Caroline Duwaerts, PhD

Title(s)Professional Researcher, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
ORCID ORCID Icon0000-0002-2086-5197 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Loyola University Chicago, Chicago, ILB.S.05/2008Biology & Minor in Chemistry
    Brown University, Providence, RIPh.D.01/2013Medical Sciences: Pathobiology
    University of California, San Francisco, San Francisco, CAPost-Doctoral Fellowship05/2016Hepatology
    Collapse Awards and Honors
    Loyola University Chicago2008  - 2008Excellence in Biological Research Award
    Brown University2009  - 2009Poole Gorham Philanthropy Fellow

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Role of ER Stress in NAFLD Development and Progression
    American Association for the Study of Liver Disease Foundation AASLD Pinnacle Research AwardJul 1, 2019 - Jun 30, 2022
    Role: Principal Investigator
    The Role of Regulated IRE1 Dependent Decay (RIDD) in Endoplasmic Reticulum Stress-Induced Liver Cell Death
    NIH/NIDDK UCSF Liver Center Pilot/Feasibility AwardJun 1, 2018 - May 31, 2019
    Role: Principal Investigator
    Graduate Women in Science - Sigma Delta Epsilon Fellowship Pre-Doctoral FellowshipJun 1, 2012 - May 31, 2013
    Role: Principal Investigator
    NRSA Hepatology Training Grant
    NIH T32DK060414Dec 1, 2001 - Jun 30, 2022
    Role: Trainee 05/06/2013 - 05/05/2016

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ER Disposal Pathways in Chronic Liver Disease: Protective, Pathogenic, and Potential Therapeutic Targets. Front Mol Biosci. 2021; 8:804097. Duwaerts CC, Maiers JL. PMID: 35174209; PMCID: PMC8841999.
      View in: PubMed   Mentions:
    2. Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation. Hepatology. 2021 10; 74(4):2102-2117. Peaslee C, Esteva-Font C, Su T, Munoz-Howell A, Duwaerts CC, Liu Z, Rao S, Liu K, Medina M, Sneddon JB, Maher JJ, Mattis AN. PMID: 33982322; PMCID: PMC8544023.
      View in: PubMed   Mentions:    Fields:    
    3. Induced Pluripotent Stem Cell-derived Hepatocytes From Patients With Nonalcoholic Fatty Liver Disease Display a Disease-specific Gene Expression Profile. Gastroenterology. 2021 06; 160(7):2591-2594.e6. Duwaerts CC, Le Guillou D, Her CL, Phillips NJ, Willenbring H, Mattis AN, Maher JJ. PMID: 33640436; PMCID: PMC8169560.
      View in: PubMed   Mentions:    Fields:    
    4. Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α. Cell Death Differ. 2021 05; 28(5):1455-1465. Duwaerts CC, Siao K, Soon RK, Her C, Iwawaki T, Kohno K, Mattis AN, Maher JJ. PMID: 33219328; PMCID: PMC8166833.
      View in: PubMed   Mentions: 3     Fields:    
    5. Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Sci Transl Med. 2020 08 19; 12(557). Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY. PMID: 32817366; PMCID: PMC7976849.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    6. Polycystic ovary syndrome (PCOS) is associated with NASH severity and advanced fibrosis. Liver Int. 2020 02; 40(2):355-359. Sarkar M, Terrault N, Chan W, Cedars MI, Huddleston HG, Duwaerts CC, Balitzer D, Gill RM. PMID: 31627243; PMCID: PMC6980925.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    7. Macronutrients and the Adipose-Liver Axis in Obesity and Fatty Liver. Cell Mol Gastroenterol Hepatol. 2019; 7(4):749-761. Duwaerts CC, Maher JJ. PMID: 30763771; PMCID: PMC6463203.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    8. The Association of Hispanic Ethnicity with Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome. Curr Opin Gynecol Obstet. 2018 02 20; 1(1):24-33. Sarkar M, Terrault N, Duwaerts CC, Tien P, Cedars MI, Huddleston H. PMID: 30112518; PMCID: PMC6089370.
      View in: PubMed   Mentions: 3  
    9. CD18 deficiency improves liver injury in the MCD model of steatohepatitis. PLoS One. 2017; 12(9):e0183912. Pierce AA, Duwaerts CC, Siao K, Mattis AN, Goodsell A, Baron JL, Maher JJ. PMID: 28873429; PMCID: PMC5584926.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. Specific Macronutrients Exert Unique Influences on the Adipose-Liver Axis to Promote Hepatic Steatosis in Mice. Cell Mol Gastroenterol Hepatol. 2017 Sep; 4(2):223-236. Duwaerts CC, Amin AM, Siao K, Her C, Fitch M, Beysen C, Turner SM, Goodsell A, Baron JL, Grenert JP, Cho SJ, Maher JJ. PMID: 28649594; PMCID: PMC5472193.
      View in: PubMed   Mentions: 5     Fields:    
    11. Isocaloric manipulation of macronutrients within a high-carbohydrate/moderate-fat diet induces unique effects on hepatic lipogenesis, steatosis and liver injury. J Nutr Biochem. 2016 Mar; 29:12-20. Pierce AA, Duwaerts CC, Soon RK, Siao K, Grenert JP, Fitch M, Hellerstein MK, Beysen C, Turner SM, Maher JJ. PMID: 26895660; PMCID: PMC4761406.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    12. Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis. Curr Hepatol Rep. 2014 Jun 01; 13(2):119-129. Duwaerts CC, Maher JJ. PMID: 25045618; PMCID: PMC4097318.
      View in: PubMed   Mentions: 14  
    13. Cross-activating invariant NKT cells and kupffer cells suppress cholestatic liver injury in a mouse model of biliary obstruction. PLoS One. 2013; 8(11):e79702. Duwaerts CC, Sun EP, Cheng CW, van Rooijen N, Gregory SH. PMID: 24260285; PMCID: PMC3829879.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    14. Contrasting responses of Kupffer cells and inflammatory mononuclear phagocytes to biliary obstruction in a mouse model of cholestatic liver injury. Liver Int. 2013 Feb; 33(2):255-65. Duwaerts CC, Gehring S, Cheng CW, van Rooijen N, Gregory SH. PMID: 23240869; PMCID: PMC3540118.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    15. Effects of recovery from immobilization stress on striatal preprodynorphin- and kappa opioid receptor-mRNA levels of the male rat. Physiol Behav. 2011 Oct 24; 104(5):972-80. Lucas LR, Dragisic T, Duwaerts CC, Swiatkowski M, Suzuki H. PMID: 21723305.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    16. Targeting the diverse immunological functions expressed by hepatic NKT cells. Expert Opin Ther Targets. 2011 Aug; 15(8):973-88. Duwaerts CC, Gregory SH. PMID: 21564001; PMCID: PMC3133853.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    17. NK cells suppress experimental cholestatic liver injury by an interleukin-6-mediated, Kupffer cell-dependent mechanism. J Hepatol. 2011 Apr; 54(4):746-52. Cheng CW, Duwaerts CC, Rooijen Nv, Wintermeyer P, Mott S, Gregory SH. PMID: 21129806; PMCID: PMC3060960.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    18. Effects of acute diuresis stress on egr-1 (zif268) mRNA levels in brain regions associated with motivated behavior. Brain Res Bull. 2010 Jan 15; 81(1):114-9. Aher CV, Duwaerts CC, Akama KT, Lucas LR. PMID: 19835936.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
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