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Brent Molden, MD, PhD

Title(s)CLINICAL FELLOW, Pathology
SchoolSchool of Medicine
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    Mechanism of the desensitization of MC4R
    NIH/NIDDK F30DK095569Jul 1, 2012 - Jun 30, 2015
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cooney KA, Molden BM, Kowalczyk NS, Russell S, Baldini G. Lipid stress inhibits endocytosis of melanocortin-4 receptor from modified clathrin-enriched sites and impairs receptor desensitization. J Biol Chem. 2017 10 27; 292(43):17731-17745. PMID: 28878020.
      View in: PubMed
    2. Molden BM, Cooney KA, West K, Van Der Ploeg LH, Baldini G. Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists. Mol Endocrinol. 2015 Nov; 29(11):1619-33. PMID: 26418335; PMCID: PMC4627605 [Available on 11/01/16].
      View in: PubMed, PubMed Central
    3. Granell S, Molden BM, Baldini G. Exposure of MC4R to agonist in the endoplasmic reticulum stabilizes an active conformation of the receptor that does not desensitize. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):E4733-42. PMID: 24248383; PMCID: PMC3856822.
      View in: PubMed, PubMed Central
    4. McDaniel FK, Molden BM, Mohammad S, Baldini G, McPike L, Narducci P, Granell S, Baldini G. Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to a-melanocyte-stimulating hormone (a-MSH). J Biol Chem. 2012 Jun 22; 287(26):21873-90. PMID: 22544740; PMCID: PMC3381150.
      View in: PubMed, PubMed Central
    5. Kuo MM, Maslennikov I, Molden B, Choe S. The desensitization gating of the MthK K+ channel is governed by its cytoplasmic amino terminus. PLoS Biol. 2008 Oct 28; 6(10):e223. PMID: 18959476; PMCID: PMC2573919.
      View in: PubMed, PubMed Central
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