Claire O'Leary, PhD

Title(s)Postdoctoral Scholar, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB
San Francisco CA 94117
Phone415-476-1550
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    Collapse Biography 
    Collapse Education and Training
    University of Wisconsin - Madison, Madison, WIBA04/2009Molecular Biology, Spanish
    University of Pennsylvania, Philadelphia, PAPhD12/2015Cell and Molecular Biology - Immunology

    Collapse Research 
    Collapse Research Activities and Funding
    Development and Function of Biliary Tuft Cells
    NIH F32DK121476Apr 1, 2020 - Mar 31, 2022
    Role: Principal Investigator
    Ndfip2 limits Th17 pathogenicity to attenuate colitis-associated colon cancer
    NIH F31CA180300Jul 1, 2013 - Jun 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Interrogating the Small Intestine Tuft Cell-ILC2 Circuit Using In Vivo Manipulations. Curr Protoc. 2021 Mar; 1(3):e77. O'Leary CE, Feng X, Cortez VS, Locksley RM, Schneider C. PMID: 33740294.
      View in: PubMed   Mentions:
    2. An Integrated Strategy for Identifying Targets of Ubiquitin-Mediated Degradation in CD4+ T Cells. Methods Mol Biol. 2020; 2111:239-256. Field NS, O'Leary CE, Dybas JM, Ding H, Oliver PM. PMID: 31933212.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    3. Regulation of immune responses by tuft cells. Nat Rev Immunol. 2019 09; 19(9):584-593. Schneider C, O'Leary CE, Locksley RM. PMID: 31114038.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    4. Integrative proteomics reveals an increase in non-degradative ubiquitylation in activated CD4+ T cells. Nat Immunol. 2019 06; 20(6):747-755. Dybas JM, O'Leary CE, Ding H, Spruce LA, Seeholzer SH, Oliver PM. PMID: 31061531.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    5. Tuft Cells-Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry. Annu Rev Immunol. 2019 04 26; 37:47-72. O'Leary CE, Schneider C, Locksley RM. PMID: 30379593.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    6. A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling. Cell. 2018 07 12; 174(2):271-284.e14. Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM. PMID: 29887373.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    7. Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy. Brain. 2018 01 01; 141(1):99-116. Holley RJ, Ellison SM, Fil D, O'Leary C, McDermott J, Senthivel N, Langford-Smith AWW, Wilkinson FL, D'Souza Z, Parker H, Liao A, Rowlston S, Gleitz HFE, Kan SH, Dickson PI, Bigger BW. PMID: 29186350.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    8. Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease. Nat Commun. 2017 06 05; 8:15677. Layman AAK, Deng G, O'Leary CE, Tadros S, Thomas RM, Dybas JM, Moser EK, Wells AD, Doliba NM, Oliver PM. PMID: 28580955.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    9. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. J Exp Med. 2017 01; 214(1):27-37. von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM. PMID: 28011865.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    10. Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells. Nat Commun. 2016 Apr 18; 7:11226. O'Leary CE, Riling CR, Spruce LA, Ding H, Kumar S, Deng G, Liu Y, Seeholzer SH, Oliver PM. PMID: 27088444.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    11. Ubiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global Profiling. Front Immunol. 2015; 6:618. O'Leary CE, Lewis EL, Oliver PM. PMID: 26732666.
      View in: PubMed   Mentions: 6     Fields:    
    12. Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation. J Biol Chem. 2015 Sep 25; 290(39):23875-87. Riling C, Kamadurai H, Kumar S, O'Leary CE, Wu KP, Manion EE, Ying M, Schulman BA, Oliver PM. PMID: 26245901.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    13. CD11b+Ly6G+ cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis. Oncoimmunology. 2016; 5(1):e1061175. Liu Y, O'Leary CE, Wang LS, Bhatti TR, Dai N, Kapoor V, Liu P, Mei J, Guo L, Oliver PM, Albelda SM, Worthen GS. PMID: 26942073.
      View in: PubMed   Mentions:
    14. The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice. Nat Med. 2014 May; 20(5):524-30. Deshmukh HS, Liu Y, Menkiti OR, Mei J, Dai N, O'Leary CE, Oliver PM, Kolls JK, Weiser JN, Worthen GS. PMID: 24747744.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    15. Major histocompatibility complex genotyping with massively parallel pyrosequencing. Nat Med. 2009 Nov; 15(11):1322-6. Wiseman RW, Karl JA, Bimber BN, O'Leary CE, Lank SM, Tuscher JJ, Detmer AM, Bouffard P, Levenkova N, Turcotte CL, Szekeres E, Wright C, Harkins T, O'Connor DH. PMID: 19820716.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    16. Identification of novel MHC class I sequences in pig-tailed macaques by amplicon pyrosequencing and full-length cDNA cloning and sequencing. Immunogenetics. 2009 Oct; 61(10):689-701. O'Leary CE, Wiseman RW, Karl JA, Bimber BN, Lank SM, Tuscher JJ, O'Connor DH. PMID: 19777225.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
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