Loading...

Brian Hearn, PhD

Title(s)Associate Director, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
AddressQB3 Fifth Floor South
San Francisco Ca 94158
Phone--
vCardDownload vCard

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine. ACS Chem Biol. 2020 06 19; 15(6):1392-1400. Bashore C, Jaishankar P, Skelton NJ, Fuhrmann J, Hearn BR, Liu PS, Renslo AR, Dueber EC. PMID: 32302100.
      View in: PubMed   Mentions: 2     Fields:    
    2. PET Imaging of the EPR Effect in Tumor Xenografts Using Small 15 nm Diameter Polyethylene Glycols Labeled with Zirconium-89. Mol Cancer Ther. 2020 02; 19(2):673-679. Beckford Vera DR, Fontaine SD, VanBrocklin HF, Hearn BR, Reid R, Ashley GW, Santi DV. PMID: 31744896.
      View in: PubMed   Mentions:    Fields:    
    3. Primary deuterium kinetic isotope effects prolong drug release and polymer biodegradation in a drug delivery system. J Control Release. 2018 05 28; 278:74-79. Hearn BR, Fontaine SD, Pfaff SJ, Schneider EL, Henise J, Ashley GW, Santi DV. PMID: 29577950.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation. Structure. 2018 01 02; 26(1):72-84.e7. Özen A, Rougé L, Bashore C, Hearn BR, Skelton NJ, Dueber EC. PMID: 29249604.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    5. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 10 26; 550(7677):534-538. Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, Bainbridge TW, Kwok MCM, Ma TP, Stiffler Z, Brasher B, Tang Y, Jaishankar P, Hearn BR, Renslo AR, Arkin MR, Cohen F, Yu K, Peale F, Gnad F, Chang MT, Klijn C, Blackwood E, Martin SE, Forrest WF, Ernst JA, Ndubaku C, Wang X, Beresini MH, Tsui V, Schwerdtfeger C, Blake RA, Murray J, Maurer T, Wertz IE. PMID: 29045385.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    6. A Hydrogel-Microsphere Drug Delivery System That Supports Once-Monthly Administration of a GLP-1 Receptor Agonist. ACS Chem Biol. 2017 08 18; 12(8):2107-2116. Schneider EL, Hearn BR, Pfaff SJ, Reid R, Parkes DG, Vrang N, Ashley GW, Santi DV. PMID: 28605180.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake. Bioconjug Chem. 2016 Oct 19; 27(10):2534-2539. Schneider EL, Hearn BR, Pfaff SJ, Fontaine SD, Reid R, Ashley GW, Grabulovski S, Strassberger V, Vogt L, Jung T, Santi DV. PMID: 27657443.
      View in: PubMed   Mentions: 2     Fields:    
    8. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6a branch. Elife. 2016 07 20; 5. Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P. PMID: 27435960.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    9. Surgical sealants with tunable swelling, burst pressures, and biodegradation rates. J Biomed Mater Res B Appl Biomater. 2017 08; 105(6):1602-1611. Henise J, Hearn BR, Santi DV, Kamata H, Sakai T, Ashley GW. PMID: 27149244.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response. ChemMedChem. 2016 Apr 19; 11(8):870-80. Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. PMID: 26789650.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015 Apr 15; 4:e07314. Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. PMID: 25875391.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    12. Biodegradable tetra-PEG hydrogels as carriers for a releasable drug delivery system. Bioconjug Chem. 2015 Feb 18; 26(2):270-8. Henise J, Hearn BR, Ashley GW, Santi DV. PMID: 25584814.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    13. Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry. 2014 Jul 22; 53(28):4648-60. Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS. PMID: 24977643.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    14. Tailoring small molecules for an allosteric site on procaspase-6. ChemMedChem. 2014 Jan; 9(1):73-7, 2. Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, Arkin MR, Flygare J, Renslo AR. PMID: 24259468.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    15. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28; 2:e00498. Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P. PMID: 23741617.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansAnimalsCells
    16. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. PLoS One. 2012; 7(12):e50864. Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, Tang Y, Zhao X, Lewcock JW, Renslo AR, Flygare J, Arkin MR. PMID: 23227217.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    17. Predicting and improving the membrane permeability of peptidic small molecules. J Med Chem. 2012 Apr 12; 55(7):3163-9. Rafi SB, Hearn BR, Vedantham P, Jacobson MP, Renslo AR. PMID: 22394492.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    18. Semisynthesis and cytotoxicity of hypothemycin analogues. ChemMedChem. 2007 Nov; 2(11):1598-600. Hearn BR, Sundermann K, Cannoy J, Santi DV. PMID: 17691074.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. C-15 thiazol-4-yl analogues of (E)-9,10-didehydroepothilone D: synthesis and cytotoxicity. Org Lett. 2006 Jul 06; 8(14):3057-9. Hearn BR, Zhang D, Li Y, Myles DC. PMID: 16805551.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    20. Methanolysis products of disorazole A1. J Nat Prod. 2006 Jan; 69(1):148-50. Hearn BR, Arslanian RL, Fu H, Liu F, Gramajo H, Myles DC. PMID: 16441089.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    21. A divergent approach to the myriaporones and tedanolide: completion of the carbon skeleton of myriaporone 1. Org Lett. 2002 Aug 22; 4(17):2953-5. Taylor RE, Hearn BR, Ciavarri JP. PMID: 12182597.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    Brian's Networks
    Concepts (155)
    Derived automatically from this person's publications.
    _
    Co-Authors (17)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _