Loading...

Cory Nicholas, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentNeurology
AddressLocation Required
Varies CA 00000
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.2009 Graduate Division (Biomedical Sciences)

    Collapse Overview 
    Collapse Overview
    We are investigating the molecular mechanisms that regulate human cortical interneuron development, pathophysiology, and regeneration, utilizing both primary fetal and pluripotent stem cell systems. Several intractable neuro-developmental, -psychiatric, and –degenerative disorders have been linked, at least in part, to deficiencies in cortical interneurons and consequent imbalances in neuronal excitation and inhibition. Our goals are to understand how interneuron dysfunction contributes to the initiation and progression of neurological disorders and to develop effective interneuron-based treatments for patients with epilepsy, neuropathic pain, autism, schizophrenia, Parkinson's, Huntington's, and Alzheimer's disease.


    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Raju CS, Spatazza J, Stanco A, Larimer P, Sorrells SF, Kelley KW, Nicholas C, Paredes MF, Lui JH, Hasenstaub AR, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL, Oldham MC. Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity. Cereb Cortex. 2017 Apr 26; 1-13. PMID: 28449024.
      View in: PubMed
    2. Fandel TM, Trivedi A, Nicholas C, Zhang H, Chen J, Martinez AF, Noble-Haeusslein LJ, Kriegstein AR. Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury. Cell Stem Cell. 2016 Oct 06; 19(4):544-557. PMID: 27666009.
      View in: PubMed
    3. Pollen AA, Nowakowski TJ, Chen J, Retallack H, Sandoval-Espinosa C, Nicholas C, Shuga J, Liu SJ, Oldham MC, Diaz A, Lim DA, Leyrat AA, West JA, Kriegstein AR. Molecular identity of human outer radial glia during cortical development. Cell. 2015 Sep 24; 163(1):55-67. PMID: 26406371; PMCID: PMC4583716.
    4. Southwell DG, Nicholas C, Basbaum AI, Stryker MP, Kriegstein AR, Rubenstein JL, Alvarez-Buylla A. Interneurons from embryonic development to cell-based therapy. Science. 2014 Apr 11; 344(6180):1240622. PMID: 24723614; PMCID: PMC4056344.
    5. Nicholas C, Chen J, Tang Y, Southwell DG, Chalmers N, Vogt D, Arnold CM, Chen YJ, Stanley EG, Elefanty AG, Sasai Y, Alvarez-Buylla A, Rubenstein JL, Kriegstein AR. Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell. 2013 May 02; 12(5):573-86. PMID: 23642366; PMCID: PMC3699205.
    6. Chen YJ, Vogt D, Wang Y, Visel A, Silberberg SN, Nicholas C, Danjo T, Pollack JL, Pennacchio LA, Anderson S, Sasai Y, Baraban SC, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL. Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons. PLoS One. 2013; 8(5):e61956. PMID: 23658702; PMCID: PMC3641041.
    7. Nicholas C, Kriegstein AR. Regenerative medicine: Cell reprogramming gets direct. Nature. 2010 Feb 25; 463(7284):1031-2. PMID: 20182502.
      View in: PubMed
    8. Nicholas C, Haston KM, Pera RA. Intact fetal ovarian cord formation promotes mouse oocyte survival and development. BMC Dev Biol. 2010 Jan 08; 10:2. PMID: 20064216; PMCID: PMC2830955.
    9. Nicholas C, Haston KM, Grewall AK, Longacre TA, Reijo Pera RA. Transplantation directs oocyte maturation from embryonic stem cells and provides a therapeutic strategy for female infertility. Hum Mol Genet. 2009 Nov 15; 18(22):4376-89. PMID: 19696121; PMCID: PMC2766296.
    10. Nicholas C, Chavez SL, Baker VL, Reijo Pera RA. Instructing an embryonic stem cell-derived oocyte fate: lessons from endogenous oogenesis. Endocr Rev. 2009 May; 30(3):264-83. PMID: 19366753; PMCID: PMC2726843.
    11. Nicholas C, Xu EY, Banani SF, Hammer RE, Hamra FK, Reijo Pera RA. Characterization of a Dazl-GFP germ cell-specific reporter. Genesis. 2009 Feb; 47(2):74-84. PMID: 19133679; PMCID: PMC3000528.
    12. Kossack N, Meneses J, Shefi S, Nguyen HN, Chavez S, Nicholas C, Gromoll J, Turek PJ, Reijo-Pera RA. Isolation and characterization of pluripotent human spermatogonial stem cell-derived cells. Stem Cells. 2009 Jan; 27(1):138-49. PMID: 18927477; PMCID: PMC2729695.
    13. Nicholas C, Reijo Pera RA. Method for single-cell sorting and expansion of genetically modified human embryonic stem cells. CSH Protoc. 2008 Sep 01; 2008:pdb.prot5045. PMID: 21356914.
      View in: PubMed
    14. Nicholas C, Gaur M, Wang S, Pera RA, Leavitt AD. A method for single-cell sorting and expansion of genetically modified human embryonic stem cells. Stem Cells Dev. 2007 Feb; 16(1):109-17. PMID: 17348809.
      View in: PubMed
    15. O'Shea CC, Johnson L, Bagus B, Choi S, Nicholas C, Shen A, Boyle L, Pandey K, Soria C, Kunich J, Shen Y, Habets G, Ginzinger D, McCormick F. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell. 2004 Dec; 6(6):611-23. PMID: 15607965.
      View in: PubMed
    Cory's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _
    Back to TOP