Christine Guthrie, PhD

TitleProfessor Emeritus
SchoolUCSF School of Medicine
DepartmentBiochemistry and Biophysics
Address600 16th St
San Francisco CA 94158
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    Collapse Research 
    Collapse Research Activities and Funding
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    Biosynthesis of RNAs
    NIH/NIGMS R01GM021119Feb 1, 1977 - Mar 31, 2016
    Role: Principal Investigator
    NIH/NIGMS R37GM021119Feb 1, 1977 - Mar 31, 2000
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. MacRae AJ, Mayerle M, Hrabeta-Robinson E, Chalkley RJ, Guthrie C, Burlingame AL, Jurica M. Prp8 positioning of U5 snRNA is linked to 5' splice site recognition. RNA. 2018 Feb 27. PMID: 29487104.
      View in: PubMed
    2. Mayerle M, Raghavan M, Ledoux S, Price A, Stepankiw N, Hadjivassiliou H, Moehle EA, Mendoza SD, Pleiss JA, Guthrie C, Abelson J. Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency. Proc Natl Acad Sci U S A. 2017 May 02; 114(18):4739-4744. PMID: 28416677.
      View in: PubMed
    3. Nissen KE, Homer CM, Ryan CJ, Shales M, Krogan NJ, Patrick KL, Guthrie C. The histone variant H2A.Z promotes splicing of weak introns. Genes Dev. 2017 04 01; 31(7):688-701. PMID: 28446597.
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    4. Mayerle M, Guthrie C. Genetics and biochemistry remain essential in the structural era of the spliceosome. Methods. 2017 Aug 01; 125:3-9. PMID: 28132896.
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    5. Ledoux S, Guthrie C. Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase Activity. J Biol Chem. 2016 Jun 03; 291(23):11954-65. PMID: 27072132; PMCID: PMC4933248 [Available on 06/03/17].
    6. Mayerle M, Guthrie C. Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing. RNA. 2016 May; 22(5):793-809. PMID: 26968627; PMCID: PMC4836653 [Available on 05/01/17].
    7. Mayerle M, Guthrie C. A new communication hub in the RNA world. Nat Struct Mol Biol. 2016 Mar; 23(3):189-90. PMID: 26931416.
      View in: PubMed
    8. Holmes RK, Tuck AC, Zhu C, Dunn-Davies HR, Kudla G, Clauder-Munster S, Granneman S, Steinmetz LM, Guthrie C, Tollervey D. Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough. PLoS Genet. 2015 Dec; 11(12):e1005735. PMID: 26694144; PMCID: PMC4687934.
    9. Lipp JJ, Marvin MC, Shokat KM, Guthrie C. SR protein kinases promote splicing of nonconsensus introns. Nat Struct Mol Biol. 2015 Aug; 22(8):611-7. PMID: 26167880.
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    10. Guthrie C. Present at the creation. RNA. 2015 Apr; 21(4):481. PMID: 25780103; PMCID: PMC4371245.
    11. Patrick KL, Ryan CJ, Xu J, Lipp JJ, Nissen KE, Roguev A, Shales M, Krogan NJ, Guthrie C. Genetic interaction mapping reveals a role for the SWI/SNF nucleosome remodeler in spliceosome activation in fission yeast. PLoS Genet. 2015 Mar; 11(3):e1005074. PMID: 25825871; PMCID: PMC4380400.
    12. Braberg H, Moehle EA, Shales M, Guthrie C, Krogan NJ. Genetic interaction analysis of point mutations enables interrogation of gene function at a residue-level resolution: exploring the applications of high-resolution genetic interaction mapping of point mutations. Bioessays. 2014 Jul; 36(7):706-13. PMID: 24842270; PMCID: PMC4289610.
    13. Moehle EA, Braberg H, Krogan NJ, Guthrie C. Adventures in time and space: splicing efficiency and RNA polymerase II elongation rate. RNA Biol. 2014; 11(4):313-9. PMID: 24717535; PMCID: PMC4075515.
    14. Hadjivassiliou H, Rosenberg OS, Guthrie C. The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing. RNA. 2014 May; 20(5):656-69. PMID: 24681967; PMCID: PMC3988567.
    15. Hérissant L, Moehle EA, Bertaccini D, Van Dorsselaer A, Schaeffer-Reiss C, Guthrie C, Dargemont C. H2B ubiquitylation modulates spliceosome assembly and function in budding yeast. Biol Cell. 2014 Apr; 106(4):126-38. PMID: 24476359; PMCID: PMC3989899.
    16. Krishnan R, Blanco MR, Kahlscheuer ML, Abelson J, Guthrie C, Walter NG. Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing. Nat Struct Mol Biol. 2013 Dec; 20(12):1450-7. PMID: 24240612; PMCID: PMC3867266.
    17. Price AM, Görnemann J, Guthrie C, Brow DA. An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8. RNA. 2014 Jan; 20(1):46-60. PMID: 24231520.
      View in: PubMed
    18. Braberg H, Jin H, Moehle EA, Chan YA, Wang S, Shales M, Benschop JJ, Morris JH, Qiu C, Hu F, Tang LK, Fraser JS, Holstege FC, Hieter P, Guthrie C, Kaplan CD, Krogan NJ. From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II. Cell. 2013 Aug 15; 154(4):775-88. PMID: 23932120; PMCID: PMC3932829.
    19. Liachko NF, McMillan PJ, Guthrie C, Bird TD, Leverenz JB, Kraemer BC. CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration. Ann Neurol. 2013 Jul; 74(1):39-52. PMID: 23424178; PMCID: PMC3775949.
    20. Bergkessel M, Guthrie C. Chemical transformation of yeast. Methods Enzymol. 2013; 529:311-20. PMID: 24011057.
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    21. Bergkessel M, Guthrie C. Colony PCR. Methods Enzymol. 2013; 529:299-309. PMID: 24011056.
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    22. Bergkessel M, Guthrie C, Abelson J. Yeast-gene replacement using PCR products. Methods Enzymol. 2013; 533:43-55. PMID: 24182917.
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    23. Moehle EA, Ryan CJ, Krogan NJ, Kress TL, Guthrie C. The yeast SR-like protein Npl3 links chromatin modification to mRNA processing. PLoS Genet. 2012; 8(11):e1003101. PMID: 23209445; PMCID: PMC3510044.
    24. Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, Edelmann W, Keogh MC, Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan NJ. Hierarchical modularity and the evolution of genetic interactomes across species. Mol Cell. 2012 Jun 08; 46(5):691-704. PMID: 22681890; PMCID: PMC3380636.
    25. Plocik AM, Guthrie C. Diverse forms of RPS9 splicing are part of an evolving autoregulatory circuit. PLoS Genet. 2012; 8(3):e1002620. PMID: 22479208; PMCID: PMC3315480.
    26. Bergkessel M, Whitworth GB, Guthrie C. Diverse environmental stresses elicit distinct responses at the level of pre-mRNA processing in yeast. RNA. 2011 Aug; 17(8):1461-78. PMID: 21697354; PMCID: PMC3153971.
    27. Ledoux S, Guthrie C. Regulation of the Dbp5 ATPase cycle in mRNP remodeling at the nuclear pore: a lively new paradigm for DEAD-box proteins. Genes Dev. 2011 Jun 01; 25(11):1109-14. PMID: 21632821; PMCID: PMC3110949.
    28. Huff JT, Plocik AM, Guthrie C, Yamamoto KR. Reciprocal intronic and exonic histone modification regions in humans. Nat Struct Mol Biol. 2010 Dec; 17(12):1495-9. PMID: 21057525; PMCID: PMC3057557.
    29. Mitrovich QM, Tuch BB, De La Vega FM, Guthrie C, Johnson AD. Evolution of yeast noncoding RNAs reveals an alternative mechanism for widespread intron loss. Science. 2010 Nov 05; 330(6005):838-41. PMID: 21051641; PMCID: PMC3496775.
    30. Abelson J, Blanco M, Ditzler MA, Fuller F, Aravamudhan P, Wood M, Villa T, Ryan DE, Pleiss JA, Maeder C, Guthrie C, Walter NG. Conformational dynamics of single pre-mRNA molecules during in vitro splicing. Nat Struct Mol Biol. 2010 Apr; 17(4):504-12. PMID: 20305654; PMCID: PMC2881217.
    31. Abelson J, Hadjivassiliou H, Guthrie C. Preparation of fluorescent pre-mRNA substrates for an smFRET study of pre-mRNA splicing in yeast. Methods Enzymol. 2010; 472:31-40. PMID: 20580958.
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    32. Guthrie C. From the ribosome to the spliceosome and back again. J Biol Chem. 2010 Jan 01; 285(1):1-12. PMID: 19880518; PMCID: PMC2804153.
    33. Zhang L, Xu T, Maeder C, Bud LO, Shanks J, Nix J, Guthrie C, Pleiss JA, Zhao R. Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2. Nat Struct Mol Biol. 2009 Jul; 16(7):731-9. PMID: 19525970; PMCID: PMC2743687.
    34. Wilmes GM, Guthrie C. Getting to the gate: crystallization of a Sac3(CID):Sus1:Cdc31 complex. Mol Cell. 2009 Mar 27; 33(6):671-2. PMID: 19328059.
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    35. Guthrie C, Schellenberg GD, Kraemer BC. SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans. Hum Mol Genet. 2009 May 15; 18(10):1825-38. PMID: 19273536; PMCID: PMC2722225.
    36. Bergkessel M, Wilmes GM, Guthrie C. SnapShot: Formation of mRNPs. Cell. 2009 Feb 20; 136(4):794, 794.e1. PMID: 19239896.
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    37. Maeder C, Kutach AK, Guthrie C. ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8. Nat Struct Mol Biol. 2009 Jan; 16(1):42-8. PMID: 19098916; PMCID: PMC2707180.
    38. Wilmes GM, Bergkessel M, Bandyopadhyay S, Shales M, Braberg H, Cagney G, Collins SR, Whitworth GB, Kress TL, Weissman JS, Ideker T, Guthrie C, Krogan NJ. A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell. 2008 Dec 05; 32(5):735-46. PMID: 19061648; PMCID: PMC2644724.
    39. Kress TL, Krogan NJ, Guthrie C. A single SR-like protein, Npl3, promotes pre-mRNA splicing in budding yeast. Mol Cell. 2008 Dec 05; 32(5):727-34. PMID: 19061647; PMCID: PMC2677966.
    40. Maeder C, Guthrie C. Modifications target spliceosome dynamics. Nat Struct Mol Biol. 2008 May; 15(5):426-8. PMID: 18461042.
      View in: PubMed
    41. Lund MK, Kress TL, Guthrie C. Autoregulation of Npl3, a yeast SR protein, requires a novel downstream region and serine phosphorylation. Mol Cell Biol. 2008 Jun; 28(11):3873-81. PMID: 18391019; PMCID: PMC2423289.
    42. Mitrovich QM, Guthrie C. Evolution of small nuclear RNAs in S. cerevisiae, C. albicans, and other hemiascomycetous yeasts. RNA. 2007 Dec; 13(12):2066-80. PMID: 17956975; PMCID: PMC2080600.
    43. Pleiss JA, Whitworth GB, Bergkessel M, Guthrie C. Rapid, transcript-specific changes in splicing in response to environmental stress. Mol Cell. 2007 Sep 21; 27(6):928-37. PMID: 17889666; PMCID: PMC2081968.
    44. Pleiss JA, Whitworth GB, Bergkessel M, Guthrie C. Transcript specificity in yeast pre-mRNA splicing revealed by mutations in core spliceosomal components. PLoS Biol. 2007 Apr; 5(4):e90. PMID: 17388687; PMCID: PMC1831718.
    45. Mitrovich QM, Tuch BB, Guthrie C, Johnson AD. Computational and experimental approaches double the number of known introns in the pathogenic yeast Candida albicans. Genome Res. 2007 Apr; 17(4):492-502. PMID: 17351132; PMCID: PMC1832096.
    46. Kim Guisbert KS, Li H, Guthrie C. Alternative 3' pre-mRNA processing in Saccharomyces cerevisiae is modulated by Nab4/Hrp1 in vivo. PLoS Biol. 2007 Jan; 5(1):e6. PMID: 17194212; PMCID: PMC1717019.
    47. Kress TL, Guthrie C. Molecular biology. Accurate RNA siting and splicing gets help from a DEK-hand. Science. 2006 Jun 30; 312(5782):1886-7. PMID: 16809518.
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    48. Preker PJ, Guthrie C. Autoregulation of the mRNA export factor Yra1p requires inefficient splicing of its pre-mRNA. RNA. 2006 Jun; 12(6):994-1006. PMID: 16618971; PMCID: PMC1464842.
    49. Brenner TJ, Guthrie C. Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain. RNA. 2006 May; 12(5):862-71. PMID: 16540695; PMCID: PMC1440915.
    50. Bellare P, Kutach AK, Rines AK, Guthrie C, Sontheimer EJ. Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. RNA. 2006 Feb; 12(2):292-302. PMID: 16428608; PMCID: PMC1370909.
    51. Lund MK, Guthrie C. The DEAD-box protein Dbp5p is required to dissociate Mex67p from exported mRNPs at the nuclear rim. Mol Cell. 2005 Nov 23; 20(4):645-51. PMID: 16307927.
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    52. Villa T, Guthrie C. The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing. Genes Dev. 2005 Aug 15; 19(16):1894-904. PMID: 16103217; PMCID: PMC1186189.
    53. Brenner TJ, Guthrie C. Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation. Genetics. 2005 Jul; 170(3):1063-80. PMID: 15911574; PMCID: PMC1451163.
    54. Kim Guisbert K, Duncan K, Li H, Guthrie C. Functional specificity of shuttling hnRNPs revealed by genome-wide analysis of their RNA binding profiles. RNA. 2005 Apr; 11(4):383-93. PMID: 15703440; PMCID: PMC1370728.
    55. Gilbert W, Guthrie C. The Glc7p nuclear phosphatase promotes mRNA export by facilitating association of Mex67p with mRNA. Mol Cell. 2004 Jan 30; 13(2):201-12. PMID: 14759366.
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    56. Inada M, Guthrie C. Identification of Lhp1p-associated RNAs by microarray analysis in Saccharomyces cerevisiae reveals association with coding and noncoding RNAs. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):434-9. PMID: 14704279; PMCID: PMC327165.
    57. Rader SD, Guthrie C. A conserved Lsm-interaction motif in Prp24 required for efficient U4/U6 di-snRNP formation. RNA. 2002 Nov; 8(11):1378-92. PMID: 12458792; PMCID: PMC1370345.
    58. Preker PJ, Kim KS, Guthrie C. Expression of the essential mRNA export factor Yra1p is autoregulated by a splicing-dependent mechanism. RNA. 2002 Aug; 8(8):969-80. PMID: 12212852; PMCID: PMC1370319.
    59. Villa T, Pleiss JA, Guthrie C. Spliceosomal snRNAs: Mg(2+)-dependent chemistry at the catalytic core? Cell. 2002 Apr 19; 109(2):149-52. PMID: 12007401.
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    60. Collins CA, Guthrie C. Genetic interactions between the 5' and 3' splice site consensus sequences and U6 snRNA during the second catalytic step of pre-mRNA splicing. RNA. 2001 Dec; 7(12):1845-54. PMID: 11780639; PMCID: PMC1370222.
    61. de Bruyn Kops A, Guthrie C. An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport. EMBO J. 2001 Aug 01; 20(15):4183-93. PMID: 11483521; PMCID: PMC149179.
    62. Gilbert W, Siebel CW, Guthrie C. Phosphorylation by Sky1p promotes Npl3p shuttling and mRNA dissociation. RNA. 2001 Feb; 7(2):302-13. PMID: 11233987; PMCID: PMC1370088.
    63. Kistler AL, Guthrie C. Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase. Genes Dev. 2001 Jan 01; 15(1):42-9. PMID: 11156604; PMCID: PMC312603.
    64. Collins CA, Guthrie C. The question remains: is the spliceosome a ribozyme? Nat Struct Biol. 2000 Oct; 7(10):850-4. PMID: 11017191.
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    65. Duncan K, Umen JG, Guthrie C. A putative ubiquitin ligase required for efficient mRNA export differentially affects hnRNP transport. Curr Biol. 2000 Jun 15; 10(12):687-96. PMID: 10873801.
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    66. Collins CA, Guthrie C. Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome. Genes Dev. 1999 Aug 01; 13(15):1970-82. PMID: 10444595; PMCID: PMC316919.
    67. Siebel CW, Feng L, Guthrie C, Fu XD. Conservation in budding yeast of a kinase specific for SR splicing factors. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5440-5. PMID: 10318902; PMCID: PMC21878.
    68. Staley JP, Guthrie C. An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p. Mol Cell. 1999 Jan; 3(1):55-64. PMID: 10024879.
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    69. Wang Y, Guthrie C. PRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domain. RNA. 1998 Oct; 4(10):1216-29. PMID: 9769096; PMCID: PMC1369694.
    70. Raghunathan PL, Guthrie C. RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2. Curr Biol. 1998 Jul 16; 8(15):847-55. PMID: 9705931.
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    71. Wang Y, Wagner JD, Guthrie C. The DEAH-box splicing factor Prp16 unwinds RNA duplexes in vitro. Curr Biol. 1998 Apr 09; 8(8):441-51. PMID: 9550699.
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    72. Staley JP, Guthrie C. Mechanical devices of the spliceosome: motors, clocks, springs, and things. Cell. 1998 Feb 06; 92(3):315-26. PMID: 9476892.
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    73. Raghunathan PL, Guthrie C. A spliceosomal recycling factor that reanneals U4 and U6 small nuclear ribonucleoprotein particles. Science. 1998 Feb 06; 279(5352):857-60. PMID: 9452384.
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    74. Guthrie C, Skâlhegg BS, McKnight GS. Two novel brain-specific splice variants of the murine Cbeta gene of cAMP-dependent protein kinase. J Biol Chem. 1997 Nov 21; 272(47):29560-5. PMID: 9368018.
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    75. Chanfreau G, Elela SA, Ares M, Guthrie C. Alternative 3'-end processing of U5 snRNA by RNase III. Genes Dev. 1997 Oct 15; 11(20):2741-51. PMID: 9334335; PMCID: PMC316607.
    76. Stade K, Ford CS, Guthrie C, Weis K. Exportin 1 (Crm1p) is an essential nuclear export factor. Cell. 1997 Sep 19; 90(6):1041-50. PMID: 9323132.
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    77. Chanfreau G, Noble SM, Guthrie C. Essential yeast protein with unexpected similarity to subunits of mammalian cleavage and polyadenylation specificity factor (CPSF). Science. 1996 Nov 29; 274(5292):1511-4. PMID: 8929408.
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    78. Siebel CW, Guthrie C. The essential yeast RNA binding protein Np13p is methylated. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):13641-6. PMID: 8942987; PMCID: PMC19378.
    79. Noble SM, Guthrie C. Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs. EMBO J. 1996 Aug 15; 15(16):4368-79. PMID: 8861964; PMCID: PMC452161.
    80. Umen JG, Guthrie C. Mutagenesis of the yeast gene PRP8 reveals domains governing the specificity and fidelity of 3' splice site selection. Genetics. 1996 Jun; 143(2):723-39. PMID: 8725222; PMCID: PMC1207332.
    81. Noble SM, Guthrie C. Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics. 1996 May; 143(1):67-80. PMID: 8722763; PMCID: PMC1207296.
    82. Umen JG, Guthrie C. The second catalytic step of pre-mRNA splicing. RNA. 1995 Nov; 1(9):869-85. PMID: 8548652; PMCID: PMC1369336.
    83. Jones MH, Frank DN, Guthrie C. Characterization and functional ordering of Slu7p and Prp17p during the second step of pre-mRNA splicing in yeast. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9687-91. PMID: 7568198; PMCID: PMC40867.
    84. Umen JG, Guthrie C. Prp16p, Slu7p, and Prp8p interact with the 3' splice site in two distinct stages during the second catalytic step of pre-mRNA splicing. RNA. 1995 Aug; 1(6):584-97. PMID: 7489518; PMCID: PMC1369303.
    85. Umen JG, Guthrie C. A novel role for a U5 snRNP protein in 3' splice site selection. Genes Dev. 1995 Apr 01; 9(7):855-68. PMID: 7535718.
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    86. Jandrositz A, Guthrie C. Evidence for a Prp24 binding site in U6 snRNA and in a putative intermediate in the annealing of U6 and U4 snRNAs. EMBO J. 1995 Feb 15; 14(4):820-32. PMID: 7882985; PMCID: PMC398149.
    87. Matthews RP, Guthrie C, Wailes LM, Zhao X, Means AR, McKnight GS. Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. Mol Cell Biol. 1994 Sep; 14(9):6107-16. PMID: 8065343; PMCID: PMC359137.
    88. Strauss EJ, Guthrie C. PRP28, a 'DEAD-box' protein, is required for the first step of mRNA splicing in vitro. Nucleic Acids Res. 1994 Aug 11; 22(15):3187-93. PMID: 7520570; PMCID: PMC310295.
    89. Madhani HD, Guthrie C. Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase. Genetics. 1994 Jul; 137(3):677-87. PMID: 8088513; PMCID: PMC1206027.
    90. Madhani HD, Guthrie C. Randomization-selection analysis of snRNAs in vivo: evidence for a tertiary interaction in the spliceosome. Genes Dev. 1994 May 01; 8(9):1071-86. PMID: 7926788.
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    91. Frank DN, Roiha H, Guthrie C. Architecture of the U5 small nuclear RNA. Mol Cell Biol. 1994 Mar; 14(3):2180-90. PMID: 8114748; PMCID: PMC358578.
    92. Madhani HD, Guthrie C. Dynamic RNA-RNA interactions in the spliceosome. Annu Rev Genet. 1994; 28:1-26. PMID: 7534458.
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    93. Guthrie C. The spliceosome is a dynamic ribonucleoprotein machine. Harvey Lect. 1994-1995; 90:59-80. PMID: 8803319.
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    94. Lesser CF, Guthrie C. Mutations in U6 snRNA that alter splice site specificity: implications for the active site. Science. 1993 Dec 24; 262(5142):1982-8. PMID: 8266093.
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    95. Burgess SM, Guthrie C. A mechanism to enhance mRNA splicing fidelity: the RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates. Cell. 1993 Jul 02; 73(7):1377-91. PMID: 8324826.
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    96. Lesser CF, Guthrie C. Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1. Genetics. 1993 Apr; 133(4):851-63. PMID: 8462846; PMCID: PMC1205405.
    97. Schwer B, Guthrie C. A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis. EMBO J. 1992 Dec; 11(13):5033-9. PMID: 1464325; PMCID: PMC556981.
    98. Madhani HD, Guthrie C. A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome. Cell. 1992 Nov 27; 71(5):803-17. PMID: 1423631.
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    99. Frank D, Guthrie C. An essential splicing factor, SLU7, mediates 3' splice site choice in yeast. Genes Dev. 1992 Nov; 6(11):2112-24. PMID: 1427075.
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    100. Frank D, Patterson B, Guthrie C. Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing. Mol Cell Biol. 1992 Nov; 12(11):5197-205. PMID: 1406691; PMCID: PMC360453.
    101. Schwer B, Guthrie C. A dominant negative mutation in a spliceosomal ATPase affects ATP hydrolysis but not binding to the spliceosome. Mol Cell Biol. 1992 Aug; 12(8):3540-7. PMID: 1385854; PMCID: PMC364619.
    102. Bordonné R, Guthrie C. Human and human-yeast chimeric U6 snRNA genes identify structural elements required for expression in yeast. Nucleic Acids Res. 1992 Feb 11; 20(3):479-85. PMID: 1741282; PMCID: PMC310411.
    103. Siliciano PG, Kivens WJ, Guthrie C. More than half of yeast U1 snRNA is dispensable for growth. Nucleic Acids Res. 1991 Dec 11; 19(23):6367-72. PMID: 1754372; PMCID: PMC329179.
    104. Guthrie C. Messenger RNA splicing in yeast: clues to why the spliceosome is a ribonucleoprotein. Science. 1991 Jul 12; 253(5016):157-63. PMID: 1853200.
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    105. Shannon KW, Guthrie C. Suppressors of a U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifs. Genes Dev. 1991 May; 5(5):773-85. PMID: 1827420.
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    106. Strauss EJ, Guthrie C. A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family. Genes Dev. 1991 Apr; 5(4):629-41. PMID: 2010088.
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    107. Schwer B, Guthrie C. PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome. Nature. 1991 Feb 07; 349(6309):494-9. PMID: 1825134.
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    108. Patterson B, Guthrie C. A U-rich tract enhances usage of an alternative 3' splice site in yeast. Cell. 1991 Jan 11; 64(1):181-7. PMID: 1846089.
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    109. Madhani HD, Bordonné R, Guthrie C. Multiple roles for U6 snRNA in the splicing pathway. Genes Dev. 1990 Dec; 4(12B):2264-77. PMID: 2149118.
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    110. Brow DA, Guthrie C. Transcription of a yeast U6 snRNA gene requires a polymerase III promoter element in a novel position. Genes Dev. 1990 Aug; 4(8):1345-56. PMID: 2227412.
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    111. Guthrie C, Madhani HD. Greetings from the RNA world. RNA Processing sponsored by the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA, May 16-20, 1990. New Biol. 1990 Aug; 2(8):684-7. PMID: 1704252.
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    112. Jones MH, Guthrie C. Unexpected flexibility in an evolutionarily conserved protein-RNA interaction: genetic analysis of the Sm binding site. EMBO J. 1990 Aug; 9(8):2555-61. PMID: 2142451; PMCID: PMC552286.
    113. Bordonné R, Banroques J, Abelson J, Guthrie C. Domains of yeast U4 spliceosomal RNA required for PRP4 protein binding, snRNP-snRNP interactions, and pre-mRNA splicing in vivo. Genes Dev. 1990 Jul; 4(7):1185-96. PMID: 2145195.
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    114. Shuster EO, Guthrie C. Human U2 snRNA can function in pre-mRNA splicing in yeast. Nature. 1990 May 17; 345(6272):270-3. PMID: 2185425.
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    115. Burgess S, Couto JR, Guthrie C. A putative ATP binding protein influences the fidelity of branchpoint recognition in yeast splicing. Cell. 1990 Mar 09; 60(5):705-17. PMID: 2138057.
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    116. Guthrie C, Shannon K, Bordonne R. Genetic dissection of the U4/U6/U5 snRNP "cycle" in yeast. Mol Biol Rep. 1990; 14(2-3):139-40. PMID: 2141896.
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    117. Roiha H, Shuster EO, Brow DA, Guthrie C. Small nuclear RNAs from budding yeasts: phylogenetic comparisons reveal extensive size variation. Gene. 1989 Oct 15; 82(1):137-44. PMID: 2684769.
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    118. Shuster EO, Guthrie C. Two conserved domains of yeast U2 snRNA are separated by 945 nonessential nucleotides. Cell. 1988 Oct 07; 55(1):41-8. PMID: 3048702.
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    119. Siliciano PG, Guthrie C. 5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements. Genes Dev. 1988 Oct; 2(10):1258-67. PMID: 3060402.
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    120. Parker R, Simmons T, Shuster EO, Siliciano PG, Guthrie C. Genetic analysis of small nuclear RNAs in Saccharomyces cerevisiae: viable sextuple mutant. Mol Cell Biol. 1988 Aug; 8(8):3150-9. PMID: 2905424; PMCID: PMC363543.
    121. Brow DA, Guthrie C. Spliceosomal RNA U6 is remarkably conserved from yeast to mammals. Nature. 1988 Jul 21; 334(6179):213-8. PMID: 3041282.
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    122. Guthrie C, Patterson B. Spliceosomal snRNAs. Annu Rev Genet. 1988; 22:387-419. PMID: 2977088.
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    123. Couto JR, Tamm J, Parker R, Guthrie C. A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation. Genes Dev. 1987 Jul; 1(5):445-55. PMID: 2890553.
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