Charline Bachus Ep Souffan, PhD

Title(s)Assistant Researcher, Medicine
SchoolSchool of Medicine
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    Pierre & Marie Curie University, Paris VI, Paris, FranceBachelor2008Cellular and Molecular Biology
    Pierre & Marie Curie University, Paris VI, Paris, FranceMaster2010Cell Biology and Immunology
    Pasteur Institute , Paris, FranceMaster2010Basic Immunology
    Pierre & Marie Curie University, Paris VI, Paris, FrancePhD2013Immunology of Infectious Diseases

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    My research interest is to understand the multiple ways by which HIV interacts with the immune system and persists permanently. I have been fascinated by this complex relationship since 8th grade and pursuing it ever since. Beginning as an intern during my Master’s degree, I studied how a cytokine involved in lymphoid homeostasis, interleukin-7, modulates the CD4 T cell compartment and affects HIV infection and, in particular, the HIV reservoir. During that time, I developed a strong interest in the problem of HIV persistence and in the identification of the mechanisms by which we can define and eradicate it. My PhD work focused on defining how the CD4 T cell compartment homeostasis modulates the HIV reservoirs in acute infection, and in models of spontaneous and therapeutic control over HIV-1 infection, particularly in the VISCONTI cohort of Post-Treatment Controllers. This work led to several high impact research findings and peer-reviewed publications, as well as a number of other publications that are currently ongoing. In 2013, I joined Dr. Joseph “Mike” McCune’s lab at the University of California, San Francisco, as a postdoctoral researcher to study the role of immune homeostasis mechanisms in HIV persistence as a function of the timing and duration of antiretroviral therapy, under the auspice of a R01 that I wrote and have been managing. Ultimately, translating basic research to clinical applications is my main goal, with the intent of identifying eradication strategies for therapeutic intervention in the HIV-infected population.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART. PLoS Pathog. 2021 01; 17(1):e1009214. Bacchus-Souffan C, Fitch M, Symons J, Abdel-Mohsen M, Reeves DB, Hoh R, Stone M, Hiatt J, Kim P, Chopra A, Ahn H, York VA, Cameron DL, Hecht FM, Martin JN, Yukl SA, Mallal S, Cameron PU, Deeks SG, Schiffer JT, Lewin SR, Hellerstein MK, McCune JM, Hunt PW. PMID: 33465157; PMCID: PMC7846027.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    2. Polyfunctional HIV-specific T cells in Post-Treatment Controllers. AIDS. 2016 09 24; 30(15):2299-302. Samri A, Bacchus-Souffan C, Hocqueloux L, Avettand-Fenoel V, Descours B, Theodorou I, Larsen M, Saez-Cirion A, Rouzioux C, Autran B, ANRS VISCONTI study group. PMID: 27428742.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCellsPHPublic Health
    3. Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission. J Antimicrob Chemother. 2015 Jul; 70(7):2108-20. Chéret A, Bacchus-Souffan C, Avettand-Fenoël V, Mélard A, Nembot G, Blanc C, Samri A, Sáez-Cirión A, Hocqueloux L, Lascoux-Combe C, Allavena C, Goujard C, Valantin MA, Leplatois A, Meyer L, Rouzioux C, Autran B, OPTIPRIM ANRS-147 Study Group. PMID: 25900157.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCellsPHPublic Health
    4. A single HIV-1 cluster and a skewed immune homeostasis drive the early spread of HIV among resting CD4+ cell subsets within one month post-infection. PLoS One. 2013; 8(5):e64219. Bacchus C, Cheret A, Avettand-Fenoël V, Nembot G, Mélard A, Blanc C, Lascoux-Combe C, Slama L, Allegre T, Allavena C, Yazdanpanah Y, Duvivier C, Katlama C, Goujard C, Seksik BC, Leplatois A, Molina JM, Meyer L, Autran B, Rouzioux C, OPTIPRIM ANRS 147 study group. PMID: 23691172; PMCID: PMC3653877.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    5. Immune control of HIV-1 reservoirs. Curr Opin HIV AIDS. 2013 May; 8(3):204-10. Autran B, Descours B, Bacchus C. PMID: 23493099.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    6. Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. PLoS Pathog. 2013 Mar; 9(3):e1003211. Sáez-Cirión A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, Potard V, Versmisse P, Melard A, Prazuck T, Descours B, Guergnon J, Viard JP, Boufassa F, Lambotte O, Goujard C, Meyer L, Costagliola D, Venet A, Pancino G, Autran B, Rouzioux C, ANRS VISCONTI Study Group. PMID: 23516360; PMCID: PMC3597518.
      View in: PubMed   Mentions: 424     Fields:    Translation:HumansCells
    7. Direct quantification of cell-associated HIV DNA in isolated rectal and blood memory CD4 T cells revealed their similar and low infection levels in long-term treated HIV-infected patients. J Acquir Immune Defic Syndr. 2013 Mar 01; 62(3):255-9. Descours B, Lambert-Niclot S, Mory B, Samri A, Charlotte F, Peytavin G, Tubiana R, Papagno L, Bacchus C, Lecardonnel F, Katlama C, Autran B, Marcelin AG, Valantin MA, Carcelain G, DECAMUNE and ORVACS Study Groups. PMID: 23274932.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
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