Christine Hsieh, PhD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
Address4150 Clement St
San Francisco CA 94121
Phone415-221-4810 ext. 23683
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral Fellowship2010Department of Medicine, Rheumatology Division
    Stanford UniversityPh.D.2006School of Medicine, Immunology Program
    University of California, Los AngelesB.S.1999Molecular, Cell and Developmental Biology
    Collapse Awards and Honors
    International Transplant Society2004Travel Award
    International Transplant Society2002Travel Award
    Stanford University2002Katherine McCormick Travel Award
    Stanford University2001Katherine McCormick Travel Award
    University of California, Los Angeles1999B.S. Magna Cum Laude Honors and College Honors
    University of California, Los Angeles1997Barry M. Goldwater National Scholarship Finalist
    University of California, Los Angeles1995Rosalind Ferrini Academic Award

    Collapse Overview 
    Collapse Overview
    I am interested in understanding innate immune mechanisms that contribute to inflammation and wound healing during traumatic brain injury. One of my main interests is to investigate the roles and heterogeneity of macrophage and microglia cells. These cells are among the first lines of defense in brain injury that serve to sterilize the wound and to set up the brain for wound repair. My goal is to better understand the cellular mechanisms and dynamics of the immune response after TBI, and seek ways to modulate the immune response to improve TBI outcomes.

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting Innate Immunity in Traumatic Brain Injury
    Biogen, Industry Sponsored Research Project Apr 3, 2018 - Apr 2, 2020
    Role: Principal Investigator
    Stroke in Females with Metabolic Syndrome, A Vascular Perspective
    NIH Apr 1, 2018 - Mar 31, 2020
    Role: Co-Investigator
    Immune Modulation and Cardiac Remodeling
    VA I01BX002994Oct 1, 2016 - Sep 30, 2020
    Role: Co-Investigator
    Collateral flow and stroke outcome
    VA I01BX003335Jul 1, 2016 - Jun 30, 2020
    Role: Co-Investigator
    Targeting CCR2 (CC Chemokine Receptor 2) to treat TBI
    VA I01BX002690Oct 1, 2015 - Sep 30, 2019
    Role: Principal Investigator
    Innovative Research Grant: Immune Modulation and Myocardial Infarction in Arthritis
    Rheumatology Research Foundation Jul 1, 2015 - Jun 30, 2018
    Role: Co-Investigator
    The Role of CCR2 and Macrophages in Traumatic Brain Injury
    VA BLR&D Career Development Award-2 Jan 1, 2011 - Sep 30, 2015
    Role: Principal Investigator
    The Role of Triggering Receptor Expressed on Myeloid Cells-2 (Trem2) on Microglia
    NIH/NINDS F32NS060338Sep 1, 2007 - Aug 31, 2009
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Bucay N, Sekhon K, Yang T, Majid S, Shahryari V, Hsieh C, Mitsui Y, Deng G, Tabatabai ZL, Yamamura S, Calin GA, Dahiya R, Tanaka Y, Saini S. MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer. Oncogene. 2017 May 11; 36(19):2667-2679. PMID: 27893706.
      View in: PubMed
    2. Kim CC, Nakamura MC, Hsieh CL. Brain trauma elicits non-canonical macrophage activation states. J Neuroinflammation. 2016 05 24; 13(1):117. PMID: 27220367.
      View in: PubMed
    3. Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R, Farese RV, Paz JT, Barres BA, Huang EJ. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell. 2016 May 05; 165(4):921-35. PMID: 27114033.
      View in: PubMed
    4. Kawabori M, Kacimi R, Kauppinen T, Calosing C, Kim JY, Hsieh CL, Nakamura MC, Yenari MA. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. J Neurosci. 2015 Feb 25; 35(8):3384-96. PMID: 25716838; PMCID: PMC4339351.
    5. Hsieh CL, Niemi EC, Wang SH, Lee CC, Bingham D, Zhang J, Cozen ML, Charo I, Huang EJ, Liu J, Nakamura MC. CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury. J Neurotrauma. 2014 Oct 15; 31(20):1677-88. PMID: 24806994; PMCID: PMC4545982.
    6. Kawabori M, Hokari M, Zheng Z, Kim JY, Calosing C, Hsieh CL, Nakamura MC, Yenari MA. Triggering Receptor Expressed on Myeloid Cells-2 Correlates to Hypothermic Neuroprotection in Ischemic Stroke. Ther Hypothermia Temp Manag. 2013 Dec 01; 3(4):189-198. PMID: 24380032.
      View in: PubMed
    7. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. Traumatic brain injury induces macrophage subsets in the brain. Eur J Immunol. 2013 Aug; 43(8):2010-22. PMID: 23630120; PMCID: PMC4210355.
    8. Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem. 2009 May; 109(4):1144-56. PMID: 19302484; PMCID: PMC3087597.
    9. Hsieh CL, Nagasaki K, Martinez OM, Krams SM. NKp30 is a functional activation receptor on a subset of rat natural killer cells. Eur J Immunol. 2006 Aug; 36(8):2170-80. PMID: 16821237; PMCID: PMC4084722.
    10. Obara H, Nagasaki K, Hsieh CL, Ogura Y, Esquivel CO, Martinez OM, Krams SM. IFN-gamma, produced by NK cells that infiltrate liver allografts early after transplantation, links the innate and adaptive immune responses. Am J Transplant. 2005 Sep; 5(9):2094-103. PMID: 16095488; PMCID: PMC1473982.
    11. Hsieh CL, Ogura Y, Obara H, Ali UA, Rodriguez GM, Nepomuceno RR, Martinez OM, Krams SM. Identification, cloning, and characterization of a novel rat natural killer receptor, RNKP30: a molecule expressed in liver allografts. Transplantation. 2004 Jan 15; 77(1):121-8. PMID: 14724446.
      View in: PubMed
    12. Land KM, Delgadillo-Correa MG, Tachezy J, Vanacova S, Hsieh CL, Sutak R, Johnson PJ. Targeted gene replacement of a ferredoxin gene in Trichomonas vaginalis does not lead to metronidazole resistance. Mol Microbiol. 2004 Jan; 51(1):115-22. PMID: 14651615.
      View in: PubMed
    13. Bradley PJ, Hsieh CL, Boothroyd JC. Unprocessed Toxoplasma ROP1 is effectively targeted and secreted into the nascent parasitophorous vacuole. Mol Biochem Parasitol. 2002 Nov-Dec; 125(1-2):189-93. PMID: 12467986.
      View in: PubMed
    14. Hsieh CL, Obara H, Ogura Y, Martinez OM, Krams SM. NK cells and transplantation. Transpl Immunol. 2002 May; 9(2-4):111-4. PMID: 12180816.
      View in: PubMed
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