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Bob Farese, MD

Title(s)PROFESSOR IN RESIDENCE - FY, Gladstone Institutes
SchoolSchool of Medicine
Address1650 Owens St
San Francisco CA 94107
Phone415-734-2000
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Overview 
    Collapse Overview
    EDUCATION
    University of Florida, Gainesville, FL, B.S., 1981 (Chemistry)
    Vanderbilt Medical School, Nashville, TN, M.D., 1985


    POSTDOCTORAL TRAINING
    Internship And Residency
    1985–1988 Internal Medicine, University of Colorado Affiliated Hospitals, Denver, CO
    1988–1989 Chief Resident, Internal Medicine, University of Colorado Affiliated Hospitals,
    Denver, CO

    FELLOWSHIPS
    1989–1992 Endocrinology, Diabetes, and Metabolism, UCSF
    1990–1992 Postdoctoral Fellow, Gladstone Institute of Cardiovascular Disease

    Collapse Research 
    Collapse Research Activities and Funding
    2014 Lipoprotein Metabolism Gordon Research Conference and Gordon Research Semina
    NIH R13HL123268Jun 10, 2014 - May 31, 2015
    Role: Principal Investigator
    Physiology of Lipid Droplets and Triglyceride Storage
    NIH R01DK101579May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    The Mechanisms of Lipid Droplet Formation and Regulation
    NIH R01GM099844Mar 1, 2012 - Nov 30, 2015
    Role: Principal Investigator
    Role of DGAT in Triacyglycerol Metabolism
    NIH R56DK056084Sep 30, 2010 - Aug 31, 2011
    Role: Principal Investigator
    Enhancing Progranulin Expression - a Therapy for Frontotemporal Dementia
    NIH RC1NS068697Sep 30, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Functional Analysis of MGAT Enzymes
    NIH R01DK077233Aug 1, 2007 - Oct 31, 2011
    Role: Principal Investigator
    Identification of Genes that Regulate Cellular Lipid Storage
    NIH R21DK078254Apr 20, 2007 - Mar 31, 2009
    Role: Principal Investigator
    New Approaches to Dementia Heterogeneity
    NIH/NIA P50AG023501Apr 1, 2004 - Mar 31, 2019
    Role: Co-Investigator
    Triglyceride Synthesis and Lipotoxicity
    NIH R01DK065599Apr 15, 2003 - Mar 31, 2007
    Role: Principal Investigator
    Role of DGAT in Triacyglycerol Metabolism
    NIH R01DK056084May 1, 2000 - Jul 31, 2015
    Role: Principal Investigator
    Investigation of ACAT Functions Using Knockout
    NIH R01HL057170Feb 1, 1997 - Jan 31, 2008
    Role: Principal Investigator
    LIPOPROTEIN STRUCTURE/FUNCTION IN CHOLESTEROL METABOLISM
    NIH/NHLBI P01HL041633Feb 1, 1989 - Jan 31, 2005
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. J Cell Biol. 2020 Oct 05; 219(10). Becuwe M, Bond LM, Pinto AFM, Boland S, Mejhert N, Elliott SD, Cicconet M, Graham MM, Liu XN, Ilkayeva O, Saghatelian A, Walther TC, Farese RV. PMID: 32915949.
      View in: PubMed   Mentions:    Fields:    
    2. Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature. 2020 Aug 31. Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ. PMID: 32866962.
      View in: PubMed   Mentions: 1     Fields:    
    3. Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting. Dev Cell. 2020 Aug 24; 54(4):471-487.e7. Olarte MJ, Kim S, Sharp ME, Swanson JMJ, Farese RV, Walther TC. PMID: 32730754.
      View in: PubMed   Mentions:    Fields:    
    4. Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature. 2020 05; 581(7808):323-328. Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV. PMID: 32433611.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration. Proc Natl Acad Sci U S A. 2020 05 12; 117(19):10565-10574. Petit CS, Lee JJ, Boland S, Swarup S, Christiano R, Lai ZW, Mejhert N, Elliott SD, McFall D, Haque S, Huang EJ, Bronson RT, Harper JW, Farese RV, Walther TC. PMID: 32345721.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression. Mol Cell. 2020 03 19; 77(6):1251-1264.e9. Mejhert N, Kuruvilla L, Gabriel KR, Elliott SD, Guie MA, Wang H, Lai ZW, Lane EA, Christiano R, Danial NN, Farese RV, Walther TC. PMID: 32023484.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. LDAF1 and Seipin Form a Lipid Droplet Assembly Complex. Dev Cell. 2019 12 02; 51(5):551-563.e7. Chung J, Wu X, Lambert TJ, Lai ZW, Walther TC, Farese RV. PMID: 31708432.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    8. Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics. Dev Cell. 2019 09 09; 50(5):530-532. Walther TC, Farese RV. PMID: 31505174.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    9. Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice. Hepatology. 2019 12; 70(6):1972-1985. Gluchowski NL, Gabriel KR, Chitraju C, Bronson RT, Mejhert N, Boland S, Wang K, Lai ZW, Farese RV, Walther TC. PMID: 31081165.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes. J Lipid Res. 2019 06; 60(6):1112-1120. Chitraju C, Walther TC, Farese RV. PMID: 30936184.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids. Mol Cell. 2019 04 04; 74(1):32-44.e8. Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV. PMID: 30846318.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    12. Atypical PKC: therapeutic target for Alzheimer's? Aging (Albany NY). 2018 12 20; 11(1):13-14. Farese RV, Sajan MP. PMID: 30573704.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Lipidomic Analysis of a-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019 03 07; 73(5):1001-1014.e8. Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. PMID: 30527540.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    14. Cryo-electron microscopy structure of the lipid droplet-formation protein seipin. J Cell Biol. 2018 12 03; 217(12):4080-4091. Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV, Walther TC. PMID: 30327422.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    15. Progranulin in the hematopoietic compartment protects mice from atherosclerosis. Atherosclerosis. 2018 10; 277:145-154. Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV. PMID: 30212683.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    16. Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells. Mol Biol Cell. 2018 08 15; 29(17):2045-2054. Jayson CBK, Arlt H, Fischer AW, Lai ZW, Farese RV, Walther TC. PMID: 29949452.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):E2849-E2858. Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV. PMID: 29511098.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    18. Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity. Mol Cell Proteomics. 2018 05; 17(5):836-849. Li Z, Lai ZW, Christiano R, Gazos-Lopes F, Walther TC, Farese RV. PMID: 29414761.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets. Dev Cell. 2018 Jan 08; 44(1):73-86.e4. Prévost C, Sharp ME, Kory N, Lin Q, Voth GA, Farese RV, Walther TC. PMID: 29316443.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    20. Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets. Biochemistry. 2018 Feb 06; 57(5):827-838. Inloes JM, Kiosses WB, Wang H, Walther TC, Farese RV, Cravatt BF. PMID: 29278326.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    21. Coordinated regulation of hepatic FoxO1, PGC-1a and SREBP-1c facilitates insulin action and resistance. Cell Signal. 2018 03; 43:62-70. Sajan MP, Lee MC, Foufelle F, Sajan J, Cleland C, Farese RV. PMID: 29269047.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    22. Atypical PKC, PKC?/?, activates ß-secretase and increases Aß1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease. Neurobiol Aging. 2018 01; 61:225-237. Sajan MP, Hansen BC, Higgs MG, Kahn CR, Braun U, Leitges M, Park CR, Diamond DM, Farese RV. PMID: 29032894.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    23. An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations. Alzheimers Dement (N Y). 2017 Nov; 3(4):507-512. Sha SJ, Miller ZA, Min SW, Zhou Y, Brown J, Mitic LL, Karydas A, Koestler M, Tsai R, Corbetta-Rastelli C, Lin S, Hare E, Fields S, Fleischmann KE, Powers R, Fitch R, Martens LH, Shamloo M, Fagan AM, Farese RV, Pearlman R, Seeley W, Miller BL, Gan L, Boxer AL. PMID: 29124108.
      View in: PubMed   Mentions:
    24. Lipid Droplet Biogenesis. Annu Rev Cell Dev Biol. 2017 10 06; 33:491-510. Walther TC, Chung J, Farese RV. PMID: 28793795.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    25. Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis. Cell Metab. 2017 Aug 01; 26(2):407-418.e3. Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV. PMID: 28768178.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    26. Microglial NF?B-TNFa hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):5029-5034. Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL, Farese RV, Gan L. PMID: 28438992.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    27. Lipid droplets and liver disease: from basic biology to clinical implications. Nat Rev Gastroenterol Hepatol. 2017 Jun; 14(6):343-355. Gluchowski NL, Becuwe M, Walther TC, Farese RV. PMID: 28428634.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    28. Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea. J Lipid Res. 2017 06; 58(6):1230-1237. Gluchowski NL, Chitraju C, Picoraro JA, Mejhert N, Pinto S, Xin W, Kamin DS, Winter HS, Chung WK, Walther TC, Farese RV. PMID: 28373485.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    29. Deletion of Protein Kinase C ? in POMC Neurons Predisposes to Diet-Induced Obesity. Diabetes. 2017 04; 66(4):920-934. Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP. PMID: 28073831.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism. J Lipid Res. 2017 01; 58(1):226-235. Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing C, Zechner R, Cravatt BF, Farese RV, Walther TC. PMID: 27836991.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    31. Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion. Proteomics. 2016 11; 16(21):2759-2763. Fröhlich F, Olson DK, Christiano R, Farese RV, Walther TC. PMID: 27717283.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    32. Seipin is required for converting nascent to mature lipid droplets. Elife. 2016 Aug 26; 5. Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV. PMID: 27564575.
      View in: PubMed   Mentions: 55     Fields:    
    33. Compensation for PKM? in long-term potentiation and spatial long-term memory in mutant mice. Elife. 2016 05 17; 5. Tsokas P, Hsieh C, Yao Y, Lesburguères E, Wallace EJC, Tcherepanov A, Jothianandan D, Hartley BR, Pan L, Rivard B, Farese RV, Sajan MP, Bergold PJ, Hernández AI, Cottrell JE, Shouval HZ, Fenton AA, Sacktor TC. PMID: 27187150.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    34. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell. 2016 May 05; 165(4):921-35. Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R, Farese RV, Paz JT, Barres BA, Huang EJ. PMID: 27114033.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    35. Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets. Trends Cell Biol. 2016 07; 26(7):535-546. Kory N, Farese RV, Walther TC. PMID: 26995697.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    36. Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1a and Increases in Aß1-40/42 and Phospho-Tau May Abet Alzheimer Development. Diabetes. 2016 07; 65(7):1892-903. Sajan M, Hansen B, Ivey R, Sajan J, Ari C, Song S, Braun U, Leitges M, Farese-Higgs M, Farese RV. PMID: 26895791.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    37. Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice. J Lipid Res. 2016 Apr; 57(4):616-30. Agarwal AK, Tunison K, Dalal JS, Yen CL, Farese RV, Horton JD, Garg A. PMID: 26880786.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    38. Lipid droplets go nuclear. J Cell Biol. 2016 Jan 04; 212(1):7-8. Farese RV, Walther TC. PMID: 26728852.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    39. Contraction stimulates muscle glucose uptake independent of atypical PKC. Physiol Rep. 2015 Nov; 3(11). Yu H, Fujii NL, Toyoda T, An D, Farese RV, Leitges M, Hirshman MF, Mul JD, Goodyear LJ. PMID: 26564060.
      View in: PubMed   Mentions:    Fields:    
    40. The GARP complex is required for cellular sphingolipid homeostasis. Elife. 2015 Sep 10; 4. Fröhlich F, Petit C, Kory N, Christiano R, Hannibal-Bach HK, Graham M, Liu X, Ejsing CS, Farese RV, Walther TC. PMID: 26357016.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    41. BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1a in livers of obese and type 2 diabetic humans. Metabolism. 2015 Nov; 64(11):1454-65. Sajan MP, Ivey RA, Farese RV. PMID: 26386696.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    42. Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. Dev Cell. 2015 Aug 10; 34(3):351-63. Kory N, Thiam AR, Farese RV, Walther TC. PMID: 26212136.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    43. Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats. PLoS One. 2015; 10(7):e0132575. Zhang N, Liang H, Farese RV, Li J, Musi N, Hussey SE. PMID: 26196892.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    44. Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation. J Lipid Res. 2015 Jan; 56(1):70-80. Sajan MP, Ivey RA, Lee MC, Farese RV. PMID: 25395359.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    45. The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets. J Biol Chem. 2014 Dec 26; 289(52):35770-80. Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M. PMID: 25381252.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    46. MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse. Am J Physiol Endocrinol Metab. 2014 Dec 01; 307(11):E1065-72. Mul JD, Begg DP, Haller AM, Pressler JW, Sorrell J, Woods SC, Farese RV, Seeley RJ, Sandoval DA. PMID: 25315695.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    47. Atypical PKC: a target for treating insulin-resistant disorders of obesity, the metabolic syndrome and type 2 diabetes mellitus. Expert Opin Ther Targets. 2014 Oct; 18(10):1163-75. Farese RV, Lee MC, Sajan MP. PMID: 25213731.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    48. Progranulin protects against amyloid ß deposition and toxicity in Alzheimer's disease mouse models. Nat Med. 2014 Oct; 20(10):1157-64. Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV, Gan L. PMID: 25261995.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    49. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. J Exp Med. 2014 Sep 22; 211(10):1937-45. Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV, Green A, Gan L. PMID: 25155018.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    50. Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure. J Biol Chem. 2014 Oct 24; 289(43):29881-91. Liu L, Trent CM, Fang X, Son NH, Jiang H, Blaner WS, Hu Y, Yin YX, Farese RV, Homma S, Turnbull AV, Eriksson JW, Hu SL, Ginsberg HN, Huang LS, Goldberg IJ. PMID: 25157099.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    51. Requirements for pseudosubstrate arginine residues during autoinhibition and phosphatidylinositol 3,4,5-(PO4)3-dependent activation of atypical PKC. J Biol Chem. 2014 Sep 05; 289(36):25021-30. Ivey RA, Sajan MP, Farese RV. PMID: 25035426.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    52. Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus. J Clin Med. 2014 Jul 07; 3(3):724-40. Farese RV, Lee MC, Sajan MP. PMID: 26237474.
      View in: PubMed   Mentions:
    53. In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy. J Am Chem Soc. 2014 Jun 18; 136(24):8820-8. Fu D, Yu Y, Folick A, Currie E, Farese RV, Tsai TH, Xie XS, Wang MC. PMID: 24869754.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    54. PKC? haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. Mol Endocrinol. 2014 Jul; 28(7):1097-107. Sajan MP, Ivey RA, Lee M, Mastorides S, Jurczak MJ, Samuels VT, Shulman GI, Braun U, Leitges M, Farese RV. PMID: 24877563.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    55. High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. J Lipid Res. 2014 07; 55(7):1465-77. Currie E, Guo X, Christiano R, Chitraju C, Kory N, Harrison K, Haas J, Walther TC, Farese RV. PMID: 24868093.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    56. Lipid droplet biogenesis. Curr Opin Cell Biol. 2014 Aug; 29:39-45. Wilfling F, Haas JT, Walther TC, Farese RV. PMID: 24736091.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    57. Akt-dependent phosphorylation of hepatic FoxO1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity. Diabetes. 2014 Aug; 63(8):2690-701. Sajan MP, Acevedo-Duncan ME, Standaert ML, Ivey RA, Lee M, Farese RV. PMID: 24705403.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    58. Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. Elife. 2014; 3:e01607. Wilfling F, Thiam AR, Olarte MJ, Wang J, Beck R, Gould TJ, Allgeyer ES, Pincet F, Bewersdorf J, Farese RV, Walther TC. PMID: 24497546.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    59. The biophysics and cell biology of lipid droplets. Nat Rev Mol Cell Biol. 2013 Dec; 14(12):775-86. Thiam AR, Farese RV, Walther TC. PMID: 24220094.
      View in: PubMed   Mentions: 157     Fields:    Translation:HumansAnimalsCells
    60. Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One. 2013; 8(10):e76055. Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, Farese RV, Moore MJ, Shaw CE, Gao FB. PMID: 24143176.
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    61. Progranulin: at the interface of neurodegenerative and metabolic diseases. Trends Endocrinol Metab. 2013 Dec; 24(12):597-606. Nguyen AD, Nguyen TA, Martens LH, Mitic LL, Farese RV. PMID: 24035620.
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    62. Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-? produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis. Adipocyte. 2014 Jan 01; 3(1):19-29. Sajan MP, Jurzak MJ, Samuels VT, Shulman GI, Braun U, Leitges M, Farese RV. PMID: 24575365.
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    63. Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression. Diabetologia. 2013 Nov; 56(11):2507-16. Sajan MP, Ivey RA, Farese RV. PMID: 23933835.
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    64. A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress. Mol Cell. 2013 Aug 22; 51(4):519-30. Surma MA, Klose C, Peng D, Shales M, Mrejen C, Stefanko A, Braberg H, Gordon DE, Vorkel D, Ejsing CS, Farese R, Simons K, Krogan NJ, Ernst R. PMID: 23891562.
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    65. Cellular fatty acid metabolism and cancer. Cell Metab. 2013 Aug 06; 18(2):153-61. Currie E, Schulze A, Zechner R, Walther TC, Farese RV. PMID: 23791484.
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    66. Balancing the fat: lipid droplets and human disease. EMBO Mol Med. 2013 Jul; 5(7):973-83. Krahmer N, Farese RV, Walther TC. PMID: 23740690.
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    67. Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. J Neurosci. 2013 May 22; 33(21):9202-13. Chen X, Chang J, Deng Q, Xu J, Nguyen TA, Martens LH, Cenik B, Taylor G, Hudson KF, Chung J, Yu K, Yu P, Herz J, Farese RV, Kukar T, Tansey MG. PMID: 23699531.
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    68. A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep. 2013 May 30; 3(5):1465-75. Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, Li L, Jin D, Boye-Doe A, Liu TY, Shibata Y, Lu H, Rapoport TA, Farese RV, Blackstone C, Guo Y, Mak HY. PMID: 23684613.
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    69. Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice. J Neurosci. 2013 Mar 20; 33(12):5352-61. Filiano AJ, Martens LH, Young AH, Warmus BA, Zhou P, Diaz-Ramirez G, Jiao J, Zhang Z, Huang EJ, Gao FB, Farese RV, Roberson ED. PMID: 23516300.
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    70. Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. J Biol Chem. 2013 Apr 05; 288(14):9915-23. Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Ott M. PMID: 23420847.
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    71. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell. 2013 Feb 25; 24(4):384-99. Wilfling F, Wang H, Haas JT, Krahmer N, Gould TJ, Uchida A, Cheng JX, Graham M, Christiano R, Fröhlich F, Liu X, Buhman KK, Coleman RA, Bewersdorf J, Farese RV, Walther TC. PMID: 23415954.
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    72. Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL). J Biol Chem. 2013 Mar 22; 288(12):8627-35. Nguyen AD, Nguyen TA, Cenik B, Yu G, Herz J, Walther TC, Davidson WS, Farese RV. PMID: 23364791.
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    73. Protein correlation profiles identify lipid droplet proteins with high confidence. Mol Cell Proteomics. 2013 May; 12(5):1115-26. Krahmer N, Hilger M, Kory N, Wilfling F, Stoehr G, Mann M, Farese RV, Walther TC. PMID: 23319140.
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    74. Suppression of oxidative stress by ß-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013 Jan 11; 339(6116):211-4. Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, Verdin E. PMID: 23223453.
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    75. DGAT1 mutation is linked to a congenital diarrheal disorder. J Clin Invest. 2012 Dec; 122(12):4680-4. Haas JT, Winter HS, Lim E, Kirby A, Blumenstiel B, DeFelice M, Gabriel S, Jalas C, Branski D, Grueter CA, Toporovski MS, Walther TC, Daly MJ, Farese RV. PMID: 23114594.
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    76. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nat Genet. 2012 Dec; 44(12):1302-9. Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV, Gitler AD. PMID: 23104007.
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    77. Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases. J Biol Chem. 2012 Nov 30; 287(49):41446-57. Eichmann TO, Kumari M, Haas JT, Farese RV, Zimmermann R, Lass A, Zechner R. PMID: 23066022.
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    78. Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects. Cell Rep. 2012 Oct 25; 2(4):789-98. Almeida S, Zhang Z, Coppola G, Mao W, Futai K, Karydas A, Geschwind MD, Tartaglia MC, Gao F, Gianni D, Sena-Esteves M, Geschwind DH, Miller BL, Farese RV, Gao FB. PMID: 23063362.
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    79. The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier). Alzheimers Dement. 2013 Mar; 9(2):189-98. Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Jackson G, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian ZS, Sutherland M, Abushakra S, Lewcock J, Farese R, Kenet RO, Laferla F, Perrin S, Whitaker S, Honig L, Mesulam MM, Boeve B, Grossman M, Miller BL, Cummings JL. PMID: 23062850.
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    80. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. J Clin Invest. 2012 Nov; 122(11):3955-9. Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Farese RV. PMID: 23041626.
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    81. Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development. Alzheimers Dement. 2013 Mar; 9(2):176-88. Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian Z, Sutherland M, Farese R, Miller BL, Cummings J. PMID: 23043900.
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    82. The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface. J Cell Biol. 2012 Sep 03; 198(5):895-911. Xu N, Zhang SO, Cole RA, McKinney SA, Guo F, Haas JT, Bobba S, Farese RV, Mak HY. PMID: 22927462.
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    83. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Cell Metab. 2012 Jun 06; 15(6):873-84. Haas JT, Miao J, Chanda D, Wang Y, Zhao E, Haas ME, Hirschey M, Vaitheesvaran B, Farese RV, Kurland IJ, Graham M, Crooke R, Foufelle F, Biddinger SB. PMID: 22682225.
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    84. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab. 2012 May 02; 15(5):570-3. Farese RV, Zechner R, Newgard CB, Walther TC. PMID: 22560209.
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    85. Lipid droplets and cellular lipid metabolism. Annu Rev Biochem. 2012; 81:687-714. Walther TC, Farese RV. PMID: 22524315.
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    86. Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood. J Lipid Res. 2012 Jun; 53(6):1144-52. Zhang J, Kelley KL, Marshall SM, Davis MA, Wilson MD, Sawyer JK, Farese RV, Brown JM, Rudel LL. PMID: 22460046.
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    87. Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging (Albany NY). 2012 Jan; 4(1):13-27. Streeper RS, Grueter CA, Salomonis N, Cases S, Levin MC, Koliwad SK, Zhou P, Hirschey MD, Verdin E, Farese RV. PMID: 22291164.
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    88. A guide to analysis of mouse energy metabolism. Nat Methods. 2011 Dec 28; 9(1):57-63. Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E. PMID: 22205519.
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    89. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell. 2011 Oct 21; 44(2):177-90. Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stancáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV, Kahn CR, Verdin E. PMID: 21856199.
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    90. Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis. J Biol Chem. 2011 Dec 09; 286(49):42615-25. Harris C, Herker E, Farese RV, Ott M. PMID: 21984835.
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    91. Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Cell Metab. 2011 Oct 05; 14(4):504-15. Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, Newman HW, Schmidt-Supprian M, Vance DE, Mann M, Farese RV, Walther TC. PMID: 21982710.
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    92. Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling. Neuron. 2011 Sep 22; 71(6):1030-42. Rosen EY, Wexler EM, Versano R, Coppola G, Gao F, Winden KD, Oldham MC, Martens LH, Zhou P, Farese RV, Geschwind DH. PMID: 21943601.
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    93. Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):E523; author reply E524. Monetti M, Levin MC, Watt MJ, Hubbard BK, Newgard C, Farese RV, Hevener AL, Farese RV. PMID: 21807991.
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    94. Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia. J Biol Chem. 2011 May 06; 286(18):16101-8. Cenik B, Sephton CF, Dewey CM, Xian X, Wei S, Yu K, Niu W, Coppola G, Coughlin SE, Lee SE, Dries DR, Almeida S, Geschwind DH, Gao FB, Miller BL, Farese RV, Posner BA, Yu G, Herz J. PMID: 21454553.
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    95. A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4441-6. Kao AW, Eisenhut RJ, Martens LH, Nakamura A, Huang A, Bagley JA, Zhou P, de Luis A, Neukomm LJ, Cabello J, Farese RV, Kenyon C. PMID: 21368173.
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    96. DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes. J Lipid Res. 2011 Apr; 52(4):657-67. Harris CA, Haas JT, Streeper RS, Stone SJ, Kumari M, Yang K, Han X, Brownell N, Gross RW, Zechner R, Farese RV. PMID: 21317108.
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    97. A new way to look at fat. Nat Methods. 2011 Feb; 8(2):132-3. Bewersdorf J, Farese RV, Walther TC. PMID: 21278725.
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    98. Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nat Med. 2010 Nov; 16(11):1295-8. Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV, Ott M. PMID: 20935628.
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    99. MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia. PLoS One. 2010 May 10; 5(5):e10551. Jiao J, Herl LD, Farese RV, Gao FB. PMID: 20479936.
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    100. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010 Mar 04; 464(7285):121-5. Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Alt FW, Kahn CR, Verdin E. PMID: 20203611.
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    101. DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. J Clin Invest. 2010 Mar; 120(3):756-67. Koliwad SK, Streeper RS, Monetti M, Cornelissen I, Chan L, Terayama K, Naylor S, Rao M, Hubbard B, Farese RV. PMID: 20124729.
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    102. Lipid droplets finally get a little R-E-S-P-E-C-T. Cell. 2009 Nov 25; 139(5):855-60. Farese RV, Walther TC. PMID: 19945371.
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    103. SnapShot: Lipid Droplets. Cell. 2009 Nov 25; 139(5):1024-1024.e1. Krahmer N, Guo Y, Farese RV, Walther TC. PMID: 19945384.
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    104. Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids. Hepatology. 2009 Aug; 50(2):434-42. Villanueva CJ, Monetti M, Shih M, Zhou P, Watkins SM, Bhanot S, Farese RV. PMID: 19472314.
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    105. Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism. J Biol Chem. 2009 Sep 18; 284(38):25593-601. Koliwad SK, Kuo T, Shipp LE, Gray NE, Backhed F, So AY, Farese RV, Wang JC. PMID: 19628874.
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    106. Lipid droplets at a glance. J Cell Sci. 2009 Mar 15; 122(Pt 6):749-52. Guo Y, Cordes KR, Farese RV, Walther TC. PMID: 19261844.
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    107. Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding. Nat Med. 2009 Apr; 15(4):442-6. Yen CL, Cheong ML, Grueter C, Zhou P, Moriwaki J, Wong JS, Hubbard B, Marmor S, Farese RV. PMID: 19287392.
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    108. The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. J Biol Chem. 2009 Feb 20; 284(8):5352-61. Stone SJ, Levin MC, Zhou P, Han J, Walther TC, Farese RV. PMID: 19049983.
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    109. Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin. J Biol Chem. 2009 Feb 13; 284(7):4292-9. Shih MY, Kane MA, Zhou P, Yen CL, Streeper RS, Napoli JL, Farese RV. PMID: 19028692.
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    110. The life of lipid droplets. Biochim Biophys Acta. 2009 Jun; 1791(6):459-66. Walther TC, Farese RV. PMID: 19041421.
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    111. Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res. 2008 Nov; 49(11):2283-301. Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV. PMID: 18757836.
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    112. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res. 2008 Sep; 49(9):2038-44. Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV, Horton JD, Preitner F, Thorens B, Tappy L. PMID: 18515909.
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    113. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature. 2008 May 29; 453(7195):657-61. Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV. PMID: 18408709.
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    114. Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1772-81. Levin MC, Monetti M, Watt MJ, Sajan MP, Stevens RD, Bain JR, Newgard CB, Farese RV, Farese RV. PMID: 17940217.
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    115. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec; 27(24):8807-14. Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B. PMID: 17923681.
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    116. LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA). J Leukoc Biol. 2007 Nov; 82(5):1193-200. Chan LC, Peters W, Xu Y, Chun J, Farese RV, Cases S. PMID: 17709403.
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    117. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 2007 Jul; 6(1):69-78. Monetti M, Levin MC, Watt MJ, Sajan MP, Marmor S, Hubbard BK, Stevens RD, Bain JR, Newgard CB, Farese RV, Hevener AL, Farese RV. PMID: 17618857.
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    118. Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2. J Biol Chem. 2006 Dec 29; 281(52):40273-82. Stone SJ, Levin MC, Farese RV. PMID: 17035227.
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    119. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15675-80. Feldman BJ, Streeper RS, Farese RV, Yamamoto KR. PMID: 17030820.
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    120. The nine lives of ACAT inhibitors. Arterioscler Thromb Vasc Biol. 2006 Aug; 26(8):1684-6. Farese RV. PMID: 16857957.
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    121. Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production. J Lipid Res. 2006 Oct; 47(10):2297-305. Millar JS, Stone SJ, Tietge UJ, Tow B, Billheimer JT, Wong JS, Hamilton RL, Farese RV, Rader DJ. PMID: 16877777.
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    122. ACAT inhibition and the progression of coronary atherosclerosis. N Engl J Med. 2006 Jun 15; 354(24):2616-7; author reply 2616-7. Rudel LL, Farese RV. PMID: 16775245.
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    123. Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle. Cell Metab. 2006 May; 3(5):305-7. Yen CL, Farese RV. PMID: 16679288.
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    124. Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin. Am J Physiol Endocrinol Metab. 2006 Aug; 291(2):E388-94. Streeper RS, Koliwad SK, Villanueva CJ, Farese RV. PMID: 16595853.
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    125. A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters. J Lipid Res. 2005 Nov; 46(11):2388-97. Yen CL, Brown CH, Monetti M, Farese RV. PMID: 16106050.
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    126. The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters. J Lipid Res. 2005 Jul; 46(7):1502-11. Yen CL, Monetti M, Burri BJ, Farese RV. PMID: 15834126.
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    127. Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice. Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):482-6. Chen HC, Farese RV. PMID: 15569818.
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    128. ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis. Hepatology. 2004 Nov; 40(5):1088-97. Repa JJ, Buhman KK, Farese RV, Dietschy JM, Turley SD. PMID: 15486928.
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    129. Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential. Circ Res. 2004 Nov 12; 95(10):998-1004. Lee RG, Kelley KL, Sawyer JK, Farese RV, Parks JS, Rudel LL. PMID: 15486318.
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    130. Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1. Diabetes. 2004 Jun; 53(6):1445-51. Chen HC, Rao M, Sajan MP, Standaert M, Kanoh Y, Miura A, Farese RV, Farese RV. PMID: 15161747.
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    131. Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues. Development. 2004 Jul; 131(13):3047-55. Cases S, Zhou P, Shillingford JM, Wiseman BS, Fish JD, Angle CS, Hennighausen L, Werb Z, Farese RV. PMID: 15163627.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    132. Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high fat-induced insulin-resistant states. J Biol Chem. 2004 Jun 11; 279(24):24929-34. Standaert ML, Sajan MP, Miura A, Kanoh Y, Chen HC, Farese RV, Farese RV. PMID: 15069067.
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    133. Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J Biol Chem. 2004 Mar 19; 279(12):11767-76. Stone SJ, Myers HM, Watkins SM, Brown BE, Feingold KR, Elias PM, Farese RV. PMID: 14668353.
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    134. Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein. Free Radic Biol Med. 2003 Dec 01; 35(11):1343-54. Gohil K, Schock BC, Chakraborty AA, Terasawa Y, Raber J, Farese RV, Packer L, Cross CE, Traber MG. PMID: 14642382.
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    135. Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest. 2003 Jun; 111(11):1715-22. Chen HC, Jensen DR, Myers HM, Eckel RH, Farese RV. PMID: 12782674.
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    136. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3077-82. Listenberger LL, Han X, Lewis SE, Cases S, Farese RV, Ory DS, Schaffer JE. PMID: 12629214.
      View in: PubMed   Mentions: 532     Fields:    Translation:AnimalsCells
    137. MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine. J Biol Chem. 2003 May 16; 278(20):18532-7. Yen CL, Farese RV. PMID: 12621063.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    138. Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1262-7. Willner EL, Tow B, Buhman KK, Wilson M, Sanan DA, Rudel LL, Farese RV. PMID: 12538880.
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    139. Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue. Diabetes. 2002 Nov; 51(11):3189-95. Chen HC, Stone SJ, Zhou P, Buhman KK, Farese RV. PMID: 12401709.
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    140. Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1. Am J Physiol Endocrinol Metab. 2003 Jan; 284(1):E213-8. Chen HC, Ladha Z, Smith SJ, Farese RV. PMID: 12388146.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    141. Deficiency of acyl coenzyme a:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models. Endocrinology. 2002 Aug; 143(8):2893-8. Chen HC, Ladha Z, Farese RV. PMID: 12130553.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    142. Fatty acids, triglycerides, and glucose metabolism: recent insights from knockout mice. Curr Opin Clin Nutr Metab Care. 2002 Jul; 5(4):359-63. Chen HC, Farese RV. PMID: 12107369.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    143. Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8512-7. Yen CL, Stone SJ, Cases S, Zhou P, Farese RV. PMID: 12077311.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    144. Determination of adipocyte size by computer image analysis. J Lipid Res. 2002 Jun; 43(6):986-9. Chen HC, Farese RV. PMID: 12032175.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    145. Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport. J Biol Chem. 2002 Jun 28; 277(26):23554-62. Chen HC, Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert M, Farese RV, Farese RV. PMID: 11978788.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    146. DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis. J Biol Chem. 2002 Jul 12; 277(28):25474-9. Buhman KK, Smith SJ, Stone SJ, Repa JJ, Wong JS, Knapp FF, Burri BJ, Hamilton RL, Abumrad NA, Farese RV. PMID: 11959864.
      View in: PubMed   Mentions: 71     Fields:    Translation:Animals
    147. Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest. 2002 Apr; 109(8):1049-55. Chen HC, Smith SJ, Ladha Z, Jensen DR, Ferreira LD, Pulawa LK, McGuire JG, Pitas RE, Eckel RH, Farese RV. PMID: 11956242.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    148. Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein--null mice. Am J Clin Nutr. 2002 Mar; 75(3):555-60. Leonard SW, Terasawa Y, Farese RV, Traber MG. PMID: 11864863.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    149. Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands. J Clin Invest. 2002 Jan; 109(2):175-81. Chen HC, Smith SJ, Tow B, Elias PM, Farese RV. PMID: 11805129.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    150. Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase. Curr Opin Lipidol. 2000 Jun; 11(3):229-34. Farese RV, Cases S, Smith SJ. PMID: 10882337.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
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