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Charline Bachus Ep. Souffan, PhD

Title(s)Assistant Researcher, Medicine
SchoolSchool of Medicine
Phone628-206-8113
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    Collapse Biography 
    Collapse Education and Training
    Pierre & Marie Curie University, Paris VI, Paris, FranceBachelor2008Cellular and Molecular Biology
    Pierre & Marie Curie University, Paris VI, Paris, FranceMaster2010Cell Biology and Immunology
    Pasteur Institute , Paris, FranceMaster2010Basic Immunology
    Pierre & Marie Curie University, Paris VI, Paris, FrancePhD2013Immunology of Infectious Diseases

    Collapse Overview 
    Collapse Overview
    My research interest is to understand the multiple ways by which HIV interacts with the immune system and persists permanently. I have been fascinated by this complex relationship since 8th grade and pursuing it ever since. Beginning as an intern during my Master’s degree, I studied how a cytokine involved in lymphoid homeostasis, interleukin-7, modulates the CD4 T cell compartment and affects HIV infection and, in particular, the HIV reservoir. During that time, I developed a strong interest in the problem of HIV persistence and in the identification of the mechanisms by which we can define and eradicate it. My PhD work focused on defining how the CD4 T cell compartment homeostasis modulates the HIV reservoirs in acute infection, and in models of spontaneous and therapeutic control over HIV-1 infection, particularly in the VISCONTI cohort of Post-Treatment Controllers. This work led to several high impact research findings and peer-reviewed publications, as well as a number of other publications that are currently ongoing. In 2013, I joined Dr. Joseph “Mike” McCune’s lab at the University of California, San Francisco, as a postdoctoral researcher to study the role of immune homeostasis mechanisms in HIV persistence as a function of the timing and duration of antiretroviral therapy, under the auspice of a R01 that I wrote and have been managing. Ultimately, translating basic research to clinical applications is my main goal, with the intent of identifying eradication strategies for therapeutic intervention in the HIV-infected population.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Samri A, Bacchus-Souffan C, Hocqueloux L, Avettand-Fenoel V, Descours B, Theodorou I, Larsen M, Saez-Cirion A, Rouzioux C, Autran B. Polyfunctional HIV-specific T cells in Post-Treatment Controllers. AIDS. 2016 09 24; 30(15):2299-302. PMID: 27428742.
      View in: PubMed
    2. Chéret A, Bacchus-Souffan C, Avettand-Fenoël V, Mélard A, Nembot G, Blanc C, Samri A, Sáez-Cirión A, Hocqueloux L, Lascoux-Combe C, Allavena C, Goujard C, Valantin MA, Leplatois A, Meyer L, Rouzioux C, Autran B. Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission. J Antimicrob Chemother. 2015 Jul; 70(7):2108-20. PMID: 25900157.
      View in: PubMed
    3. Bacchus C, Cheret A, Avettand-Fenoël V, Nembot G, Mélard A, Blanc C, Lascoux-Combe C, Slama L, Allegre T, Allavena C, Yazdanpanah Y, Duvivier C, Katlama C, Goujard C, Seksik BC, Leplatois A, Molina JM, Meyer L, Autran B, Rouzioux C. A single HIV-1 cluster and a skewed immune homeostasis drive the early spread of HIV among resting CD4+ cell subsets within one month post-infection. PLoS One. 2013; 8(5):e64219. PMID: 23691172.
      View in: PubMed
    4. Autran B, Descours B, Bacchus C. Immune control of HIV-1 reservoirs. Curr Opin HIV AIDS. 2013 May; 8(3):204-10. PMID: 23493099.
      View in: PubMed
    5. Sáez-Cirión A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, Potard V, Versmisse P, Melard A, Prazuck T, Descours B, Guergnon J, Viard JP, Boufassa F, Lambotte O, Goujard C, Meyer L, Costagliola D, Venet A, Pancino G, Autran B, Rouzioux C. Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. PLoS Pathog. 2013 Mar; 9(3):e1003211. PMID: 23516360.
      View in: PubMed
    6. Descours B, Lambert-Niclot S, Mory B, Samri A, Charlotte F, Peytavin G, Tubiana R, Papagno L, Bacchus C, Lecardonnel F, Katlama C, Autran B, Marcelin AG, Valantin MA, Carcelain G. Direct quantification of cell-associated HIV DNA in isolated rectal and blood memory CD4 T cells revealed their similar and low infection levels in long-term treated HIV-infected patients. J Acquir Immune Defic Syndr. 2013 Mar 01; 62(3):255-9. PMID: 23274932.
      View in: PubMed