Constance John, PhD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
AddressLocation Required, #001
Varies CA 00000
Phone415-221-4810 ext. 3788
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1990 Graduate Division (Pharmaceutical Chemistry)
    Collapse Awards and Honors
    Reproduction - The official journal of the Society for Reproduction and Fertility2018SRF-Reproduction prize

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation. mBio. 2024 Apr 09; e0011924. Cardenas AJ, Thomas KS, Broden MW, Ferraro NJ, Pires MM, John CM, Jarvis GA, Criss AK. PMID: 38587424.
      View in: PubMed   Mentions:
    2. Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation. bioRxiv. 2024 Jan 18. Cardenas AJ, Thomas KS, Broden MW, Ferraro NJ, John CM, Pires MM, Jarvis GA, Criss AK. PMID: 38293026; PMCID: PMC10827150.
      View in: PubMed   Mentions:
    3. Inhibition of galectin-3 post-infarction impedes progressive fibrosis by regulating inflammatory profibrotic cascades. Cardiovasc Res. 2023 11 25; 119(15):2536-2549. Wang X, Gaur M, Mounzih K, Rodriguez HJ, Qiu H, Chen M, Yan L, Cooper BA, Narayan S, Derakhshandeh R, Rao P, Han DD, Nabavizadeh P, Springer ML, John CM. PMID: 37602717; PMCID: PMC10676456.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    4. Comparison of lipooligosaccharides from human challenge strains of Neisseria gonorrhoeae. Front Microbiol. 2023; 14:1215946. John CM, Phillips NJ, Cardenas AJ, Criss AK, Jarvis GA. PMID: 37779694; PMCID: PMC10540682.
      View in: PubMed   Mentions: 1  
    5. Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase. J Antimicrob Chemother. 2022 08 25; 77(9):2441-2447. Mullally C, Stubbs KA, Thai VC, Anandan A, Bartley S, Scanlon MJ, Jarvis GA, John CM, Lim KYL, Sullivan CM, Sarkar-Tyson M, Vrielink A, Kahler CM. PMID: 35770844; PMCID: PMC9410672.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. Roles of Spermatogonial Stem Cells in Spermatogenesis and Fertility Restoration. Front Endocrinol (Lausanne). 2022; 13:895528. Diao L, Turek PJ, John CM, Fang F, Reijo Pera RA. PMID: 35634498; PMCID: PMC9135128.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    7. Predominant phosphorylation patterns in Neisseria meningitidis lipid A determined by top-down MS/MS. J Lipid Res. 2020 11; 61(11):1437-1449. John CM, Phillips NJ, Jarvis GA. PMID: 32839198; PMCID: PMC7604717.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    8. The chimera-type galectin-3 is a positive modulator of trophoblast functions with dysregulated expression in gestational diabetes mellitus. Am J Reprod Immunol. 2020 12; 84(6):e13311. Freitag N, Tirado-González I, Barrientos G, Cohen M, Daher S, Goldman-Wohl D, Mincheva-Nilsson L, John CM, Jeschke U, Blois SM. PMID: 32691950.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    9. Cationic cell-penetrating peptide is bactericidal against Neisseria gonorrhoeae. J Antimicrob Chemother. 2019 11 01; 74(11):3245-3251. John CM, Li M, Feng D, Jarvis GA. PMID: 31424547.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    10. Spiral steroids as potential markers for pre-eclampsia: A pilot study. Steroids. 2019 11; 151:108466. Chasalow F, John CM, Bochner R. PMID: 31351941.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    11. Treatment of human challenge and MDR strains of Neisseria gonorrhoeae with LpxC inhibitors. J Antimicrob Chemother. 2018 08 01; 73(8):2064-2071. John CM, Feng D, Jarvis GA. PMID: 29726994.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Novel Campylobacter concisus lipooligosaccharide is a determinant of inflammatory potential and virulence. J Lipid Res. 2018 10; 59(10):1893-1905. Brunner K, John CM, Phillips NJ, Alber DG, Gemmell MR, Hansen R, Nielsen HL, Hold GL, Bajaj-Elliott M, Jarvis GA. PMID: 30049709; PMCID: PMC6168313.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Isolation of human testicular cells and co-culture with embryonic stem cells. Reproduction. 2018 02; 155(2):153-166. Gaur M, Ramathal C, Reijo Pera RA, Turek PJ, John CM. PMID: 29326135.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    14. Rescue of PFOS-induced human Sertoli cell injury by overexpressing a p-FAK-Y407E phosphomimetic mutant. Sci Rep. 2017 Nov 17; 7(1):15810. Chen H, Gao Y, Mruk DD, Xiao X, John CM, Turek PJ, Lui WY, Lee WM, Silvestrini B, Cheng CY. PMID: 29150642; PMCID: PMC5693862.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    15. Innate immune response to lipooligosaccharide: pivotal regulator of the pathobiology of invasive Neisseria meningitidis infections. Pathog Dis. 2017 Apr 01; 75(3). John CM, Phillips NJ, Stein DC, Jarvis GA. PMID: 28423169.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    16. Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2218-2223. Anandan A, Evans GL, Condic-Jurkic K, O'Mara ML, John CM, Phillips NJ, Jarvis GA, Wills SS, Stubbs KA, Moraes I, Kahler CM, Vrielink A. PMID: 28193899; PMCID: PMC5338521.
      View in: PubMed   Mentions: 63     Fields:    Translation:Cells
    17. Analysis of Bacterial Lipooligosaccharides by MALDI-TOF MS with Traveling Wave Ion Mobility. J Am Soc Mass Spectrom. 2016 07; 27(7):1263-76. Phillips NJ, John CM, Jarvis GA. PMID: 27056565.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    18. Lipooligosaccharide Structures of Invasive and Carrier Isolates of Neisseria meningitidis Are Correlated with Pathogenicity and Carriage. J Biol Chem. 2016 Feb 12; 291(7):3224-38. John CM, Phillips NJ, Din R, Liu M, Rosenqvist E, Høiby EA, Stein DC, Jarvis GA. PMID: 26655715; PMCID: PMC4751370.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    19. Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins. Hum Reprod. 2014 Jun; 29(6):1279-91. Xiao X, Mruk DD, Tang EI, Wong CK, Lee WM, John CM, Turek PJ, Silvestrini B, Cheng CY. PMID: 24532171; PMCID: PMC4017941.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    20. Induction of endotoxin tolerance by pathogenic Neisseria is correlated with the inflammatory potential of lipooligosaccharides and regulated by microRNA-146a. J Immunol. 2014 Feb 15; 192(4):1768-77. Liu M, John CM, Jarvis GA. PMID: 24442429.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    21. Campylobacter jejuni lipooligosaccharide sialylation, phosphorylation, and amide/ester linkage modifications fine-tune human Toll-like receptor 4 activation. J Biol Chem. 2013 Jul 05; 288(27):19661-72. Stephenson HN, John CM, Naz N, Gundogdu O, Dorrell N, Wren BW, Jarvis GA, Bajaj-Elliott M. PMID: 23629657; PMCID: PMC3707672.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    22. Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells. Mol Pharmacol. 2013 Jul; 84(1):25-40. Dovizio M, Maier TJ, Alberti S, Di Francesco L, Marcantoni E, Münch G, John CM, Suess B, Sgambato A, Steinhilber D, Patrignani P. PMID: 23580446.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    23. Post-injury conditioning with lipopolysaccharide or lipooligosaccharide reduces inflammation in the brain. J Neuroimmunol. 2013 Mar 15; 256(1-2):28-37. Bingham D, John CM, Levin J, Panter SS, Jarvis GA. PMID: 23333234.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    24. Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals. Infect Immun. 2012 Nov; 80(11):4014-26. John CM, Liu M, Phillips NJ, Yang Z, Funk CR, Zimmerman LI, Griffiss JM, Stein DC, Jarvis GA. PMID: 22949553; PMCID: PMC3486066.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    25. Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure. J Biol Chem. 2011 Dec 23; 286(51):43622-43633. Cheng H, Yang Z, Estabrook MM, John CM, Jarvis GA, McLaughlin S, Griffiss JM. PMID: 22027827; PMCID: PMC3243514.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    26. Tracking human multiple myeloma xenografts in NOD-Rag-1/IL-2 receptor gamma chain-null mice with the novel biomarker AKAP-4. BMC Cancer. 2011 Sep 16; 11:394. Mirandola L, Yu Y, Jenkins MR, Chiaramonte R, Cobos E, John CM, Chiriva-Internati M. PMID: 21923911; PMCID: PMC3189930.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    27. Galectin-3C inhibits tumor growth and increases the anticancer activity of bortezomib in a murine model of human multiple myeloma. PLoS One. 2011; 6(7):e21811. Mirandola L, Yu Y, Chui K, Jenkins MR, Cobos E, John CM, Chiriva-Internati M. PMID: 21765917; PMCID: PMC3135605.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    28. Post-injury treatment with lipopolysaccharide or lipooligosaccharide protects rat neuronal and glial cell cultures. Brain Res Bull. 2011 Jul 15; 85(6):403-9. Bingham D, John CM, Panter SS, Jarvis GA. PMID: 21571046.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    29. Characterization and functionality of proliferative human Sertoli cells. Cell Transplant. 2011; 20(5):619-35. Chui K, Trivedi A, Cheng CY, Cherbavaz DB, Dazin PF, Huynh AL, Mitchell JB, Rabinovich GA, Noble-Haeusslein LJ, John CM. PMID: 21054948; PMCID: PMC4096632.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    30. Phosphoryl moieties of lipid A from Neisseria meningitidis and N. gonorrhoeae lipooligosaccharides play an important role in activation of both MyD88- and TRIF-dependent TLR4-MD-2 signaling pathways. J Immunol. 2010 Dec 01; 185(11):6974-84. Liu M, John CM, Jarvis GA. PMID: 21037101; PMCID: PMC3059745.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    31. Human galectin-3 interacts with two anticancer drugs. Proteomics. 2010 May; 10(10):1946-53. Bogoeva VP, Varriale A, John CM, D'Auria S. PMID: 20209510.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. Tumor-specific protein human galectin-1 interacts with anticancer agents. Mol Biosyst. 2009 Nov; 5(11):1331-6. D'Auria S, Petrova L, John C, Russev G, Varriale A, Bogoeva V. PMID: 19823749.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    33. Natural phosphoryl and acyl variants of lipid A from Neisseria meningitidis strain 89I differentially induce tumor necrosis factor-alpha in human monocytes. J Biol Chem. 2009 Aug 07; 284(32):21515-25. John CM, Liu M, Jarvis GA. PMID: 19531474; PMCID: PMC2755876.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    34. Profiles of structural heterogeneity in native lipooligosaccharides of Neisseria and cytokine induction. J Lipid Res. 2009 Mar; 50(3):424-438. John CM, Liu M, Jarvis GA. PMID: 18832773; PMCID: PMC2638105.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    35. Deviations in gait pattern in experimental models of hindlimb paresis shown by a novel pressure mapping system. J Neurosci Res. 2007 Aug 01; 85(10):2272-83. Boyd BS, Puttlitz C, Noble-Haeusslein LJ, John CM, Trivedi A, Topp KS. PMID: 17539027.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    36. Suitability of allogeneic sertoli cells for ex vivo gene delivery in the injured spinal cord. Exp Neurol. 2006 Mar; 198(1):88-100. Trivedi AA, Igarashi T, Compagnone N, Fan X, Hsu JY, Hall DE, John CM, Noble-Haeusslein LJ. PMID: 16387298.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    37. Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains. Infect Immun. 2003 Jul; 71(7):3901-8. Pridmore AC, Jarvis GA, John CM, Jack DL, Dower SK, Read RC. PMID: 12819075; PMCID: PMC161978.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    38. Truncated galectin-3 inhibits tumor growth and metastasis in orthotopic nude mouse model of human breast cancer. Clin Cancer Res. 2003 Jun; 9(6):2374-83. John CM, Leffler H, Kahl-Knutsson B, Svensson I, Jarvis GA. PMID: 12796408.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    39. Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected. Cell Microbiol. 2002 Oct; 4(10):649-62. John CM, Jarvis GA, Swanson KV, Leffler H, Cooper MD, Huflejt ME, Griffiss JM. PMID: 12366402.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    40. Neisseria gonorrhoeae that infect men have lipooligosaccharides with terminal N-acetyllactosamine repeats. J Biol Chem. 1999 Jan 08; 274(2):1017-25. John CM, Schneider H, Griffiss JM. PMID: 9873046.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    41. Characterization of a sialyltransferase-deficient mutant of Neisseria gonorrhoeae strain F62: instability of transposon Tn1545 delta3 in gonococci and evidence that multiple genetic loci are essential for lipooligosaccharide sialylation. Microb Pathog. 1998 Nov; 25(5):237-52. Crooke H, Griffiss JM, John CM, Lissenden S, Bramley J, Regan T, Smith H, Cole J. PMID: 9878453.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    42. XPS and TOF-SIMS microanalysis of a peptide/polymer drug delivery device. Anal Chem. 1995 Nov 01; 67(21):3871-8. John CM, Odom RW, Salvati L, Annapragada A, Fu Lu MY. PMID: 8633755.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    43. The structural basis for pyocin resistance in Neisseria gonorrhoeae lipooligosaccharides. J Biol Chem. 1991 Oct 15; 266(29):19303-11. John CM, Griffiss JM, Apicella MA, Mandrell RE, Gibson BW. PMID: 1918047.
      View in: PubMed   Mentions: 53     Fields:    Translation:Cells
    44. Endogenous sialylation of the lipooligosaccharides of Neisseria meningitidis. J Bacteriol. 1991 May; 173(9):2823-32. Mandrell RE, Kim JJ, John CM, Gibson BW, Sugai JV, Apicella MA, Griffiss JM, Yamasaki R. PMID: 1708379; PMCID: PMC207863.
      View in: PubMed   Mentions: 58     Fields:    Translation:Cells
    45. Structural models for the cell surface lipooligosaccharides of Neisseria gonorrhoeae and Haemophilus influenzae. Biomed Environ Mass Spectrom. 1990 Nov; 19(11):731-45. Phillips NJ, John CM, Reinders LG, Gibson BW, Apicella MA, Griffiss JM. PMID: 2127548.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    46. Amino and hydrazino alkyl benzoates as derivatizing agents for the separation and mass spectrometric analysis of oligosaccharides from bacterial lipooligosaccharides. Anal Biochem. 1990 Jun; 187(2):281-91. John CM, Gibson BW. PMID: 2200308.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
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