Chang Xie, PhD

TitlePostdoctoral Scholar
InstitutionUniversity of California San Francisco
DepartmentBiochemistry and Biophysics
Address555 Mission Bay Blvd South
San Francisco CA 94158
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    1. Yang Z, Lu D, Zhang L, Hu J, Nie Z, Xie C, Qiu F, Cheng H, Yan Y. p.N1380del mutation in the pore-forming region of SCN5A gene is associated with cardiac conduction disturbance and ventricular tachycardia. Acta Biochim Biophys Sin (Shanghai). 2017 Mar 01; 49(3):270-276. PMID: 28159958.
      View in: PubMed
    2. Xie C, Gong XM, Luo J, Li BL, Song BL. AAV9-NPC1 significantly ameliorates Purkinje cell death and behavioral abnormalities in mouse NPC disease. J Lipid Res. 2017 Mar; 58(3):512-518. PMID: 28053186.
      View in: PubMed
    3. Xie C, Zhang YP, Song L, Luo J, Qi W, Hu J, Lu D, Yang Z, Zhang J, Xiao J, Zhou B, Du JL, Jing N, Liu Y, Wang Y, Li BL, Song BL, Yan Y. Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome. Cell Res. 2016 Oct; 26(10):1099-1111. PMID: 27573176.
      View in: PubMed
    4. Zhang HL, Zheng YJ, Pan YD, Xie C, Sun H, Zhang YH, Yuan MY, Song BL, Chen JF. Regulatory T-cell depletion in the gut caused by integrin ß7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity. Mucosal Immunol. 2016 Mar; 9(2):391-400. PMID: 26220167.
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    5. Chu BB, Liao YC, Qi W, Xie C, Du X, Wang J, Yang H, Miao HH, Li BL, Song BL. Cholesterol transport through lysosome-peroxisome membrane contacts. Cell. 2015 Apr 09; 161(2):291-306. PMID: 25860611.
      View in: PubMed
    6. Xie C, Zhou ZS, Li N, Bian Y, Wang YJ, Wang LJ, Li BL, Song BL. Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine. J Lipid Res. 2012 Oct; 53(10):2092-101. PMID: 22811412; PMCID: PMC3435542.
    7. Xie C, Li N, Chen ZJ, Li BL, Song BL. The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner. J Biol Chem. 2011 Oct 14; 286(41):35933-42. PMID: 21844200; PMCID: PMC3195612.
    8. Chu BB, Ge L, Xie C, Zhao Y, Miao HH, Wang J, Li BL, Song BL. Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. J Biol Chem. 2009 Aug 14; 284(33):22481-90. PMID: 19542231; PMCID: PMC2755969.
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