Christopher Waddling, PhD

TitleEmployee of Contracting Firm
InstitutionUniversity of California San Francisco
DepartmentBiochemistry and Biophysics
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    Collapse Biography 
    Collapse Awards and Honors
    University of California, San Francisco2011Chancellor's Award for GLBT Leadership
    University of California, San Francisco2014Chancellor's Award for Public Service

    Collapse Overview 
    Collapse Overview
    • Experienced in project management including: work plan development; problem solving; personnel management; and complex coordination of, and consensus building with, internal and external parties
    • Skilled at taking projects from planning to implementation
    • Experienced in resource allocation and management of sizable operating budgets
    • Advocate for funding and resources to maintain the crystallography group's competitive edge
    • Graduate-level educator
    • Authored successful collaborative grant applications that secured core lab equipment and salary funding
    • Facilitate networking between local crystallographers
    • Maintain comprehensive and detailed website for both the MSG and the Crystallography lab, which includes instructional and safety videos, links to the latest software, and information on the latest techniques
    • Rapid response to queries and calls for assistance
    • Experienced crystallographer with skills in screening; optimization; data collection (including SAD and MAD); structure solution and refinement; analysis of structural and functional properties of proteins and the exploration of small molecule inhibitors, ligands and targets of interest
    • Ability to be detail oriented while remaining to see the bigger picture


    Laboratory management; instrument maintenance; grant writing; crystallography (crystallization, optimization, data collection - rotating anode and synchrotron - ultra high-resolution protein structure solution and analysis); software maintenance; project management; budget and purchasing; teaching complex subjects; public speaking; web site design and maintenance; networking.


    Responsible for day-to-day management of a 150-client, 30-lab supported core facility with an annual operating budget of over $250000; annually teaching two graduate-level courses; grant writing; policy making; software and equipment; contributing to crystallography research efforts at UCSF.


    · X-ray Facility Management: management and policy initiatives and improvements quadrupled the UCSF Crystallography Facility client base; positively impacted the learning environment and quality of scientific study; increased Facility throughput; directed grant applications for new equipment and salary support; implemented acquisition of state-of-the-art technological advances; managed cooperative agreements with private sector; maintain Crystallography Facility equipment, software, and web site.
    · Teaching and Training: Initiated, developed, and teach the practical section of two graduate-level crystallography courses; developed and filmed an iBioSeminars online lecture course; on-going training of all users of our facility at UCSF and at the Advanced Light Source at the Lawrence Berkeley National Labs.
    - Maintain relationships with equipment and software specialists in crystallography to remain current with the state of the art in our and related fields
    · Research: experienced in protein crystallization, optimization and data collection, refinement, and structure solution; experienced at analyzing the structural and functional properties of proteins and exploring their interactions with ligands, inhibitors, and therapeutic small molecules.
    · Experienced user of the ALS synchrotron beamlines (SAD, MAD) and rotating anode x-ray equipment


    08/2008 – 08/2009 QB3 UCSF 08-09 R1 Award, Fund 09515/DPA 555262, PI: David Agard
    Salary support for James Holton (UCSF/ALS) and Chris Waddling (UCSF) $75,000
    04/2006 – 04/2007 NIH Shared Instrument Grant, S10 RR0222322, PI: Robert Fletterick
    Role: Grant coordination, consultant, and equipment staff person $280,353

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Madrona Y, Waddling CA, Ortiz de Montellano PR. Crystal structures of the CO and NOBound DosS GAF-A domain and implications for DosS signaling in Mycobacterium tuberculosis. Arch Biochem Biophys. 2016 Dec 15; 612:1-8. PMID: 27729224.
      View in: PubMed
    2. Frank DJ, Waddling CA, La M, Ortiz de Montellano PR. Cytochrome P450 125A4, the Third Cholesterol C-26 Hydroxylase from Mycobacterium smegmatis. Biochemistry. 2015 Nov 24; 54(46):6909-16. PMID: 26522442; PMCID: PMC4660985 [Available on 11/01/16].
    3. Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS. Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry. 2014 Jul 22; 53(28):4648-60. PMID: 24977643; PMCID: PMC4108181.
    4. Kraemer JA, Erb ML, Waddling CA, Montabana EA, Zehr EA, Wang H, Nguyen K, Pham DS, Agard DA, Pogliano J. A phage tubulin assembles dynamic filaments by an atypical mechanism to center viral DNA within the host cell. Cell. 2012 Jun 22; 149(7):1488-99. PMID: 22726436; PMCID: PMC3401054.
    5. Christopher A. Waddling Roger Cramer.Journal of Inclusion Phenomena and Macrocyclic Chemistry. Crystal structures of the dinitrate-bis-(acetylenedicarboxylate) and acetylenedicarboxylate pseudorotaxane complexes of [24-pyrimidinium crown 6]. 2008; (60):1-8.
    6. Van Roey P, Waddling CA, Fox KM, Belfort M, Derbyshire V. Intertwined structure of the DNA-binding domain of intron endonuclease I-TevI with its substrate. EMBO J. 2001 Jul 16; 20(14):3631-7. PMID: 11447104; PMCID: PMC125541.
    7. Almog R, Waddling CA, Maley F, Maley GF, Van Roey P. Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP. Protein Sci. 2001 May; 10(5):988-96. PMID: 11316879; PMCID: PMC2374201.
    8. Waddling CA, Plummer TH, Tarentino AL, Van Roey P. Structural basis for the substrate specificity of endo-beta-N-acetylglucosaminidase F(3). Biochemistry. 2000 Jul 11; 39(27):7878-85. PMID: 10891067.
      View in: PubMed
    9. El Sayed KA, Hamann MT, Waddling CA, Jensen C, Lee SK, Dunstan CA, Pezzuto JM. Structurally Novel Bioconversion Products of the Marine Natural Product Sarcophine Effectively Inhibit JB6 Cell Transformation. J Org Chem. 1998 Oct 16; 63(21):7449-7455. PMID: 11672397.
      View in: PubMed
    10. Khalid A. El Sayed Mark Hamann Christopher A. Waddling Craig Jensen Sang Kook Lee John M. Pezzuto Christina Andersson Dunstan .Journal of Organic Chemistry. Structurally novel bioconversion products of the marine natural product sarcophine effectively inhibit JB6 cell transformation. 1998; 21(63):7449-7455.
    11. Christopher A. Waddling Cy Fujimoto David Smith K. E. Kim Roger Cramer.Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry. Crystal structures of the nitrate salt of 24-pyrimidinium crown 6 {5,12,19,26,33,40-hexaamino-3,10,17,24,31,38-hexamethyl[1.6](1,5)pyrimidiniophane} and its degradation product in water-methanol mixtures. 1997; 1675-84.
    12. Christopher A. Waddling Yizeng Ni Mong Liang Ian Manners Peter Park Jason Massey .Macromolecules. Polymers with Sulfur(VI)-Nitrogen-Phosphorus Backbones: Synthesis, Characterization, and Properties of Atactic Poly[(amino)thionylphosphazenes]. 1996; 10(29):3401-8.
    13. Christopher A. Waddling Donal H. Macartney .Inorganic Chemistry. Kinetic and Spectroscopic Studies on Pentacyano(N-heterocycle)ferrate(II) Rotaxanes of a-Cyclodextrin with Symmetric and Asymmetric Threads. 1994; 33(25):5912-19.
    14. Christopher A. Waddling Keith J Kutchcoskie Sam Suppiah.Studies in Surface Science and Catalysis. Catalytic elimination of organics over noble metal catalysts deposited on metal structures of low mass. 1992; 187-96.
    15. Christopher A. Waddling Mong Liang Ian A. Manners Daniel Foucher Charles Honeyman.Phosphorus, Sulfur and Silicon and the Related Elements. Ring-opening polymerization as a route to new inorganic macromolecules. 1992; 113-20.
    16. Christopher A. Waddling Mong Liang Ian A. Manners.Polymer Preprints. Poly(thionylphosphazenes); a new class of inorganic polymers with skeletal phosphorus, nitrogen, and sulfur(VI) atoms. 1991.