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Chelsea Bahney, PhD

Title(s)Associate Professor, Orthopaedic Surgery
SchoolSchool of Medicine
Address1001 Potrero Ave, SFGH 9
San Francisco CA 94110
Phone628-206-5362
ORCID ORCID Icon0000-0001-9808-8888 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Colorado, Boulder, COBS06/2001Chemical Engineering
    Valleylab (now Medtronic), Boulder, CO08/2005R&D Engineer
    Oregon Health & Science University, Portland, ORPhD08/2010Stem Cell & Developmental Biology
    University of California, San Francisco, San Francisco, CAPost-Doctoral Fellowship04/2014Orthopaedic Surgery

    Collapse Overview 
    Collapse Overview
    The overall goal of my research is to develop novel therapies for the treatment of musculoskeletal diseases and injuries. Specifically, I believe we can drive improved tissue regeneration by recapitulating the normal sequences of development and repair. To accomplish this “Developmental Engineering” approach our laboratory utilizes a cross-disciplinary tools combining biologically modified synthetic polymers, stem cell biology, and murine models of orthopaedic injuries. The long-term goal of our research is to solve problems that will have a direct and significant impact on human health.

    Current Projects:

    (1) Tissue engineering strategies to promote endochondral bone regeneration
    (2) Transdifferentiation of cartilage to bone during fracture repair and osteoarthritis
    (3) The role of the nerve in fracture repair
    (4) Polytraumatic Injuries: How brain trauma influences fracture healing
    (5) Impedance sensors to monitor fracture healing

    Collapse Research 
    Collapse Research Activities and Funding
    Bimodal therapeutic application of LIF for regulating chondrogenic fate
    UCSF Center for Center for Musculoskeletal Biology and Medicine Jul 1, 2017 - Jul 1, 2018
    Role: PI
    Innervation during fracture repair: exploring functional mechanisms and innovative therapeutic repair strategies.
    Foundation of Orthopaedic Trauma Oct 1, 2015 - Oct 1, 2017
    Role: PI
    Promoting vascularized bone regeneration with endochondral cartilage grafts
    AO Foundation Start Up Grant Jun 1, 2015 - Jan 1, 2018
    Role: PI
    A Murine Model of Polytrauma: Understanding the molecular basis of accelerated bone repair with concomitant traumatic brain injury.
    NIH R21May 1, 2015 - Dec 31, 2017
    Role: Co-Investigator
    OsteoNova: Tissue Engineering Approach to Translating Endochondral Bone Regeneration
    UCSF Catalyst Mar 1, 2015 - Jun 30, 2017
    Role: PI
    Development of a Novel Impedance Sensor to Monitor Fracture Healing
    NSF Center for Disruptive Musculoskeletal Innovation Aug 1, 2014 - Aug 1, 2017
    Role: Co-PI
    Tissue engineering application of endochondral ossification for bone regeneration
    NIH/NIAMS F32AR062469Mar 1, 2012 - Feb 28, 2015
    Role: Principal Investigator

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    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Microvascular Anatomy and Intrinsic Gene Expression of Menisci From Young Adults. Am J Sports Med. 2020 Oct 12; 363546520961555. Crawford MD, Hellwinkel JE, Aman Z, Akamefula R, Singleton JT, Bahney C, LaPrade RF. PMID: 33044839.
      View in: PubMed   Mentions:    Fields:    
    2. The Life of a Fracture: Biologic Progression, Healing Gone Awry, and Evaluation of Union. JBJS Rev. 2020 Aug; 8(8):e1900221. Hellwinkel JE, Miclau T, Provencher MT, Bahney CS, Working ZM. PMID: 32796195.
      View in: PubMed   Mentions:    Fields:    
    3. The platelet-rich plasma and mesenchymal stem cell milieu: A review of therapeutic effects on bone healing. J Orthop Res. 2020 Jun 26. Liebig BE, Kisiday JD, Bahney CS, Ehrhart NP, Goodrich LR. PMID: 32589800.
      View in: PubMed   Mentions:    Fields:    
    4. A quantitative serum biomarker of circulating collagen X effectively correlates with endochondral fracture healing. J Orthop Res. 2020 Jun 13. Working ZM, Morris ER, Chang JC, Coghlan RF, Johnstone B, Miclau T, Horton WA, Bahney CS. PMID: 32533783.
      View in: PubMed   Mentions:    Fields:    
    5. Exosome Production and Regenerative Potential is Influenced by Mechanical Stimulus and Cell Origin. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. Michael Mullen, Chelsea Bahney, Sudheer Ravuri, Johnny Huard, Nicole Ehrhart. .
      View in: Publisher Site   Mentions:
    6. Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma. Sci Rep. 2019 08 21; 9(1):12199. Morioka K, Marmor Y, Sacramento JA, Lin A, Shao T, Miclau KR, Clark DR, Beattie MS, Marcucio RS, Miclau T, Ferguson AR, Bresnahan JC, Bahney CS. PMID: 31434912.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via ß-AR signaling. Proc Natl Acad Sci U S A. 2019 04 23; 116(17):8615-8622. Haffner-Luntzer M, Foertsch S, Fischer V, Prystaz K, Tschaffon M, Mödinger Y, Bahney CS, Marcucio RS, Miclau T, Ignatius A, Reber SO. PMID: 30948630.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. Challenging the paradigms in the classroom: the fate of chondrocytes. The FASEB Journal. 2019 Apr 1; 33(S1):80.2-80.2. Chelsea S. Bahney. .
      View in: Publisher Site   Mentions:
    9. Smart bone plates can monitor fracture healing. Sci Rep. 2019 02 14; 9(1):2122. Lin MC, Hu D, Marmor M, Herfat ST, Bahney CS, Maharbiz MM. PMID: 30765721.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    10. Cellular biology of fracture healing. J Orthop Res. 2019 01; 37(1):35-50. Bahney CS, Zondervan RL, Allison P, Theologis A, Ashley JW, Ahn J, Miclau T, Marcucio RS, Hankenson KD. PMID: 30370699.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    11. A degradation fragment of type X collagen is a real-time marker for bone growth velocity. . 2018 Sep 11. Coghlan RF, Oberdorf JA, Sienko S, Aiona MD, Boston BA, Connelly KJ, Bahney C, LaRouche J, Almubarak SM, Coleman DT, Girkontaite I, von der Mark K, Lunstrum GP, Horton WA. .
      View in: Publisher Site   Mentions:
    12. Origin of Reparative Stem Cells in Fracture Healing. Curr Osteoporos Rep. 2018 08; 16(4):490-503. Bragdon BC, Bahney CS. PMID: 29959723.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    13. Microenvironmental Regulation of Chondrocyte Plasticity in Endochondral Repair-A New Frontier for Developmental Engineering. Front Bioeng Biotechnol. 2018; 6:58. Wong SA, Rivera KO, Miclau T, Alsberg E, Marcucio RS, Bahney CS. PMID: 29868574.
      View in: PubMed   Mentions:
    14. A degradation fragment of type X collagen is a real-time marker for bone growth velocity. Sci Transl Med. 2017 Dec 06; 9(419). Coghlan RF, Oberdorf JA, Sienko S, Aiona MD, Boston BA, Connelly KJ, Bahney C, LaRouche J, Almubarak SM, Coleman DT, Girkontaite I, von der Mark K, Lunstrum GP, Horton WA. PMID: 29212713.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    15. Using impedance to track fracture healing rates in mice in vivo: A pilot study. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:1724-1727. Lin MC, Hu D, Yang F, Herfat ST, Bahney CS, Marmor M, Maharbiz MM. PMID: 29060219.
      View in: PubMed   Mentions:
    16. New opportunities for fracture healing detection: Impedance spectroscopy measurements correlate to tissue composition in fractures. J Orthop Res. 2017 12; 35(12):2620-2629. Lin MC, Yang F, Herfat ST, Bahney CS, Marmor M, Maharbiz MM. PMID: 28383765.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    17. Fortifying the Bone-Implant Interface Part 1: An In Vitro Evaluation of 3D-Printed and TPS Porous Surfaces. Int J Spine Surg. 2017; 11:15. MacBarb RF, Lindsey DP, Bahney CS, Woods SA, Wolfe ML, Yerby SA. PMID: 28765799.
      View in: PubMed   Mentions:
    18. Stimulating Fracture Healing in Ischemic Environments: Does Oxygen Direct Stem Cell Fate during Fracture Healing? Front Cell Dev Biol. 2017; 5:45. Miclau KR, Brazina SA, Bahney CS, Hankenson KD, Hunt TK, Marcucio RS, Miclau T. PMID: 28523266.
      View in: PubMed   Mentions:
    19. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes. Development. 2017 01 15; 144(2):221-234. Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS. PMID: 28096214.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    20. Accelerating the pace of discovery in orthopaedic research: A vision toward team science. J Orthop Res. 2016 10; 34(10):1673-1679. Bahney CS, Bruder SP, Cain JD, Keyak JH, Killian ML, Shapiro IM, Jones LC. PMID: 27219218.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes. Tissue Eng Part A. 2016 Mar; 22(5-6):427-35. Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC. PMID: 26830207.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. Stem Cell Therapies in Orthopaedic Trauma. J Orthop Trauma. 2015 Dec; 29 Suppl 12:S24-7. Marcucio RS, Nauth A, Giannoudis PV, Bahney C, Piuzzi NS, Muschler G, Miclau T. PMID: 26584262.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    23. Inflammation, Bone Healing, and Anti-Inflammatory Drugs: An Update. J Orthop Trauma. 2015 Dec; 29 Suppl 12:S6-9. Giannoudis PV, Hak D, Sanders D, Donohoe E, Tosounidis T, Bahney C. PMID: 26584270.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. Tissue engineering strategies for promoting vascularized bone regeneration. Bone. 2016 Feb; 83:197-209. Almubarak S, Nethercott H, Freeberg M, Beaudon C, Jha A, Jackson W, Marcucio R, Miclau T, Healy K, Bahney C. PMID: 26608518.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    25. The synergistic effect of micro-topography and biochemical culture environment to promote angiogenesis and osteogenic differentiation of human mesenchymal stem cells. Acta Biomater. 2015 May; 18:100-11. Song S, Kim EJ, Bahney CS, Miclau T, Marcucio R, Roy S. PMID: 25735800.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    26. The multifaceted role of the vasculature in endochondral fracture repair. Front Endocrinol (Lausanne). 2015; 6:4. Bahney CS, Hu DP, Miclau T, Marcucio RS. PMID: 25699016.
      View in: PubMed   Mentions:
    27. Review Article. The multifaceted role of the vasculature in endochondral fracture repair. 2015. Bahney, CS; Hu, DP; Miclau, T; Marcucio, RS. View Publication.
    28. Impedance spectroscopy to monitor fracture healing. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:5138-41. Lin MC, Herfat ST, Bahney CS, Marmor M, Maharbiz MM. PMID: 26737448.
      View in: PubMed   Mentions:
    29. Therapeutic delivery of placental stem cells to modulate vasculature and promote fracture repair (342.6). The FASEB Journal. 2014 Apr 1; 28. Chelsea Bahney, Aaron Taylor, Ali Sadat, Kathryn Tormos, Ted Miclau, Emin Maltepe, Ralph Marcucio. .
      View in: Publisher Site   Mentions:
    30. Endochondral bone tissue engineering: using cartilage to drive vascularized bone regeneration (87.6). The FASEB Journal. 2014 Apr 1; 28. Chelsea Bahney, Amit Jha, Diane Hu, Aaron Taylor, Hayley Britz, Benedikt Hallgrimsson, Ted Miclau, Ralph Marcucio. .
      View in: Publisher Site   Mentions:
    31. Transdifferentiation of hypertrophic chondrocytes during endochondral bone repair by activation of pluripotent stem cell programs (216.1). The FASEB Journal. 2014 Apr 1; 28. Chelsea Bahney, Diane Hu, Federico Ferro, Aaron Taylor, Ted Miclau, Ralph Marcucio. .
      View in: Publisher Site   Mentions:
    32. Contributor contact details. Bone Substitute Biomaterials. 2014 Jan 1; xi-xiii. K.K. Mallick, S. Sprio, M. Sandri, M. Iafisco, A. Ruffini, S. Minardi, A. Tampieri, P. Bhattacharya, G.H. van Lenthe, E.B. Hunziker, T.J. Blokhuis, V. Guarino, M.G. Raucci, A. Ronca, V. Cirillo, L. Ambrosio, K.K. Mallick, J. Winnett, A. Bansiddhi, D.C. Dunand, G.C. Wang, Z.F. Lu, H. Zreiqat, C.S. Bahney, R.S. Marcucio, J. Venkatesan, S.K. Kim, L. Grøndahl, C.S. Goonasekera, K.S. Jack, S.A. Clarke, P. Walsh. .
      View in: Publisher Site   Mentions:
    33. 9 Cartilage grafts for bone repair and regeneration. Bone Substitute Biomaterials. 2014 Jan 1; 219-243. C.S. Bahney, R.S. Marcucio. .
      View in: Publisher Site   Mentions:
    34. Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation. J Bone Miner Res. 2014; 29(5):1269-82. Bahney CS, Hu DP, Taylor AJ, Ferro F, Britz HM, Hallgrimsson B, Johnstone B, Miclau T, Marcucio RS. PMID: 24259230.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    35. Creating rigidly stabilized fractures for assessing intramembranous ossification, distraction osteogenesis, or healing of critical sized defects. J Vis Exp. 2012 Apr 11; (62). Yu YY, Bahney C, Hu D, Marcucio RS, Miclau T. PMID: 22525683.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    36. Tissue engineering bone by recapitulating developmental and repair programs offers improved biological outcomes. The FASEB Journal. 2012 Apr 1; 26:917.7-917.7. Chelsea Shields Bahney, Diane Hu, Theodore Miclau, Ralph Marcucio. .
      View in: Publisher Site   Mentions:
    37. Therapeutic potential of stem cells in orthopedics. Indian J Orthop. 2012 Jan; 46(1):4-9. Bahney CS, Miclau T. PMID: 22345800.
      View in: PubMed   Mentions:
    38. Visible light photoinitiation of mesenchymal stem cell-laden bioresponsive hydrogels. Eur Cell Mater. 2011 Jul 15; 22:43-55; discussion 55. Bahney CS, Lujan TJ, Hsu CW, Bottlang M, West JL, Johnstone B. PMID: 21761391.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    39. A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells. FASEB J. 2011 May; 25(5):1486-96. Bahney CS, Hsu CW, Yoo JU, West JL, Johnstone B. PMID: 21282205.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    40. A novel bioreactor for the dynamic stimulation and mechanical evaluation of multiple tissue-engineered constructs. Tissue Eng Part C Methods. 2011 Mar; 17(3):367-74. Lujan TJ, Wirtz KM, Bahney CS, Madey SM, Johnstone B, Bottlang M. PMID: 20950252.
      View in: PubMed   Mentions: 10     Fields:    
    41. Temporal exposure to chondrogenic factors modulates human mesenchymal stem cell chondrogenesis in hydrogels. Tissue Eng Part A. 2011 Feb; 17(3-4):371-80. Buxton AN, Bahney CS, Yoo JU, Johnstone B. PMID: 20799905.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
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