Christine Hsieh, PhD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address4150 Clement St, #500
San Francisco CA 94121
Phone415-221-4810 ext. 23683
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral Fellowship2010Department of Medicine, Rheumatology Division
    Stanford UniversityPh.D.2006School of Medicine, Immunology Program
    University of California, Los AngelesB.S.1999Molecular, Cell and Developmental Biology
    Collapse Awards and Honors
    Curia Biologics2022Innovation Award
    VA Biomedical Laboratory Research & Development2011  - 2015Career Development Award-2
    NIH National Institute of Neurological Disorders and Stroke2007  - 2009NIH Ruth L. Kirschstein National Research Service Award
    University of California, Los Angeles1999B.S. with Magna Cum Laude Honors and College Honors

    Collapse Overview 
    Collapse Overview
    Dr. Christine Hsieh is a cellular neuroimmunologist focused on understanding mechanisms of inflammation that contribute to diseases with an urgent need for therapies, such as lupus, frontotemporal dementia (FTD) and traumatic brain injury (TBI). Her research has largely focused on the roles of innate immune receptors expressed by macrophages, microglia, B cells, and/or NK cells in disease, and how receptor activity can be modulated for therapy.

    Collapse Research 
    Collapse Research Activities and Funding
    Neuroinflammation and vascular development in GMH
    NIH NINDS 1R01NS132595 - 01Apr 1, 2023 - Mar 31, 2028
    Role: Co-Investigator
    Shared Equipment Award for Leica Stellaris Confocal Microscope
    VA IS1BX005516Feb 1, 2022 - Mar 1, 2023
    Role: PI
    Description: Procure a state-of-the-art confocal microscope for the VA Microscopy Core Facility
    Analysis of a Type I Interferon Responsive Microglia Subset in Traumatic Brain Injury
    Veterans Affairs Biomedical Laboratory Research & Development TBI Merit I01BX002690Oct 1, 2020 - Sep 30, 2024
    Role: Principal Investigator
    Inflammatory mechanisms in cerebral ischemia
    NIH R01NS106441Mar 15, 2019 - Jan 31, 2024
    Role: Co-Investigator
    ShEEP Request for a Replacement Cell Sorting Flow Cytometer for the Flow Cytometry Core Facility
    NIH IS1BX004776Jan 1, 2019 - Sep 30, 2019
    Role: Principal Investigator
    Single Cell Analyses of Neuroimmune Dysfunctions in the Thalamocortical Circuit in FTLD
    NIH R01AA027074Sep 15, 2018 - Jun 30, 2023
    Role: Co-Investigator
    Targeting Innate Immunity in Traumatic Brain Injury
    Biogen, Industry Sponsored Research Project NCIRE Project 1201Apr 3, 2018 - Apr 2, 2020
    Role: Principal Investigator
    Stroke in females with metabolic syndrome, a vascular perspective
    NIH R01NS102886Feb 1, 2018 - Jan 31, 2023
    Role: Co-Investigator
    Immune Modulation and Cardiac Remodeling
    NIH I01BX002994Oct 1, 2016 - Mar 31, 2021
    Role: Co-Investigator
    Collateral flow and stroke outcome
    NIH I01BX003335Jul 1, 2016 - Mar 31, 2025
    Role: Co-Investigator
    Targeting CCR2 (CC Chemokine Receptor 2) to treat TBI
    NIH I01BX002690Oct 1, 2015 - Sep 30, 2024
    Role: Principal Investigator
    Immune Modulation and Myocardial Infarction in Arthritis
    Rheumatology Research Foundation Innovative Research GrantJul 1, 2015 - Jun 30, 2018
    Role: Co-Investigator
    The Role of CCR2 and Macrophages in Traumatic Brain Injury
    VA BLR&D VA Career Development Award-2Jan 1, 2011 - Sep 30, 2015
    Role: Principal Investigator
    The Role of Triggering Receptor Expressed on Myeloid Cells-2 (Trem2) on Microglia
    NIH F32NS060338Sep 1, 2007 - Aug 31, 2009
    Role: Principal Investigator
    S Scott Panter Research Donation
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CCR2 deficiency alters activation of microglia subsets in traumatic brain injury. Cell Rep. 2021 09 21; 36(12):109727. Somebang K, Rudolph J, Imhof I, Li L, Niemi EC, Shigenaga J, Tran H, Gill TM, Lo I, Zabel BA, Schmajuk G, Wipke BT, Gyoneva S, Jandreski L, Craft M, Benedetto G, Plowey ED, Charo I, Campbell J, Ye CJ, Panter SS, Nakamura MC, Eckalbar W, Hsieh CL. PMID: 34551293; PMCID: PMC8594931.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    2. The effect of type 2 diabetes on CD36 expression and the uptake of oxLDL: Diabetes affects CD36 and oxLDL uptake. Exp Neurol. 2020 12; 334:113461. Kanoke A, Nishijima Y, Ljungberg M, Omodaka S, Yang SY, Wong S, Rabiller G, Tominaga T, Hsieh CL, Liu J. PMID: 32926860; PMCID: PMC8504205.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    3. Age-related changes to macrophages are detrimental to fracture healing in mice. Aging Cell. 2020 03; 19(3):e13112. Clark D, Brazina S, Yang F, Hu D, Hsieh CL, Niemi EC, Miclau T, Nakamura MC, Marcucio R. PMID: 32096907; PMCID: PMC7059136.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    4. Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency. Retrovirology. 2019 11 11; 16(1):32. Telwatte S, Morón-López S, Aran D, Kim P, Hsieh C, Joshi S, Montano M, Greene WC, Butte AJ, Wong JK, Yukl SA. PMID: 31711503; PMCID: PMC6849327.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    5. Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease. Acta Neuropathol. 2019 08; 138(2):251-273. Boza-Serrano A, Ruiz R, Sanchez-Varo R, García-Revilla J, Yang Y, Jimenez-Ferrer I, Paulus A, Wennström M, Vilalta A, Allendorf D, Davila JC, Stegmayr J, Jiménez S, Roca-Ceballos MA, Navarro-Garrido V, Swanberg M, Hsieh CL, Real LM, Englund E, Linse S, Leffler H, Nilsson UJ, Brown GC, Gutierrez A, Vitorica J, Venero JL, Deierborg T. PMID: 31006066; PMCID: PMC6660511.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    6. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke. J Cereb Blood Flow Metab. 2019 10; 39(10):1906-1918. Kurisu K, Zheng Z, Kim JY, Shi J, Kanoke A, Liu J, Hsieh CL, Yenari MA. PMID: 30523715; PMCID: PMC6775587.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    7. ADAM17 Is The Main Sheddase For The Generation Of Human Triggering Receptor Expressed In Myeloid Cells (hTREM2) Ectodomain And Cleaves TREM2 After Histidine 157. bioRxiv. 2017 May 3; 133751. Feuerbach FD, Schindler SP, Barske BC, Joller JS, Beng-Louka BE, Worringer WK, Kommineni KS, Kaykas KA, Ho HD, Ye YC, Welzenbach WK, Elain EG, Klein KL, Brzak BI, Mir MA, Faraday FC, Aichholz AR, Popp PS, George GN, Hsieh HC, Nakamura NM, Neumann NU. .
      View in: Publisher Site   Mentions:
    8. MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer. Oncogene. 2017 05 11; 36(19):2667-2679. Bucay N, Sekhon K, Yang T, Majid S, Shahryari V, Hsieh C, Mitsui Y, Deng G, Tabatabai ZL, Yamamura S, Calin GA, Dahiya R, Tanaka Y, Saini S. PMID: 27893706; PMCID: PMC5426972.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    9. Brain trauma elicits non-canonical macrophage activation states. J Neuroinflammation. 2016 05 24; 13(1):117. Kim CC, Nakamura MC, Hsieh CL. PMID: 27220367; PMCID: PMC4879757.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    10. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell. 2016 May 05; 165(4):921-35. Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R, Farese RV, Paz JT, Barres BA, Huang EJ. PMID: 27114033; PMCID: PMC4860138.
      View in: PubMed   Mentions: 352     Fields:    Translation:HumansAnimalsCells
    11. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. J Neurosci. 2015 Feb 25; 35(8):3384-96. Kawabori M, Kacimi R, Kauppinen T, Calosing C, Kim JY, Hsieh CL, Nakamura MC, Yenari MA. PMID: 25716838; PMCID: PMC4339351.
      View in: PubMed   Mentions: 171     Fields:    Translation:AnimalsCells
    12. CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury. J Neurotrauma. 2014 Oct 15; 31(20):1677-88. Hsieh CL, Niemi EC, Wang SH, Lee CC, Bingham D, Zhang J, Cozen ML, Charo I, Huang EJ, Liu J, Nakamura MC. PMID: 24806994; PMCID: PMC4545982.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    13. Triggering Receptor Expressed on Myeloid Cells-2 Correlates to Hypothermic Neuroprotection in Ischemic Stroke. Ther Hypothermia Temp Manag. 2013 Dec 01; 3(4):189-198. Kawabori M, Hokari M, Zheng Z, Kim JY, Calosing C, Hsieh CL, Nakamura MC, Yenari MA. PMID: 24380032; PMCID: PMC3868297.
      View in: PubMed   Mentions: 20     Fields:    
    14. Traumatic brain injury induces macrophage subsets in the brain. Eur J Immunol. 2013 Aug; 43(8):2010-22. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. PMID: 23630120; PMCID: PMC4210355.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    15. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem. 2009 May; 109(4):1144-56. Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE. PMID: 19302484; PMCID: PMC3087597.
      View in: PubMed   Mentions: 224     Fields:    Translation:AnimalsCells
    16. NKp30 is a functional activation receptor on a subset of rat natural killer cells. Eur J Immunol. 2006 Aug; 36(8):2170-80. Hsieh CL, Nagasaki K, Martinez OM, Krams SM. PMID: 16821237; PMCID: PMC4084722.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    17. IFN-gamma, produced by NK cells that infiltrate liver allografts early after transplantation, links the innate and adaptive immune responses. Am J Transplant. 2005 Sep; 5(9):2094-103. Obara H, Nagasaki K, Hsieh CL, Ogura Y, Esquivel CO, Martinez OM, Krams SM. PMID: 16095488; PMCID: PMC1473982.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    18. Identification, cloning, and characterization of a novel rat natural killer receptor, RNKP30: a molecule expressed in liver allografts. Transplantation. 2004 Jan 15; 77(1):121-8. Hsieh CL, Ogura Y, Obara H, Ali UA, Rodriguez GM, Nepomuceno RR, Martinez OM, Krams SM. PMID: 14724446.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    19. Targeted gene replacement of a ferredoxin gene in Trichomonas vaginalis does not lead to metronidazole resistance. Mol Microbiol. 2004 Jan; 51(1):115-22. Land KM, Delgadillo-Correa MG, Tachezy J, Vanacova S, Hsieh CL, Sutak R, Johnson PJ. PMID: 14651615.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    20. Unprocessed Toxoplasma ROP1 is effectively targeted and secreted into the nascent parasitophorous vacuole. Mol Biochem Parasitol. 2002 Nov-Dec; 125(1-2):189-93. Bradley PJ, Hsieh CL, Boothroyd JC. PMID: 12467986.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    21. NK cells and transplantation. Transpl Immunol. 2002 May; 9(2-4):111-4. Hsieh CL, Obara H, Ogura Y, Martinez OM, Krams SM. PMID: 12180816.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
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