 Charline Bachus Ep. Souffan, PhD
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| Title(s) | Assistant Researcher, Medicine |
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| School | School of Medicine |
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| Address | 1001 Potrero Ave
San Francisco CA 94110
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| Phone | 628-206-8113 |
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| vCard | Download vCard |
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 Biography | Pierre & Marie Curie University, Paris VI, Paris, France | Bachelor | 2008 | Cellular and Molecular Biology | | Pierre & Marie Curie University, Paris VI, Paris, France | Master | 2010 | Cell Biology and Immunology | | Pasteur Institute , Paris, France | Master | 2010 | Basic Immunology | | Pierre & Marie Curie University, Paris VI, Paris, France | PhD | 2013 | Immunology of Infectious Diseases |
Overview My research interest is to understand the multiple ways by which HIV interacts with the immune system and persists permanently. I have been fascinated by this complex relationship since 8th grade and pursuing it ever since. Beginning as an intern during my Master’s degree, I studied how a cytokine involved in lymphoid homeostasis, interleukin-7, modulates the CD4 T cell compartment and affects HIV infection and, in particular, the HIV reservoir. During that time, I developed a strong interest in the problem of HIV persistence and in the identification of the mechanisms by which we can define and eradicate it. My PhD work focused on defining how the CD4 T cell compartment homeostasis modulates the HIV reservoirs in acute infection, and in models of spontaneous and therapeutic control over HIV-1 infection, particularly in the VISCONTI cohort of Post-Treatment Controllers. This work led to several high impact research findings and peer-reviewed publications, as well as a number of other publications that are currently ongoing. In 2013, I joined Dr. Joseph “Mike” McCune’s lab at the University of California, San Francisco, as a postdoctoral researcher to study the role of immune homeostasis mechanisms in HIV persistence as a function of the timing and duration of antiretroviral therapy, under the auspice of a R01 that I wrote and have been managing. Ultimately, translating basic research to clinical applications is my main goal, with the intent of identifying eradication strategies for therapeutic intervention in the HIV-infected population.
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Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART. PLoS Pathog. 2021 Jan 19; 17(1):e1009214.
Bacchus-Souffan C, Fitch M, Symons J, Abdel-Mohsen M, Reeves DB, Hoh R, Stone M, Hiatt J, Kim P, Chopra A, Ahn H, York VA, Cameron DL, Hecht FM, Martin JN, Yukl SA, Mallal S, Cameron PU, Deeks SG, Schiffer JT, Lewin SR, Hellerstein MK, McCune JM, Hunt PW. PMID: 33465157.
View in: PubMed Mentions: Fields:
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Polyfunctional HIV-specific T cells in Post-Treatment Controllers. AIDS. 2016 09 24; 30(15):2299-302.
Samri A, Bacchus-Souffan C, Hocqueloux L, Avettand-Fenoel V, Descours B, Theodorou I, Larsen M, Saez-Cirion A, Rouzioux C, Autran B, . PMID: 27428742.
View in: PubMed Mentions: 7 Fields: Translation: HumansCellsPHPublic Health
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Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission. J Antimicrob Chemother. 2015 Jul; 70(7):2108-20.
Chéret A, Bacchus-Souffan C, Avettand-Fenoël V, Mélard A, Nembot G, Blanc C, Samri A, Sáez-Cirión A, Hocqueloux L, Lascoux-Combe C, Allavena C, Goujard C, Valantin MA, Leplatois A, Meyer L, Rouzioux C, Autran B, . PMID: 25900157.
View in: PubMed Mentions: 38 Fields: Translation: HumansCellsPHPublic Health
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A single HIV-1 cluster and a skewed immune homeostasis drive the early spread of HIV among resting CD4+ cell subsets within one month post-infection. PLoS One. 2013; 8(5):e64219.
Bacchus C, Cheret A, Avettand-Fenoël V, Nembot G, Mélard A, Blanc C, Lascoux-Combe C, Slama L, Allegre T, Allavena C, Yazdanpanah Y, Duvivier C, Katlama C, Goujard C, Seksik BC, Leplatois A, Molina JM, Meyer L, Autran B, Rouzioux C, . PMID: 23691172.
View in: PubMed Mentions: 24 Fields: Translation: HumansCells
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Immune control of HIV-1 reservoirs. Curr Opin HIV AIDS. 2013 May; 8(3):204-10.
Autran B, Descours B, Bacchus C. PMID: 23493099.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
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Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. PLoS Pathog. 2013 Mar; 9(3):e1003211.
Sáez-Cirión A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, Potard V, Versmisse P, Melard A, Prazuck T, Descours B, Guergnon J, Viard JP, Boufassa F, Lambotte O, Goujard C, Meyer L, Costagliola D, Venet A, Pancino G, Autran B, Rouzioux C, . PMID: 23516360.
View in: PubMed Mentions: 381 Fields: Translation: HumansCells
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Direct quantification of cell-associated HIV DNA in isolated rectal and blood memory CD4 T cells revealed their similar and low infection levels in long-term treated HIV-infected patients. . 2013 Mar 01; 62(3):255-9.
Descours B, Lambert-Niclot S, Mory B, Samri A, Charlotte F, Peytavin G, Tubiana R, Papagno L, Bacchus C, Lecardonnel F, Katlama C, Autran B, Marcelin AG, Valantin MA, Carcelain G, . PMID: 23274932.
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| Year | Publications |
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| 2013 | 4 | | 2015 | 1 | | 2016 | 1 | | 2021 | 1 |
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