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Connie John, PhD

Title(s)Associate Professor, Laboratory Medicine
SchoolSchool of Medicine
Phone415-221-4810 ext. 3788
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1990 Graduate Division (Pharmaceutical Chemistry)
    Collapse Awards and Honors
    Reproduction - The official journal of the Society for Reproduction and Fertility2018SRF-Reproduction prize

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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. John CM, Feng D, Jarvis GA. Treatment of human challenge and MDR strains of Neisseria gonorrhoeae with LpxC inhibitors. J Antimicrob Chemother. 2018 Aug 01; 73(8):2064-2071. PMID: 29726994.
      View in: PubMed
    2. Brunner K, John CM, Phillips NJ, Alber DG, Gemmell MR, Hansen R, Nielsen HL, Hold GL, Bajaj-Elliott M, Jarvis GA. Novel Campylobacter concisus lipooligosaccharide is a determinant of inflammatory potential and virulence. J Lipid Res. 2018 Oct; 59(10):1893-1905. PMID: 30049709.
      View in: PubMed
    3. Gaur M, Ramathal C, Reijo Pera RA, Turek PJ, John CM. Isolation of human testicular cells and co-culture with embryonic stem cells. Reproduction. 2018 02; 155(2):153-166. PMID: 29326135.
      View in: PubMed
    4. Chen H, Gao Y, Mruk DD, Xiao X, John CM, Turek PJ, Lui WY, Lee WM, Silvestrini B, Cheng CY. Rescue of PFOS-induced human Sertoli cell injury by overexpressing a p-FAK-Y407E phosphomimetic mutant. Sci Rep. 2017 Nov 17; 7(1):15810. PMID: 29150642.
      View in: PubMed
    5. John CM, Phillips NJ, Stein DC, Jarvis GA. Innate immune response to lipooligosaccharide: pivotal regulator of the pathobiology of invasive Neisseria meningitidis infections. Pathog Dis. 2017 Apr 01; 75(3). PMID: 28423169.
      View in: PubMed
    6. Anandan A, Evans GL, Condic-Jurkic K, O'Mara ML, John CM, Phillips NJ, Jarvis GA, Wills SS, Stubbs KA, Moraes I, Kahler CM, Vrielink A. Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2218-2223. PMID: 28193899.
      View in: PubMed
    7. Phillips NJ, John CM, Jarvis GA. Analysis of Bacterial Lipooligosaccharides by MALDI-TOF MS with Traveling Wave Ion Mobility. J Am Soc Mass Spectrom. 2016 07; 27(7):1263-76. PMID: 27056565.
      View in: PubMed
    8. John CM, Phillips NJ, Din R, Liu M, Rosenqvist E, Høiby EA, Stein DC, Jarvis GA. Lipooligosaccharide Structures of Invasive and Carrier Isolates of Neisseria meningitidis Are Correlated with Pathogenicity and Carriage. J Biol Chem. 2016 Feb 12; 291(7):3224-38. PMID: 26655715; PMCID: PMC4751370 [Available on 02/12/17].
    9. Xiao X, Mruk DD, Tang EI, Wong CK, Lee WM, John CM, Turek PJ, Silvestrini B, Cheng CY. Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins. Hum Reprod. 2014 Jun; 29(6):1279-91. PMID: 24532171; PMCID: PMC4017941.
    10. Liu M, John CM, Jarvis GA. Induction of endotoxin tolerance by pathogenic Neisseria is correlated with the inflammatory potential of lipooligosaccharides and regulated by microRNA-146a. J Immunol. 2014 Feb 15; 192(4):1768-77. PMID: 24442429.
      View in: PubMed
    11. Stephenson HN, John CM, Naz N, Gundogdu O, Dorrell N, Wren BW, Jarvis GA, Bajaj-Elliott M. Campylobacter jejuni lipooligosaccharide sialylation, phosphorylation, and amide/ester linkage modifications fine-tune human Toll-like receptor 4 activation. J Biol Chem. 2013 Jul 05; 288(27):19661-72. PMID: 23629657; PMCID: PMC3707672.
    12. Dovizio M, Maier TJ, Alberti S, Di Francesco L, Marcantoni E, Münch G, John CM, Suess B, Sgambato A, Steinhilber D, Patrignani P. Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells. Mol Pharmacol. 2013 Jul; 84(1):25-40. PMID: 23580446.
      View in: PubMed
    13. Bingham D, John CM, Levin J, Panter SS, Jarvis GA. Post-injury conditioning with lipopolysaccharide or lipooligosaccharide reduces inflammation in the brain. J Neuroimmunol. 2013 Mar 15; 256(1-2):28-37. PMID: 23333234.
      View in: PubMed
    14. John CM, Liu M, Phillips NJ, Yang Z, Funk CR, Zimmerman LI, Griffiss JM, Stein DC, Jarvis GA. Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals. Infect Immun. 2012 Nov; 80(11):4014-26. PMID: 22949553.
      View in: PubMed
    15. Cheng H, Yang Z, Estabrook MM, John CM, Jarvis GA, McLaughlin S, Griffiss JM. Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure. J Biol Chem. 2011 Dec 23; 286(51):43622-33. PMID: 22027827.
      View in: PubMed
    16. Mirandola L, Yu Y, Jenkins MR, Chiaramonte R, Cobos E, John CM, Chiriva-Internati M. Tracking human multiple myeloma xenografts in NOD-Rag-1/IL-2 receptor gamma chain-null mice with the novel biomarker AKAP-4. BMC Cancer. 2011 Sep 16; 11:394. PMID: 21923911; PMCID: PMC3189930.
    17. Mirandola L, Yu Y, Chui K, Jenkins MR, Cobos E, John CM, Chiriva-Internati M. Galectin-3C inhibits tumor growth and increases the anticancer activity of bortezomib in a murine model of human multiple myeloma. PLoS One. 2011; 6(7):e21811. PMID: 21765917; PMCID: PMC3135605.
    18. Bingham D, John CM, Panter SS, Jarvis GA. Post-injury treatment with lipopolysaccharide or lipooligosaccharide protects rat neuronal and glial cell cultures. Brain Res Bull. 2011 Jul 15; 85(6):403-9. PMID: 21571046.
      View in: PubMed
    19. Chui K, Trivedi A, Cheng CY, Cherbavaz DB, Dazin PF, Huynh AL, Mitchell JB, Rabinovich GA, Noble-Haeusslein LJ, John CM. Characterization and functionality of proliferative human Sertoli cells. Cell Transplant. 2011; 20(5):619-35. PMID: 21054948; PMCID: PMC4096632.
    20. Liu M, John CM, Jarvis GA. Phosphoryl moieties of lipid A from Neisseria meningitidis and N. gonorrhoeae lipooligosaccharides play an important role in activation of both MyD88- and TRIF-dependent TLR4-MD-2 signaling pathways. J Immunol. 2010 Dec 01; 185(11):6974-84. PMID: 21037101; PMCID: PMC3059745.
    21. Bogoeva VP, Varriale A, John CM, D'Auria S. Human galectin-3 interacts with two anticancer drugs. Proteomics. 2010 May; 10(10):1946-53. PMID: 20209510.
      View in: PubMed
    22. D'Auria S, Petrova L, John C, Russev G, Varriale A, Bogoeva V. Tumor-specific protein human galectin-1 interacts with anticancer agents. Mol Biosyst. 2009 Nov; 5(11):1331-6. PMID: 19823749.
      View in: PubMed
    23. John CM, Liu M, Jarvis GA. Natural phosphoryl and acyl variants of lipid A from Neisseria meningitidis strain 89I differentially induce tumor necrosis factor-alpha in human monocytes. J Biol Chem. 2009 Aug 07; 284(32):21515-25. PMID: 19531474; PMCID: PMC2755876.
    24. John CM, Liu M, Jarvis GA. Profiles of structural heterogeneity in native lipooligosaccharides of Neisseria and cytokine induction. J Lipid Res. 2009 Mar; 50(3):424-38. PMID: 18832773; PMCID: PMC2638105.
    25. Boyd BS, Puttlitz C, Noble-Haeusslein LJ, John CM, Trivedi A, Topp KS. Deviations in gait pattern in experimental models of hindlimb paresis shown by a novel pressure mapping system. J Neurosci Res. 2007 Aug 01; 85(10):2272-83. PMID: 17539027.
      View in: PubMed
    26. Trivedi AA, Igarashi T, Compagnone N, Fan X, Hsu JY, Hall DE, John CM, Noble-Haeusslein LJ. Suitability of allogeneic sertoli cells for ex vivo gene delivery in the injured spinal cord. Exp Neurol. 2006 Mar; 198(1):88-100. PMID: 16387298.
      View in: PubMed
    27. Pridmore AC, Jarvis GA, John CM, Jack DL, Dower SK, Read RC. Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains. Infect Immun. 2003 Jul; 71(7):3901-8. PMID: 12819075; PMCID: PMC161978.
    28. John CM, Leffler H, Kahl-Knutsson B, Svensson I, Jarvis GA. Truncated galectin-3 inhibits tumor growth and metastasis in orthotopic nude mouse model of human breast cancer. Clin Cancer Res. 2003 Jun; 9(6):2374-83. PMID: 12796408.
      View in: PubMed
    29. John CM, Jarvis GA, Swanson KV, Leffler H, Cooper MD, Huflejt ME, Griffiss JM. Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected. Cell Microbiol. 2002 Oct; 4(10):649-62. PMID: 12366402.
      View in: PubMed
    30. John CM, Schneider H, Griffiss JM. Neisseria gonorrhoeae that infect men have lipooligosaccharides with terminal N-acetyllactosamine repeats. J Biol Chem. 1999 Jan 08; 274(2):1017-25. PMID: 9873046.
      View in: PubMed
    31. Crooke H, Griffiss JM, John CM, Lissenden S, Bramley J, Regan T, Smith H, Cole J. Characterization of a sialyltransferase-deficient mutant of Neisseria gonorrhoeae strain F62: instability of transposon Tn1545 delta3 in gonococci and evidence that multiple genetic loci are essential for lipooligosaccharide sialylation. Microb Pathog. 1998 Nov; 25(5):237-52. PMID: 9878453.
      View in: PubMed
    32. John CM, Odom RW, Salvati L, Annapragada A, Fu Lu MY. XPS and TOF-SIMS microanalysis of a peptide/polymer drug delivery device. Anal Chem. 1995 Nov 01; 67(21):3871-8. PMID: 8633755.
      View in: PubMed
    33. John CM, Griffiss JM, Apicella MA, Mandrell RE, Gibson BW. The structural basis for pyocin resistance in Neisseria gonorrhoeae lipooligosaccharides. J Biol Chem. 1991 Oct 15; 266(29):19303-11. PMID: 1918047.
      View in: PubMed
    34. Mandrell RE, Kim JJ, John CM, Gibson BW, Sugai JV, Apicella MA, Griffiss JM, Yamasaki R. Endogenous sialylation of the lipooligosaccharides of Neisseria meningitidis. J Bacteriol. 1991 May; 173(9):2823-32. PMID: 1708379.
      View in: PubMed
    35. Phillips NJ, John CM, Reinders LG, Gibson BW, Apicella MA, Griffiss JM. Structural models for the cell surface lipooligosaccharides of Neisseria gonorrhoeae and Haemophilus influenzae. Biomed Environ Mass Spectrom. 1990 Nov; 19(11):731-45. PMID: 2127548.
      View in: PubMed
    36. John CM, Gibson BW. Amino and hydrazino alkyl benzoates as derivatizing agents for the separation and mass spectrometric analysis of oligosaccharides from bacterial lipooligosaccharides. Anal Biochem. 1990 Jun; 187(2):281-91. PMID: 2200308.
      View in: PubMed