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Daniel Bikle, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address4150 Clement St
San Francisco CA 94121
Phone415-575-0557
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    Collapse Biography 
    Collapse Education and Training
    HarvardAB1965Harvard
    University of PennsylvaniaMD1969School of Medicine
    University of PennsylvaniaPhD1974Graduate School of Arts and Sciences

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms Underlying Hormonal Regulation of Fracture Repair
    VA IP1BX001599Jan 1, 2012 - Dec 31, 2015
    Role: Principal Investigator
    Role of vitamin D and calcium signaling in wound healing
    VA I01BX001066Apr 1, 2011 - Mar 31, 2015
    Role: Principal Investigator
    Role of IGF-I/integrin signaling in the periosteal response to load
    NIH/NIAMS R01AR055924Apr 1, 2008 - Jan 31, 2020
    Role: Principal Investigator
    Vitamin D Receptor Coactivators in Keratinocytes
    NIH/NIAMS R01AR050023Jul 1, 2003 - May 31, 2015
    Role: Principal Investigator
    IGF-1 Mediates the Anabolic Effects of PTH on Bone
    NIH/NIDDK R01DK054793Feb 15, 2001 - Aug 31, 2014
    Role: Principal Investigator
    ESTROGEN/CALCITRIOL IN THE ETIOLOGY OF BREAST CANCER
    NIH/NCI R03CA070572Sep 30, 1995 - Mar 31, 1999
    Role: Principal Investigator
    Relationship of Keratinocyte Function to Differentiation
    NIH/NIAMS P01AR039448Jul 15, 1988 - Jul 31, 2010
    Role: Principal Investigator
    VITAMIN D AND THE DIFFERENTIATION OF KERATINOCYTES
    NIH/NIAMS R01AR038386May 1, 1987 - Mar 31, 2005
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    REGULATION OF INTESTINAL CALCIUM TRANSPORT BY VITAMIN D
    NIH/NIDDK R01DK028116Apr 1, 1981 - Jun 30, 2004
    Role: Principal Investigator
    VITAMIN D STIMULATED INTESTINAL CALCIUM TRANSPORT
    NIH/NIADDK R01AM028116Apr 1, 1981 - Mar 31, 1987
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Jassil NK, Sharma A, Bikle D, Wang X. VITAMIN D BINDING PROTEIN AND 25-HYDROXYVITAMIN D LEVELS: EMERGING CLINICAL APPLICATIONS. Endocr Pract. 2017 Jan 17. PMID: 28095044.
      View in: PubMed
    2. Bikle D, Bouillon R, Thadhani R, Schoenmakers I. Vitamin D metabolites in captivity? Should we measure free or total 25(OH)D to assess vitamin D status? J Steroid Biochem Mol Biol. 2017 Jan 16. PMID: 28093353.
      View in: PubMed
    3. Wang T, Zhang X, Bikle D. Osteogenic Differentiation of Periosteal Cells During Fracture Healing. J Cell Physiol. 2016 Oct 12. PMID: 27731505.
      View in: PubMed
    4. Xie Z, Yuan Y, Jiang Y, Shrestha C, Chen Y, Liao L, Ji S, Deng X, Liao E, Bikle D. p120-Catenin Is Required for Dietary Calcium Suppression of Oral Carcinogenesis in Mice. J Cell Physiol. 2016 Sep 28. PMID: 27682597.
      View in: PubMed
    5. Elias PM, Williams ML, Bikle D. The vitamin D hypothesis: Dead or alive?: Response to Dr. William Grant's "The UVB-vitamin D3-pigment hypothesis is alive and well-AJPA-2016-00237". Am J Phys Anthropol. 2016 Dec; 161(4):756-757. PMID: 27634223.
      View in: PubMed
    6. Bikle D, Jiang Y, Nguyen T, Oda Y, Tu CL. Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. Front Physiol. 2016; 7:296. PMID: 27462278.
      View in: PubMed
    7. Bikle D. Extraskeletal actions of vitamin D. Ann N Y Acad Sci. 2016 Jul; 1376(1):29-52. PMID: 27649525.
      View in: PubMed
    8. Shrestha C, Tang Y, Fan H, Li L, Zeng Q, Pennypacker SD, Bikle D, Xie Z. Phosphoprotein Phosphatase 1 Is Required for Extracellular Calcium-Induced Keratinocyte Differentiation. Biomed Res Int. 2016; 2016:3062765. PMID: 27340655.
      View in: PubMed
    9. Bikle D. The Endocrine Society Centennial: Extrarenal Production of 1,25 Dihyroxyvitamin D Is Now Proven. Endocrinology. 2016 May; 157(5):1717-8. PMID: 27014941.
      View in: PubMed
    10. Mady LJ, Ajibade DV, Hsaio C, Teichert A, Fong C, Wang Y, Christakos S, Bikle D. The Transient Role for Calcium and Vitamin D during the Developmental Hair Follicle Cycle. J Invest Dermatol. 2016 Jul; 136(7):1337-45. PMID: 26994969.
      View in: PubMed
    11. Tahimic CG, Long RK, Kubota T, Sun MY, Elalieh H, Fong C, Menendez AT, Wang Y, Vilardaga JP, Bikle D. Regulation of Ligand and Shear Stress-induced Insulin-like Growth Factor 1 (IGF1) Signaling by the Integrin Pathway. J Biol Chem. 2016 Apr 8; 291(15):8140-9. PMID: 26865633.
      View in: PubMed
    12. Teske KA, Bogart JW, Sanchez LM, Yu OB, Preston JV, Cook JM, Silvaggi NR, Bikle D, Arnold LA. Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites. Eur J Med Chem. 2016 Feb 15; 109:238-46. PMID: 26774929.
      View in: PubMed
    13. Schwartz JB, Kane L, Bikle D. Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial. J Am Geriatr Soc. 2016 Jan; 64(1):65-72. PMID: 26782853.
      View in: PubMed
    14. Guthrie ML, Sidhu PS, Hill EK, Horan TC, Nandhikonda P, Teske KA, Yuan NY, Sidorko M, Rodali R, Cook JM, Han L, Silvaggi NR, Bikle D, Moore RG, Singh RK, Arnold LA. Antitumor Activity of 3-Indolylmethanamines 31B and PS121912. Anticancer Res. 2015 Nov; 35(11):6001-7. PMID: 26504023; PMCID: PMC4633305 [Available on 03/01/16].
    15. Bikle D, Tahimic C, Chang W, Wang Y, Philippou A, Barton ER. Role of IGF-I signaling in muscle bone interactions. Bone. 2015 Nov; 80:79-88. PMID: 26453498; PMCID: PMC4600536 [Available on 11/01/16].
    16. Bikle D. Pregnane X receptor expression in skin: the good and the bad. Exp Dermatol. 2015 Nov; 24(11):829-30. PMID: 26269123.
      View in: PubMed
    17. Wang T, Wang Y, Menendez A, Fong C, Babey M, Tahimic CG, Cheng Z, Li A, Chang W, Bikle D. Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing. J Bone Miner Res. 2015 Sep; 30(9):1572-84. PMID: 25801198.
      View in: PubMed
    18. Oda Y, Tu CL, Menendez A, Nguyen T, Bikle D. Vitamin D and calcium regulation of epidermal wound healing. J Steroid Biochem Mol Biol. 2016 Nov; 164:379-385. PMID: 26282157.
      View in: PubMed
    19. Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC. A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting. Calcif Tissue Int. 2015 Dec; 97(6):634-9. PMID: 26253396.
      View in: PubMed
    20. Wang Y, Menendez A, Fong C, ElAlieh HZ, Kubota T, Long R, Bikle D. IGF-I Signaling in Osterix-Expressing Cells Regulates Secondary Ossification Center Formation, Growth Plate Maturation, and Metaphyseal Formation During Postnatal Bone Development. J Bone Miner Res. 2015 Dec; 30(12):2239-48. PMID: 26011431.
      View in: PubMed
    21. Shah AD, Hsiao EC, O'Donnell B, Salmeen K, Nussbaum R, Krebs M, Baumgartner-Parzer S, Kaufmann M, Jones G, Bikle D, Wang Y, Mathew AS, Shoback D, Block-Kurbisch I. Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations. J Clin Endocrinol Metab. 2015 Aug; 100(8):2832-6. PMID: 26097993; PMCID: PMC4524985 [Available on 08/01/16].
    22. Babey M, Wang Y, Kubota T, Fong C, Menendez A, ElAlieh HZ, Bikle D. Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts. J Bone Miner Res. 2015 Jun; 30(6):1064-76. PMID: 25502173.
      View in: PubMed
    23. Bourguignon LY, Bikle D. Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation. Front Immunol. 2015; 6:224. PMID: 26029210; PMCID: PMC4429634.
    24. Tiganescu A, Hupe M, Jiang YJ, Celli A, Uchida Y, Mauro TM, Bikle D, Elias PM, Holleran WM. UVB induces epidermal 11ß-hydroxysteroid dehydrogenase type 1 activity in vivo. Exp Dermatol. 2015 May; 24(5):370-6. PMID: 25739654.
      View in: PubMed
    25. Lai JC, Bikle D, Lizaola B, Hayssen H, Terrault NA, Schwartz JB. Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction. Liver Int. 2015 Oct; 35(10):2294-300. PMID: 25757956; PMCID: PMC4567539 [Available on 10/01/16].
    26. Welsh J, Bikle D, Lips P. Highlights from the 17th workshop on vitamin D, Chicago, IL, June 17-21, 2014. J Steroid Biochem Mol Biol. 2015 Apr; 148:1-2. PMID: 25641118.
      View in: PubMed
    27. Bikle D. Vitamin D receptor, a tumor suppressor in skin. Can J Physiol Pharmacol. 2015 May; 93(5):349-54. PMID: 25559384.
      View in: PubMed
    28. Bikle D, Oda Y, Tu CL, Jiang Y. Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer. J Steroid Biochem Mol Biol. 2015 Apr; 148:47-51. PMID: 25445917; PMCID: PMC4361259 [Available on 04/01/16].
    29. Thyssen JP, Bikle D, Elias PM. Evidence That Loss-of-Function Filaggrin Gene Mutations Evolved in Northern Europeans to Favor Intracutaneous Vitamin D3 Production. Evol Biol. 2014 Sep 1; 41(3):388-396. PMID: 25506102.
      View in: PubMed
    30. Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle D, Arnold LA. Anticancer activity of VDR-coregulator inhibitor PS121912. Cancer Chemother Pharmacol. 2014 Oct; 74(4):787-98. PMID: 25107568; PMCID: PMC4177010.
    31. Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle D. Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation. J Bone Miner Res. 2014 Aug; 29(8):1900-13. PMID: 24677183; PMCID: PMC4108521.
    32. Yoshizaki K, Hu L, Nguyen T, Sakai K, He B, Fong C, Yamada Y, Bikle D, Oda Y. Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair. PLoS One. 2014; 9(6):e99991. PMID: 24949995; PMCID: PMC4065011.
    33. Bikle D, Mauro TM. Calcium, Orai1, and epidermal proliferation. J Invest Dermatol. 2014 Jun; 134(6):1506-8. PMID: 24825060; PMCID: PMC4023905.
    34. Bikle D. Highlights from the 16th Vitamin D Workshop, San Francisco, CA, June 11-14, 2013. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:1-4. PMID: 24793579.
      View in: PubMed
    35. Jiang YJ, Bikle D. LncRNA: a new player in 1a, 25(OH)(2) vitamin D(3) /VDR protection against skin cancer formation. Exp Dermatol. 2014 Mar; 23(3):147-50. PMID: 24499465; PMCID: PMC4103949.
    36. Hollis BW, Bikle D. Vitamin D-binding protein and vitamin D in blacks and whites. N Engl J Med. 2014 Feb 27; 370(9):879-80. PMID: 24571766; PMCID: PMC4165606.
    37. Bikle D. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014 Mar 20; 21(3):319-29. PMID: 24529992; PMCID: PMC3968073.
    38. Sidhu PS, Nassif N, McCallum MM, Teske K, Feleke B, Yuan NY, Nandhikonda P, Cook JM, Singh RK, Bikle D, Arnold LA. Development of novel Vitamin D Receptor-Coactivator Inhibitors. ACS Med Chem Lett. 2014 Feb 13; 5(2):199-204. PMID: 24799995.
      View in: PubMed
    39. Schwartz JB, Lai J, Lizaola B, Kane L, Markova S, Weyland P, Terrault NA, Stotland N, Bikle D. A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations. J Clin Endocrinol Metab. 2014 May; 99(5):1631-7. PMID: 24483159; PMCID: PMC4010704.
    40. Bikle D. Vitamin D and cancer: the promise not yet fulfilled. Endocrine. 2014 May; 46(1):29-38. PMID: 24402695; PMCID: PMC3976762.
    41. Bikle D. The vitamin D receptor: a tumor suppressor in skin. Adv Exp Med Biol. 2014; 810:282-302. PMID: 25207372.
      View in: PubMed
    42. Teske K, Nandhikonda P, Bogart JW, Feleke B, Sidhu P, Yuan N, Preston J, Goy R, Han L, Silvaggi NR, Singh RK, Bikle D, Cook JM, Arnold LA. IDENTIFICATION OF VDR ANTAGONISTS AMONG NUCLEAR RECEPTOR LIGANDS USING VIRTUAL SCREENING. Nucl Receptor Res. 2014; 1. PMID: 25419525.
      View in: PubMed
    43. Jiang YJ, Bikle D. LncRNA profiling reveals new mechanism for VDR protection against skin cancer formation. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:87-90. PMID: 24342142.
      View in: PubMed
    44. Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich, et al. Front Neuroendocrinol. 2014 Jan; 35(1):2-5. PMID: 24268499.
      View in: PubMed
    45. Schwartz JB, Lai J, Lizaola B, Kane L, Weyland P, Terrault NA, Stotland N, Bikle D. Variability in free 25(OH) vitamin D levels in clinical populations. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:156-8. PMID: 24240067; PMCID: PMC4022715.
    46. Hu L, Bikle D, Oda Y. Reciprocal role of vitamin D receptor on ß-catenin regulated keratinocyte proliferation and differentiation. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:237-41. PMID: 24239508; PMCID: PMC4061268.
    47. Bikle D, Jiang Y. The protective role of vitamin d signaling in non-melanoma skin cancer. Cancers (Basel). 2013; 5(4):1426-38. PMID: 24202452; PMCID: PMC3875946.
    48. Kubota T, Elalieh HZ, Saless N, Fong C, Wang Y, Babey M, Cheng Z, Bikle D. Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading. Acta Astronaut. 2013 Nov; 92(1):73-78. PMID: 23976802.
      View in: PubMed
    49. Wang Y, Bikle D, Chang W. Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development. Bone Res. 2013 Sep; 1(3):249-59. PMID: 26273506; PMCID: PMC4472106.
    50. Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth M, Power DM, Prins GS, Ridgway EC, Rissman EF, Romijn JA, Sawchenko PE, Sly PD, Söder O, Taylor HS, Tena-Sempere M, Vaudry H, Wallen K, Wang Z, Wartofsky L, Watson CS. Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Endocrinology. 2013 Nov; 154(11):3957-60. PMID: 24048095.
      View in: PubMed
    51. Kane L, Moore K, Lütjohann D, Bikle D, Schwartz JB. Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships. J Clin Endocrinol Metab. 2013 Nov; 98(11):4400-9. PMID: 24030939; PMCID: PMC3816263.
    52. Norman AW, Bikle D, Bouillon R. Fifteenth vitamin D workshop. J Steroid Biochem Mol Biol. 2013 Jul; 136:1-2. PMID: 23768771; PMCID: PMC4102609.
    53. Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology. 2013 Sep; 154(9):3031-42. PMID: 23782944; PMCID: PMC3749485.
    54. Nandhikonda P, Yasgar A, Baranowski AM, Sidhu PS, McCallum MM, Pawlak AJ, Teske K, Feleke B, Yuan NY, Kevin C, Bikle D, Ayers SD, Webb P, Rai G, Simeonov A, Jadhav A, Maloney D, Arnold LA. Peroxisome proliferation-activated receptor d agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor. Biochemistry. 2013 Jun 18; 52(24):4193-203. PMID: 23713684; PMCID: PMC3724348.
    55. Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle D. Vitamin D: beyond bone. Ann N Y Acad Sci. 2013 May; 1287:45-58. PMID: 23682710; PMCID: PMC3717170.
    56. Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W. Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice. J Bone Miner Res. 2013 May; 28(5):1087-100. PMID: 23239173; PMCID: PMC3617088.
    57. Tu CL, Bikle D. Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function. Best Pract Res Clin Endocrinol Metab. 2013 Jun; 27(3):415-27. PMID: 23856269; PMCID: PMC3713412.
    58. Tahimic CG, Wang Y, Bikle D. Anabolic effects of IGF-1 signaling on the skeleton. Front Endocrinol (Lausanne). 2013; 4:6. PMID: 23382729; PMCID: PMC3563099.
    59. Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle D, Grunfeld C, Feingold KR. Ceramides stimulate caspase-14 expression in human keratinocytes. Exp Dermatol. 2013 Feb; 22(2):113-8. PMID: 23362869; PMCID: PMC4099380.
    60. Bikle D. Protective actions of vitamin D in UVB induced skin cancer. Photochem Photobiol Sci. 2012 Dec; 11(12):1808-16. PMID: 22990497; PMCID: PMC3501582.
    61. Tang JY, Fu T, Lau C, Oh DH, Bikle D, Asgari MM. Vitamin D in cutaneous carcinogenesis: part II. J Am Acad Dermatol. 2012 Nov; 67(5):817.e1-11; quiz 827-8. PMID: 23062904; PMCID: PMC3706259.
    62. Tang JY, Fu T, Lau C, Oh DH, Bikle D, Asgari MM. Vitamin D in cutaneous carcinogenesis: part I. J Am Acad Dermatol. 2012 Nov; 67(5):803.e1-12, quiz 815-6. PMID: 23062903; PMCID: PMC3688468.
    63. Shahnazari M, Kurimoto P, Boudignon BM, Orwoll BE, Bikle D, Halloran BP. Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice. Am J Physiol Endocrinol Metab. 2012 Dec 1; 303(11):E1354-62. PMID: 23047986; PMCID: PMC3774081.
    64. Bikle D, Elalieh H, Welsh J, Oh D, Cleaver J, Teichert A. Protective role of vitamin D signaling in skin cancer formation. J Steroid Biochem Mol Biol. 2013 Jul; 136:271-9. PMID: 23059470; PMCID: PMC3596439.
    65. Jiang YJ, Teichert AE, Fong F, Oda Y, Bikle D. 1a,25(OH)2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the ß-catenin pathway. J Steroid Biochem Mol Biol. 2013 Jul; 136:229-32. PMID: 23026511; PMCID: PMC4102608.
    66. Bikle D, Xie Z, Tu CL. Calcium regulation of keratinocyte differentiation. Expert Rev Endocrinol Metab. 2012 Jul; 7(4):461-472. PMID: 23144648.
      View in: PubMed
    67. Bikle D, Wang Y. Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormone. Curr Mol Pharmacol. 2012 Jun; 5(2):135-42. PMID: 21787292; PMCID: PMC3690777.
    68. Bikle D. Vitamin D and bone. Curr Osteoporos Rep. 2012 Jun; 10(2):151-9. PMID: 22544628; PMCID: PMC3688475.
    69. Tu CL, Crumrine DA, Man MQ, Chang W, Elalieh H, You M, Elias PM, Bikle D. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J Invest Dermatol. 2012 Oct; 132(10):2350-9. PMID: 22622426; PMCID: PMC3434298.
    70. Muehleisen B, Bikle D, Aguilera C, Burton DW, Sen GL, Deftos LJ, Gallo RL. PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection. Sci Transl Med. 2012 May 23; 4(135):135ra66. PMID: 22623742; PMCID: PMC3725981.
    71. Rosen CJ, Adams JS, Bikle D, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev. 2012 Jun; 33(3):456-92. PMID: 22596255; PMCID: PMC3365859.
    72. Nandhikonda P, Lynt WZ, McCallum MM, Ara T, Baranowski AM, Yuan NY, Pearson D, Bikle D, Guy RK, Arnold LA. Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators. J Med Chem. 2012 May 24; 55(10):4640-51. PMID: 22563729; PMCID: PMC3364162.
    73. Demetriou SK, Ona-Vu K, Teichert AE, Cleaver JE, Bikle D, Oh DH. Vitamin D receptor mediates DNA repair and is UV inducible in intact epidermis but not in cultured keratinocytes. J Invest Dermatol. 2012 Aug; 132(8):2097-100. PMID: 22495177; PMCID: PMC3396713.
    74. Bikle D. Vitamin D and the skin: Physiology and pathophysiology. Rev Endocr Metab Disord. 2012 Mar; 13(1):3-19. PMID: 21845365; PMCID: PMC3687803.
    75. Celli A, Mackenzie DS, Zhai Y, Tu CL, Bikle D, Holleran WM, Uchida Y, Mauro TM. SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease. J Invest Dermatol. 2012 Apr; 132(4):1188-95. PMID: 22277942; PMCID: PMC3305850.
    76. Oda Y, Hu L, Bul V, Elalieh H, Reddy JK, Bikle D. Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterations. J Invest Dermatol. 2012 Apr; 132(4):1075-83. PMID: 22189783; PMCID: PMC3400544.
    77. Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle D, Shoback DM. Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover. J Bone Miner Res. 2011 Dec; 26(12):2935-47. PMID: 21956637; PMCID: PMC3222747.
    78. Long RK, Nishida S, Kubota T, Wang Y, Sakata T, Elalieh HZ, Halloran BP, Bikle D. Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling. J Bone Miner Res. 2011 Dec; 26(12):2948-58. PMID: 21932337; PMCID: PMC3222734.
    79. Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E. Negative cross-talk between calcium-sensing receptor and ß-catenin signaling systems in colonic epithelium. J Biol Chem. 2012 Jan 6; 287(2):1158-67. PMID: 22094462; PMCID: PMC3256874.
    80. Teichert AE, Elalieh H, Elias PM, Welsh J, Bikle D. Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice. J Invest Dermatol. 2011 Nov; 131(11):2289-97. PMID: 21814234; PMCID: PMC3193543.
    81. Wang Y, Cheng Z, Elalieh HZ, Nakamura E, Nguyen MT, Mackem S, Clemens TL, Bikle D, Chang W. IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway. J Bone Miner Res. 2011 Jul; 26(7):1437-46. PMID: 21312270; PMCID: PMC3530140.
    82. Bikle D. Vitamin D metabolism and function in the skin. Mol Cell Endocrinol. 2011 Dec 5; 347(1-2):80-9. PMID: 21664236; PMCID: PMC3188673.
    83. Tang JY, Xiao TZ, Oda Y, Chang KS, Shpall E, Wu A, So PL, Hebert J, Bikle D, Epstein EH. Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas. Cancer Prev Res (Phila). 2011 May; 4(5):744-51. PMID: 21436386; PMCID: PMC3088781.
    84. Tu CL, Chang W, Bikle D. The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A. J Invest Dermatol. 2011 May; 131(5):1119-28. PMID: 21209619; PMCID: PMC3078217.
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    186. Halloran BP, Bikle D, Harris J, Tanner S, Curren T, Morey-Holton E. Regional responsiveness of the tibia to intermittent administration of parathyroid hormone as affected by skeletal unloading. J Bone Miner Res. 1997 Jul; 12(7):1068-74. PMID: 9200006.
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    187. Bikle D, Halloran BP, Morey-Holton E. Spaceflight and the skeleton: lessons for the earthbound. Gravit Space Biol Bull. 1997 Jun; 10(2):119-35. PMID: 11540113.
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    188. Xie Z, Bikle D. Cloning of the human phospholipase C-gamma1 promoter and identification of a DR6-type vitamin D-responsive element. J Biol Chem. 1997 Mar 7; 272(10):6573-7. PMID: 9045685.
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    189. Ettinger B, Sidney S, Cummings SR, Libanati C, Bikle D, Tekawa IS, Tolan K, Steiger P. Racial differences in bone density between young adult black and white subjects persist after adjustment for anthropometric, lifestyle, and biochemical differences. J Clin Endocrinol Metab. 1997 Feb; 82(2):429-34. PMID: 9024231.
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    191. Love-Schimenti CD, Gibson DF, Ratnam AV, Bikle D. Antiestrogen potentiation of antiproliferative effects of vitamin D3 analogues in breast cancer cells. Cancer Res. 1996 Jun 15; 56(12):2789-94. PMID: 8665515.
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    192. Bikle D, Munson S, Komuves L. Zipper protein, a B-G protein with the ability to regulate actin/myosin 1 interactions in the intestinal brush border. J Biol Chem. 1996 Apr 12; 271(15):9075-83. PMID: 8621557.
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    193. Bikle D. 1,25(OH)2D3-modulated calcium induced keratinocyte differentiation. J Investig Dermatol Symp Proc. 1996 Apr; 1(1):22-7. PMID: 9627687.
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    194. Ratnam AV, Bikle D, Su MJ, Pillai S. Squamous carcinoma cell lines fail to respond to 1,25-Dihydroxyvitamin D despite normal levels of the vitamin D receptor. J Invest Dermatol. 1996 Mar; 106(3):522-5. PMID: 8648187.
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    195. Bikle D, Ratnam A, Mauro T, Harris J, Pillai S. Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor. J Clin Invest. 1996 Feb 15; 97(4):1085-93. PMID: 8613532; PMCID: PMC507156.
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    197. Ng DC, Su MJ, Kim R, Bikle D. Regulation of involucrin gene expression by calcium in normal human keratinocytes. Front Biosci. 1996 Jan 1; 1:a16-24. PMID: 9159190.
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    198. Bikle D, Abe-Hashimoto J, Su MJ, Felt S, Gibson DF, Pillai S. 22-Oxa calcitriol is a less potent regulator of keratinocyte proliferation and differentiation due to decreased cellular uptake and enhanced catabolism. J Invest Dermatol. 1995 Nov; 105(5):693-8. PMID: 7594646.
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    199. Halloran BP, Bikle D, Harris J, Autry CP, Currier PA, Tanner S, Patterson-Buckendahl P, Morey-Holton E. Skeletal unloading induces selective resistance to the anabolic actions of growth hormone on bone. J Bone Miner Res. 1995 Aug; 10(8):1168-76. PMID: 8585419.
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    200. Pillai S, Bikle D, Su MJ, Ratnam A, Abe J. 1,25-Dihydroxyvitamin D3 upregulates the phosphatidylinositol signaling pathway in human keratinocytes by increasing phospholipase C levels. J Clin Invest. 1995 Jul; 96(1):602-9. PMID: 7615834; PMCID: PMC185235.
    201. Bikle D. 1,25(OH)2D3-regulated human keratinocyte proliferation and differentiation: basic studies and their clinical application. J Nutr. 1995 Jun; 125(6 Suppl):1709S-1714S. PMID: 7782932.
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    202. Bikle D, Harris J, Halloran BP, Currier PA, Tanner S, Morey-Holton E. The molecular response of bone to growth hormone during skeletal unloading: regional differences. Endocrinology. 1995 May; 136(5):2099-109. PMID: 7720659.
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    203. Pettifor JM, Bikle D, Cavaleros M, Zachen D, Kamdar MC, Ross FP. Serum levels of free 1,25-dihydroxyvitamin D in vitamin D toxicity. Ann Intern Med. 1995 Apr 1; 122(7):511-3. PMID: 7872586.
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    204. Bikle D, Harris J, Halloran BP, Morey-Holton E. Altered skeletal pattern of gene expression in response to spaceflight and hindlimb elevation. Am J Physiol. 1994 Dec; 267(6 Pt 1):E822-7. PMID: 7810622.
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    205. Bikle D, Harris J, Halloran BP, Morey-Holton ER. Skeletal unloading induces resistance to insulin-like growth factor I. J Bone Miner Res. 1994 Nov; 9(11):1789-96. PMID: 7532347.
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    206. Bikle D, Morey-Holton ER, Doty SB, Currier PA, Tanner SJ, Halloran BP. Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage. J Bone Miner Res. 1994 Nov; 9(11):1777-87. PMID: 7863829.
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    207. Bikle D. Role of vitamin D, its metabolites, and analogs in the management of osteoporosis. Rheum Dis Clin North Am. 1994 Aug; 20(3):759-75. PMID: 7984788.
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    208. Bikle D, Harris J, Halloran BP, Roberts CT, Leroith D, Morey-Holton E. Expression of the genes for insulin-like growth factors and their receptors in bone during skeletal growth. Am J Physiol. 1994 Aug; 267(2 Pt 1):E278-86. PMID: 8074208.
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    209. Bikle D, Halloran BP, Morey-Holton E. Impact of skeletal unloading on bone formation: role of systemic and local factors. Acta Astronaut. 1994 Jul; 33:119-29. PMID: 11539511.
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    210. Su MJ, Bikle D, Mancianti ML, Pillai S. 1,25-Dihydroxyvitamin D3 potentiates the keratinocyte response to calcium. J Biol Chem. 1994 May 20; 269(20):14723-9. PMID: 7910167.
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    211. Bikle D, Halloran BP, Riviere JE. Production of 1,25 dihydroxyvitamin D3 by perfused pig skin. J Invest Dermatol. 1994 May; 102(5):796-8. PMID: 8176265.
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    212. Kaune R, Munson S, Bikle D. Regulation of calmodulin binding to the ATP extractable 110 kDa protein (myosin I) from chicken duodenal brush border by 1,25-(OH)2D3. Biochim Biophys Acta. 1994 Mar 23; 1190(2):329-36. PMID: 8142433.
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    213. Bikle D, Gee E, Pillai S. Regulation of keratinocyte growth, differentiation, and vitamin D metabolism by analogs of 1,25-dihydroxyvitamin D. J Invest Dermatol. 1993 Nov; 101(5):713-8. PMID: 8228333.
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    214. Bikle D, Stesin A, Halloran B, Steinbach L, Recker R. Alcohol-induced bone disease: relationship to age and parathyroid hormone levels. Alcohol Clin Exp Res. 1993 Jun; 17(3):690-5. PMID: 8333602.
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    215. Halloran BP, Bikle D, Harris J, Foskett HC, Morey-Holton E. Skeletal unloading decreases production of 1,25-dihydroxyvitamin D. Am J Physiol. 1993 May; 264(5 Pt 1):E712-6. PMID: 8498493.
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    216. Bikle D, Pillai S. Vitamin D, calcium, and epidermal differentiation. Endocr Rev. 1993 Feb; 14(1):3-19. PMID: 8491153.
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    217. Bikle D, Halloran B, Fong L, Steinbach L, Shellito J. Elevated 1,25-dihydroxyvitamin D levels in patients with chronic obstructive pulmonary disease treated with prednisone. J Clin Endocrinol Metab. 1993 Feb; 76(2):456-61. PMID: 8432789.
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    218. Bikle D, Munson S, Morrison N, Eisman J. Zipper protein, a newly described tropomyosin-like protein of the intestinal brush border. J Biol Chem. 1993 Jan 5; 268(1):620-6. PMID: 7678004.
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    219. Bikle D. Alcohol-induced bone disease. World Rev Nutr Diet. 1993; 73:53-79. PMID: 8367983.
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    220. Pillai S, Menon GK, Bikle D, Elias PM. Localization and quantitation of calcium pools and calcium binding sites in cultured human keratinocytes. J Cell Physiol. 1993 Jan; 154(1):101-12. PMID: 8419397.
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    221. Portale AA, Halloran BP, Harris ST, Bikle D, Morris RC. Metabolic acidosis reverses the increase in serum 1,25(OH)2D in phosphorus-restricted normal men. Am J Physiol. 1992 Dec; 263(6 Pt 1):E1164-70. PMID: 1476189.
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    222. Bikle D. Clinical counterpoint: vitamin D: new actions, new analogs, new therapeutic potential. Endocr Rev. 1992 Nov; 13(4):765-84. PMID: 1459048.
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    223. Orwoll E, Ware M, Stribrska L, Bikle D, Sanchez T, Andon M, Li H. Effects of dietary protein deficiency on mineral metabolism and bone mineral density. Am J Clin Nutr. 1992 Aug; 56(2):314-9. PMID: 1636610.
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    224. Bikle D, Halloran BP, Harris ST, Portale AA. Progestin antagonism of estrogen stimulated 1,25-dihydroxyvitamin D levels. J Clin Endocrinol Metab. 1992 Aug; 75(2):519-23. PMID: 1639954.
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    225. Pillai S, Bikle D. Adenosine triphosphate stimulates phosphoinositide metabolism, mobilizes intracellular calcium, and inhibits terminal differentiation of human epidermal keratinocytes. J Clin Invest. 1992 Jul; 90(1):42-51. PMID: 1321844; PMCID: PMC443061.
    226. Pillai S, Bikle D. Lanthanum influx into cultured human keratinocytes: effect on calcium flux and terminal differentiation. J Cell Physiol. 1992 Jun; 151(3):623-9. PMID: 1363554.
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    227. Bikle D, Pillai S, Gee E. Squamous carcinoma cell lines produce 1,25 dihydroxyvitamin D, but fail to respond to its prodifferentiating effect. J Invest Dermatol. 1991 Sep; 97(3):435-41. PMID: 1875043.
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    228. Bikle D, Pillai S, Gee E, Hincenbergs M. Tumor necrosis factor-alpha regulation of 1,25-dihydroxyvitamin D production by human keratinocytes. Endocrinology. 1991 Jul; 129(1):33-8. PMID: 1675987.
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    229. Bikle D, Munson S, Mancianti ML. Limited tissue distribution of the intestinal brush border myosin I protein. Gastroenterology. 1991 Feb; 100(2):395-402. PMID: 1985037.
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    230. Pillai S, Bikle D, Mancianti ML, Hincenbergs M. Uncoupling of the calcium-sensing mechanism and differentiation in squamous carcinoma cell lines. Exp Cell Res. 1991 Feb; 192(2):567-73. PMID: 1988295.
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    231. Pillai S, Bikle D. Epidermal vitamin D metabolism, function, and regulation. Adv Lipid Res. 1991; 24:321-41. PMID: 1763717.
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    232. Pillai S, Bikle D. Role of intracellular-free calcium in the cornified envelope formation of keratinocytes: differences in the mode of action of extracellular calcium and 1,25 dihydroxyvitamin D3. J Cell Physiol. 1991 Jan; 146(1):94-100. PMID: 1990023.
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    233. Bikle D, Halloran BP, McGalliard-Cone C, Morey-Holton E. Different responses of trabecular and cortical bone to 1,25(OH)2D3 infusion. Am J Physiol. 1990 Nov; 259(5 Pt 1):E715-22. PMID: 2240210.
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    234. Pillai S, Bikle D, Mancianti ML, Cline P, Hincenbergs M. Calcium regulation of growth and differentiation of normal human keratinocytes: modulation of differentiation competence by stages of growth and extracellular calcium. J Cell Physiol. 1990 May; 143(2):294-302. PMID: 1970572.
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    235. Diamond T, Stiel D, Mason R, Lissner D, Bikle D, Wilson S, Posen S. Serum vitamin D metabolites are not responsible for low turnover osteoporosis in chronic liver disease. J Clin Endocrinol Metab. 1989 Dec; 69(6):1234-9. PMID: 2584358.
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    236. Patterson-Buckendahl P, Globus RK, Bikle D, Cann CE, Morey-Holton E. Effects of simulated weightlessness on rat osteocalcin and bone calcium. Am J Physiol. 1989 Nov; 257(5 Pt 2):R1103-9. PMID: 2589536.
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    237. Sessions ND, Halloran BP, Bikle D, Wronski TJ, Cone CM, Morey-Holton E. Bone response to normal weight bearing after a period of skeletal unloading. Am J Physiol. 1989 Oct; 257(4 Pt 1):E606-10. PMID: 2801939.
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    238. Barnes PF, Modlin RL, Bikle D, Adams JS. Transpleural gradient of 1,25-dihydroxyvitamin D in tuberculous pleuritis. J Clin Invest. 1989 May; 83(5):1527-32. PMID: 2540219; PMCID: PMC303857.
    239. Pillai S, Bikle D, Eessalu TE, Aggarwal BB, Elias PM. Binding and biological effects of tumor necrosis factor alpha on cultured human neonatal foreskin keratinocytes. J Clin Invest. 1989 Mar; 83(3):816-21. PMID: 2466051; PMCID: PMC303753.
    240. Halloran BP, Bikle D, Castro ME, Gee E. Isotopic labeling affects 1,25-dihydroxyvitamin D metabolism. Biochemistry. 1989 Feb 7; 28(3):1278-81. PMID: 2713363.
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    241. Bikle D, Gee E. Free, and not total, 1,25-dihydroxyvitamin D regulates 25-hydroxyvitamin D metabolism by keratinocytes. Endocrinology. 1989 Feb; 124(2):649-54. PMID: 2463902.
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    242. Bikle D, Pillai S, Gee E, Hincenbergs M. Regulation of 1,25-dihydroxyvitamin D production in human keratinocytes by interferon-gamma. Endocrinology. 1989 Feb; 124(2):655-60. PMID: 2463903.
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    243. Bikle D, Munson S, Christakos S, Kumar R, Buckendahl P. Calmodulin binding to the intestinal brush-border membrane: comparison to other calcium-binding proteins. Biochim Biophys Acta. 1989 Jan 17; 1010(1):122-7. PMID: 2909247.
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    244. Halloran BP, Bikle D, Cone CM, Morey-Holton E. Glucocorticoids and inhibition of bone formation induced by skeletal unloading. Am J Physiol. 1988 Dec; 255(6 Pt 1):E875-9. PMID: 3202163.
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    245. Taylor A, Bikle D, Norman ME. Serum dihydrotachysterol levels and biological action in normal man. J Clin Endocrinol Metab. 1988 Jul; 67(1):198-202. PMID: 3379133.
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    246. Pillai S, Bikle D, Elias PM. 1,25-Dihydroxyvitamin D production and receptor binding in human keratinocytes varies with differentiation. J Biol Chem. 1988 Apr 15; 263(11):5390-5. PMID: 2451669.
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    247. Bikle D. Effects of alcohol abuse on bone. Compr Ther. 1988 Feb; 14(2):16-20. PMID: 3278834.
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    248. Pillai S, Bikle D, Hincenbergs M, Elias PM. Biochemical and morphological characterization of growth and differentiation of normal human neonatal keratinocytes in a serum-free medium. J Cell Physiol. 1988 Feb; 134(2):229-37. PMID: 2450102.
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    249. Pillai S, Bikle D, Elias PM. Vitamin D and epidermal differentiation: evidence for a role of endogenously produced vitamin D metabolites in keratinocyte differentiation. Skin Pharmacol. 1988; 1(3):149-60. PMID: 3078531.
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    250. Bikle D, Pillai S. Vitamin D metabolite production and function in keratinocytes. Ann N Y Acad Sci. 1988; 548:27-44. PMID: 2470300.
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    251. Feingold KR, Williams ML, Pillai S, Menon GK, Halloran BP, Bikle D, Elias PM. The effect of vitamin D status on cutaneous sterologenesis in vivo and in vitro. Biochim Biophys Acta. 1987 Sep 14; 930(2):193-200. PMID: 3040120.
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    252. Cunningham J, Bikle D, Avioli LV. Effect of dietary acid and calcium on 25-hydroxyvitamin D metabolism by chick kidney. J Bone Miner Res. 1987 Aug; 2(4):289-96. PMID: 3455615.
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    253. Bikle D, Halloran BP, Cone CM, Globus RK, Morey-Holton E. The effects of simulated weightlessness on bone maturation. Endocrinology. 1987 Feb; 120(2):678-84. PMID: 3803298.
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    254. Long RG, Bikle D, Munson SJ. Stimulation by 1,25-dihydroxyvitamin D3 of adenylate cyclase along the villus of chick duodenum. Endocrinology. 1986 Dec; 119(6):2568-73. PMID: 3780539.
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    255. Wronski TJ, Halloran BP, Bikle D, Globus RK, Morey-Holton ER. Chronic administration of 1,25-dihydroxyvitamin D3: increased bone but impaired mineralization. Endocrinology. 1986 Dec; 119(6):2580-5. PMID: 3780540.
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    256. Bikle D, Gee EA, Munson SJ. Effect of ethanol on intestinal calcium transport in chicks. Gastroenterology. 1986 Oct; 91(4):870-6. PMID: 3743964.
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    257. Bikle D, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab. 1986 Oct; 63(4):954-9. PMID: 3745408.
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    258. Halloran BP, Bikle D, Levens MJ, Castro ME, Globus RK, Holton E. Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate. J Clin Invest. 1986 Sep; 78(3):622-8. PMID: 3489007; PMCID: PMC423635.
    259. Bikle D, Halloran BP, Gee E, Ryzen E, Haddad JG. Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels. J Clin Invest. 1986 Sep; 78(3):748-52. PMID: 3745436; PMCID: PMC423667.
    260. Bikle D, Nemanic MK, Gee E, Elias P. 1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation. J Clin Invest. 1986 Aug; 78(2):557-66. PMID: 2426308; PMCID: PMC423594.
    261. Bikle D, Nemanic MK, Whitney JO, Elias PW. Neonatal human foreskin keratinocytes produce 1,25-dihydroxyvitamin D3. Biochemistry. 1986 Apr 8; 25(7):1545-8. PMID: 2423114.
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    262. Globus RK, Bikle D, Halloran B, Morey-Holton E. Skeletal response to dietary calcium in a rat model simulating weightlessness. J Bone Miner Res. 1986 Apr; 1(2):191-7. PMID: 3503537.
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    263. Halloran BP, Bikle D, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E. The role of 1,25-dihydroxyvitamin D in the inhibition of bone formation induced by skeletal unloading. Endocrinology. 1986 Mar; 118(3):948-54. PMID: 3485043.
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    264. Globus RK, Bikle D, Morey-Holton E. The temporal response of bone to unloading. Endocrinology. 1986 Feb; 118(2):733-42. PMID: 3943489.
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    265. Bikle D, Munson S. The villus gradient of brush border membrane calmodulin and the calcium-independent calmodulin-binding protein parallels that of calcium-accumulating ability. Endocrinology. 1986 Feb; 118(2):727-32. PMID: 3753677.
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    266. Halloran BP, Bikle D, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E. Effect of simulated weightlessness and chronic 1,25-dihydroxyvitamin D administration on bone metabolism. Physiologist. 1985 Dec; 28(6 Suppl):S127-8. PMID: 3841737.
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    267. Bikle D, Munson S. 1,25-Dihydroxyvitamin D increases calmodulin binding to specific proteins in the chick duodenal brush border membrane. J Clin Invest. 1985 Dec; 76(6):2312-6. PMID: 3841129; PMCID: PMC424356.
    268. Bikle D, Halloran BP, Cone CM, Morey-Holton E. Bone loss during simulated weightlessness: is it glucocorticoid mediated? Physiologist. 1985 Dec; 28(6 Suppl):S123-4. PMID: 3834430.
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    269. Bikle D, Siiteri PK, Ryzen E, Haddad JG. Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels. J Clin Endocrinol Metab. 1985 Nov; 61(5):969-75. PMID: 3840175.
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    270. Bikle D, Genant HK, Cann C, Recker RR, Halloran BP, Strewler GJ. Bone disease in alcohol abuse. Ann Intern Med. 1985 Jul; 103(1):42-8. PMID: 2988390.
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    271. Bikle D, Halloran BP, Whitney JO, Hollis BW. Measurement of 25,26-dihydroxyvitamin D: importance of the configuration of the C-25 hydroxyl group. Biochemistry. 1984 Dec 18; 23(26):6920-5. PMID: 6543324.
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    272. Bikle D, Zolock DT, Munson S. Differential response of duodenal epithelial cells to 1,25-dihydroxyvitamin D3 according to position on the villus: a comparison of calcium uptake, calcium-binding protein, and alkaline phosphatase activity. Endocrinology. 1984 Dec; 115(6):2077-84. PMID: 6548695.
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    273. Bikle D, Gee E, Halloran B, Haddad JG. Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J Clin Invest. 1984 Dec; 74(6):1966-71. PMID: 6549014; PMCID: PMC425383.
    274. Halloran BP, Bikle D, Whitney JO. Separation of isotopically labeled vitamin D metabolites by high-performance liquid chromatography. J Chromatogr. 1984 Oct 26; 303(1):229-33. PMID: 6511833.
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    275. Bikle D, Munson S, Chafouleas J. Calmodulin may mediate 1,25-dihydroxyvitamin D-stimulated intestinal calcium transport. FEBS Lett. 1984 Aug 20; 174(1):30-3. PMID: 6547914.
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    276. Globus RK, Bikle D, Morey-Holton E. Effects of simulated weightlessness on bone mineral metabolism. Endocrinology. 1984 Jun; 114(6):2264-70. PMID: 6723581.
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    277. Bikle D, Munson S, Chafouleas JG. The role of calmodulin in 1,25-dihydroxyvitamin D regulation of calcium transport across the intestinal brush border membrane. Prog Clin Biol Res. 1984; 168:193-8. PMID: 6549067.
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    278. Bikle D, Whitney J, Munson S. The relationship of membrane fluidity to calcium flux in chick intestinal brush border membranes. Endocrinology. 1984 Jan; 114(1):260-7. PMID: 6546306.
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    279. Cunningham J, Bikle D, Avioli LV. Acute, but not chronic, metabolic acidosis disturbs 25-hydroxyvitamin D3 metabolism. Kidney Int. 1984 Jan; 25(1):47-52. PMID: 6610073.
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    280. Simmons DJ, Grazman B, Russell JE, Walker WV, Bikle D, Morey ER. Simulating certain aspects of hypogravity: effects on bone maturation in the non-weight bearing skeleton. Aviat Space Environ Med. 1983 Dec; 54(12 Pt 1):1080-4. PMID: 6661121.
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    281. Bikle D, Munson S, Zolock DT. Calcium flux across chick duodenal brush border membrane vesicles: regulation by 1,25-dihydroxyvitamin D. Endocrinology. 1983 Dec; 113(6):2072-80. PMID: 6416812.
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    282. Bikle D. Fluoride treatment of osteoporosis: a new look at an old drug. Ann Intern Med. 1983 Jun; 98(6):1013-5. PMID: 6859684.
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    283. Bikle D. Calcium absorption and vitamin D metabolism. Clin Gastroenterol. 1983 May; 12(2):379-94. PMID: 6347462.
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    284. Bikle D, Herman RH, Hull S, Hagler L, Harris D, Halloran B. Adaptive response of humans to changes in dietary calcium: relationship between vitamin D regulated intestinal function and serum 1,25-dihydroxyvitamin D levels. Gastroenterology. 1983 Feb; 84(2):314-23. PMID: 6687358.
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    285. Bikle D, Herman RH. Calcium potentiates the cyclic nucleotide and phosphaturic response to parathyroid hormone infusion. J Clin Endocrinol Metab. 1983 Jan; 56(1):11-7. PMID: 6292254.
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    286. Bikle D, Peck CC, Holford NH, Zolock DT, Morrissey RL. Pharmacokinetics and pharmacodynamics of 1,25-dihydroxyvitamin D3 in the chick. Endocrinology. 1982 Sep; 111(3):939-46. PMID: 6896685.
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    287. Bikle D. The vitamin D endocrine system. Adv Intern Med. 1982; 27:45-71. PMID: 7041549.
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    288. Rost CR, Bikle D, Kaplan RA. In vitro stimulation of 25-hydroxycholecalciferol 1 alpha-hydroxylation by parathyroid hormone in chick kidney slices: evidence for a role for adenosine 3',5'-monophosphate. Endocrinology. 1981 Mar; 108(3):1002-6. PMID: 6257493.
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    289. Bikle D, Morrissey RL, Zolock DT, Rasmussen H. The intestinal response to vitamin D. Rev Physiol Biochem Pharmacol. 1981; 89:63-142. PMID: 7015459.
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    290. Bikle D, Zolock DT, Morrissey RL. Action of vitamin D on intestinal calcium transport. Ann N Y Acad Sci. 1981; 372:481-501. PMID: 6951425.
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    291. Bikle D. Studies of the chick renal mitochondrial 25-hydroxyvitamin D-3 24-hydroxylase. Biochim Biophys Acta. 1980 Sep 9; 615(1):208-22. PMID: 6775702.
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    292. Bikle D, Spencer EM, Burke WH, Rost CR. Prolactin but not growth hormone stimulates 1,25-dihydroxyvitamin D3 production by chick renal preparations in vitro. Endocrinology. 1980 Jul; 107(1):81-4. PMID: 6892897.
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    293. Bikle D, Askew EW, Zolock DT, Morrissey RL, Herman RH. Calcium accumulation by chick intestinal mitochondria. Regulation by vitamin D-3 and 1,25-dihydroxyvitamin D-3. Biochim Biophys Acta. 1980 Jun 6; 598(3):561-74. PMID: 6155944.
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    294. Bikle D, Empson RN, Morrissey RL, Zolock DT, Bucci TJ, Herman RH, Pechet MM. Effects of 1 alpha-hydroxy vitamin D3 on the rachitic chick intestine: a comparison to the effects of 1,25-dihydroxyvitamin D3. Calcif Tissue Int. 1980; 32(1):9-17. PMID: 6775785.
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    295. Bikle D, Morrissey RL, Zolock DT. The mechanism of action of vitamin D in the intestine. Am J Clin Nutr. 1979 Nov; 32(11):2322-8. PMID: 158978.
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    296. Bikle D, Morrissey RL, Zolock DT, Herman RH. Stimulation of chick gut alkaline phosphatase activity by actinomycin D and 1,25-dihydroxyvitamin D3: evidence for independent mechanisms. J Lab Clin Med. 1979 Jul; 94(1):88-94. PMID: 313969.
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    297. Bikle D, Hagler L, Lollini LO, Hull SF, Herman RH. Work-induced muscle hypertrophy in vitamin D-deficient rats. Am J Clin Nutr. 1979 Mar; 32(3):515-6. PMID: 420144.
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    298. Morrissey RL, Zolock DT, Bucci TJ, Bikle D. Immunoperoxidase localization of vitamin D dependent calcium binding protein. J Histochem Cytochem. 1978 Aug; 26(8):628-34. PMID: 357647.
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    299. Bikle D, Rasmussen H. A biochemical model for the ionic control of 25-hydroxyvitamin D3 1alpha-hydroxylase. J Biol Chem. 1978 May 10; 253(9):3042-8. PMID: 25278.
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    300. Bikle D, Zolock DT, Morrissey RL, Herman RH. Independence of 1,25-dihydroxyvitamin D3-mediated calcium transport from de novo RNA and protein synthesis. J Biol Chem. 1978 Jan 25; 253(2):484-8. PMID: 618881.
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    301. Morrissey RL, Zolock DT, Bikle D, Empson RN, Bucci TJ. Intestinal response to 1 alpha, 25-dihydroxycholecalciferol. I. RNA polymerase, alkaline phosphatase, calcium and phosphorus uptake in vitro, and in vivo calcium transport and accumulation. Biochim Biophys Acta. 1978 Jan 3; 538(1):23-33. PMID: 620061.
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    302. Morrissey RL, Empson RN, Zolock DT, Bikle D, Bucci TJ. Intestinal response to 1alpha,25-dihydroxycholecalciferol. II. A timed study of the intracellular localization of calcium binding protein. Biochim Biophys Acta. 1978 Jan 3; 538(1):34-41. PMID: 620062.
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    303. Bikle D, Rasmussen H. Ionic control of 1,25-dihydroxy vitamin D-3 production by isolated chick renal mitochondria. Influence of anions and sucrose. Biochim Biophys Acta. 1978 Jan 3; 538(1):127-38. PMID: 413585.
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    304. Bikle D, Empson RN, Herman RH, Morrissey RL, Zolock DR. The effect of 1,25-dihydroxyvitamin D-3 on the distribution of alkaline phosphatase activity along the chick intestinal villus. Biochim Biophys Acta. 1977 Aug 25; 499(1):61-6. PMID: 889896.
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    305. Bikle D, Murphy EW, Rasmussen H. The ionic control of 1,25-dihydroxyvitamin D-3 synthesis in isolated chick renal mitochondria. The role of potassium. Biochim Biophys Acta. 1976 Jul 21; 437(2):394-402. PMID: 8103.
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    306. Bikle D, Murphy EW, Rasmussen H. The ionic control of 1,25-dihydroxyvitamin D3 synthesis in isolated chick renal mitochondria. The role of calcium as influenced by inorganic phosphate and hydrogen-ion. J Clin Invest. 1975 Feb; 55(2):299-304. PMID: 236327; PMCID: PMC301748.
    307. Bikle D, Rasmussen H. The ionic control of 1,25-dihydroxyvitamin D3 production in isolated chick renal tubules. J Clin Invest. 1975 Feb; 55(2):292-8. PMID: 236326; PMCID: PMC301747.
    308. Bikle D, Rasmussen H. A comparison of the metabolism of 25-hydroxyvitamin D3 by chick renal tubules, homogenates and mitochondria. Biochim Biophys Acta. 1974 Oct 8; 362(3):439-47. PMID: 4411605.
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    309. Bikle D, Rasmussen H. The metabolism of 25-hydroxycholecalciferol by isolated renal tubules in vitro as studied by a new chromatographic technique. Biochim Biophys Acta. 1974 Oct 8; 362(3):425-38. PMID: 4370485.
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    310. Rasmussen H, Wong M, Bikle D, Goodman DB. Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. J Clin Invest. 1972 Sep; 51(9):2502-4. PMID: 4344734; PMCID: PMC292420.
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