Brent Molden, MD, PhD

Title(s)CLINICAL FELLOW, Pathology
SchoolSchool of Medicine
Address505 Parnassus Avenue
San Francisco CA 94117
Phone415-353-1613
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    Mechanism of the desensitization of MC4R
    NIH F30DK095569Jul 1, 2012 - Jun 30, 2015
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lipid stress inhibits endocytosis of melanocortin-4 receptor from modified clathrin-enriched sites and impairs receptor desensitization. J Biol Chem. 2017 10 27; 292(43):17731-17745. Cooney KA, Molden BM, Kowalczyk NS, Russell S, Baldini G. PMID: 28878020.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    2. Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists. Mol Endocrinol. 2015 Nov; 29(11):1619-33. Molden BM, Cooney KA, West K, Van Der Ploeg LH, Baldini G. PMID: 26418335.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    3. Exposure of MC4R to agonist in the endoplasmic reticulum stabilizes an active conformation of the receptor that does not desensitize. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):E4733-42. Granell S, Molden BM, Baldini G. PMID: 24248383.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    4. Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to a-melanocyte-stimulating hormone (a-MSH). J Biol Chem. 2012 Jun 22; 287(26):21873-90. McDaniel FK, Molden BM, Mohammad S, Baldini G, McPike L, Narducci P, Granell S, Baldini G. PMID: 22544740.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    5. The desensitization gating of the MthK K+ channel is governed by its cytoplasmic amino terminus. PLoS Biol. 2008 Oct 28; 6(10):e223. Kuo MM, Maslennikov I, Molden B, Choe S. PMID: 18959476.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
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