Caroline Guglielmetti, PhD

Title(s)Assistant Researcher, Physical Therapy
SchoolSchool of Medicine
Address1700 4th St
San Francisco CA 94158
Phone628-206-6973
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    Collapse Biography 
    Collapse Education and Training
    University of California San Francisco, USA2021Diversity, Equity, and Inclusion Champion Training
    University of California San Francisco, USAPostdoctoral Fellowship2021Biomedical Sciences | Biomedical Imaging
    University of Antwerp | University of California San Francisco, Belgium | USAPh.D.2016Biomedical Sciences | Biomedical Imaging
    University of Antwerp | Université Toulouse III, Belgium | FranceM.S.2010Neurosciences | Biomedical Imaging
    University of Wisconsin-Madison | Université Toulouse III, USA | FranceM.S.2009Biology | Neurosciences
    Université Toulouse III, FranceB.S2008Biology | Physiology
    Collapse Awards and Honors
    International Society for Magnetic Resonance in Medicine (ISMRM)2021ISMRM Junior Fellow
    UCSF Department of Radiology and Biological Imaging (USA)2017Annual Recipient of the Bruce Hasegawa Award for Excellence in Biomedical Imaging
    Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) (USA)2017Young Investigator Award
    National Multiple Sclerosis Society (NMSS) (USA)2016  - 2018Postdoctoral Research Fellowship
    Research Foundation – Flanders (FWO) (Belgium)2014  - 2016Travel Grant for Long Research Stay Abroad
    Science and Technology in Flanders (Belgium)2012  - 2016Ph.D. Student Fellowship

    Collapse Overview 
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    Collapse Research 
    Collapse Research Activities and Funding
    Imaging oxidative stress in multiple sclerosis using HP 13C MRSI
    UCSF Radiology and Biomedical Imaging Seed Grant UCSF Seed GrantAug 1, 2021 - Jul 31, 2022
    Role: Principal Investigator
    Imaging innate and adaptive immune response in MS using using [18F]F-AraG PET and hyperpolarized 13C MRSI
    NIH/NIAID 1R21AI153749-01Jun 1, 2020 - May 31, 2021
    Role: Principal Investigator
    Deciphering the function of astrocytes in multiple sclerosis using PET and MR imaging
    UCSF Resource Allocation Program UCSF RAPJan 1, 2020 - Dec 31, 2021
    Role: Principal Investigator
    In vivo imaging of astroglial glutamate transporter in multiple sclerosis using PET and MR imaging
    UCSF Physical Therapy and Rehabilitation Science Seed Grant UCSF PTRSJan 1, 2020 - Jun 30, 2021
    Role: Principal Investigator
    Monitoring of immune cells, lesion stage and response to therapy in a multiple sclerosis model using [18F]F-AraG PET imaging and hyperpolarized 13C MRSI
    UCSF Resource Allocation Program UCSF RAPJan 1, 2019 - Dec 31, 2021
    Role: co-Investigator
    MR Metabolic Imaging of Multiple Sclerosis
    National Multiple Sclerosis Society RG-1606-24414Oct 1, 2017 - Sep 30, 2021
    Role: Key Personnel
    Metabolic Imaging of Oxidative Stress in Multiple Sclerosis
    Conrad Hilton Foundation Jul 1, 2017 - Jun 30, 2020
    Role: Key Personnel
    MR imaging of oxidative stress in multiple sclerosis
    The National Multiple Sclerosis Society FG-1507-05297Jul 1, 2016 - Jun 30, 2018
    Role: Principal Investigator
    Studying the metabolic changes following acute inflammation in the cuprizone mouse model for multiple sclerosis using hyperpolarized 13C magnetic resonance spectroscopy
    Research Foundation - Flanders (FWO) Belgium Graduate School Fellowship - Travel grantSep 1, 2014 - Mar 1, 2015
    Role: Principal Investigator
    Modulation of neuroinflammation during de- and re-myelination processes: an in-vivo study
    Agency for Innovation by Science and Technology in Flanders (Belgium) Graduate School FellowshipJan 1, 2012 - Dec 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Longitudinal imaging of T-cells and inflammatory demyelination in a preclinical model of multiple sclerosis using 18F-FAraG PET and MRI. J Nucl Med. 2021 Apr 09. Guglielmetti C, Levi J, Huynh TL, Tiret B, Blecha J, Tang R, Van Brocklin HF, Chaumeil MM. PMID: 33837066.
      View in: PubMed   Mentions:    Fields:    
    2. Long-term ovarian hormone deprivation alters functional connectivity, brain neurochemical profile and white matter integrity in the Tg2576 amyloid mouse model of Alzheimer's disease. Neurobiol Aging. 2021 06; 102:139-150. Kara F, Belloy ME, Voncken R, Sarwari Z, Garima Y, Anckaerts C, Langbeen A, Leysen V, Shah D, Jacobs J, Hamaide J, Bols P, Van Audekerke J, Daans J, Guglielmetti C, Kantarci K, Prevot V, Roßner S, Ponsaerts P, Van der Linden A, Verhoye M. PMID: 33765427.
      View in: PubMed   Mentions:    Fields:    
    3. Long-term deprivation of ovarian hormones via ovariectomy alters functional connectivity, brain neurochemistry and white matter integrity in a mouse model of Alzheimer's disease. Alzheimer's & Dementia. 2020 Dec 7; 16(S4). Kara KF, Belloy BM, Voncken VR, Sarwari SZ, Yadav YG, Anckaerts AC, Langbeen LA, Leysen LV, Shah SD, Jacobs JJ, Hamaide HJ, Bols BP, Van Audekerke VJ, Daans DJ, Guglielmetti GC, Kantarci KK, Prevot PV, Rossner RS, Ponsaerts PP, Van Der Linden VA, Verhoye VM. .
      View in: Publisher Site   Mentions:
    4. Imaging Brain Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy. Trends Neurosci. 2020 05; 43(5):343-354. Le Page LM, Guglielmetti C, Taglang C, Chaumeil MM. PMID: 32353337.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    5. Longitudinal evaluation of demyelinated lesions in a multiple sclerosis model using ultrashort echo time magnetization transfer (UTE-MT) imaging. Neuroimage. 2020 03; 208:116415. Guglielmetti C, Boucneau T, Cao P, Van der Linden A, Larson PEZ, Chaumeil MM. PMID: 31811900.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. Hyperpolarized 13 C magnetic resonance spectroscopy detects toxin-induced neuroinflammation in mice. NMR Biomed. 2019 11; 32(11):e4164. Le Page LM, Guglielmetti C, Najac CF, Tiret B, Chaumeil MM. PMID: 31437326.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    7. Imaging toxin-induced neuroinflammation in mice using hyperpolarized 13C magnetic resonance spectroscopy. bioRxiv. 2019 Apr 11; 605568. Le Page LL, Guglielmetti GC, Najac NC, Tiret TB, Chaumeil CM. .
      View in: Publisher Site   Mentions:
    8. Molecular Imaging of Immune Cell Dynamics During De- and Remyelination in the Cuprizone Model of Multiple Sclerosis by [18F]DPA-714 PET and MRI. Theranostics. 2019; 9(6):1523-1537. Zinnhardt B, Belloy M, Fricke IB, Orije J, Guglielmetti C, Hermann S, Wagner S, Schäfers M, Van der Linden A, Jacobs AH. PMID: 31037121.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    9. Repeated Mild Head Injury Leads to Wide-Ranging Deficits in Higher-Order Cognitive Functions Associated with the Prefrontal Cortex. J Neurotrauma. 2018 10 15; 35(20):2425-2434. Nolan A, Hennessy E, Krukowski K, Guglielmetti C, Chaumeil MM, Sohal VS, Rosi S. PMID: 29732949.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    10. In vivo metabolic imaging of Traumatic Brain Injury. Sci Rep. 2017 12 13; 7(1):17525. Guglielmetti C, Chou A, Krukowski K, Najac C, Feng X, Riparip LK, Rosi S, Chaumeil MM. PMID: 29235509.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    11. Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):E6982-E6991. Guglielmetti C, Najac C, Didonna A, Van der Linden A, Ronen SM, Chaumeil MM. PMID: 28760957.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    12. Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model. J Neuroinflammation. 2016 11 09; 13(1):288. Le Blon D, Guglielmetti C, Hoornaert C, Quarta A, Daans J, Dooley D, Lemmens E, Praet J, De Vocht N, Reekmans K, Santermans E, Hens N, Goossens H, Verhoye M, Van der Linden A, Berneman Z, Hendrix S, Ponsaerts P. PMID: 27829467.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    13. IMST-04. IMAGING INFLAMMATORY CELL FUNCTION USING 13C MAGNETIC RESONANCE SPECTROSCOPY OF HYPERPOLARIZED 6-13C-LABELED ARGININE. Neuro-Oncology. 2016 Nov 1; 18(suppl_6):vi86-vi86. Najac NC, Chaumeil CM, Kohanbash KG, Guglielmetti GC, Gordon GJ, Okada OH, Ronen RS. .
      View in: Publisher Site   Mentions:
    14. Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages. Glia. 2016 12; 64(12):2181-2200. Guglielmetti C, Le Blon D, Santermans E, Salas-Perdomo A, Daans J, De Vocht N, Shah D, Hoornaert C, Praet J, Peerlings J, Kara F, Bigot C, Mai Z, Goossens H, Hens N, Hendrix S, Verhoye M, Planas AM, Berneman Z, van der Linden A, Ponsaerts P. PMID: 27685637.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    15. Monitoring Blood-Brain Barrier Integrity Following Amyloid-β Immunotherapy Using Gadolinium-Enhanced MRI in a PDAPP Mouse Model. J Alzheimers Dis. 2016 09 06; 54(2):723-35. Blockx I, Einstein S, Guns PJ, Van Audekerke J, Guglielmetti C, Zago W, Roose D, Verhoye M, Van der Linden A, Bard F. PMID: 27567811.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    16. Detection of inflammatory cell function using (13)C magnetic resonance spectroscopy of hyperpolarized [6-(13)C]-arginine. Sci Rep. 2016 08 10; 6:31397. Najac C, Chaumeil MM, Kohanbash G, Guglielmetti C, Gordon JW, Okada H, Ronen SM. PMID: 27507680.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    17. In Vivo Interleukin-13-Primed Macrophages Contribute to Reduced Alloantigen-Specific T Cell Activation and Prolong Immunological Survival of Allogeneic Mesenchymal Stem Cell Implants. Stem Cells. 2016 07; 34(7):1971-84. Hoornaert CJ, Luyckx E, Reekmans K, Dhainaut M, Guglielmetti C, Le Blon D, Dooley D, Fransen E, Daans J, Verbeeck L, Quarta A, De Vocht N, Lemmens E, Goossens H, Van der Linden A, Roobrouck VD, Verfaillie C, Hendrix S, Moser M, Berneman ZN, Ponsaerts P. PMID: 26992046.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    18. Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination. Neuroimage. 2016 Jan 15; 125:363-377. Guglielmetti C, Veraart J, Roelant E, Mai Z, Daans J, Van Audekerke J, Naeyaert M, Vanhoutte G, Delgado Y Palacios R, Praet J, Fieremans E, Ponsaerts P, Sijbers J, Van der Linden A, Verhoye M. PMID: 26525654.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    19. Longitudinal monitoring of metabolic alterations in cuprizone mouse model of multiple sclerosis using 1H-magnetic resonance spectroscopy. Neuroimage. 2015 Jul 01; 114:128-35. Orije J, Kara F, Guglielmetti C, Praet J, Van der Linden A, Ponsaerts P, Verhoye M. PMID: 25871629.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    20. Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra. NMR Biomed. 2015 Apr; 28(4):505-13. Praet J, Orije J, Kara F, Guglielmetti C, Santermans E, Daans J, Hens N, Verhoye M, Berneman Z, Ponsaerts P, Van der Linden A. PMID: 25802215.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    21. Cellular and molecular neuropathology of the cuprizone mouse model: clinical relevance for multiple sclerosis. Neurosci Biobehav Rev. 2014 Nov; 47:485-505. Praet J, Guglielmetti C, Berneman Z, Van der Linden A, Ponsaerts P. PMID: 25445182.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    22. Different anesthesia regimes modulate the functional connectivity outcome in mice. Magnetic Resonance in Medicine. 2014 Oct 1; 72(4):spcone-spcone. Jonckers JE, Delgado y Palacios DR, Shah SD, Guglielmetti GC, Verhoye VM, Linden LA. .
      View in: Publisher Site   Mentions:
    23. Multimodal imaging of micron-sized iron oxide particles following in vitro and in vivo uptake by stem cells: down to the nanometer scale. Contrast Media Mol Imaging. 2014 Nov-Dec; 9(6):400-8. Roose D, Leroux F, De Vocht N, Guglielmetti C, Pintelon I, Adriaensen D, Ponsaerts P, Van der Linden A, Bals S. PMID: 24753446.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. Oral Presentations. Regenerative Medicine. 2013 Nov 1; 8(6s):s12-s150. Andreeva AE, Korovin KS, Shubenkov SA, Pustovoy PV, Buravkova BL, Buyukoz BM, Erdal EE, Altinkaya AS, Costa CA, Aprile AP, Aulino AP, Rossi RD, Perniconi PB, Adamo AS, Coletti CD, Teodori TL, Dupin DD, Casuso CP, Prez PA, Diaz DN, Odriozola OI, Grande GH, Cabaero CG, Loinaz LI, Gangwal GS, Hoyer HJ, Schulz-Siegmund SM, Neundorf NI, Imparato IG, Urciuolo UF, Casale CC, Netti NP, Kre KS, Nickel NJ, Walles WH, Kuevda KE, Gubareva GE, Gilevich GI, Sotnichenko SA, Jungebluth JP, Haag HJ, Krasheninnikov KS, Grigoriev GT, Chvalun CS, Macchiarini MP, Logan LN, Bozec BL, Collins CS, Traynor TA, Brett BP, Chanova CE, Knotek KP, Havlikova HJ, Machova ML, Yang YY, Proks PV, Kucka KJ, Bacakova BL, Rypacek RF, Ortiz OR, Moreno-Flores MS, Toca-Herrera TJ, Quintana QI, Oshikata OA, Takezawa TT, Reibetanz RU, Rathmann RS, Schnberg SM, Strehlow SV, Gse GM, Lessig LJ, Rossi RA, Walles WH, Groll GJ, Shevtsov SM, Yudintceva YN, Blinova BM, Galibin GO, Ivanova IA, Savchenko SO, Pinaev PG, Potokin PI, Pitkin PM, Staude SM, Tchernev TC, Prnnecke PC, Schmidt SS, Ebert EH, Jahnke JH, Robitzki RA, van de Kamp vJ, Jahnen-Dechent JW, Woeltje WM, Boebel BM, Rheinnecker RM, Knuechel KR, Neuss NS, Weijers WE, van den Broek vM, Tasev TD, van den Broek vL, van Hinsbergh vV, Koolwijk KP, Amer AM, Firouzi FD, Youssef YA, Srouji SR, Foucher FD, Bougharara BH, Amleh AA, Angelozzi AM, Penolazzi PL, Lolli LA, Lambertini LE, Morganti MC, Di Ciano DM, Pedriali PN, Mazzitelli MS, Piva PR, Nastruzzi NC, Bagdonas BE, Bernotiene BE, Unguryte UA, Denkovskij DJ, Porvaneckas PN, Bernotiene BE, Denkovskij DJ, Kusleviciute KI, Bagdonas BE, Unguryte UA, Porvaneckas PN, Mackiewicz MZ, Khan KM, Salih SV, Donos DN, Brett BP, Desando DG, Cavallo CC, Sartoni SF, Martini ML, Giavaresi GG, Tschon TM, Fini FM, Giardino GR, Facchini FA, Grigolo GB, Fassbender FM, Minkwitz MS, Thiele TM, Wildemann WB, Gimona GM, Lener LT, Streif SD, Peckl-Schmid PD, ller lM, Schallmoser SK, Laner-Plamberger LS, Rohde RE, Groll GJ, Walles WH, Jorgensen JC, Lang LA, Pfeiffenberger PM, Weber WY, Schmidt SM, Manferdini MC, Maumus MM, Gabusi GE, Piacentini PA, Paolella PF, Peyrafitte PJ, Fleury-Cappellesso FS, Bourin BP, Jorgensen JC, Noel ND, Facchini FA, Lisignoli LG, Muttini MA, Mattioli MM, Tet TS, Piattelli PA, Barboni BB, Oksymets OV, Zubov ZD, Vasyliev VR, Klimovytsky KV, Rapaport RH, Peters PF, Seeliger SC, Karpinski KK, Schyschka SL, Haug HA, Vester VH, Schmitt SA, Bauer BJ, Biberthaler BP, van Griensven vM, Gardner GO, Archer AC, Alini AM, Stoddart SM, Willems WN, Tryfonidou TM, Grinwis GG, Papen-Botterhuis PN, Langelaan LM, Plomp PS, Dhert DW, Creemers CL, Meij MB, Yeung YC, Sarig SU, Bronshtein BT, Boey BF, Venkatraman VS, Machluf MM, Moreira MR, Gesch GV, Hurtado-Aguilar HL, Frese FJ, Jockenhoevel JS, Mela MP, Nguyen NE, Sarig SU, Bronshtein BT, Boey BF, Venkatraman VS, Machluf MM, Galy-Fauroux GI, Sapharikas SE, Lokajczyk LA, Boisson-Vidal BC, Fischer FA, Helley HD, Schlegel SF, Krahe KM, Mohr MF, Ftterer FC, Dhein DS, Schrder SA, Shi SY, Seekamp SA, Fuchs FS, Brandes BA, Rogowski RW, Faltus FT, Isasi IR, Koerber KF, Rolauffs RB, Rogowski RW, McCall MM, Razvi RE, Scherer SJ, Ziegele ZB, Burk BJ, Berner BD, Erbe EI, Offhaus OJ, Winter WK, Brehm BW, Hildebrandt HC, Wei WE, Lemor LR, Kasten KA, Grttner GC, Siegmund SB, Hosten HN, Frerich FB, Sapudom SJ, Franke FK, Ansorge AM, Pompe PT, Schtze SK, Koch KS, Grassner GL, Feichtner FM, Klein KB, Couillard-Despres CS, Aigner AL, Lorbach LE, Donders DR, Vanheusden VM, Ravanidis RS, Bogie BJ, Hendriks HJ, Gyselaers GW, Hellings HN, Gras GC, Goudeva GL, Immenschuh IS, Eiz-Vesper EB, Schulze SK, Guzman GC, Blasczyk BR, Figueiredo FC, Hilger HN, Schmidt SF, Svanidze SE, Emmrich EF, Fricke FS, Abdalmula AA, Bailey BS, Washington WE, Dooley DL, House HJ, Ghosh GP, Itescu IS, Kimpton KW, Nitz NK, Gomez GL, Rousselle RA, Quadri QF, Rotteveel RM, Bader BM, Duchene DJ, Ponsaerts PP, Praet PJ, Le Blon LD, Guglielmetti GC, Reekmans RK, De Vocht DN, et al. .
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    25. Different anesthesia regimes modulate the functional connectivity outcome in mice. Magn Reson Med. 2014 Oct; 72(4):1103-12. Jonckers E, Delgado y Palacios R, Shah D, Guglielmetti C, Verhoye M, Van der Linden A. PMID: 24285608.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    26. Multimodal imaging of subventricular zone neural stem/progenitor cells in the cuprizone mouse model reveals increased neurogenic potential for the olfactory bulb pathway, but no contribution to remyelination of the corpus callosum. Neuroimage. 2014 Feb 01; 86:99-110. Guglielmetti C, Praet J, Rangarajan JR, Vreys R, De Vocht N, Maes F, Verhoye M, Ponsaerts P, Van der Linden A. PMID: 23933305.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    27. Quantitative evaluation of MRI-based tracking of ferritin-labeled endogenous neural stem cell progeny in rodent brain. Neuroimage. 2012 Aug 01; 62(1):367-80. Vande Velde G, Raman Rangarajan J, Vreys R, Guglielmetti C, Dresselaers T, Verhoye M, Van der Linden A, Debyser Z, Baekelandt V, Maes F, Himmelreich U. PMID: 22677164.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
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