Connor O'Brien, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, MSB
San Francisco CA 94117
Phone--
ORCID ORCID Icon0000-0002-2325-8317 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Pennsylvania, Philadelphia, PABA05/2005Biology and Biological Basis of Behavior
    Columbia University College of Physicians and Surgeons, New York, NYMD05/2012
    Stanford University, Stanford, CA06/2015Internal Medicine Residency
    Stanford University, Stanford, CA06/2018Cardiovascular Medicine Fellowship
    Stanford University, Stanford, CA06/2019Critical Care Medicine
    Collapse Awards and Honors
    Stanford University2020Timothy F Beckett Award
    Stanford University2018Gerald Reaven Award in Basic Science
    National Institutes of Health2017  - 2019Ruth L Kirschstein National Research Service Award
    Stanford University2017Best Clinical Fellow Award
    Stanford University2016Timothy F Beckett Award
    Stanford University2013  - 2015Johnson and Johnson Fellowship in Global Health
    Columbia University2012Conrad George Lattes Fellowship
    American Society of Tropical Medicine and Hygiene2012Benjamin Kean Fellowship
    Columbia University2011Alpha Omega Alpha
    Columbia University2011Gold Humanism Society Award
    University of Pennsylvania2005Elliot Stellar Chance Award

    Collapse Overview 
    Collapse Overview
    Clinical interests: Cardiologist with expertise in echocardiography and critical care medicine. Focus on care for adults with severe cardiac dysfunction or systemic shock who need prompt treatment in intensive care.

    Research interests: Translating basic science discoveries to clinical applications that improve understanding of underlying disease processes and effective treatments.

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Critical Care Cardiology Trials Network (CCCTN): a cohort profile. Eur Heart J Qual Care Clin Outcomes. 2022 10 26; 8(7):703-708. Metkus TS, Baird-Zars VM, Alfonso CE, Alviar CL, Barnett CF, Barsness GW, Berg DD, Bertic M, Bohula EA, Burke J, Burstein B, Chaudhry SP, Cooper HA, Daniels LB, Fordyce CB, Ghafghazi S, Goldfarb M, Katz JN, Keeley EC, Keller NM, Kenigsberg B, Kontos MC, Kwon Y, Lawler PR, Leibner E, Liu S, Menon V, Miller PE, Newby LK, O'Brien CG, Papolos AI, Pierce MJ, Prasad R, Pisani B, Potter BJ, Roswell RO, Sinha SS, Shah KS, Smith TD, Snell RJ, So D, Solomon MA, Ternus BW, Teuteberg JJ, van Diepen S, Zakaria S, Morrow DA. PMID: 36029517; PMCID: PMC9603535.
      View in: PubMed   Mentions:
    2. Association between Obesity and Length of COVID-19 Hospitalization: Unexpected Insights from the American Heart Association National COVID-19 Registry. J Obes Metab Syndr. 2022 Sep 30; 31(3):277-281. Collins WJ, Chang AY, Weng Y, Dahlen A, O'Brien CG, Hom J, Ahuja N, Rodriguez F, Rohatgi N. PMID: 36058896; PMCID: PMC9579478.
      View in: PubMed   Mentions:
    3. Impact of Bradyarrhythmias Requiring Pacing on Outcomes in Patients With COVID-19. 2022; (epub). Vasti EC MD, MPH; Ashland MD MS, O'Donnell C MD; Rodriguez F MD, MPH; Wang P MD; O'Brien CG MD. View Publication.
    4. The shock team: a multidisciplinary approach to early patient phenotyping and appropriate care escalation in cardiogenic shock. Curr Opin Cardiol. 2022 05 01; 37(3):241-249. Brusca SB, Caughron H, Njoroge JN, Cheng R, O'Brien CG, Barnett CF. PMID: 35612936.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Training in Critical Care Cardiology Within Critical Care Medicine Fellowship: A Novel Pathway. J Am Coll Cardiol. 2022 02 15; 79(6):609-613. O'Brien CG, Barnett CF, Dudzinski DM, Sanchez PA, Katz JN, Harold JG, Hennessey EK, Mohabir PK. PMID: 35144752.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Critical care management of the patient with pulmonary hypertension. Eur Heart J Acute Cardiovasc Care. 2022 Jan 12; 11(1):77-83. Barnett CF, O'Brien C, De Marco T. PMID: 34966914.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. N-Terminal Pro-B-Type Natriuretic Peptide as a Biomarker for the Severity and Outcomes With COVID-19 in a Nationwide Hospitalized Cohort. J Am Heart Assoc. 2021 12 21; 10(24):e022913. O'Donnell C, Ashland MD, Vasti EC, Lu Y, Chang AY, Wang P, Daniels LB, de Lemos JA, Morrow DA, Rodriguez F, O'Brien CG. PMID: 34889112; PMCID: PMC9075235.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury: Insights Into the SENECA Trial. JACC CardioOncol. 2021 Sep; 3(3):428-440. O'Brien CG, Ozen MO, Ikeda G, Vaskova E, Jung JH, Bayardo N, Santoso MR, Shi L, Wahlquist C, Jiang Z, Jung Y, Zeng Y, Egan E, Sinclair R, Gee A, Witteles R, Mercola M, Svensson KJ, Demirci U, Yang PC. PMID: 34604804; PMCID: PMC8463733.
      View in: PubMed   Mentions: 8  
    9. The Use of Factor Eight Inhibitor Bypass Activity (FEIBA) for the Treatment of Perioperative Hemorrhage in Left Ventricular Assist Device Implantation. J Cardiothorac Vasc Anesth. 2021 09; 35(9):2651-2658. O'Donnell C, Rodriguez AJ, Madhok J, Sharifi H, Wang H, O'Brien CG, Boyd J, Hiesinger W, Hsu J, Hill CC. PMID: 34034934; PMCID: PMC8842836.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. A Phase II study of autologous mesenchymal stromal cells and c-kit positive cardiac cells, alone or in combination, in patients with ischaemic heart failure: the CCTRN CONCERT-HF trial. Eur J Heart Fail. 2021 04; 23(4):661-674. Bolli R, Mitrani RD, Hare JM, Pepine CJ, Perin EC, Willerson JT, Traverse JH, Henry TD, Yang PC, Murphy MP, March KL, Schulman IH, Ikram S, Lee DP, O'Brien C, Lima JA, Ostovaneh MR, Ambale-Venkatesh B, Lewis G, Khan A, Bacallao K, Valasaki K, Longsomboon B, Gee AP, Richman S, Taylor DA, Lai D, Sayre SL, Bettencourt J, Vojvodic RW, Cohen ML, Simpson L, Aguilar D, Loghin C, Moyé L, Ebert RF, Davis BR, Simari RD, Cardiovascular Cell Therapy Research Network (CCTRN). PMID: 33811444; PMCID: PMC8357352.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCellsCTClinical Trials
    11. miR-106a-363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury. Basic Res Cardiol. 2021 03 19; 116(1):19. Jung JH, Ikeda G, Tada Y, von Bornstädt D, Santoso MR, Wahlquist C, Rhee S, Jeon YJ, Yu AC, O'brien CG, Red-Horse K, Appel EA, Mercola M, Woo J, Yang PC. PMID: 33742276; PMCID: PMC8601755.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    12. Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium. J Am Coll Cardiol. 2021 03 02; 77(8):1073-1088. Ikeda G, Santoso MR, Tada Y, Li AM, Vaskova E, Jung JH, O'Brien C, Egan E, Ye J, Yang PC. PMID: 33632482; PMCID: PMC8626617.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    13. Worldwide Survey of COVID-19-Associated Arrhythmias. Circ Arrhythm Electrophysiol. 2021 03; 14(3):e009458. Coromilas EJ, Kochav S, Goldenthal I, Biviano A, Garan H, Goldbarg S, Kim JH, Yeo I, Tracy C, Ayanian S, Akar J, Singh A, Jain S, Zimerman L, Pimentel M, Osswald S, Twerenbold R, Schaerli N, Crotti L, Fabbri D, Parati G, Li Y, Atienza F, Zatarain E, Tse G, Leung KSK, Guevara-Valdivia ME, Rivera-Santiago CA, Soejima K, De Filippo P, Ferrari P, Malanchini G, Kanagaratnam P, Khawaja S, Mikhail GW, Scanavacca M, Abrahão Hajjar L, Rizerio B, Sacilotto L, Mollazadeh R, Eslami M, Laleh Far V, Mattioli AV, Boriani G, Migliore F, Cipriani A, Donato F, Compagnucci P, Casella M, Dello Russo A, Coromilas J, Aboyme A, O'Brien CG, Rodriguez F, Wang PJ, Naniwadekar A, Moey M, Kow CS, Cheah WK, Auricchio A, Conte G, Hwang J, Han S, Lazzerini PE, Franchi F, Santoro A, Capecchi PL, Joglar JA, Rosenblatt AG, Zardini M, Bricoli S, Bonura R, Echarte-Morales J, Benito-González T, Minguito-Carazo C, Fernández-Vázquez F, Wan EY. PMID: 33554620; PMCID: PMC7982128.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    14. Allogeneic Mesenchymal Cell Therapy in Anthracycline-Induced Cardiomyopathy Heart Failure Patients: The CCTRN SENECA Trial. JACC CardioOncol. 2020 Nov; 2(4):581-595. Bolli R, Perin EC, Willerson JT, Yang PC, Traverse JH, Henry TD, Pepine CJ, Mitrani RD, Hare JM, Murphy MP, March KL, Ikram S, Lee DP, O'Brien C, Durand JB, Miller K, Lima JA, Ostovaneh MR, Ambale-Venkatesh B, Gee AP, Richman S, Taylor DA, Sayre SL, Bettencourt J, Vojvodic RW, Cohen ML, Simpson LM, Lai D, Aguilar D, Loghin C, Moyé L, Ebert RF, Davis BR, Simari RD, Cardiovascular Cell Therapy Research Network (CCTRN). PMID: 33403362; PMCID: PMC7781291.
      View in: PubMed   Mentions: 12  
    15. Electrical Storm in COVID-19. JACC Case Rep. 2020 Jul 15; 2(9):1256-1260. O'Brien C, Ning N, McAvoy J, Mitchell JE, Kalwani N, Wang P, Nguyen D, Reejhsinghani R, Rogers A, Lorenzo J. PMID: 32835266; PMCID: PMC7259914.
      View in: PubMed   Mentions: 1  
    16. COVID-19 and Disruptive Modifications to Cardiac Critical Care Delivery: JACC Review Topic of the Week. J Am Coll Cardiol. 2020 07 07; 76(1):72-84. Katz JN, Sinha SS, Alviar CL, Dudzinski DM, Gage A, Brusca SB, Flanagan MC, Welch T, Geller BJ, Miller PE, Leonardi S, Bohula EA, Price S, Chaudhry SP, Metkus TS, O'Brien CG, Sionis A, Barnett CF, Jentzer JC, Solomon MA, Morrow DA, van Diepen S. PMID: 32305402; PMCID: PMC7161519.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCellsPHPublic Health
    17. Cardiogenic Shock: Reflections at the Crossroad Between Perfusion, Tissue Hypoxia, and Mitochondrial Function. Can J Cardiol. 2020 02; 36(2):184-196. O'Brien C, Beaubien-Souligny W, Amsallem M, Denault A, Haddad F. PMID: 32036863.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation. N Engl J Med. 2019 11 14; 381(20):1909-1917. Perez MV, Mahaffey KW, Hedlin H, Rumsfeld JS, Garcia A, Ferris T, Balasubramanian V, Russo AM, Rajmane A, Cheung L, Hung G, Lee J, Kowey P, Talati N, Nag D, Gummidipundi SE, Beatty A, Hills MT, Desai S, Granger CB, Desai M, Turakhia MP, Apple Heart Study Investigators. PMID: 31722151; PMCID: PMC8112605.
      View in: PubMed   Mentions: 303     Fields:    Translation:Humans
    19. Meta-analysis of short- and long-term efficacy of mononuclear cell transplantation in patients with myocardial infarction. Am Heart J. 2020 02; 220:155-175. Yang D, O'Brien CG, Ikeda G, Traverse JH, Taylor DA, Henry TD, Bolli R, Yang PC. PMID: 31821904; PMCID: PMC7173405.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Routine Indwelling Urethral Catheterization in Acute Heart Failure Patients Is Associated With Increased Urinary Tract Complications Without Improved Heart Failure Outcomes. Circ J. 2018 05 25; 82(6):1632-1639. Jang AY, O'Brien C, Chung WJ, Oh PC, Yu J, Lee K, Kang WC, Moon J. PMID: 29593145.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Alternative Therapies for Chronic Hepatitis B Patients With Partial Virological Response to Standard Entecavir Monotherapy. J Clin Gastroenterol. 2016 Apr; 50(4):338-44. Chaung KT, O'Brien C, Ha NB, Nguyen NH, Trinh HN, Nguyen MH. PMID: 26646801.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    22. Hurdles to clinical translation of human induced pluripotent stem cells. J Clin Invest. 2015 Jul 01; 125(7):2551-7. Neofytou E, O'Brien CG, Couture LA, Wu JC. PMID: 26132109; PMCID: PMC4563685.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    23. Current treatment guidelines for chronic hepatitis B and their applications. J Clin Gastroenterol. 2014 Oct; 48(9):773-83. Uribe LA, O'Brien CG, Wong RJ, Gish RR, Tsai N, Nguyen MH. PMID: 24859715.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    24. Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model. Antimicrob Agents Chemother. 2014; 58(1):183-95. Henrich PP, O'Brien C, Sáenz FE, Cremers S, Kyle DE, Fidock DA. PMID: 24145526; PMCID: PMC3910733.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    25. Tuberculosis associated with transient hemolytic anemia responsive to tuberculosis chemotherapy: a case report. Braz J Infect Dis. 2013 Jan-Feb; 17(1):110-1. Safe IP, O'brien C, Ferreira FR, Souza ML, Ramasawmy R. PMID: 23290474; PMCID: PMC9427378.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. Risk factors and characterization of Plasmodium vivax-associated admissions to pediatric intensive care units in the Brazilian Amazon. PLoS One. 2012; 7(4):e35406. Lança EF, Magalhães BM, Vitor-Silva S, Siqueira AM, Benzecry SG, Alexandre MA, O'Brien C, Bassat Q, Lacerda MV. PMID: 22523591; PMCID: PMC3327677.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    27. Pfatp6 molecular profile of Plasmodium falciparum isolates in the western Brazilian Amazon. Malar J. 2012 Apr 10; 11:111. Brasil LW, Areas AL, Melo GC, Oliveira CM, Alecrim MG, Lacerda MV, O'Brien C, Oelemann WM, Zalis MG. PMID: 22487143; PMCID: PMC3350389.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    28. Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum. Curr Opin Infect Dis. 2011 Dec; 24(6):570-7. O'Brien C, Henrich PP, Passi N, Fidock DA. PMID: 22001944; PMCID: PMC3268008.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    29. In vitro and in vivo activity of frenolicin B against Plasmodium falciparum and P berghei. J Antibiot (Tokyo). 2011 Dec; 64(12):799-801. Fitzgerald JT, Henrich PP, O'Brien C, Krause M, Ekland EH, Mattheis C, Sá JM, Fidock D, Khosla C. PMID: 22008701; PMCID: PMC5568418.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    30. In vivo and in vitro antimalarial properties of azithromycin-chloroquine combinations that include the resistance reversal agent amlodipine. Antimicrob Agents Chemother. 2011 Jul; 55(7):3115-24. Pereira MR, Henrich PP, Sidhu AB, Johnson D, Hardink J, Van Deusen J, Lin J, Gore K, O'Brien C, Wele M, Djimde A, Chandra R, Fidock DA. PMID: 21464242; PMCID: PMC3122405.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
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