Christopher Allen, PhD
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Title(s) | Associate Professor, Cardiovascular Research Inst |
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School | School of Medicine |
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Address | 555 Mission Bay Blvd South San Francisco CA 94158
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Phone | 415-476-5178 |
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ORCID
.gif) | 0000-0002-1879-9047  |
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vCard | Download vCard |
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Biography University of California, San Francisco, CA | Ph.D. | 2007 | Graduate Division (Biomedical Sciences) | University of California, San Francisco, CA | | 12/2020 | Diversity, Equity, and Inclusion Champion Training |
| 2012
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| 2017 | NIH Director's New Innovator Award | | 2016 | | Pew Scholar in the Biomedical Sciences |
Overview My laboratory is interested in the cellular communication and differentiation programs in allergic immune responses, particularly in asthma. My laboratory is applying sophisticated imaging, flow cytometry, mouse genetics, and other techniques to uncover novel paradigms underlying allergic inflammation. As a major area of emphasis, we are studying the generation and function of IgE antibodies that initiate allergic inflammation. We generated fluorescent IgE reporter mice and allowing us to identify and track rare IgE-producing B cells in vivo. We also optimized a flow cytometry procedure to identify rare IgE-producing B cells in both mouse and human samples, facilitating mechanistic studies. Our work has revealed that the IgE B cell receptor exhibits antigen (ligand)-independent signaling that promotes plasma cell differentiation and limits IgE germinal center B cell responses. We are also imaging the lungs and associated lymphoid tissues by two-photon laser scanning microscopy to directly visualize cellular interactions in situ. Using this approach, we achieved the first in vivo analysis of the interactions of CD4 T cells with basophils, which are rare IgE effector cells. We are now analyzing the interactions of basophils with other cell types during secondary immune responses to further elucidate the functions of these cells. More broadly, we are considering the combined cellular interactions among various types of inflammatory cells in the lungs in mouse models of asthma.
Research ORNG Applications Bibliographic
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IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells. J Exp Med. 2020 05 04; 217(5).
Yang Z, Wu CM, Targ S, Allen CDC. PMID: 32130409.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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B Cell Responses: Cell Interaction Dynamics and Decisions. Cell. 2019 04 18; 177(3):524-540.
Cyster JG, Allen CDC. PMID: 31002794.
View in: PubMed Mentions: 33 Fields: Translation: HumansAnimalsCells
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A case of mistaken identity: The MAR-1 antibody to mouse FcεRIα cross-reacts with FcγRI and FcγRIV. J Allergy Clin Immunol. 2019 04; 143(4):1643-1646.e6.
Tang XZ, Jung JB, Allen CDC. PMID: 30639345.
View in: PubMed Mentions: 5 Fields: Translation: AnimalsCells
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Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins. J Immunol Methods. 2018 06; 457:33-40.
Wu CM, Roth TL, Baglaenko Y, Ferri DM, Brauer P, Zuniga-Pflucker JC, Rosbe KW, Wither JE, Marson A, Allen CDC. PMID: 29614266.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
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Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration. Dev Biol. 2018 12 01; 444 Suppl 1:S252-S261.
Genuth MA, Allen CDC, Mikawa T, Weiner OD. PMID: 29501457.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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The Affinity of IgE for Antigen is a Primary Determinant of Basophil Activation. Journal of Allergy and Clinical Immunology. 2018 Feb 1; 141(2):ab191.
James B. Jung, Christopher D.C. Allen. .
View in: Publisher Site Mentions:
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Study of IgE-Producing B Cells Using the Verigem Fluorescent Reporter Mouse. Methods Mol Biol. 2018; 1799:247-264.
Yang Z, Jung JB, Allen CDC. PMID: 29956157.
View in: PubMed Mentions: Fields: Translation: AnimalsCellsPHPublic Health
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Expression of Exogenous Genes in Murine Primary B Cells and B Cell Lines Using Retroviral Vectors. Methods Mol Biol. 2018; 1707:39-49.
Yang Z, Allen CDC. PMID: 29388098.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells. J Exp Med. 2017 03 06; 214(3):639-649.
Laidlaw BJ, Schmidt TH, Green JA, Allen CD, Okada T, Cyster JG. PMID: 28143955.
View in: PubMed Mentions: 19 Fields: Translation: AnimalsCells
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IL-4 Haploinsufficiency Specifically Impairs IgE Responses against Allergens in Mice. J Immunol. 2017 03 01; 198(5):1815-1822.
Robinson MJ, Prout M, Mearns H, Kyle R, Camberis M, Forbes-Blom EE, Paul WE, Allen CD, Le Gros G. PMID: 28115531.
View in: PubMed Mentions: 5 Fields: Translation: AnimalsCells
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Regulation of B cell fate by chronic activity of the IgE B cell receptor. Elife. 2016 12 09; 5.
Yang Z, Robinson MJ, Chen X, Smith GA, Taunton J, Liu W, Allen CD. PMID: 27935477.
View in: PubMed Mentions: 13 Fields: Translation: AnimalsCells
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Germinal center quality control: death by Fas. Immunity. 2015 May 19; 42(5):783-5.
Allen CD. PMID: 25992852.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. The Journal of Cell Biology. 2015 Mar 30; 208(7):2087oia41.
Laurence E. Cheng, Brandon M. Sullivan, Lizett E. Retana, Christopher D.C. Allen, Hong-Erh Liang, Richard M. Locksley. .
View in: Publisher Site Mentions:
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IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015 Apr 06; 212(4):513-24.
Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM. PMID: 25779634.
View in: PubMed Mentions: 16 Fields: Translation: AnimalsCells
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Regulatory constraints in the generation and differentiation of IgE-expressing B cells. Curr Opin Immunol. 2014 Jun; 28:64-70.
Yang Z, Robinson MJ, Allen CD. PMID: 24632082.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection. Immunity. 2013 Dec 1; 39(6):1182.
Oliver Bannard, Robert M. Horton, Christopher D.C. Allen, Jinping An, Takashi Nagasawa, Jason G. Cyster. .
View in: Publisher Site Mentions:
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Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection. Immunity. 2013 Nov 14; 39(5):912-24.
Bannard O, Horton RM, Allen CD, An J, Nagasawa T, Cyster JG. PMID: 24184055.
View in: PubMed Mentions: 68 Fields: Translation: AnimalsCells
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Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition. Immunity. 2012 May 25; 36(5):857-72.
Yang Z, Sullivan BM, Allen CD. PMID: 22406270.
View in: PubMed Mentions: 55 Fields: Translation: AnimalsCells
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MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells. Immunity. 2011 Aug 26; 35(2):169-81.
Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD, Matloubian M, Blelloch R, Ansel KM. PMID: 21820330.
View in: PubMed Mentions: 122 Fields: Translation: AnimalsCells
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The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol. 2011 Jun 05; 12(7):672-80.
Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CD, Schmidt TH, Xu Y, Proia RL, Coughlin SR, Cyster JG. PMID: 21642988.
View in: PubMed Mentions: 78 Fields: Translation: AnimalsCells
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B cells within germinal centers migrate preferentially from dark to light zone. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8755-60.
Beltman JB, Allen CD, Cyster JG, de Boer RJ. PMID: 21555569.
View in: PubMed Mentions: 17 Fields: Translation: HumansCells
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Genetic analysis of basophil function in vivo. Nat Immunol. 2011 Jun; 12(6):527-35.
Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM. PMID: 21552267.
View in: PubMed Mentions: 101 Fields: Translation: HumansAnimalsCells
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Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function. Semin Immunol. 2008 Feb; 20(1):14-25.
Allen CD, Cyster JG. PMID: 18261920.
View in: PubMed Mentions: 126 Fields: Translation: HumansAnimalsCells
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Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol. 2007 Oct 15; 179(8):5099-108.
Haynes NM, Allen CD, Lesley R, Ansel KM, Killeen N, Cyster JG. PMID: 17911595.
View in: PubMed Mentions: 270 Fields: Translation: AnimalsCells
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Germinal-center organization and cellular dynamics. Immunity. 2007 Aug; 27(2):190-202.
Allen CD, Okada T, Cyster JG. PMID: 17723214.
View in: PubMed Mentions: 311 Fields: Translation: HumansAnimalsCells
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Imaging of germinal center selection events during affinity maturation. Science. 2007 Jan 26; 315(5811):528-31.
Allen CD, Okada T, Tang HL, Cyster JG. PMID: 17185562.
View in: PubMed Mentions: 265 Fields: Translation: AnimalsCells
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TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med. 2005 Oct 03; 202(7):955-65.
Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR. PMID: 16203866.
View in: PubMed Mentions: 73 Fields: Translation: AnimalsCells
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Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol. 2004 Sep; 5(9):943-52.
Allen CD, Ansel KM, Low C, Lesley R, Tamamura H, Fujii N, Cyster JG. PMID: 15300245.
View in: PubMed Mentions: 232 Fields: Translation: AnimalsCells
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Year | Publications |
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2004 | 1 | 2005 | 1 | 2006 | 1 | 2007 | 2 | 2008 | 1 | 2011 | 4 | 2012 | 1 | 2013 | 2 | 2014 | 1 | 2015 | 3 | 2016 | 1 | 2017 | 2 | 2018 | 5 | 2019 | 2 | 2020 | 1 |
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