PMC6339803.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    39. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019 03 07; 73(5):1001-1014.e8. Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. PMID: 30527540; PMCID: PMC6408259.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    40. Cryo-electron microscopy structure of the lipid droplet-formation protein seipin. J Cell Biol. 2018 12 03; 217(12):4080-4091. Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV, Walther TC. PMID: 30327422; PMCID: PMC6279392.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    41. Progranulin in the hematopoietic compartment protects mice from atherosclerosis. Atherosclerosis. 2018 10; 277:145-154. Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV. PMID: 30212683; PMCID: PMC6432779.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    42. Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells. Mol Biol Cell. 2018 08 15; 29(17):2045-2054. Jayson CBK, Arlt H, Fischer AW, Lai ZW, Farese RV, Walther TC. PMID: 29949452; PMCID: PMC6232964.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    43. Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):E2849-E2858. Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV. PMID: 29511098; PMCID: PMC5866607.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    44. Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity. Mol Cell Proteomics. 2018 05; 17(5):836-849. Li Z, Lai ZW, Christiano R, Gazos-Lopes F, Walther TC, Farese RV. PMID: 29414761; PMCID: PMC5930403.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    45. Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets. Dev Cell. 2018 Jan 08; 44(1):73-86.e4. Prévost C, Sharp ME, Kory N, Lin Q, Voth GA, Farese RV, Walther TC. PMID: 29316443; PMCID: PMC5764114.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    46. Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets. Biochemistry. 2018 Feb 06; 57(5):827-838. Inloes JM, Kiosses WB, Wang H, Walther TC, Farese RV, Cravatt BF. PMID: 29278326; PMCID: PMC5854151.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    47. Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance. Cell Signal. 2018 03; 43:62-70. Sajan MP, Lee MC, Foufelle F, Sajan J, Cleland C, Farese RV. PMID: 29269047.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    48. Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease. Neurobiol Aging. 2018 01; 61:225-237. Sajan MP, Hansen BC, Higgs MG, Kahn CR, Braun U, Leitges M, Park CR, Diamond DM, Farese RV. PMID: 29032894; PMCID: PMC5705272.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    49. An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations. Alzheimers Dement (N Y). 2017 Nov; 3(4):507-512. Sha SJ, Miller ZA, Min SW, Zhou Y, Brown J, Mitic LL, Karydas A, Koestler M, Tsai R, Corbetta-Rastelli C, Lin S, Hare E, Fields S, Fleischmann KE, Powers R, Fitch R, Martens LH, Shamloo M, Fagan AM, Farese RV, Pearlman R, Seeley W, Miller BL, Gan L, Boxer AL. PMID: 29124108; PMCID: PMC5671622.
      View in: PubMed   Mentions: 16  
    50. Lipid Droplet Biogenesis. Annu Rev Cell Dev Biol. 2017 10 06; 33:491-510. Walther TC, Chung J, Farese RV. PMID: 28793795; PMCID: PMC6986389.
      View in: PubMed   Mentions: 312     Fields:    Translation:HumansAnimalsCells
    51. Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis. Cell Metab. 2017 Aug 01; 26(2):407-418.e3. Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV. PMID: 28768178; PMCID: PMC6195226.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    52. Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):5029-5034. Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL, Farese RV, Gan L. PMID: 28438992; PMCID: PMC5441749.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    53. Lipid droplets and liver disease: from basic biology to clinical implications. Nat Rev Gastroenterol Hepatol. 2017 Jun; 14(6):343-355. Gluchowski NL, Becuwe M, Walther TC, Farese RV. PMID: 28428634; PMCID: PMC6319657.
      View in: PubMed   Mentions: 237     Fields:    Translation:HumansCells
    54. Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea. J Lipid Res. 2017 06; 58(6):1230-1237. Gluchowski NL, Chitraju C, Picoraro JA, Mejhert N, Pinto S, Xin W, Kamin DS, Winter HS, Chung WK, Walther TC, Farese RV. PMID: 28373485; PMCID: PMC5454518.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    55. Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity. Diabetes. 2017 04; 66(4):920-934. Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP. PMID: 28073831; PMCID: PMC5360303.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    56. Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism. J Lipid Res. 2017 01; 58(1):226-235. Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing C, Zechner R, Cravatt BF, Farese RV, Walther TC. PMID: 27836991; PMCID: PMC5234725.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    57. Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion. Proteomics. 2016 11; 16(21):2759-2763. Fröhlich F, Olson DK, Christiano R, Farese RV, Walther TC. PMID: 27717283; PMCID: PMC5688516.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    58. Seipin is required for converting nascent to mature lipid droplets. Elife. 2016 Aug 26; 5. Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV. PMID: 27564575; PMCID: PMC5035145.
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    59. Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice. Elife. 2016 05 17; 5. Tsokas P, Hsieh C, Yao Y, Lesburguères E, Wallace EJC, Tcherepanov A, Jothianandan D, Hartley BR, Pan L, Rivard B, Farese RV, Sajan MP, Bergold PJ, Hernández AI, Cottrell JE, Shouval HZ, Fenton AA, Sacktor TC. PMID: 27187150; PMCID: PMC4869915.
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    60. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell. 2016 May 05; 165(4):921-35. Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R, Farese RV, Paz JT, Barres BA, Huang EJ. PMID: 27114033; PMCID: PMC4860138.
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    61. Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets. Trends Cell Biol. 2016 07; 26(7):535-546. Kory N, Farese RV, Walther TC. PMID: 26995697; PMCID: PMC4976449.
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    62. Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development. Diabetes. 2016 07; 65(7):1892-903. Sajan M, Hansen B, Ivey R, Sajan J, Ari C, Song S, Braun U, Leitges M, Farese-Higgs M, Farese RV. PMID: 26895791; PMCID: PMC4915579.
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    63. Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice. J Lipid Res. 2016 Apr; 57(4):616-30. Agarwal AK, Tunison K, Dalal JS, Yen CL, Farese RV, Horton JD, Garg A. PMID: 26880786; PMCID: PMC4808770.
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    64. Lipid droplets go nuclear. J Cell Biol. 2016 Jan 04; 212(1):7-8. Farese RV, Walther TC. PMID: 26728852; PMCID: PMC4700486.
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    65. Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis. Biochim Biophys Acta. 2016 Aug; 1861(8 Pt B):784-792. Olson DK, Fröhlich F, Farese RV, Walther TC. PMID: 26747648; PMCID: PMC4907851.
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    66. Contraction stimulates muscle glucose uptake independent of atypical PKC. Physiol Rep. 2015 Nov; 3(11). Yu H, Fujii NL, Toyoda T, An D, Farese RV, Leitges M, Hirshman MF, Mul JD, Goodyear LJ. PMID: 26564060; PMCID: PMC4673624.
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    67. The GARP complex is required for cellular sphingolipid homeostasis. Elife. 2015 Sep 10; 4. Fröhlich F, Petit C, Kory N, Christiano R, Hannibal-Bach HK, Graham M, Liu X, Ejsing CS, Farese RV, Walther TC. PMID: 26357016; PMCID: PMC4600884.
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    68. BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans. Metabolism. 2015 Nov; 64(11):1454-65. Sajan MP, Ivey RA, Farese RV. PMID: 26386696; PMCID: PMC4576742.
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    69. Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. Dev Cell. 2015 Aug 10; 34(3):351-63. Kory N, Thiam AR, Farese RV, Walther TC. PMID: 26212136; PMCID: PMC4536137.
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    70. Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats. PLoS One. 2015; 10(7):e0132575. Zhang N, Liang H, Farese RV, Li J, Musi N, Hussey SE. PMID: 26196892; PMCID: PMC4510579.
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    71. Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation. J Lipid Res. 2015 Jan; 56(1):70-80. Sajan MP, Ivey RA, Lee MC, Farese RV. PMID: 25395359; PMCID: PMC4274073.
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    72. The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets. J Biol Chem. 2014 Dec 26; 289(52):35770-80. Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M. PMID: 25381252; PMCID: PMC4276846.
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    73. MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse. Am J Physiol Endocrinol Metab. 2014 Dec 01; 307(11):E1065-72. Mul JD, Begg DP, Haller AM, Pressler JW, Sorrell J, Woods SC, Farese RV, Seeley RJ, Sandoval DA. PMID: 25315695; PMCID: PMC4254982.
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    74. Atypical PKC: a target for treating insulin-resistant disorders of obesity, the metabolic syndrome and type 2 diabetes mellitus. Expert Opin Ther Targets. 2014 Oct; 18(10):1163-75. Farese RV, Lee MC, Sajan MP. PMID: 25213731.
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    75. Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models. Nat Med. 2014 Oct; 20(10):1157-64. Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV, Gan L. PMID: 25261995; PMCID: PMC4196723.
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    76. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. J Exp Med. 2014 Sep 22; 211(10):1937-45. Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV, Green A, Gan L. PMID: 25155018; PMCID: PMC4172214.
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    77. Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure. J Biol Chem. 2014 Oct 24; 289(43):29881-91. Liu L, Trent CM, Fang X, Son NH, Jiang H, Blaner WS, Hu Y, Yin YX, Farese RV, Homma S, Turnbull AV, Eriksson JW, Hu SL, Ginsberg HN, Huang LS, Goldberg IJ. PMID: 25157099; PMCID: PMC4207999.
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    78. Requirements for pseudosubstrate arginine residues during autoinhibition and phosphatidylinositol 3,4,5-(PO₄)₃-dependent activation of atypical PKC. J Biol Chem. 2014 Sep 05; 289(36):25021-30. Ivey RA, Sajan MP, Farese RV. PMID: 25035426; PMCID: PMC4155669.
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    79. Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus. J Clin Med. 2014 Jul 07; 3(3):724-40. Farese RV, Lee MC, Sajan MP. PMID: 26237474; PMCID: PMC4449650.
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    80. In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy. J Am Chem Soc. 2014 Jun 18; 136(24):8820-8. Fu D, Yu Y, Folick A, Currie E, Farese RV, Tsai TH, Xie XS, Wang MC. PMID: 24869754; PMCID: PMC4073829.
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    81. PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. Mol Endocrinol. 2014 Jul; 28(7):1097-107. Sajan MP, Ivey RA, Lee M, Mastorides S, Jurczak MJ, Samuels VT, Shulman GI, Braun U, Leitges M, Farese RV. PMID: 24877563; PMCID: PMC4075159.
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    82. High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. J Lipid Res. 2014 07; 55(7):1465-77. Currie E, Guo X, Christiano R, Chitraju C, Kory N, Harrison K, Haas J, Walther TC, Farese RV. PMID: 24868093; PMCID: PMC4076087.
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    83. Lipid droplet biogenesis. Curr Opin Cell Biol. 2014 Aug; 29:39-45. Wilfling F, Haas JT, Walther TC, Farese RV. PMID: 24736091; PMCID: PMC4526149.
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    84. Akt-dependent phosphorylation of hepatic FoxO1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity. Diabetes. 2014 Aug; 63(8):2690-701. Sajan MP, Acevedo-Duncan ME, Standaert ML, Ivey RA, Lee M, Farese RV. PMID: 24705403; PMCID: PMC4113067.
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    85. Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. Elife. 2014; 3:e01607. Wilfling F, Thiam AR, Olarte MJ, Wang J, Beck R, Gould TJ, Allgeyer ES, Pincet F, Bewersdorf J, Farese RV, Walther TC. PMID: 24497546; PMCID: PMC3913038.
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    86. The biophysics and cell biology of lipid droplets. Nat Rev Mol Cell Biol. 2013 Dec; 14(12):775-86. Thiam AR, Farese RV, Walther TC. PMID: 24220094; PMCID: PMC4526153.
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    87. Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One. 2013; 8(10):e76055. Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, Farese RV, Moore MJ, Shaw CE, Gao FB. PMID: 24143176; PMCID: PMC3797144.
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    88. Progranulin: at the interface of neurodegenerative and metabolic diseases. Trends Endocrinol Metab. 2013 Dec; 24(12):597-606. Nguyen AD, Nguyen TA, Martens LH, Mitic LL, Farese RV. PMID: 24035620; PMCID: PMC3842380.
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    89. Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis. Adipocyte. 2014 Jan 01; 3(1):19-29. Sajan MP, Jurzak MJ, Samuels VT, Shulman GI, Braun U, Leitges M, Farese RV. PMID: 24575365; PMCID: PMC3917928.
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    90. Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression. Diabetologia. 2013 Nov; 56(11):2507-16. Sajan MP, Ivey RA, Farese RV. PMID: 23933835; PMCID: PMC3973184.
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    91. A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress. Mol Cell. 2013 Aug 22; 51(4):519-30. Surma MA, Klose C, Peng D, Shales M, Mrejen C, Stefanko A, Braberg H, Gordon DE, Vorkel D, Ejsing CS, Farese R, Simons K, Krogan NJ, Ernst R. PMID: 23891562; PMCID: PMC3791312.
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    92. Cellular fatty acid metabolism and cancer. Cell Metab. 2013 Aug 06; 18(2):153-61. Currie E, Schulze A, Zechner R, Walther TC, Farese RV. PMID: 23791484; PMCID: PMC3742569.
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    93. Balancing the fat: lipid droplets and human disease. EMBO Mol Med. 2013 Jul; 5(7):973-83. Krahmer N, Farese RV, Walther TC. PMID: 23740690; PMCID: PMC3721468.
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    94. Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. J Neurosci. 2013 May 22; 33(21):9202-13. Chen X, Chang J, Deng Q, Xu J, Nguyen TA, Martens LH, Cenik B, Taylor G, Hudson KF, Chung J, Yu K, Yu P, Herz J, Farese RV, Kukar T, Tansey MG. PMID: 23699531; PMCID: PMC3707136.
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    95. A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep. 2013 May 30; 3(5):1465-75. Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, Li L, Jin D, Boye-Doe A, Liu TY, Shibata Y, Lu H, Rapoport TA, Farese RV, Blackstone C, Guo Y, Mak HY. PMID: 23684613; PMCID: PMC3742324.
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    96. Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice. J Neurosci. 2013 Mar 20; 33(12):5352-61. Filiano AJ, Martens LH, Young AH, Warmus BA, Zhou P, Diaz-Ramirez G, Jiao J, Zhang Z, Huang EJ, Gao FB, Farese RV, Roberson ED. PMID: 23516300; PMCID: PMC3740510.
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    97. Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. J Biol Chem. 2013 Apr 05; 288(14):9915-9923. Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Ott M. PMID: 23420847; PMCID: PMC3617291.
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    98. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell. 2013 Feb 25; 24(4):384-99. Wilfling F, Wang H, Haas JT, Krahmer N, Gould TJ, Uchida A, Cheng JX, Graham M, Christiano R, Fröhlich F, Liu X, Buhman KK, Coleman RA, Bewersdorf J, Farese RV, Walther TC. PMID: 23415954; PMCID: PMC3727400.
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    99. Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL). J Biol Chem. 2013 Mar 22; 288(12):8627-8635. Nguyen AD, Nguyen TA, Cenik B, Yu G, Herz J, Walther TC, Davidson WS, Farese RV. PMID: 23364791; PMCID: PMC3605681.
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    100. Protein correlation profiles identify lipid droplet proteins with high confidence. Mol Cell Proteomics. 2013 May; 12(5):1115-26. Krahmer N, Hilger M, Kory N, Wilfling F, Stoehr G, Mann M, Farese RV, Walther TC. PMID: 23319140; PMCID: PMC3650325.
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    101. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013 Jan 11; 339(6116):211-4. Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, Verdin E. PMID: 23223453; PMCID: PMC3735349.
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    102. DGAT1 mutation is linked to a congenital diarrheal disorder. J Clin Invest. 2012 Dec; 122(12):4680-4. Haas JT, Winter HS, Lim E, Kirby A, Blumenstiel B, DeFelice M, Gabriel S, Jalas C, Branski D, Grueter CA, Toporovski MS, Walther TC, Daly MJ, Farese RV. PMID: 23114594; PMCID: PMC3533555.
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    103. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nat Genet. 2012 Dec; 44(12):1302-9. Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV, Gitler AD. PMID: 23104007; PMCID: PMC3510335.
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    104. Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases. J Biol Chem. 2012 Nov 30; 287(49):41446-57. Eichmann TO, Kumari M, Haas JT, Farese RV, Zimmermann R, Lass A, Zechner R. PMID: 23066022; PMCID: PMC3510842.
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    105. Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects. Cell Rep. 2012 Oct 25; 2(4):789-98. Almeida S, Zhang Z, Coppola G, Mao W, Futai K, Karydas A, Geschwind MD, Tartaglia MC, Gao F, Gianni D, Sena-Esteves M, Geschwind DH, Miller BL, Farese RV, Gao FB. PMID: 23063362; PMCID: PMC3532907.
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    106. The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier). Alzheimers Dement. 2013 Mar; 9(2):189-98. Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Jackson G, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian ZS, Sutherland M, Abushakra S, Lewcock J, Farese R, Kenet RO, Laferla F, Perrin S, Whitaker S, Honig L, Mesulam MM, Boeve B, Grossman M, Miller BL, Cummings JL. PMID: 23062850; PMCID: PMC3562382.
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    107. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. J Clin Invest. 2012 11; 122(11):3955-9. Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Farese RV. PMID: 23041626; PMCID: PMC3484443.
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    108. Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development. Alzheimers Dement. 2013 Mar; 9(2):176-88. Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian Z, Sutherland M, Farese R, Miller BL, Cummings J. PMID: 23043900; PMCID: PMC3542408.
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    109. The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface. J Cell Biol. 2012 Sep 03; 198(5):895-911. Xu N, Zhang SO, Cole RA, McKinney SA, Guo F, Haas JT, Bobba S, Farese RV, Mak HY. PMID: 22927462; PMCID: PMC3432760.
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    110. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Cell Metab. 2012 Jun 06; 15(6):873-84. Haas JT, Miao J, Chanda D, Wang Y, Zhao E, Haas ME, Hirschey M, Vaitheesvaran B, Farese RV, Kurland IJ, Graham M, Crooke R, Foufelle F, Biddinger SB. PMID: 22682225; PMCID: PMC3383842.
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    111. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab. 2012 May 02; 15(5):570-3. Farese RV, Zechner R, Newgard CB, Walther TC. PMID: 22560209; PMCID: PMC3767424.
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    112. Lipid droplets and cellular lipid metabolism. Annu Rev Biochem. 2012; 81:687-714. Walther TC, Farese RV. PMID: 22524315; PMCID: PMC3767414.
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    113. Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood. J Lipid Res. 2012 Jun; 53(6):1144-52. Zhang J, Kelley KL, Marshall SM, Davis MA, Wilson MD, Sawyer JK, Farese RV, Brown JM, Rudel LL. PMID: 22460046; PMCID: PMC3351821.
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    114. Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging (Albany NY). 2012 Jan; 4(1):13-27. Streeper RS, Grueter CA, Salomonis N, Cases S, Levin MC, Koliwad SK, Zhou P, Hirschey MD, Verdin E, Farese RV. PMID: 22291164; PMCID: PMC3292902.
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    115. A guide to analysis of mouse energy metabolism. Nat Methods. 2011 Dec 28; 9(1):57-63. Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E. PMID: 22205519; PMCID: PMC3654855.
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    116. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell. 2011 Oct 21; 44(2):177-90. Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stancáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV, Kahn CR, Verdin E. PMID: 21856199; PMCID: PMC3563434.
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    117. Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis. J Biol Chem. 2011 Dec 09; 286(49):42615-42625. Harris C, Herker E, Farese RV, Ott M. PMID: 21984835; PMCID: PMC3234948.
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    118. Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Cell Metab. 2011 Oct 05; 14(4):504-15. Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, Newman HW, Schmidt-Supprian M, Vance DE, Mann M, Farese RV, Walther TC. PMID: 21982710; PMCID: PMC3735358.
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    119. Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling. Neuron. 2011 Sep 22; 71(6):1030-42. Rosen EY, Wexler EM, Versano R, Coppola G, Gao F, Winden KD, Oldham MC, Martens LH, Zhou P, Farese RV, Geschwind DH. PMID: 21943601; PMCID: PMC3633414.
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    120. Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):E523; author reply E524. Monetti M, Levin MC, Watt MJ, Hubbard BK, Newgard C, Farese RV, Hevener AL, Farese RV. PMID: 21807991; PMCID: PMC3161537.
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    121. Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia. J Biol Chem. 2011 May 06; 286(18):16101-8. Cenik B, Sephton CF, Dewey CM, Xian X, Wei S, Yu K, Niu W, Coppola G, Coughlin SE, Lee SE, Dries DR, Almeida S, Geschwind DH, Gao FB, Miller BL, Farese RV, Posner BA, Yu G, Herz J. PMID: 21454553; PMCID: PMC3091219.
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    122. A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4441-6. Kao AW, Eisenhut RJ, Martens LH, Nakamura A, Huang A, Bagley JA, Zhou P, de Luis A, Neukomm LJ, Cabello J, Farese RV, Kenyon C. PMID: 21368173; PMCID: PMC3060230.
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    123. DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes. J Lipid Res. 2011 Apr; 52(4):657-67. Harris CA, Haas JT, Streeper RS, Stone SJ, Kumari M, Yang K, Han X, Brownell N, Gross RW, Zechner R, Farese RV. PMID: 21317108; PMCID: PMC3284159.
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    124. A new way to look at fat. Nat Methods. 2011 Feb; 8(2):132-3. Bewersdorf J, Farese RV, Walther TC. PMID: 21278725.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    125. Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nat Med. 2010 Nov; 16(11):1295-8. Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV, Ott M. PMID: 20935628; PMCID: PMC3431199.
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    126. MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia. PLoS One. 2010 May 10; 5(5):e10551. Jiao J, Herl LD, Farese RV, Gao FB. PMID: 20479936; PMCID: PMC2866661.
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    127. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010 Mar 04; 464(7285):121-5. Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Alt FW, Kahn CR, Verdin E. PMID: 20203611; PMCID: PMC2841477.
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    128. DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. J Clin Invest. 2010 Mar; 120(3):756-67. Koliwad SK, Streeper RS, Monetti M, Cornelissen I, Chan L, Terayama K, Naylor S, Rao M, Hubbard B, Farese RV. PMID: 20124729; PMCID: PMC2827941.
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    129. Lipid droplets finally get a little R-E-S-P-E-C-T. Cell. 2009 Nov 25; 139(5):855-60. Farese RV, Walther TC. PMID: 19945371; PMCID: PMC3097139.
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    130. SnapShot: Lipid Droplets. Cell. 2009 Nov 25; 139(5):1024-1024.e1. Krahmer N, Guo Y, Farese RV, Walther TC. PMID: 19945384.
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    131. Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids. Hepatology. 2009 Aug; 50(2):434-42. Villanueva CJ, Monetti M, Shih M, Zhou P, Watkins SM, Bhanot S, Farese RV. PMID: 19472314; PMCID: PMC3097135.
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    132. Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism. J Biol Chem. 2009 Sep 18; 284(38):25593-601. Koliwad SK, Kuo T, Shipp LE, Gray NE, Backhed F, So AY, Farese RV, Wang JC. PMID: 19628874; PMCID: PMC2757961.
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    133. Lipid droplets at a glance. J Cell Sci. 2009 Mar 15; 122(Pt 6):749-52. Guo Y, Cordes KR, Farese RV, Walther TC. PMID: 19261844; PMCID: PMC2714424.
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    134. Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding. Nat Med. 2009 Apr; 15(4):442-6. Yen CL, Cheong ML, Grueter C, Zhou P, Moriwaki J, Wong JS, Hubbard B, Marmor S, Farese RV. PMID: 19287392; PMCID: PMC2786494.
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    135. The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. J Biol Chem. 2009 Feb 20; 284(8):5352-61. Stone SJ, Levin MC, Zhou P, Han J, Walther TC, Farese RV. PMID: 19049983; PMCID: PMC2643492.
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    136. Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin. J Biol Chem. 2009 Feb 13; 284(7):4292-9. Shih MY, Kane MA, Zhou P, Yen CL, Streeper RS, Napoli JL, Farese RV. PMID: 19028692; PMCID: PMC2640966.
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    137. The life of lipid droplets. Biochim Biophys Acta. 2009 Jun; 1791(6):459-66. Walther TC, Farese RV. PMID: 19041421; PMCID: PMC2782899.
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    138. Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res. 2008 Nov; 49(11):2283-301. Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV. PMID: 18757836; PMCID: PMC3837458.
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    139. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res. 2008 Sep; 49(9):2038-44. Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV, Horton JD, Preitner F, Thorens B, Tappy L. PMID: 18515909; PMCID: PMC3837456.
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    140. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature. 2008 May 29; 453(7195):657-61. Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV. PMID: 18408709; PMCID: PMC2734507.
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    141. Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1772-81. Levin MC, Monetti M, Watt MJ, Sajan MP, Stevens RD, Bain JR, Newgard CB, Farese RV, Farese RV. PMID: 17940217.
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    142. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec; 27(24):8807-14. Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B. PMID: 17923681; PMCID: PMC2169418.
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    143. LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA). J Leukoc Biol. 2007 Nov; 82(5):1193-200. Chan LC, Peters W, Xu Y, Chun J, Farese RV, Cases S. PMID: 17709403.
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    144. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 2007 Jul; 6(1):69-78. Monetti M, Levin MC, Watt MJ, Sajan MP, Marmor S, Hubbard BK, Stevens RD, Bain JR, Newgard CB, Farese RV, Hevener AL, Farese RV. PMID: 17618857.
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    145. Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2. J Biol Chem. 2006 Dec 29; 281(52):40273-82. Stone SJ, Levin MC, Farese RV. PMID: 17035227.
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    146. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15675-80. Feldman BJ, Streeper RS, Farese RV, Yamamoto KR. PMID: 17030820; PMCID: PMC1592529.
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    147. The nine lives of ACAT inhibitors. Arterioscler Thromb Vasc Biol. 2006 Aug; 26(8):1684-6. Farese RV. PMID: 16857957.
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    148. Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production. J Lipid Res. 2006 Oct; 47(10):2297-305. Millar JS, Stone SJ, Tietge UJ, Tow B, Billheimer JT, Wong JS, Hamilton RL, Farese RV, Rader DJ. PMID: 16877777.
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    149. ACAT inhibition and the progression of coronary atherosclerosis. N Engl J Med. 2006 Jun 15; 354(24):2616-7; author reply 2616-7. Rudel LL, Farese RV. PMID: 16775245.
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    150. Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle. Cell Metab. 2006 May; 3(5):305-7. Yen CL, Farese RV. PMID: 16679288.
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    151. Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin. Am J Physiol Endocrinol Metab. 2006 Aug; 291(2):E388-94. Streeper RS, Koliwad SK, Villanueva CJ, Farese RV. PMID: 16595853; PMCID: PMC1552042.
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    152. A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters. J Lipid Res. 2005 Nov; 46(11):2388-97. Yen CL, Brown CH, Monetti M, Farese RV. PMID: 16106050; PMCID: PMC1540095.
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    153. The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters. J Lipid Res. 2005 Jul; 46(7):1502-11. Yen CL, Monetti M, Burri BJ, Farese RV. PMID: 15834126.
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    154. Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice. Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):482-6. Chen HC, Farese RV. PMID: 15569818.
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    155. ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis. Hepatology. 2004 Nov; 40(5):1088-97. Repa JJ, Buhman KK, Farese RV, Dietschy JM, Turley SD. PMID: 15486928.
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    156. Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential. Circ Res. 2004 Nov 12; 95(10):998-1004. Lee RG, Kelley KL, Sawyer JK, Farese RV, Parks JS, Rudel LL. PMID: 15486318.
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    157. Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1. Diabetes. 2004 Jun; 53(6):1445-51. Chen HC, Rao M, Sajan MP, Standaert M, Kanoh Y, Miura A, Farese RV, Farese RV. PMID: 15161747.
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    158. Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues. Development. 2004 Jul; 131(13):3047-55. Cases S, Zhou P, Shillingford JM, Wiseman BS, Fish JD, Angle CS, Hennighausen L, Werb Z, Farese RV. PMID: 15163627; PMCID: PMC2775443.
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    159. Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high fat-induced insulin-resistant states. J Biol Chem. 2004 Jun 11; 279(24):24929-34. Standaert ML, Sajan MP, Miura A, Kanoh Y, Chen HC, Farese RV, Farese RV. PMID: 15069067.
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    160. Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J Biol Chem. 2004 Mar 19; 279(12):11767-76. Stone SJ, Myers HM, Watkins SM, Brown BE, Feingold KR, Elias PM, Farese RV. PMID: 14668353.
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    161. Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein. Free Radic Biol Med. 2003 Dec 01; 35(11):1343-54. Gohil K, Schock BC, Chakraborty AA, Terasawa Y, Raber J, Farese RV, Packer L, Cross CE, Traber MG. PMID: 14642382.
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    162. Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest. 2003 Jun; 111(11):1715-22. Chen HC, Jensen DR, Myers HM, Eckel RH, Farese RV. PMID: 12782674; PMCID: PMC156099.
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    163. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3077-82. Listenberger LL, Han X, Lewis SE, Cases S, Farese RV, Ory DS, Schaffer JE. PMID: 12629214; PMCID: PMC152249.
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    164. MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine. J Biol Chem. 2003 May 16; 278(20):18532-7. Yen CL, Farese RV. PMID: 12621063.
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    165. Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1262-7. Willner EL, Tow B, Buhman KK, Wilson M, Sanan DA, Rudel LL, Farese RV. PMID: 12538880; PMCID: PMC298761.
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    166. Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue. Diabetes. 2002 Nov; 51(11):3189-95. Chen HC, Stone SJ, Zhou P, Buhman KK, Farese RV. PMID: 12401709.
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    167. Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1. Am J Physiol Endocrinol Metab. 2003 Jan; 284(1):E213-8. Chen HC, Ladha Z, Smith SJ, Farese RV. PMID: 12388146.
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    168. Deficiency of acyl coenzyme a:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models. Endocrinology. 2002 Aug; 143(8):2893-8. Chen HC, Ladha Z, Farese RV. PMID: 12130553.
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    169. Fatty acids, triglycerides, and glucose metabolism: recent insights from knockout mice. Curr Opin Clin Nutr Metab Care. 2002 Jul; 5(4):359-63. Chen HC, Farese RV. PMID: 12107369.
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    170. DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women. Clin Genet. 2002 Jul; 62(1):68-73. Ludwig EH, Mahley RW, Palaoglu E, Ozbayrakçi S, Balestra ME, Borecki IB, Innerarity TL, Farese RV. PMID: 12123490.
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    171. Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8512-7. Yen CL, Stone SJ, Cases S, Zhou P, Farese RV. PMID: 12077311; PMCID: PMC124292.
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    172. Determination of adipocyte size by computer image analysis. J Lipid Res. 2002 Jun; 43(6):986-9. Chen HC, Farese RV. PMID: 12032175.
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    173. Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport. J Biol Chem. 2002 Jun 28; 277(26):23554-62. Chen HC, Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert M, Farese RV, Farese RV. PMID: 11978788.
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    174. DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis. J Biol Chem. 2002 Jul 12; 277(28):25474-9. Buhman KK, Smith SJ, Stone SJ, Repa JJ, Wong JS, Knapp FF, Burri BJ, Hamilton RL, Abumrad NA, Farese RV. PMID: 11959864.
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    175. Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest. 2002 Apr; 109(8):1049-55. Chen HC, Smith SJ, Ladha Z, Jensen DR, Ferreira LD, Pulawa LK, McGuire JG, Pitas RE, Eckel RH, Farese RV. PMID: 11956242; PMCID: PMC150948.
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    176. Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein--null mice. Am J Clin Nutr. 2002 Mar; 75(3):555-60. Leonard SW, Terasawa Y, Farese RV, Traber MG. PMID: 11864863.
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    177. Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands. J Clin Invest. 2002 Jan; 109(2):175-81. Chen HC, Smith SJ, Tow B, Elias PM, Farese RV. PMID: 11805129; PMCID: PMC150839.
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    178. Turning WAT into BAT gets rid of fat. Nat Med. 2001 Oct; 7(10):1102-3. Chen HC, Farese RV. PMID: 11590426.
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    179. Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11587-91. Raffai RL, Dong LM, Farese RV, Weisgraber KH. PMID: 11553788; PMCID: PMC58773.
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    180. The enzymes of neutral lipid synthesis. J Biol Chem. 2001 Nov 02; 276(44):40369-72. Buhman KK, Chen HC, Farese RV. PMID: 11544264.
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    181. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. J Biol Chem. 2001 Oct 19; 276(42):38870-6. Cases S, Stone SJ, Zhou P, Yen E, Tow B, Lardizabal KD, Voelker T, Farese RV. PMID: 11481335.
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    182. Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii. J Biol Chem. 2001 Sep 14; 276(37):34434-40. Sonda S, Ting LM, Novak S, Kim K, Maher JJ, Farese RV, Ernst JD. PMID: 11457847.
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    183. Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages. J Clin Invest. 2001 Jan; 107(2):163-71. Fazio S, Major AS, Swift LL, Gleaves LA, Accad M, Linton MF, Farese RV. PMID: 11160132; PMCID: PMC198874.
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    184. Mammalian acyl-CoA:cholesterol acyltransferases. Biochim Biophys Acta. 2000 Dec 15; 1529(1-3):142-54. Buhman KF, Accad M, Farese RV. PMID: 11111084.
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    185. Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13830-4. Terasawa Y, Ladha Z, Leonard SW, Morrow JD, Newland D, Sanan D, Packer L, Traber MG, Farese RV. PMID: 11095717; PMCID: PMC17661.
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    186. Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Nat Med. 2000 Dec; 6(12):1341-7. Buhman KK, Accad M, Novak S, Choi RS, Wong JS, Hamilton RL, Turley S, Farese RV. PMID: 11100118.
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    187. Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway. EMBO J. 2000 Oct 16; 19(20):5533-41. Yamanaka S, Zhang XY, Maeda M, Miura K, Wang S, Farese RV, Iwao H, Innerarity TL. PMID: 11032820; PMCID: PMC314019.
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    188. Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine. J Biol Chem. 2000 Sep 08; 275(36):28083-92. Chang CC, Sakashita N, Ornvold K, Lee O, Chang ET, Dong R, Lin S, Lee CY, Strom SC, Kashyap R, Fung JJ, Farese RV, Patoiseau JF, Delhon A, Chang TY. PMID: 10846185.
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    189. DGAT and triglyceride synthesis: a new target for obesity treatment? Trends Cardiovasc Med. 2000 Jul; 10(5):188-92. Chen HC, Farese RV. PMID: 11282293.
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    190. Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1. Mol Cell Biol. 2000 Jul; 20(14):5208-15. Huang XZ, Wu JF, Ferrando R, Lee JH, Wang YL, Farese RV, Sheppard D. PMID: 10866676; PMCID: PMC85969.
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    191. Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase. Curr Opin Lipidol. 2000 Jun; 11(3):229-34. Farese RV, Cases S, Smith SJ. PMID: 10882337.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    192. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat Genet. 2000 May; 25(1):87-90. Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, Sanan DA, Raber J, Eckel RH, Farese RV. PMID: 10802663.
      View in: PubMed   Mentions: 282     Fields:    Translation:AnimalsCells
    193. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1. J Clin Invest. 2000 Mar; 105(6):711-9. Accad M, Smith SJ, Newland DL, Sanan DA, King LE, Linton MF, Fazio S, Farese RV. PMID: 10727439; PMCID: PMC377465.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    194. Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice. Mol Cell Biol. 2000 Feb; 20(3):755-9. Huang X, Griffiths M, Wu J, Farese RV, Sheppard D. PMID: 10629031; PMCID: PMC85191.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    195. Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development. J Lipid Res. 1999 Nov; 40(11):1967-77. Terasawa Y, Cases SJ, Wong JS, Jamil H, Jothi S, Traber MG, Packer L, Gordon DA, Hamilton RL, Farese RV. PMID: 10553000.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    196. Steroid hormones: Interactions with membrane-bound receptors. Curr Biol. 1999 Jul 01; 9(13):R478-81. Chen HC, Farese RV. PMID: 10395533.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    197. The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development. J Nutr. 1999 02; 129(2S Suppl):473S-475S. Herz J, Farese RV. PMID: 10064312.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    198. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13018-23. Cases S, Smith SJ, Zheng YW, Myers HM, Lear SR, Sande E, Novak S, Collins C, Welch CB, Lusis AJ, Erickson SK, Farese RV. PMID: 9789033; PMCID: PMC23692.
      View in: PubMed   Mentions: 361     Fields:    Translation:HumansAnimalsCells
    199. ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. J Biol Chem. 1998 Oct 09; 273(41):26755-64. Cases S, Novak S, Zheng YW, Myers HM, Lear SR, Sande E, Welch CB, Lusis AJ, Spencer TA, Krause BR, Erickson SK, Farese RV. PMID: 9756919.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    200. Cholesterol homeostasis: a role for oxysterols. Curr Biol. 1998 Aug 27; 8(17):R601-4. Accad M, Farese RV. PMID: 9742388.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    201. A dual thrombin receptor system for platelet activation. Nature. 1998 Aug 13; 394(6694):690-4. Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV, Tam C, Coughlin SR. PMID: 9716134.
      View in: PubMed   Mentions: 259     Fields:    Translation:HumansAnimalsCells
    202. Immunolocalization of acyl-coenzyme A:cholesterol O-acyltransferase in macrophages. J Biol Chem. 1998 May 01; 273(18):11218-24. Khelef N, Buton X, Beatini N, Wang H, Meiner V, Chang TY, Farese RV, Maxfield FR, Tabas I. PMID: 9556612.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    203. Acyl CoA:cholesterol acyltransferase genes and knockout mice. Curr Opin Lipidol. 1998 Apr; 9(2):119-23. Farese RV. PMID: 9559268.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    204. Cholesterol metabolism and embryogenesis. Trends Genet. 1998 Mar; 14(3):115-20. Farese RV, Herz J. PMID: 9540409.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    205. Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation. J Biol Chem. 1998 Jan 09; 273(2):1064-9. Meiner VL, Welch CL, Cases S, Myers HM, Sande E, Lusis AJ, Farese RV. PMID: 9422770.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    206. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest. 1997 Nov 15; 100(10):2552-61. Boring L, Gosling J, Chensue SW, Kunkel SL, Farese RV, Broxmeyer HE, Charo IF. PMID: 9366570; PMCID: PMC508456.
      View in: PubMed   Mentions: 412     Fields:    Translation:HumansAnimalsCells
    207. Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice. J Lipid Res. 1997 Sep; 38(9):1928-33. Meiner V, Tam C, Gunn MD, Dong LM, Weisgraber KH, Novak S, Myers HM, Erickson SK, Farese RV. PMID: 9323603.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    208. Cholesterol, hedgehog and embryogenesis. Nat Genet. 1997 Feb; 15(2):123-4. Herz J, Willnow TE, Farese RV. PMID: 9020834.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    209. Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14041-6. Meiner VL, Cases S, Myers HM, Sande ER, Bellosta S, Schambelan M, Pitas RE, McGuire J, Herz J, Farese RV. PMID: 8943057; PMCID: PMC19491.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    210. Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul; 37(7):1406-21. Welch CL, Xia YR, Shechter I, Farese R, Mehrabian M, Mehdizadeh S, Warden CH, Lusis AJ. PMID: 8827514.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    211. Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6393-8. Farese RV, Véniant MM, Cham CM, Flynn LM, Pierotti V, Loring JF, Traber M, Ruland S, Stokowski RS, Huszar D, Young SG. PMID: 8692825; PMCID: PMC39033.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    212. Role of the thrombin receptor in development and evidence for a second receptor. Nature. 1996 Jun 06; 381(6582):516-9. Connolly AJ, Ishihara H, Kahn ML, Farese RV, Coughlin SR. PMID: 8632823.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    213. Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol. 1996 May; 133(4):921-8. Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV, Sheppard D. PMID: 8666675; PMCID: PMC2120829.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    214. Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48. J Biol Chem. 1996 Apr 26; 271(17):9887-90. Hirano K, Young SG, Farese RV, Ng J, Sande E, Warburton C, Powell-Braxton LM, Davidson NO. PMID: 8626621.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    215. A novel function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice. J Lipid Res. 1996 Feb; 37(2):347-60. Farese RV, Cases S, Ruland SL, Kayden HJ, Wong JS, Young SG, Hamilton RL. PMID: 9026532.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    216. A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine. J Clin Invest. 1995 Dec; 96(6):2932-46. Young SG, Cham CM, Pitas RE, Burri BJ, Connolly A, Flynn L, Pappu AS, Wong JS, Hamilton RL, Farese RV. PMID: 8675665; PMCID: PMC186005.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    217. Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet. J Clin Invest. 1995 May; 95(5):2246-57. Purcell-Huynh DA, Farese RV, Johnson DF, Flynn LM, Pierotti V, Newland DL, Linton MF, Sanan DA, Young SG. PMID: 7738190; PMCID: PMC295837.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    218. Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1774-8. Farese RV, Ruland SL, Flynn LM, Stokowski RP, Young SG. PMID: 7878058; PMCID: PMC42602.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimals
    219. The apolipoprotein C-II variant apoC-IILys19-->Thr is not associated with dyslipidemia in an affected kindred. Clin Genet. 1994 Jun; 45(6):292-7. Zysow BR, Pullinger CR, Hennessy LK, Farese RV, Ghassemzadeh M, Kane JP. PMID: 7923858.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    220. Transgenic mice expressing human apoB100 and apoB48. Curr Opin Lipidol. 1994 Apr; 5(2):94-101. Young SG, Farese RV, Pierotti VR, Taylor S, Grass DS, Linton MF. PMID: 8044422.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    221. Familial hypobetalipoproteinemia. J Lipid Res. 1993 Apr; 34(4):521-41. Linton MF, Farese RV, Young SG. PMID: 8496659.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    222. Four new mutations in the apolipoprotein B gene causing hypobetalipoproteinemia, including two different frameshift mutations that yield truncated apolipoprotein B proteins of identical length. J Lipid Res. 1993 Mar; 34(3):501-7. Young SG, Pullinger CR, Zysow BR, Hofmann-Radvani H, Linton MF, Farese RV, Terdiman JF, Snyder SM, Grundy SM, Vega GL, et al. PMID: 8468533.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    223. Modification of the apolipoprotein B gene in HepG2 cells by gene targeting. J Clin Invest. 1992 Jul; 90(1):256-61. Farese RV, Flynn LM, Young SG. PMID: 1321843; PMCID: PMC443089.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    224. Apolipoprotein B gene mutations affecting cholesterol levels. J Intern Med. 1992 Jun; 231(6):643-52. Farese RV, Linton MF, Young SG. PMID: 1619387.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    225. A truncated species of apolipoprotein B, B-83, associated with hypobetalipoproteinemia. J Lipid Res. 1992 Apr; 33(4):569-77. Farese RV, Garg A, Pierotti VR, Vega GL, Young SG. PMID: 1527480.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    226. Tissue-specific regulation of lipoprotein lipase activity by insulin/glucose in normal-weight humans. Metabolism. 1991 Feb; 40(2):214-6. Farese RV, Yost TJ, Eckel RH. PMID: 1988780.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    227. The mechanism of action of insulin on phospholipid metabolism in rat adipose tissue. Requirement for protein synthesis and a carbohydrate source, and relationship to activation of pyruvate dehydrogenase. Diabetes. 1984 Jul; 33(7):648-55. Farese RV, Farese RV, Sabir MA, Larson RE, Trudeau WL, Barnes D. PMID: 6329860.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
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