Brent Molden, MD, PhD

Address505 Parnassus Avenue
San Francisco CA 94117
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    Mechanism of the desensitization of MC4R
    NIH/NIDDK F30DK095569Jul 1, 2012 - Jun 30, 2015
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cooney KA, Molden B, Kowalczyk NS, Russell S, Baldini G. Lipid stress inhibits endocytosis of Melanocortin-4 Receptor from modified clathrin-enriched sites and impairs receptor desensitization. J Biol Chem. 2017 Sep 06. PMID: 28878020.
      View in: PubMed
    2. Molden B, Cooney KA, West K, Van Der Ploeg LH, Baldini G. Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists. Mol Endocrinol. 2015 Nov; 29(11):1619-33. PMID: 26418335; PMCID: PMC4627605 [Available on 11/01/16].
    3. Granell S, Molden B, Baldini G. Exposure of MC4R to agonist in the endoplasmic reticulum stabilizes an active conformation of the receptor that does not desensitize. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):E4733-42. PMID: 24248383; PMCID: PMC3856822.
    4. McDaniel FK, Molden B, Mohammad S, Baldini G, McPike L, Narducci P, Granell S, Baldini G. Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to a-melanocyte-stimulating hormone (a-MSH). J Biol Chem. 2012 Jun 22; 287(26):21873-90. PMID: 22544740; PMCID: PMC3381150.
    5. Kuo MM, Maslennikov I, Molden B, Choe S. The desensitization gating of the MthK K+ channel is governed by its cytoplasmic amino terminus. PLoS Biol. 2008 Oct 28; 6(10):e223. PMID: 18959476; PMCID: PMC2573919.
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