Crystal Conn, PhD

Title(s)Postdoctoral Scholar, Urology
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Cornell UniversityPhD2013Molecular Biology & Genetics
    Penn State UniversityBS2007Biochemical Molecular Biology
    Collapse Awards and Honors
    Cornell University2011  - 2012NIH Training Grant (T32GM00761), extended Research Fellowship
    UCSF2014  - 2015NIH, NCI Postdoctoral National Research Service Award (F32), 1F32CA189696
    UCSF2015  - 2017American Cancer Society, Postdoctoral Fellowship, PF-14-212-01-RMC
    UCSF2017  - 2019AACR-Bayer Prostate Cancer Fellow

    Collapse Research 
    Collapse Research Activities and Funding
    Decoding the Translational Program Underlying the Oncogenic Stress Response
    NIH/NCI F32CA189696Sep 1, 2014 - Aug 31, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse In The News
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salas Salinas C, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C. ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nat Cell Biol. 2019 Jul; 21(7):889-899. PMID: 31263264.
      View in: PubMed
    2. Wei J, Kishton RJ, Angel M, Conn CS, Dalla-Venezia N, Marcel V, Vincent A, Catez F, Ferré S, Ayadi L, Marchand V, Dersh D, Gibbs JS, Ivanov IP, Fridlyand N, Couté Y, Diaz JJ, Qian SB, Staudt LM, Restifo NP, Yewdell JW. Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance. Mol Cell. 2019 Mar 21; 73(6):1162-1173.e5. PMID: 30712990.
      View in: PubMed
    3. Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D. Development of a stress response therapy targeting aggressive prostate cancer. Sci Transl Med. 2018 May 02; 10(439). PMID: 29720449.
      View in: PubMed
    4. Gwinn DM, Lee AG, Briones-Martin-Del-Campo M, Conn CS, Simpson DR, Scott AI, Le A, Cowan TM, Ruggero D, Sweet-Cordero EA. Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase. Cancer Cell. 2018 01 08; 33(1):91-107.e6. PMID: 29316436.
      View in: PubMed
    5. Truillet C, Cunningham JT, Parker MFL, Huynh LT, Conn CS, Ruggero D, Lewis JS, Evans MJ. Noninvasive Measurement of mTORC1 Signaling with 89Zr-Transferrin. Clin Cancer Res. 2017 Jun 15; 23(12):3045-3052. PMID: 28007777.
      View in: PubMed
    6. Truitt ML, Conn CS, Shi Z, Pang X, Tokuyasu T, Coady AM, Seo Y, Barna M, Ruggero D. Differential Requirements for eIF4E Dose in Normal Development and Cancer. Cell. 2015 Jul 02; 162(1):59-71. PMID: 26095252; PMCID: PMC4491046.
    7. Zhang X, Gao X, Coots RA, Conn CS, Liu B, Qian SB. Translational control of the cytosolic stress response by mitochondrial ribosomal protein L18. Nat Struct Mol Biol. 2015 May; 22(5):404-10. PMID: 25866880; PMCID: PMC4424103.
    8. Conn CS, Qian SB. Nutrient signaling in protein homeostasis: an increase in quantity at the expense of quality. Sci Signal. 2013 Apr 16; 6(271):ra24. PMID: 23592839; PMCID: PMC3992710.
    9. Liu B, Conn CS, Qian SB. Viewing folding of nascent polypeptide chains from ribosomes. Expert Rev Proteomics. 2012 Dec; 9(6):579-81. PMID: 23256666; PMCID: PMC3971927.
    10. Conn CS, Qian SB. mTOR signaling in protein homeostasis: less is more? Cell Cycle. 2011 Jun 15; 10(12):1940-7. PMID: 21555915.
      View in: PubMed
    11. Sun J, Conn CS, Han Y, Yeung V, Qian SB. PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 translation. J Biol Chem. 2011 Feb 25; 286(8):6791-800. PMID: 21177857; PMCID: PMC3057780.