Charline Bachus Ep. Souffan, PhD
|
Title(s) | Assistant Researcher, Medicine |
---|
School | School of Medicine |
---|
Address | 1001 Potrero Ave San Francisco CA 94110
|
---|
Phone | 628-206-8113 |
---|
vCard | Download vCard |
---|
|
|
Biography Pierre & Marie Curie University, Paris VI, Paris, France | Bachelor | 2008 | Cellular and Molecular Biology | Pierre & Marie Curie University, Paris VI, Paris, France | Master | 2010 | Cell Biology and Immunology | Pasteur Institute , Paris, France | Master | 2010 | Basic Immunology | Pierre & Marie Curie University, Paris VI, Paris, France | PhD | 2013 | Immunology of Infectious Diseases |
Overview My research interest is to understand the multiple ways by which HIV interacts with the immune system and persists permanently. I have been fascinated by this complex relationship since 8th grade and pursuing it ever since. Beginning as an intern during my Master’s degree, I studied how a cytokine involved in lymphoid homeostasis, interleukin-7, modulates the CD4 T cell compartment and affects HIV infection and, in particular, the HIV reservoir. During that time, I developed a strong interest in the problem of HIV persistence and in the identification of the mechanisms by which we can define and eradicate it. My PhD work focused on defining how the CD4 T cell compartment homeostasis modulates the HIV reservoirs in acute infection, and in models of spontaneous and therapeutic control over HIV-1 infection, particularly in the VISCONTI cohort of Post-Treatment Controllers. This work led to several high impact research findings and peer-reviewed publications, as well as a number of other publications that are currently ongoing. In 2013, I joined Dr. Joseph “Mike” McCune’s lab at the University of California, San Francisco, as a postdoctoral researcher to study the role of immune homeostasis mechanisms in HIV persistence as a function of the timing and duration of antiretroviral therapy, under the auspice of a R01 that I wrote and have been managing. Ultimately, translating basic research to clinical applications is my main goal, with the intent of identifying eradication strategies for therapeutic intervention in the HIV-infected population.
Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.)
Click a Field or Translation tag to filter the publications.
-
Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART. PLoS Pathog. 2021 Jan 19; 17(1):e1009214.
Bacchus-Souffan C, Fitch M, Symons J, Abdel-Mohsen M, Reeves DB, Hoh R, Stone M, Hiatt J, Kim P, Chopra A, Ahn H, York VA, Cameron DL, Hecht FM, Martin JN, Yukl SA, Mallal S, Cameron PU, Deeks SG, Schiffer JT, Lewin SR, Hellerstein MK, McCune JM, Hunt PW. PMID: 33465157.
View in: PubMed Mentions: Fields:
-
Polyfunctional HIV-specific T cells in Post-Treatment Controllers. AIDS. 2016 09 24; 30(15):2299-302.
Samri A, Bacchus-Souffan C, Hocqueloux L, Avettand-Fenoel V, Descours B, Theodorou I, Larsen M, Saez-Cirion A, Rouzioux C, Autran B, . PMID: 27428742.
View in: PubMed Mentions: 7 Fields: Translation: HumansCellsPHPublic Health
-
Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission. J Antimicrob Chemother. 2015 Jul; 70(7):2108-20.
Chéret A, Bacchus-Souffan C, Avettand-Fenoël V, Mélard A, Nembot G, Blanc C, Samri A, Sáez-Cirión A, Hocqueloux L, Lascoux-Combe C, Allavena C, Goujard C, Valantin MA, Leplatois A, Meyer L, Rouzioux C, Autran B, . PMID: 25900157.
View in: PubMed Mentions: 38 Fields: Translation: HumansCellsPHPublic Health
-
A single HIV-1 cluster and a skewed immune homeostasis drive the early spread of HIV among resting CD4+ cell subsets within one month post-infection. PLoS One. 2013; 8(5):e64219.
Bacchus C, Cheret A, Avettand-Fenoël V, Nembot G, Mélard A, Blanc C, Lascoux-Combe C, Slama L, Allegre T, Allavena C, Yazdanpanah Y, Duvivier C, Katlama C, Goujard C, Seksik BC, Leplatois A, Molina JM, Meyer L, Autran B, Rouzioux C, . PMID: 23691172.
View in: PubMed Mentions: 24 Fields: Translation: HumansCells
-
Immune control of HIV-1 reservoirs. Curr Opin HIV AIDS. 2013 May; 8(3):204-10.
Autran B, Descours B, Bacchus C. PMID: 23493099.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
-
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. PLoS Pathog. 2013 Mar; 9(3):e1003211.
Sáez-Cirión A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, Potard V, Versmisse P, Melard A, Prazuck T, Descours B, Guergnon J, Viard JP, Boufassa F, Lambotte O, Goujard C, Meyer L, Costagliola D, Venet A, Pancino G, Autran B, Rouzioux C, . PMID: 23516360.
View in: PubMed Mentions: 381 Fields: Translation: HumansCells
-
Direct quantification of cell-associated HIV DNA in isolated rectal and blood memory CD4 T cells revealed their similar and low infection levels in long-term treated HIV-infected patients. . 2013 Mar 01; 62(3):255-9.
Descours B, Lambert-Niclot S, Mory B, Samri A, Charlotte F, Peytavin G, Tubiana R, Papagno L, Bacchus C, Lecardonnel F, Katlama C, Autran B, Marcelin AG, Valantin MA, Carcelain G, . PMID: 23274932.
View in: PubMed Mentions:
This graph shows the total number of publications by year. To see the data as text, click here.
This graph shows the total number of publications by year. To return to the graph, click here.
Year | Publications |
---|
2013 | 4 | 2015 | 1 | 2016 | 1 | 2021 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
newest
oldest
line numbers
double spacing
all authors
publication IDs
|
Derived automatically from this person's publications.
_
People in Profiles who have published with this person.
_
People who share similar concepts with this person.
_
Search Department
_
|