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Carolyn Calfee, MD, MAS

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address505 Parnassus Avenue
San Francisco CA 94117
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.A.S. in Clinical Research2009 Graduate Division (Advanced Training in Clinical Research)
    University of California, San Francisco Residency School of Medicine
    University of PensylvanniaM.D.1999School of Medicine

    Collapse Overview 
    Collapse Overview
    Carolyn S. Calfee, MD MAS is Professor in Residence of Medicine and Anesthesia at UCSF, where she attends in the intensive care units at Moffitt-Long Hospital. Dr. Calfee received her undergraduate degree from Yale University and her medical degree from the University of Pennsylvania School of Medicine. She came to UCSF for residency in Internal Medicine and stayed to complete her chief residency and Pulmonary/Critical Care Medicine fellowship. She also completed her Masters in Clinical Research at UCSF in 2009. After research training with Drs. Michael Matthay and Mark Eisner, she joined the faculty of the division in 2007. Dr. Calfee is also a member of UCSF’s Center for Tobacco Control Research and Education and an associate member of the Cardiovascular Research Institute (CVRI) and the UCSF Cancer Center.

    RESEARCH INTERESTS
    Dr. Calfee’s primary academic focus is the prevention, diagnosis, prognosis, and treatment of the acute respiratory distress syndrome (ARDS). Current research projects include: (1) molecular phenotyping of ARDS and precision medicine in the ICU; (2) the role of cigarette smoke exposure and exposure to novel tobacco products in acute lung injury; and (3) novel treatments for ARDS.

    Collapse Research 
    Collapse Research Activities and Funding
    Precision Medicine in the Acute Respiratory Distress Syndrome
    NIH/NHLBI R35HL140026Jan 16, 2018 - Dec 31, 2024
    Role: Principal Investigator
    ARDS Endotypes: Expanded Analysis of Clinical and Biological Phenotypes and Evolution Over Time
    NIH/NHLBI K24HL133390Jul 15, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Molecular Endotypes of ARDS: Identification, Biology, and Differential Response to Therapy
    NIH/NHLBI R01HL131621Mar 15, 2016 - Feb 28, 2020
    Role: Principal Investigator
    Improved Models to Inform Tobacco Product Regulation
    NIH/NCI P50CA180890Sep 19, 2013 - Aug 31, 2018
    Role: Co-Investigator
    Cigarette Smoke Exposure and Acute Lung Injury After Severe Blunt Trauma
    NIH/NHLBI R01HL110969Dec 15, 2011 - Nov 30, 2016
    Role: Principal Investigator
    Impact of Cigarette Smoke Exposure on Acute Lung Injury
    NIH/NHLBI K23HL090833Aug 1, 2008 - Jul 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted? Lancet Respir Med. 2020 Jul 06. Fan E, Beitler JR, Brochard L, Calfee CS, Ferguson ND, Slutsky AS, Brodie D. PMID: 32645311.
      View in: PubMed   Mentions: 1     Fields:    
    2. Is a "Cytokine Storm" Relevant to COVID-19? JAMA Intern Med. 2020 Jun 30. Sinha P, Matthay MA, Calfee CS. PMID: 32602883.
      View in: PubMed   Mentions: 1     Fields:    
    3. Cigarette Smoking and ARDS After Blunt Trauma: The Influence of Changing Smoking Patterns and Resuscitation Practices. Chest. 2020 Jun 20. Moazed F, Hendrickson C, Conroy A, Kornblith LZ, Benowitz NL, Delucchi K, Cohen MJ, Calfee CS. PMID: 32574574.
      View in: PubMed   Mentions:    Fields:    
    4. Machine Learning Classifier Models Can Identify ARDS Phenotypes Using Readily Available Clinical Data. Am J Respir Crit Care Med. 2020 Jun 18. Sinha P, Churpek MM, Calfee CS. PMID: 32551817.
      View in: PubMed   Mentions:    Fields:    
    5. Prone Positioning in Awake, Nonintubated Patients With COVID-19: Necessity Is the Mother of Invention. JAMA Intern Med. 2020 Jun 17. Sarma A, Calfee CS. PMID: 32584940.
      View in: PubMed   Mentions:    Fields:    
    6. Subphenotypes in critical care: translation into clinical practice. Lancet Respir Med. 2020 Jun; 8(6):631-643. Reddy K, Sinha P, O'Kane CM, Gordon AC, Calfee CS, McAuley DF. PMID: 32526190.
      View in: PubMed   Mentions: 1     Fields:    
    7. Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time. Crit Care Med. 2020 Jun; 48(6):830-837. Schwede M, Lee RY, Zhuo H, Kangelaris KN, Jauregui A, Vessel K, Belzer A, Deiss T, Matthay MA, Liu KD, Calfee CS. PMID: 32317598.
      View in: PubMed   Mentions:    Fields:    
    8. The attributable mortality of acute respiratory distress syndrome. Intensive Care Med. 2020 May 25. Auriemma CL, Delucchi K, Liu KD, Calfee CS. PMID: 32451576.
      View in: PubMed   Mentions:    Fields:    
    9. Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2. medRxiv. 2020 May 19. Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Calfee CS, Castaneda G, DeRisi JL, Detweiler AM, Hao S, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, Christenson SA, Kistler A, Langelier C. PMID: 32511476.
      View in: PubMed   Mentions:
    10. Long-term ozone exposure is positively associated with telomere length in critically ill patients. Environ Int. 2020 Aug; 141:105780. Wang C, Wolters PJ, Calfee CS, Liu S, Balmes JR, Zhao Z, Koyama T, Ware LB. PMID: 32417614.
      View in: PubMed   Mentions:    Fields:    
    11. Sonographic B-lines, Fluid Resuscitation, and Hypoxemia in Malawian Patients with Suspected Sepsis. Am J Respir Crit Care Med. 2020 Apr 14. Wang RJ, Katha G, Phiri M, Delbridge P, Gordon SB, Calfee CS, Huang L, Rylance J. PMID: 32286847.
      View in: PubMed   Mentions:    Fields:    
    12. Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis. Respir Res. 2020 Apr 07; 21(1):81. Carla A, Pereira B, Boukail H, Audard J, Pinol-Domenech N, De Carvalho M, Blondonnet R, Zhai R, Morand D, Lambert C, Sapin V, Ware LB, Calfee CS, Bastarache JA, Laffey JG, Juffermans NP, Bos LD, Artigas A, Rocco PRM, Matthay MA, McAuley DF, Constantin JM, Jabaudon M. PMID: 32264897.
      View in: PubMed   Mentions:    Fields:    
    13. NIH Workshop Report: E-cigarette or Vaping Product Use Associated Lung Injury (EVALI): Developing a Research Agenda. Am J Respir Crit Care Med. 2020 Apr 03. Crotty Alexander LE, Ware LB, Calfee CS, Callahan SJ, Eissenberg T, Farver C, Goniewicz ML, Jaspers I, Kheradmand F, King TE, Meyer NJ, Mikheev V, Shields PG, Shihadeh A, Strongin R, Tarran R. PMID: 32243764.
      View in: PubMed   Mentions: 2     Fields:    
    14. Gender Differences in Authorship of Critical Care Literature. Am J Respir Crit Care Med. 2020 04 01; 201(7):840-847. Vranas KC, Ouyang D, Lin AL, Slatore CG, Sullivan DR, Kerlin MP, Liu KD, Baron RM, Calfee CS, Ware LB, Halpern SD, Matthay MA, Herridge MS, Mehta S, Rogers AJ. PMID: 31968182.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. ARDS Subphenotypes: Understanding a Heterogeneous Syndrome. Crit Care. 2020 Mar 24; 24(1):102. Wilson JG, Calfee CS. PMID: 32204722.
      View in: PubMed   Mentions: 2     Fields:    
    16. Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. Intensive Care Med. 2020 Jun; 46(6):1222-1231. Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, Kangelaris KN, Gomez A, Hendrickson C, Liu KD, Matthay MA, Ware LB, Calfee CS. PMID: 32206845.
      View in: PubMed   Mentions: 1     Fields:    
    17. Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report. Am J Respir Crit Care Med. 2020 Mar 09. Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, Needham DM, Self WH, Seymour CW, Stapleton RD, Thompson BT, Wunderink RG, Aggarwal NR, Reineck LA. PMID: 32150460.
      View in: PubMed   Mentions:    Fields:    
    18. Lack of Clinical Benefit of Interferon ß-1a Among Patients With Severe Acute Respiratory Distress Syndrome: Time to Overhaul Drug Trials in ARDS? JAMA. 2020 Feb 17. Shankar-Hari M, Calfee CS. PMID: 32065830.
      View in: PubMed   Mentions:    Fields:    
    19. Detection of Pneumonia Pathogens from Plasma Cell-Free DNA. Am J Respir Crit Care Med. 2020 02 15; 201(4):491-495. Langelier C, Fung M, Caldera S, Deiss T, Lyden A, Prince BC, Serpa PH, Moazed F, Chin-Hong P, DeRisi JL, Calfee CS. PMID: 31647702.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment. Crit Care Med. 2020 Feb; 48(2):200-209. Prasad PA, Fang MC, Abe-Jones Y, Calfee CS, Matthay MA, Kangelaris KN. PMID: 31939788.
      View in: PubMed   Mentions:    Fields:    
    21. Peripheral blood leukocyte telomere length is associated with survival of sepsis patients. Eur Respir J. 2020 Jan; 55(1). Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ. PMID: 31619475.
      View in: PubMed   Mentions: 2     Fields:    
    22. Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials. Lancet Respir Med. 2020 Mar; 8(3):247-257. Sinha P, Delucchi KL, McAuley DF, O'Kane CM, Matthay MA, Calfee CS. PMID: 31948926.
      View in: PubMed   Mentions: 5     Fields:    
    23. Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2020 01 01; 201(1):47-56. Jones TK, Feng R, Kerchberger VE, Reilly JP, Anderson BJ, Shashaty MGS, Wang F, Dunn TG, Riley TR, Abbott J, Ittner CAG, Christiani DC, Mikacenic C, Wurfel MM, Ware LB, Calfee CS, Matthay MA, Christie JD, Meyer NJ. PMID: 31487195.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study. Crit Care. 2019 12 09; 23(1):400. Anderson BJ, Calfee CS, Liu KD, Reilly JP, Kangelaris KN, Shashaty MGS, Lazaar AL, Bayliffe AI, Gallop RJ, Miano TA, Dunn TG, Johansson E, Abbott J, Jauregui A, Deiss T, Vessel K, Belzer A, Zhuo H, Matthay MA, Meyer NJ, Christie JD. PMID: 31818332.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS. Ann Intensive Care. 2019 Nov 21; 9(1):128. Morales-Quinteros L, Schultz MJ, Bringué J, Calfee CS, Camprubí M, Cremer OL, Horn J, van der Poll T, Sinha P, Artigas A, Bos LD. PMID: 31754866.
      View in: PubMed   Mentions:
    26. Biomarkers and Precision Medicine: State of the Art. Crit Care Clin. 2020 Jan; 36(1):155-165. Sarma A, Calfee CS, Ware LB. PMID: 31733677.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice. Am J Physiol Lung Cell Mol Physiol. 2019 11 01; 317(5):L717-L736. Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA. PMID: 31509438.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    28. FLASH: a next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences. Nucleic Acids Res. 2019 08 22; 47(14):e83. Quan J, Langelier C, Kuchta A, Batson J, Teyssier N, Lyden A, Caldera S, McGeever A, Dimitrov B, King R, Wilheim J, Murphy M, Ares LP, Travisano KA, Sit R, Amato R, Mumbengegwi DR, Smith JL, Bennett A, Gosling R, Mourani PM, Calfee CS, Neff NF, Chow ED, Kim PS, Greenhouse B, DeRisi JL, Crawford ED. PMID: 31114866.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    29. A new frontier in ARDS trials: phenotyping before randomisation. Lancet Respir Med. 2019 10; 7(10):830-831. Hendrickson CM, Calfee CS. PMID: 31399380.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Inflammasomes Assemble: Cytoplasmic Guardians or Fallen Heroes? Crit Care Med. 2019 08; 47(8):1161-1163. Sinha P, Calfee CS. PMID: 31305304.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Predictors of postinjury acute respiratory distress syndrome: Lung injury persists in the era of hemostatic resuscitation. J Trauma Acute Care Surg. 2019 08; 87(2):371-378. Kornblith LZ, Robles AJ, Conroy AS, Redick BJ, Howard BM, Hendrickson CM, Moore S, Nelson MF, Moazed F, Callcut RA, Calfee CS, Cohen MJ. PMID: 31033882.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    32. Peeking under the Hood of Acute Respiratory Distress Syndrome Phenotypes: Deeper Insights into Biological Heterogeneity. Am J Respir Crit Care Med. 2019 Jul 01; 200(1):4-6. Sinha P, Calfee CS. PMID: 30753791.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    33. Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction. Respir Care. 2019 Sep; 64(9):1101-1108. Papolos AI, Schiller NB, Belzer A, Zhuo H, Gotts JE, Bibby D, Calfee CS, Matthay MA. PMID: 31138736.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Acute Respiratory Distress Syndrome Phenotypes. Semin Respir Crit Care Med. 2019 02; 40(1):19-30. Reilly JP, Calfee CS, Christie JD. PMID: 31060085.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    35. Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply. Lancet Respir Med. 2019 04; 7(4):e14. Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS. PMID: 30926051.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    36. The authors reply. Crit Care Med. 2019 04; 47(4):e375-e376. Fielding-Singh V, Matthay MA, Calfee CS. PMID: 30882440.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    37. The authors reply. Crit Care Med. 2019 04; 47(4):e380-e381. Fielding-Singh V, Matthay MA, Calfee CS. PMID: 30882446.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury. Pediatr Crit Care Med. 2019 04; 20(4):323-331. Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A. PMID: 30672838.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    39. Identification of Acute Kidney Injury Subphenotypes with Differing Molecular Signatures and Responses to Vasopressin Therapy. Am J Respir Crit Care Med. 2019 04 01; 199(7):863-872. Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, Christiani DC, Liles WC, Himmelfarb J, Wurfel MM. PMID: 30334632.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. Acute respiratory distress syndrome. Nat Rev Dis Primers. 2019 03 14; 5(1):18. Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG, Calfee CS. PMID: 30872586.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    41. Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure. Ann Am Thorac Soc. 2019 03; 16(3):356-362. Lanspa MJ, Gong MN, Schoenfeld DA, Lee KT, Grissom CK, Hou PC, Serpa-Neto A, Brown SM, Iwashyna TJ, Yealy DM, Hough CL, Brower RG, Calfee CS, Hyzy RC, Matthay MA, Miller RR, Steingrub JS, Thompson BT, Miller CD, Clemmer TP, Hendey GW, Huang DT, Mathews KS, Qadir N, Tidswell M. PMID: 30407869.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Phenotypes in acute respiratory distress syndrome: moving towards precision medicine. Curr Opin Crit Care. 2019 02; 25(1):12-20. Sinha P, Calfee CS. PMID: 30531367.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    43. Physiologic Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2019 02 01; 199(3):333-341. Sinha P, Calfee CS, Beitler JR, Soni N, Ho K, Matthay MA, Kallet RH. PMID: 30211618.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    44. Metagenomic comparison of tracheal aspirate and mini-bronchial alveolar lavage for assessment of respiratory microbiota. Am J Physiol Lung Cell Mol Physiol. 2019 03 01; 316(3):L578-L584. Kalantar KL, Moazed F, Christenson SC, Wilson J, Deiss T, Belzer A, Vessel K, Caldera S, Jauregui A, Bolourchi S, DeRisi JL, Calfee CS, Langelier C. PMID: 30652494.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    45. Early Plasma Matrix Metalloproteinase Profiles. A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2019 01 15; 199(2):181-189. Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A. PMID: 30114376.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    46. Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma. Am J Respir Crit Care Med. 2019 01 01; 199(1):62-70. Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Christie JD, Lanken PN, Wang C, Balmes JR, Matthay MA, Calfee CS, Ware LB. PMID: 30067389.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    47. Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):E12353-E12362. Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, Wilson J, Miller S, Matthay MA, Pollard KS, Christenson S, Calfee CS, DeRisi JL. PMID: 30482864.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    48. Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. Lancet Respir Med. 2019 02; 7(2):154-162. Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD. PMID: 30455077.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCTClinical Trials
    49. Beyond Low Tidal Volume Ventilation: Treatment Adjuncts for Severe Respiratory Failure in Acute Respiratory Distress Syndrome. Crit Care Med. 2018 11; 46(11):1820-1831. Fielding-Singh V, Matthay MA, Calfee CS. PMID: 30247273.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    50. Perhaps it's not the platelet: Ristocetin uncovers the potential role of von Willebrand factor in impaired platelet aggregation following traumatic brain injury. J Trauma Acute Care Surg. 2018 11; 85(5):873-880. Kornblith LZ, Robles AJ, Conroy AS, Hendrickson CM, Calfee CS, Fields AT, Callcut RA, Cohen MJ. PMID: 29985231.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    51. Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive Care Med. 2018 Nov; 44(11):1849-1858. Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ. PMID: 30343317.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    52. Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study. Intensive Care Med. 2018 Nov; 44(11):1859-1869. Sinha P, Delucchi KL, Thompson BT, McAuley DF, Matthay MA, Calfee CS. PMID: 30291376.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    53. Association between pre-operative biological phenotypes and postoperative pulmonary complications: An unbiased cluster analysis. Eur J Anaesthesiol. 2018 09; 35(9):702-709. Serpa Neto A, Bos LD, Campos PPZA, Hemmes SNT, Bluth T, Calfee CS, Ferner M, Güldner A, Hollmann MW, India I, Kiss T, Laufenberg-Feldmann R, Sprung J, Sulemanji D, Unzueta C, Vidal Melo MF, Weingarten TN, Tuip-de Boer AM, Pelosi P, Gama de Abreu M, Schultz MJ. PMID: 29957706.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    54. Assessment of industry data on pulmonary and immunosuppressive effects of IQOS. Tob Control. 2018 11; 27(Suppl 1):s20-s25. Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J. PMID: 30158203.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    55. Possible hepatotoxicity of IQOS. Tob Control. 2018 11; 27(Suppl 1):s39-s40. Chun L, Moazed F, Matthay M, Calfee C, Gotts J. PMID: 30131373.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    56. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Lancet Respir Med. 2018 09; 6(9):691-698. Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF. PMID: 30078618.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    57. Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data. Intensive Care Med. 2018 Sep; 44(9):1388-1399. Jabaudon M, Blondonnet R, Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V, Matthay MA, Constantin JM, Calfee CS. PMID: 30051136.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    58. Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis. Am J Physiol Lung Cell Mol Physiol. 2018 11 01; 315(5):L638-L644. Leligdowicz A, Chun LF, Jauregui A, Vessel K, Liu KD, Calfee CS, Matthay MA. PMID: 30024307.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    59. Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care. J Trauma Acute Care Surg. 2018 07; 85(1):148-154. Robles AJ, Kornblith LZ, Hendrickson CM, Howard BM, Conroy AS, Moazed F, Calfee CS, Cohen MJ, Callcut RA. PMID: 29958249.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    60. Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury. Trauma Surg Acute Care Open. 2018; 3(1):e000171. Hendrickson CM, Gibb SL, Miyazawa BY, Keating SM, Ross E, Conroy AS, Calfee CS, Pati S, Cohen MJ. PMID: 30023434.
      View in: PubMed   Mentions:
    61. Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS. Thorax. 2018 09; 73(9):840-846. Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB. PMID: 29903755.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
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    68. Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties". Am J Physiol Lung Cell Mol Physiol. 2017 11 01; 313(5):L966-L967. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. PMID: 29109110.
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    84. A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 10; 17(10):907-916. Spicer AC, Calfee CS, Zinter MS, Khemani RG, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay MA, Sapru A. PMID: 27487912.
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    95. Focusing on the alveolar epithelium: Alveolar fluid clearance in diffuse versus focal acute respiratory distress syndrome. Anaesth Crit Care Pain Med. 2016 Apr; 35(2):75-7. Monsel A, Calfee CS. PMID: 26924611.
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    97. The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia. J Heart Lung Transplant. 2016 Apr; 35(4):500-507. Diamond JM, Porteous MK, Roberts LJ, Wickersham N, Rushefski M, Kawut SM, Shah RJ, Cantu E, Lederer DJ, Chatterjee S, Lama VN, Bhorade S, Crespo M, McDyer J, Wille K, Orens J, Weinacker A, Arcasoy S, Shah PD, Wilkes DS, Hage C, Palmer SM, Snyder L, Calfee CS, Ware LB, Christie JD. PMID: 26856667.
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    137. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg. 2012 Feb; 255(2):379-85. Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, Pittet JF. PMID: 22133894.
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    138. Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PLoS One. 2012; 7(1):e28268. Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Maloney JP, Hakonarson H. PMID: 22295056.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    139. The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Chest. 2012 May; 141(5):1160-1169. Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA. PMID: 22207676.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    140. A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation. Crit Care Med. 2011 Dec; 39(12):2645-51. Brown LM, Calfee CS, Matthay MA, Brower RG, Thompson BT, Checkley W. PMID: 21725235.
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    141. FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study. Ann Intensive Care. 2011 Jun 14; 1(1):21. Zhang M, Hsu R, Hsu CY, Kordesch K, Nicasio E, Cortez A, McAlpine I, Brady S, Zhuo H, Kangelaris KN, Stein J, Calfee CS, Liu KD. PMID: 21906363.
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    142. Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury. Crit Care Med. 2011 Apr; 39(4):711-7. Calfee CS, Ware LB, Glidden DV, Eisner MD, Parsons PE, Thompson BT, Matthay MA. PMID: 21283009.
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    143. Active and passive cigarette smoking and acute lung injury after severe blunt trauma. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1660-5. Calfee CS, Matthay MA, Eisner MD, Benowitz N, Call M, Pittet JF, Cohen MJ. PMID: 21471091.
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    144. ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio. Am J Respir Crit Care Med. 2011 May 15; 183(10):1344-53. Meyer NJ, Li M, Feng R, Bradfield J, Gallop R, Bellamy S, Fuchs BD, Lanken PN, Albelda SM, Rushefski M, Aplenc R, Abramova H, Atochina-Vasserman EN, Beers MF, Calfee CS, Cohen MJ, Pittet JF, Christiani DC, O'Keefe GE, Ware LB, May AK, Wurfel MM, Hakonarson H, Christie JD. PMID: 21257790.
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    145. Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients. Crit Care Med. 2011 Jan; 39(1):40-5. Hsieh SJ, Ware LB, Eisner MD, Yu L, Jacob P, Havel C, Goniewicz ML, Matthay MA, Benowitz NL, Calfee CS. PMID: 20935560.
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    146. Therapeutic potential of mesenchymal stem cells for severe acute lung injury. Chest. 2010 Oct; 138(4):965-72. Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu KD, Calfee CS, Lee JW. PMID: 20923800.
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    147. Therapeutic strategies for severe acute lung injury. Crit Care Med. 2010 Aug; 38(8):1644-50. Diaz JV, Brower R, Calfee CS, Matthay MA. PMID: 20562704.
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    148. Early release of soluble receptor for advanced glycation endproducts after severe trauma in humans. J Trauma. 2010 Jun; 68(6):1273-8. Cohen MJ, Carles M, Brohi K, Calfee CS, Rahn P, Call MS, Chesebro BB, West MA, Pittet JF. PMID: 20539169.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    149. Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock. Crit Care Med. 2010 Jun; 38(6):1436-41. Calfee CS, Thompson BT, Parsons PE, Ware LB, Matthay MA, Wong HR. PMID: 20386309.
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    150. Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma. 2010 May; 68(5):1121-7. Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay MA, May AK, Ware LB. PMID: 20038857.
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    151. Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L3-7. Collard HR, Calfee CS, Wolters PJ, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay MA, Kim DS. PMID: 20418386.
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    152. Clinical immunology: Culprits with evolutionary ties. Nature. 2010 Mar 04; 464(7285):41-2. Calfee CS, Matthay MA. PMID: 20203598.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    153. Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion. Crit Care. 2009; 13(6):R174. Cohen MJ, Brohi K, Calfee CS, Rahn P, Chesebro BB, Christiaans SC, Carles M, Howard M, Pittet JF. PMID: 19887013.
      View in: PubMed   Mentions: 104     Fields:    Translation:Humans
    154. Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio. Eur Respir J. 2010 Feb; 35(2):331-7. Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA. PMID: 19741024.
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    155. Plasma granulocyte colony-stimulating factor levels correlate with clinical outcomes in patients with acute lung injury. Crit Care Med. 2009 Apr; 37(4):1322-8. Suratt BT, Eisner MD, Calfee CS, Allard JB, Whittaker LA, Engelken DT, Petty JM, Trimarchi T, Gauthier L, Parsons PE. PMID: 19242319.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    156. Identification of early acute lung injury at initial evaluation in an acute care setting prior to the onset of respiratory failure. Chest. 2009 Apr; 135(4):936-943. Levitt JE, Bedi H, Calfee CS, Gould MK, Matthay MA. PMID: 19188549.
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    157. Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury. Chest. 2009 Jun; 135(6):1440-1447. Kropski JA, Fremont RD, Calfee CS, Ware LB. PMID: 19188556.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    158. Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Chest. 2009 Feb; 135(2):269-275. Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA. PMID: 19017890.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    159. Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Intensive Care Med. 2009 Feb; 35(2):248-57. Calfee CS, Eisner MD, Parsons PE, Thompson BT, Conner ER, Matthay MA, Ware LB. PMID: 18670758.
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    160. Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. Thorax. 2008 Dec; 63(12):1083-9. Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA. PMID: 18566109.
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    161. Aerosolized beta-adrenergic agonist therapy reduces pulmonary edema following lung surgery. Chest. 2008 Apr; 133(4):833-5. Matthay MA, Calfee CS. PMID: 18398109.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    162. Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med. 2007 Oct; 35(10):2243-50. Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA. PMID: 17944012.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    163. Biomarkers of lung injury in primary graft dysfunction following lung transplantation. Biomark Med. 2007 Aug; 1(2):285-91. Calfee CS, Ware LB. PMID: 20477403.
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    164. Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation. J Heart Lung Transplant. 2007 Jul; 26(7):675-80. Calfee CS, Budev MM, Matthay MA, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes JL, deCamp MM, Arroliga AC. PMID: 17613396.
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    165. Nonventilatory treatments for acute lung injury and ARDS. Chest. 2007 Mar; 131(3):913-920. Calfee CS, Matthay MA. PMID: 17356114.
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    166. Clinical problem-solving. Anchors away. N Engl J Med. 2007 Feb 01; 356(5):504-9. Calfee CS, Shah SJ, Wolters PJ, Saint S, King TE. PMID: 17267911.
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    167. The influence of perceived control of asthma on health outcomes. Chest. 2006 Nov; 130(5):1312-8. Calfee CS, Katz PP, Yelin EH, Iribarren C, Eisner MD. PMID: 17099005.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    168. Therapeutic value of a lung protective ventilation strategy in acute lung injury. Chest. 2005 Nov; 128(5):3089-91. Matthay MA, Calfee CS. PMID: 16304246.
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    169. Recent advances in mechanical ventilation. Am J Med. 2005 Jun; 118(6):584-91. Calfee CS, Matthay MA. PMID: 15922687.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
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