Daniel Bikle, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address4150 Clement Street, #210
San Francisco CA 94121
ORCID ORCID Icon0000-0002-1040-475x Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of PennsylvaniaMD1969School of Medicine
    University of PennsylvaniaPhD1974Graduate School of Arts and Sciences
    Collapse Awards and Honors
    Harvard1965Henderson Memorial Prize in Biochemistry
    Harvard1965Magna Cum Laude
    University of Pennsylvania1966Baldwin Lucke Memorial Prize
    University of Pennsylvania1968alpha omega alpha
    University of Pennsylvania1969Horatio C Wood Prize in Pharmacology
    University of Pennsylvania1969Borden Research Award
    University of Pennsylvania1969Spencer Morris Prize
    American College of Physicians1982Fellow, American College of Physicians
    American Society of Clinical Investigation1985member American Society of Clinical Investigation
    Association of American Physicians1995member Association of American Physicians
    ASBMR2007Boy Frame Award for Clinical Excellence in Bone and Mineral Research
    International Workshop for Vitamin D2009Career Award in Vitamin D research
    ASBMR2016Louis V Avioli Founders Award
    ASBMR2019Fellowship, ASBMR

    Collapse Overview 
    Collapse Overview
    I am Professor of Medicine and Dermatology emeritus on call back at UCSF and staff Endocrinologist at SFVAMC. I continue both my clinical activities and direct a well funded laboratory investigating hormonal regulation of fracture healing and vitamin D and calcium regulation of both skin cancer and wound response.

    Collapse Research 
    Collapse Research Activities and Funding
    BCCMA: Foundational Research to Act Upon and Resist Conditions Unfavorable to bone (FRACTURECURB): Role of abaloparatide for fracture healing
    VA 1I01 BX005854Oct 1, 2022 - Sep 30, 2026
    Role: PI
    Description: This project will examine the molecular and cellular mechanisms by which abaloparatide enhances fracture repair
    Biomechanical computed tomography facilitates the diagnosis of osteoporosis and fracture prediction in patients with high risk prostate cancer
    DOD PC210172Jun 1, 2022 - May 31, 2026
    Role: PI
    Description: This project will use biomechanical computed tomography to determine the risk of osteoporosis and fracture in individuals being reated with high risk prostate cancer
    Maladaptive Plasticity in Spinal Cord Injury: Cellular Mechanisms
    NIH R01NS122888Jul 15, 2021 - Jun 3, 2026
    Role: PI of subcontract
    Description: To explore the spinal cellular mechanisms engaged by concomitant peripheral injuries and limb disuse in SCI, and to test their contribution to spasticity/hyper-reflexia and chronic spinal recovery impairments
    Vitamin D and Calcium signaling in epidermal stem cell maintenance, activation, and function
    NIH I01BX003814Jan 1, 2018 - Dec 31, 2021
    Role: Principal Investigator
    Role of IGF-I/integrin signaling in the periosteal response to load
    NIH R01AR055924Apr 1, 2008 - Jan 31, 2021
    Role: Principal Investigator
    Vitamin D Receptor Coactivators in Keratinocytes
    NIH R01AR050023Jul 1, 2003 - May 31, 2016
    Role: Principal Investigator
    IGF-1 Mediates the Anabolic Effects of PTH on Bone
    NIH R01DK054793Feb 15, 2001 - Aug 31, 2015
    Role: Principal Investigator
    NIH R03CA070572Sep 30, 1995 - Mar 31, 1999
    Role: Principal Investigator
    Relationship of Keratinocyte Function to Differentiation
    NIH P01AR039448Jul 15, 1988 - Jul 31, 2010
    Role: Principal Investigator
    NIH R01AR038386May 1, 1987 - Mar 31, 2005
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    NIH R01DK028116Apr 1, 1981 - Jun 30, 2004
    Role: Principal Investigator
    NIH R01AM028116Apr 1, 1981 - Mar 31, 1987
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Vitamin D and Long COVID: Is There a Role in Prevention or Treatment? J Clin Endocrinol Metab. 2023 Dec 21; 109(1):e430-e431. Bikle DD. PMID: 37279939.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Validation of Biomechanical Computed Tomography for Fracture Risk Classification in Metastatic Hormone-sensitive Prostate Cancer. Eur Urol Oncol. 2023 Nov 03. Lin JK, Hearn CM, Getzen E, Long Q, Lee DC, Keaveny TM, Jayadevappa R, Robinson KW, Wong YN, Maxwell KN, Narayan V, Haas NB, Takvorian SU, Bikle DD, Chiang JM, Khan AN, Rajapakse CS, Morgans AK, Parikh RB. PMID: 37926618.
      View in: PubMed   Mentions:    Fields:    
    3. Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics. Commun Biol. 2023 07 21; 6(1):766. Thaler R, Yoshizaki K, Nguyen T, Fukumoto S, Den Besten P, Bikle DD, Oda Y. PMID: 37479880; PMCID: PMC10362024.
      View in: PubMed   Mentions: 2  Translation:AnimalsCells
    4. Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate. J Steroid Biochem Mol Biol. 2023 09; 232:106352. Oda Y, Wong CT, Oh DH, Meyer MB, Pike JW, Bikle DD. PMID: 37330071.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Vitamin D and malabsorptive gastrointestinal conditions: A bidirectional relationship? Rev Endocr Metab Disord. 2023 04; 24(2):121-138. Giustina A, di Filippo L, Allora A, Bikle DD, Cavestro GM, Feldman D, Latella G, Minisola S, Napoli N, Trasciatti S, Uygur M, Bilezikian JP. PMID: 36813995; PMCID: PMC9946876.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. Highlights from the 24th workshop on vitamin D in Austin, September 2022. J Steroid Biochem Mol Biol. 2023 04; 228:106247. Meyer MB, Bernal-Mizrachi C, Bikle DD, Biyani M, Campbell MJ, Chaudhari SN, Christakos S, Ingles SA, Knuth MM, Lee SM, Lisse TS, Liu ES, Piec I, Plum LA, Rao SD, Reynolds CJ, Thacher TD, White JH, Cantorna MT. PMID: 36639037; PMCID: PMC10006320.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Prevalence of osteoporosis in older male veterans receiving hip-containing computed tomography scans: opportunistic use of biomechanical computed tomography analysis (BCT). Osteoporos Int. 2023 Mar; 34(3):551-561. Teng PF, Chiang JM, Schafer AL, Sukerkar PA, Keaveny TM, Bikle D. PMID: 36580097; PMCID: PMC9908633.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Skin and bone crosstalk during aging. Nat Aging. 2022 10; 2(10):874-875. Mauro T, Bikle D. PMID: 37118286.
      View in: PubMed   Mentions:
    9. Role of vitamin D and calcium signaling in epidermal wound healing. J Endocrinol Invest. 2023 Feb; 46(2):205-212. Bikle DD. PMID: 35963983; PMCID: PMC9859773.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    10. Response to Letters to the Editor RE: Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality. J Gen Intern Med. 2022 10; 37(13):3494. Seal KH, Bertenthal D, Bikle DD. PMID: 35727478; PMCID: PMC9209827.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Vitamin D Regulation of Immune Function. Curr Osteoporos Rep. 2022 06; 20(3):186-193. Bikle DD. PMID: 35507293; PMCID: PMC9065668.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    12. Vitamin D regulation of immune function during covid-19. Rev Endocr Metab Disord. 2022 04; 23(2):279-285. Bikle DD. PMID: 35091881; PMCID: PMC8799423.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    13. Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality. J Gen Intern Med. 2022 03; 37(4):853-861. Seal KH, Bertenthal D, Carey E, Grunfeld C, Bikle DD, Lu CM. PMID: 34981368; PMCID: PMC8723909.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    14. Ligand-Independent Actions of the Vitamin D Receptor: More Questions Than Answers. JBMR Plus. 2021 Dec; 5(12):e10578. Bikle DD. PMID: 34950833; PMCID: PMC8674770.
      View in: PubMed   Mentions: 6  
    15. Hypercalcemia in non-Hodgkin's lymphoma due to cosecretion of PTHrP and 1,25-dihydroxyvitamin D. Osteoporos Int. 2021 Dec; 32(12):2587-2592. Gonciulea AR, Wang Y, Bikle DD, Sellmeyer DE. PMID: 34230999.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Vitamin D regulation of and by long non coding RNAs. Mol Cell Endocrinol. 2021 07 15; 532:111317. Bikle DD. PMID: 34015414.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    17. Decreased Calcium-Sensing Receptor Expression Controls Calcium Signaling and Cell-To-Cell Adhesion Defects in Aged Skin. J Invest Dermatol. 2021 11; 141(11):2577-2586. Celli A, Tu CL, Lee E, Bikle DD, Mauro TM. PMID: 33862069; PMCID: PMC8526647.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    18. Introduction: Special Issue on Vitamin D Dedicated to the Memory of Anthony W Norman. JBMR Plus. 2021 Jan; 5(1):e10445. Bouillon R, Haussler M, Bikle D, Christakos S, Welsh J. PMID: 33553991; PMCID: PMC7839816.
      View in: PubMed   Mentions: 1  
    19. Ablation of Ephrin B2 in Col2 Expressing Cells Delays Fracture Repair. Endocrinology. 2020 12 01; 161(12). Wang Y, Ling L, Tian F, Won Kim SH, Ho S, Bikle DD. PMID: 32987403; PMCID: PMC7609132.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    20. Transcriptional Regulation of Dental Epithelial Cell Fate. Int J Mol Sci. 2020 Nov 25; 21(23). Yoshizaki K, Fukumoto S, Bikle DD, Oda Y. PMID: 33255698; PMCID: PMC7728066.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    21. The Free Hormone Hypothesis: When, Why, and How to Measure the Free Hormone Levels to Assess Vitamin D, Thyroid, Sex Hormone, and Cortisol Status. JBMR Plus. 2021 Jan; 5(1):e10418. Bikle DD. PMID: 33553985; PMCID: PMC7839820.
      View in: PubMed   Mentions: 23  
    22. MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19. Eur J Endocrinol. 2020 Nov; 183(5):R133-R147. Bilezikian JP, Bikle D, Hewison M, Lazaretti-Castro M, Formenti AM, Gupta A, Madhavan MV, Nair N, Babalyan V, Hutchings N, Napoli N, Accili D, Binkley N, Landry DW, Giustina A. PMID: 32755992; PMCID: PMC9494342.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansCellsPHPublic Health
    23. Deletion of Mediator 1 suppresses TGFβ signaling leading to changes in epidermal lineages and regeneration. PLoS One. 2020; 15(8):e0238076. Oda Y, Nguyen T, Hata A, Meyer MB, Pike JW, Bikle DD. PMID: 32857768; PMCID: PMC7455038.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    24. Vitamin D and calcium signaling in epidermal stem cells and their regeneration. World J Stem Cells. 2020 Jul 26; 12(7):604-611. Oda Y, Bikle DD. PMID: 32843916; PMCID: PMC7415249.
      View in: PubMed   Mentions: 6  
    25. p120-catenin suppresses proliferation and tumor growth of oral squamous cell carcinoma via inhibiting nuclear phospholipase C-γ1 signaling. J Cell Physiol. 2020 12; 235(12):9399-9413. Li L, Ji S, Shrestha C, Jiang Y, Liao L, Xu F, Liu Z, Bikle DD, Xie Z. PMID: 32356317; PMCID: PMC7529923.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    26. Editorial: Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions. Front Endocrinol (Lausanne). 2020; 11:40. Xie Z, Wang X, Bikle DD. PMID: 32117066; PMCID: PMC7026452.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    27. New aspects of vitamin D metabolism and action - addressing the skin as source and target. Nat Rev Endocrinol. 2020 04; 16(4):234-252. Bikle D, Christakos S. PMID: 32029884.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    28. Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level. J Endocr Soc. 2020 Feb 01; 4(2):bvz038. Bikle DD. PMID: 32051922; PMCID: PMC7007804.
      View in: PubMed   Mentions: 55  
    29. The Vitamin D Receptor as Tumor Suppressor in Skin. Adv Exp Med Biol. 2020; 1268:285-306. Bikle DD. PMID: 32918224.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    30. Vitamin D Metabolism Revised: Fall of Dogmas. J Bone Miner Res. 2019 11; 34(11):1985-1992. Bouillon R, Bikle D. PMID: 31589774; PMCID: PMC9000993.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    31. Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport. J Endocr Soc. 2019 Nov 01; 3(11):1993-2011. Munson S, Wang Y, Chang W, Bikle DD. PMID: 31620669; PMCID: PMC6789431.
      View in: PubMed   Mentions: 3  
    32. Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions. Endocr Rev. 2019 08 01; 40(4):1109-1151. Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J. PMID: 30321335; PMCID: PMC6626501.
      View in: PubMed   Mentions: 339     Fields:    Translation:HumansAnimalsCells
    33. Do sunscreens block vitamin D production? A critical review by an international panel of experts. Br J Dermatol. 2019 11; 181(5):884. Bikle DD. PMID: 31259384; PMCID: PMC9002342.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. New developments in our understanding of vitamin metabolism, action and treatment. Metabolism. 2019 09; 98:112-120. Christakos S, Li S, De La Cruz J, Bikle DD. PMID: 31226354; PMCID: PMC6814307.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    35. Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions. Front Endocrinol (Lausanne). 2019; 10:317. Bikle DD, Schwartz J. PMID: 31191450; PMCID: PMC6546814.
      View in: PubMed   Mentions: 127     Fields:    
    36. The Fracture Callus Is Formed by Progenitors of Different Skeletal Origins in a Site-Specific Manner. JBMR Plus. 2019 Sep; 3(9):e10193. Wang Y, Chen L, Kang M, Ling L, Tian F, Won-Kim SH, Ho S, Bikle DD. PMID: 31667451; PMCID: PMC6808225.
      View in: PubMed   Mentions: 2  
    37. Rapid onset of hypercalcemia from high-grade lymphoma in the setting of HIV-related immune reconstitution inflammatory syndrome. Bone Rep. 2019 Jun; 10:100194. Kim SJ, Peluso MJ, Wang Y, Bikle D, Shoback D, Kim S. PMID: 30627599; PMCID: PMC6319307.
      View in: PubMed   Mentions: 1  
    38. Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations. J Clin Endocrinol Metab. 2018 09 01; 103(9):3278-3288. Schwartz JB, Gallagher JC, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Holick M, Orwoll E, Nielson C, Kaufmann M, Jones G, Bouillon R, Lai J, Verotta D, Bikle D. PMID: 29955795; PMCID: PMC6126881.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    39. Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D. Br J Clin Pharmacol. 2018 10; 84(10):2194-2207. Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, DeLuca HF, Jones G, Munns CF, Bilezikian JP, Giustina A, Binkley N. PMID: 29851137; PMCID: PMC6138489.
      View in: PubMed   Mentions: 99     Fields:    Translation:Humans
    40. Vitamin D and bone and beyond. Bone Rep. 2018 Dec; 9:120-121. Bikle DD, Bouillon R. PMID: 30591929; PMCID: PMC6303270.
      View in: PubMed   Mentions: 3  
    41. p120-catenin is required for regulating epidermal proliferation, differentiation, and barrier function. J Cell Physiol. 2018 01; 234(1):427-432. Xie Z, Tang Y, Man MQ, Shrestha C, Bikle DD. PMID: 29923340; PMCID: PMC9000995.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    42. Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny during Cutaneous Wound Repair. J Invest Dermatol. 2018 11; 138(11):2423-2431. Oda Y, Hu L, Nguyen T, Fong C, Zhang J, Guo P, Bikle DD. PMID: 29787748; PMCID: PMC6903414.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    43. Vitamin D Assays. Front Horm Res. 2018; 50:14-30. Bikle DD. PMID: 29597233; PMCID: PMC9000996.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    44. Physiologic and pathophysiologic roles of extra renal CYP27b1: Case report and review. Bone Rep. 2018 Jun; 8:255-267. Bikle DD, Patzek S, Wang Y. PMID: 29963603; PMCID: PMC6021194.
      View in: PubMed   Mentions: 45  
    45. Current Controversies: Are Free Vitamin Metabolite Levels a More Accurate Assessment of Vitamin D Status than Total Levels? Endocrinol Metab Clin North Am. 2017 12; 46(4):901-918. Bikle DD, Malmstroem S, Schwartz J. PMID: 29080642; PMCID: PMC5675107.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    46. IGF-1 signaling mediated cell-specific skeletal mechano-transduction. J Orthop Res. 2018 02; 36(2):576-583. Tian F, Wang Y, Bikle DD. PMID: 28980721; PMCID: PMC5839951.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    47. Vitamin D Prevents Sunburn: Tips for the Summer? J Invest Dermatol. 2017 10; 137(10):2045-2047. Bikle DD. PMID: 28941472; PMCID: PMC9004584.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    48. Vitamin D: Mechanisms of Action and Clinical Applications. Endocrinol Metab Clin North Am. 2017 12; 46(4):xvii-xviii. Gallagher JC, Bikle DD. PMID: 29080648.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    49. Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene. J Biol Chem. 2017 08 18; 292(33):13531-13540. Yoshizaki K, Hu L, Nguyen T, Sakai K, Ishikawa M, Takahashi I, Fukumoto S, DenBesten PK, Bikle DD, Oda Y, Yamada Y. PMID: 28673966; PMCID: PMC5566513.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    50. Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization. Endocrinology. 2017 06 01; 158(6):1929-1938. Oda Y, Hu L, Nguyen T, Fong C, Tu CL, Bikle DD. PMID: 28368538; PMCID: PMC5460927.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    51. Current Assays to Determine Free 25-Hydroxyvitamin D in Serum. J AOAC Int. 2017 Sep 01; 100(5):1323-1327. Malmstroem S, Rejnmark L, Imboden JB, Shoback DM, Bikle DD. PMID: 28492133.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    52. VITAMIN D BINDING PROTEIN AND 25-HYDROXYVITAMIN D LEVELS: EMERGING CLINICAL APPLICATIONS. Endocr Pract. 2017 May; 23(5):605-613. Jassil NK, Sharma A, Bikle D, Wang X. PMID: 28095044; PMCID: PMC9000994.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    53. Vitamin D metabolites in captivity? Should we measure free or total 25(OH)D to assess vitamin D status? J Steroid Biochem Mol Biol. 2017 10; 173:105-116. Bikle D, Bouillon R, Thadhani R, Schoenmakers I. PMID: 28093353; PMCID: PMC9005158.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    54. p120-Catenin Is Required for Dietary Calcium Suppression of Oral Carcinogenesis in Mice. J Cell Physiol. 2017 Jun; 232(6):1360-1367. Xie Z, Yuan Y, Jiang Y, Shrestha C, Chen Y, Liao L, Ji S, Deng X, Liao E, Bikle DD. PMID: 27682597; PMCID: PMC9000997.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    55. Osteogenic Differentiation of Periosteal Cells During Fracture Healing. J Cell Physiol. 2017 05; 232(5):913-921. Wang T, Zhang X, Bikle DD. PMID: 27731505; PMCID: PMC5247290.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    56. The vitamin D hypothesis: Dead or alive?: Response to Dr. William Grant's "The UVB-vitamin D3-pigment hypothesis is alive and well-AJPA-2016-00237". Am J Phys Anthropol. 2016 12; 161(4):756-757. Elias PM, Williams ML, Bikle DD. PMID: 27634223; PMCID: PMC9000992.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    57. Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. Front Physiol. 2016; 7:296. Bikle DD, Jiang Y, Nguyen T, Oda Y, Tu CL. PMID: 27462278; PMCID: PMC4940389.
      View in: PubMed   Mentions: 32  
    58. Extraskeletal actions of vitamin D. Ann N Y Acad Sci. 2016 07; 1376(1):29-52. Bikle DD. PMID: 27649525; PMCID: PMC5031366.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimals
    59. Phosphoprotein Phosphatase 1 Is Required for Extracellular Calcium-Induced Keratinocyte Differentiation. Biomed Res Int. 2016; 2016:3062765. Shrestha C, Tang Y, Fan H, Li L, Zeng Q, Pennypacker SD, Bikle DD, Xie Z. PMID: 27340655; PMCID: PMC4909930.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    60. The Endocrine Society Centennial: Extrarenal Production of 1,25 Dihyroxyvitamin D Is Now Proven. Endocrinology. 2016 05; 157(5):1717-8. Bikle DD. PMID: 27014941; PMCID: PMC6415900.
      View in: PubMed   Mentions: 4     Fields:    
    61. The Transient Role for Calcium and Vitamin D during the Developmental Hair Follicle Cycle. J Invest Dermatol. 2016 07; 136(7):1337-1345. Mady LJ, Ajibade DV, Hsaio C, Teichert A, Fong C, Wang Y, Christakos S, Bikle DD. PMID: 26994969; PMCID: PMC9020884.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    62. Regulation of Ligand and Shear Stress-induced Insulin-like Growth Factor 1 (IGF1) Signaling by the Integrin Pathway. J Biol Chem. 2016 Apr 08; 291(15):8140-9. Tahimic CG, Long RK, Kubota T, Sun MY, Elalieh H, Fong C, Menendez AT, Wang Y, Vilardaga JP, Bikle DD. PMID: 26865633; PMCID: PMC4825016.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    63. Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites. Eur J Med Chem. 2016 Feb 15; 109:238-46. Teske KA, Bogart JW, Sanchez LM, Yu OB, Preston JV, Cook JM, Silvaggi NR, Bikle DD, Arnold LA. PMID: 26774929; PMCID: PMC4737989.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    64. Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial. J Am Geriatr Soc. 2016 Jan; 64(1):65-72. Schwartz JB, Kane L, Bikle D. PMID: 26782853; PMCID: PMC4724876.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    65. Antitumor Activity of 3-Indolylmethanamines 31B and PS121912. Anticancer Res. 2015 Nov; 35(11):6001-7. Guthrie ML, Sidhu PS, Hill EK, Horan TC, Nandhikonda P, Teske KA, Yuan NY, Sidorko M, Rodali R, Cook JM, Han L, Silvaggi NR, Bikle DD, Moore RG, Singh RK, Arnold LA. PMID: 26504023; PMCID: PMC4633305.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    66. Role of IGF-I signaling in muscle bone interactions. Bone. 2015 Nov; 80:79-88. Bikle DD, Tahimic C, Chang W, Wang Y, Philippou A, Barton ER. PMID: 26453498; PMCID: PMC4600536.
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    67. Pregnane X receptor expression in skin: the good and the bad. Exp Dermatol. 2015 Nov; 24(11):829-30. Bikle DD. PMID: 26269123; PMCID: PMC9000991.
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    70. A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting. Calcif Tissue Int. 2015 Dec; 97(6):634-9. Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC. PMID: 26253396; PMCID: PMC4861400.
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    73. Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts. J Bone Miner Res. 2015 Jun; 30(6):1064-76. Babey M, Wang Y, Kubota T, Fong C, Menendez A, ElAlieh HZ, Bikle DD. PMID: 25502173; PMCID: PMC9045460.
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    74. Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation. Front Immunol. 2015; 6:224. Bourguignon LY, Bikle D. PMID: 26029210; PMCID: PMC4429634.
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    76. Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction. Liver Int. 2015 Oct; 35(10):2294-300. Lai JC, Bikle DD, Lizaola B, Hayssen H, Terrault NA, Schwartz JB. PMID: 25757956; PMCID: PMC4567539.
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    80. Evidence That Loss-of-Function Filaggrin Gene Mutations Evolved in Northern Europeans to Favor Intracutaneous Vitamin D3 Production. Evol Biol. 2014 Sep 01; 41(3):388-396. Thyssen JP, Bikle DD, Elias PM. PMID: 25506102; PMCID: PMC4261051.
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    82. Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation. J Bone Miner Res. 2014 Aug; 29(8):1900-13. Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle DD. PMID: 24677183; PMCID: PMC4108521.
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    106. Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor. Biochemistry. 2013 Jun 18; 52(24):4193-203. Nandhikonda P, Yasgar A, Baranowski AM, Sidhu PS, McCallum MM, Pawlak AJ, Teske K, Feleke B, Yuan NY, Kevin C, Bikle DD, Ayers SD, Webb P, Rai G, Simeonov A, Jadhav A, Maloney D, Arnold LA. PMID: 23713684; PMCID: PMC3724348.
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    107. Vitamin D: beyond bone. Ann N Y Acad Sci. 2013 May; 1287:45-58. Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD. PMID: 23682710; PMCID: PMC3717170.
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    136. The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A. J Invest Dermatol. 2011 May; 131(5):1119-28. Tu CL, Chang W, Bikle DD. PMID: 21209619; PMCID: PMC3078217.
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    138. Vitamin D: an ancient hormone. Exp Dermatol. 2011 Jan; 20(1):7-13. Bikle DD. PMID: 21197695.
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    139. The vitamin D receptor: a tumor suppressor in skin. Discov Med. 2011 Jan; 11(56):7-17. Bikle DD. PMID: 21276406; PMCID: PMC4113511.
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    140. Endoplasmic reticulum Ca2+ depletion activates XBP1 and controls terminal differentiation in keratinocytes and epidermis. Br J Dermatol. 2011 Jan; 164(1):16-25. Celli A, Mackenzie DS, Crumrine DS, Tu CL, Hupe M, Bikle DD, Elias PM, Mauro TM. PMID: 20846312; PMCID: PMC3010253.
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    141. Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells. J Biol Chem. 2011 Jan 14; 286(2):997-1004. Palmer MT, Lee YK, Maynard CL, Oliver JR, Bikle DD, Jetten AM, Weaver CT. PMID: 21047796; PMCID: PMC3020784.
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    142. Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice. J Cell Physiol. 2010 Nov; 225(2):482-9. Teichert A, Elalieh H, Bikle D. PMID: 20458748; PMCID: PMC4103951.
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    143. The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiation. J Invest Dermatol. 2010 Oct; 130(10):2377-88. Oda Y, Chalkley RJ, Burlingame AL, Bikle DD. PMID: 20520624; PMCID: PMC4114506.
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    144. Differential regulation of epidermal function by VDR coactivators. J Steroid Biochem Mol Biol. 2010 Jul; 121(1-2):308-13. Bikle DD, Teichert A, Arnold LA, Uchida Y, Elias PM, Oda Y. PMID: 20298785; PMCID: PMC2906691.
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    145. Vitamin D: newly discovered actions require reconsideration of physiologic requirements. Trends Endocrinol Metab. 2010 Jun; 21(6):375-84. Bikle DD. PMID: 20149679; PMCID: PMC2880203.
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    146. Vitamin D and the skin. J Bone Miner Metab. 2010 Mar; 28(2):117-30. Bikle DD. PMID: 20107849.
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    147. Association of prediagnostic serum vitamin D levels with the development of basal cell carcinoma. J Invest Dermatol. 2010 May; 130(5):1438-43. Asgari MM, Tang J, Warton ME, Chren MM, Quesenberry CP, Bikle D, Horst RL, Orentreich N, Vogelman JH, Friedman GD. PMID: 20043012; PMCID: PMC2855394.
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    148. Vitamin D and immune function: understanding common pathways. Curr Osteoporos Rep. 2009 Jul; 7(2):58-63. Bikle DD. PMID: 19631030.
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    149. Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature review. J Bone Miner Res. 2009 Jun; 24(6):1135-9. Pao VY, Chang S, Shoback DM, Bikle DD. PMID: 19113910; PMCID: PMC6956690.
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    150. Quantification of the vitamin D receptor-coregulator interaction. Biochemistry. 2009 Feb 24; 48(7):1454-61. Teichert A, Arnold LA, Otieno S, Oda Y, Augustinaite I, Geistlinger TR, Kriwacki RW, Guy RK, Bikle DD. PMID: 19183053; PMCID: PMC2654718.
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    151. Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation. Mol Biol Cell. 2009 Mar; 20(6):1695-704. Xie Z, Chang SM, Pennypacker SD, Liao EY, Bikle DD. PMID: 19158393; PMCID: PMC2655244.
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    152. Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation. J Invest Dermatol. 2009 Jun; 129(6):1367-78. Oda Y, Uchida Y, Moradian S, Crumrine D, Elias PM, Bikle DD. PMID: 19052561; PMCID: PMC2843519.
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    153. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009 Jan; 94(1):26-34. Bikle D. PMID: 18854395; PMCID: PMC2630868.
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    154. Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism. J Invest Dermatol. 2008 Oct; 128(10):2357-61. Bikle DD. PMID: 18787544; PMCID: PMC9017605.
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    155. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal. 2008 Sep 02; 1(35):ra1. Chang W, Tu C, Chen TH, Bikle D, Shoback D. PMID: 18765830; PMCID: PMC3538864.
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    156. Vitamin D and the immune system: role in protection against bacterial infection. Curr Opin Nephrol Hypertens. 2008 Jul; 17(4):348-52. Bikle DD. PMID: 18660668.
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    157. Growth hormone/insulin-like growth factor-1/PTH axis in bone. J Bone Miner Res. 2008 May; 23(5):581-3. Bikle DD. PMID: 18433295.
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    158. Integrins, insulin like growth factors, and the skeletal response to load. Osteoporos Int. 2008 Sep; 19(9):1237-46. Bikle DD. PMID: 18373051; PMCID: PMC9005159.
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    159. Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes. J Biol Chem. 2008 Feb 08; 283(6):3519-3528. Tu CL, Chang W, Xie Z, Bikle DD. PMID: 18065418.
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    160. Vitamin D insufficiency/deficiency in gastrointestinal disorders. J Bone Miner Res. 2007 Dec; 22 Suppl 2:V50-4. Bikle DD. PMID: 18290722.
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    161. Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. J Invest Dermatol. 2008 Apr; 128(4):816-24. Schauber J, Oda Y, Büchau AS, Yun QC, Steinmeyer A, Zügel U, Bikle DD, Gallo RL. PMID: 17943182.
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    162. IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone. J Bone Miner Res. 2007 Sep; 22(9):1329-37. Wang Y, Nishida S, Boudignon BM, Burghardt A, Elalieh HZ, Hamilton MM, Majumdar S, Halloran BP, Clemens TL, Bikle DD. PMID: 17539737; PMCID: PMC10702248.
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    163. What is new in vitamin D: 2006-2007. Curr Opin Rheumatol. 2007 Jul; 19(4):383-8. Bikle DD. PMID: 17551371.
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    164. Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading. J Appl Physiol (1985). 2007 Jul; 103(1):125-31. Boudignon BM, Bikle DD, Kurimoto P, Elalieh H, Nishida S, Wang Y, Burghardt A, Majumdar S, Orwoll BE, Rosen C, Halloran BP. PMID: 17412794.
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    165. Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone. Endocrinology. 2007 Jul; 148(7):3156-63. Dvorak MM, Chen TH, Orwoll B, Garvey C, Chang W, Bikle DD, Shoback DM. PMID: 17412806.
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    166. Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest. 2007 Mar; 117(3):803-11. Schauber J, Dorschner RA, Coda AB, Büchau AS, Liu PT, Kiken D, Helfrich YR, Kang S, Elalieh HZ, Steinmeyer A, Zügel U, Bikle DD, Modlin RL, Gallo RL. PMID: 17290304; PMCID: PMC1784003.
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    167. The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and human keratinocyte differentiation. J Biol Chem. 2007 Mar 23; 282(12):8695-703. Xie Z, Bikle DD. PMID: 17242406.
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    168. Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):776-80. Oda Y, Ishikawa MH, Hawker NP, Yun QC, Bikle DD. PMID: 17223341.
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    169. Sequential regulation of keratinocyte differentiation by 1,25(OH)2D3, VDR, and its coregulators. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):396-404. Bikle D, Teichert A, Hawker N, Xie Z, Oda Y. PMID: 17229570.
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    170. The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes. J Invest Dermatol. 2007 May; 127(5):1074-83. Tu CL, Chang W, Bikle DD. PMID: 17124506.
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    171. Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3. J Invest Dermatol. 2007 Apr; 127(4):874-80. Hawker NP, Pennypacker SD, Chang SM, Bikle DD. PMID: 17082781.
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    172. Role of IGF-I signaling in regulating osteoclastogenesis. J Bone Miner Res. 2006 Sep; 21(9):1350-8. Wang Y, Nishida S, Elalieh HZ, Long RK, Halloran BP, Bikle DD. PMID: 16939393; PMCID: PMC10723110.
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    173. Evaluation of fetal bone structure and mineralization in IGF-I deficient mice using synchrotron radiation microtomography and Fourier transform infrared spectroscopy. Bone. 2007 Jan; 40(1):160-8. Burghardt AJ, Wang Y, Elalieh H, Thibault X, Bikle D, Peyrin F, Majumdar S. PMID: 16905376.
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    174. Insulin-like growth factor-I is essential for embryonic bone development. Endocrinology. 2006 Oct; 147(10):4753-61. Wang Y, Nishida S, Sakata T, Elalieh HZ, Chang W, Halloran BP, Doty SB, Bikle DD. PMID: 16857753; PMCID: PMC10645399.
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    175. Development and progression of alopecia in the vitamin D receptor null mouse. J Cell Physiol. 2006 May; 207(2):340-53. Bikle DD, Elalieh H, Chang S, Xie Z, Sundberg JP. PMID: 16419036.
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    176. Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I. J Endocrinol. 2006 May; 189(2):279-87. Wang Y, Sakata T, Elalieh HZ, Munson SJ, Burghardt A, Majumdar S, Halloran BP, Bikle DD. PMID: 16648295; PMCID: PMC10745196.
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    177. Hairless suppresses vitamin D receptor transactivation in human keratinocytes. Endocrinology. 2006 Jan; 147(1):314-23. Xie Z, Chang S, Oda Y, Bikle DD. PMID: 16269453.
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    178. Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. Endocrinology. 2005 Dec; 146(12):5294-303. Rodriguez L, Tu C, Cheng Z, Chen TH, Bikle D, Shoback D, Chang W. PMID: 16166224.
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    179. Vitamin D and skin cancer: a problem in gene regulation. J Steroid Biochem Mol Biol. 2005 Oct; 97(1-2):83-91. Bikle DD, Oda Y, Xie Z. PMID: 16039846.
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    180. Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1. Mol Biol Cell. 2005 Jul; 16(7):3236-46. Xie Z, Singleton PA, Bourguignon LY, Bikle DD. PMID: 15872086; PMCID: PMC1165407.
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    181. Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes. J Invest Dermatol. 2005 Jan; 124(1):187-97. Tu CL, Chang W, Bikle DD. PMID: 15654973.
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    182. Vitamin D and skin cancer. J Nutr. 2004 12; 134(12 Suppl):3472S-3478S. Bikle DD. PMID: 15570056.
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    183. The effect of LXR activators on AP-1 proteins in keratinocytes. J Invest Dermatol. 2004 Jul; 123(1):41-8. Schmuth M, Elias PM, Hanley K, Lau P, Moser A, Willson TM, Bikle DD, Feingold KR. PMID: 15191540.
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    184. Vitamin D regulated keratinocyte differentiation. J Cell Biochem. 2004 Jun 01; 92(3):436-44. Bikle DD. PMID: 15156556.
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    185. Mice lacking 25OHD 1alpha-hydroxylase demonstrate decreased epidermal differentiation and barrier function. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):347-53. Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Dardenne O, Xie Z, Arnaud RS, Feingold K, Elias PM. PMID: 15225799.
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    186. Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in VDR transactivation during keratinocyte differentiation. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):273-6. Oda Y, Sihlbom C, Chalkley RJ, Huang L, Rachez C, Chang CP, Burlingame AL, Freedman LP, Bikle DD. PMID: 15225784.
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    187. Calcium and 1,25(OH)2D: interacting drivers of epidermal differentiation. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):355-60. Bikle DD, Oda Y, Xie Z. PMID: 15225800.
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    188. 25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis. J Invest Dermatol. 2004 Apr; 122(4):984-92. Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Choi EH, Dardenne O, Xie Z, Arnaud RS, Feingold K, Elias PM. PMID: 15102089.
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    189. The role of the calcium-sensing receptor in epidermal differentiation. Cell Calcium. 2004 Mar; 35(3):265-73. Tu CL, Oda Y, Komuves L, Bikle DD. PMID: 15200150.
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    190. Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways. J Bone Miner Res. 2004 Mar; 19(3):436-46. Sakata T, Wang Y, Halloran BP, Elalieh HZ, Cao J, Bikle DD. PMID: 15040832; PMCID: PMC10720400.
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    191. PTH differentially regulates expression of RANKL and OPG. J Bone Miner Res. 2004 Feb; 19(2):235-44. Huang JC, Sakata T, Pfleger LL, Bencsik M, Halloran BP, Bikle DD, Nissenson RA. PMID: 14969393.
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    192. Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores. J Invest Dermatol. 2003 Oct; 121(4):688-94. Behne MJ, Tu CL, Aronchik I, Epstein E, Bench G, Bikle DD, Pozzan T, Mauro TM. PMID: 14632183.
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    193. bFGF administration lowers the phosphate threshold for mineralization in bone marrow stromal cells. Calcif Tissue Int. 2003 Aug; 73(2):147-52. Nauman EA, Sakata T, Keaveny TM, Halloran BP, Bikle DD. PMID: 14565596.
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    194. Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiation. Mol Endocrinol. 2003 Nov; 17(11):2329-39. Oda Y, Sihlbom C, Chalkley RJ, Huang L, Rachez C, Chang CP, Burlingame AL, Freedman LP, Bikle DD. PMID: 12893881.
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    195. The impact of skeletal unloading on bone formation. Gravit Space Biol Bull. 2003 Jun; 16(2):45-54. Bikle DD, Sakata T, Halloran BP. PMID: 12959131.
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    196. Skeletal unloading induces resistance to insulin-like growth factor I on bone formation. Bone. 2003 Jun; 32(6):669-80. Sakata T, Halloran BP, Elalieh HZ, Munson SJ, Rudner L, Venton L, Ginzinger D, Rosen CJ, Bikle DD. PMID: 12810174.
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    197. Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma. J Cell Physiol. 2003 May; 195(2):249-59. Yang LC, Ng DC, Bikle DD. PMID: 12652652.
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    198. Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. J Cell Biochem. 2003 Mar 01; 88(4):732-43. Dolezalova H, Shankar G, Huang MC, Bikle DD, Goetzl EJ. PMID: 12577307.
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    199. Vitamin D regulated keratinocyte differentiation: role of coactivators. J Cell Biochem. 2003 Feb 01; 88(2):290-5. Bikle DD, Tu CL, Xie Z, Oda Y. PMID: 12520529.
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    200. Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why? Recent Results Cancer Res. 2003; 164:111-22. Bikle DD, Xie Z, Ng D, Tu CL, Oda Y. PMID: 12899516.
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    201. Mechanical and chemical characteristics of mineral produced by basic fibroblast growth factor-treated bone marrow stromal cells in vitro. Tissue Eng. 2002 Dec; 8(6):931-9. Nauman EA, Ebenstein DM, Hughes KF, Pruitt L, Halloran BP, Bikle DD, Keaveny TM. PMID: 12542939.
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    202. The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3. J Invest Dermatol. 2002 Nov; 119(5):1109-13. Bikle DD, Ng D, Oda Y, Hanley K, Feingold K, Xie Z. PMID: 12445200.
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    203. Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone. J Bone Miner Res. 2002 Sep; 17(9):1570-8. Bikle DD, Sakata T, Leary C, Elalieh H, Ginzinger D, Rosen CJ, Beamer W, Majumdar S, Halloran BP. PMID: 12211426.
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    204. Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation. J Cell Physiol. 2002 Jul; 192(1):45-54. Komuves L, Oda Y, Tu CL, Chang WH, Ho-Pao CL, Mauro T, Bikle DD. PMID: 12115735.
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    205. Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. J Invest Dermatol. 2002 Jan; 118(1):11-6. Xie Z, Komuves L, Yu QC, Elalieh H, Ng DC, Leary C, Chang S, Crumrine D, Yoshizawa T, Kato S, Bikle DD. PMID: 11851870.
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    206. The skeletal structure of insulin-like growth factor I-deficient mice. J Bone Miner Res. 2001 Dec; 16(12):2320-9. Bikle D, Majumdar S, Laib A, Powell-Braxton L, Rosen C, Beamer W, Nauman E, Leary C, Halloran B. PMID: 11760848.
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    208. The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes. J Biol Chem. 2001 Nov 02; 276(44):41079-85. Tu CL, Chang W, Bikle DD. PMID: 11500521.
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    209. Calcium- and vitamin D-regulated keratinocyte differentiation. Mol Cell Endocrinol. 2001 May 25; 177(1-2):161-71. Bikle DD, Ng D, Tu CL, Oda Y, Xie Z. PMID: 11377831.
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    210. Osteoblasts respond to pulsatile fluid flow with short-term increases in PGE(2) but no change in mineralization. J Appl Physiol (1985). 2001 May; 90(5):1849-54. Nauman EA, Satcher RL, Keaveny TM, Halloran BP, Bikle DD. PMID: 11299276.
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    211. Selective inhibition of vitamin D hydroxylases in human keratinocytes. Steroids. 2001 Mar-May; 66(3-5):409-22. Schuster I, Egger H, Bikle D, Herzig G, Reddy GS, Stuetz A, Stuetz P, Vorisek G. PMID: 11179750.
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    212. The role of phospholipase C-gamma1 in 1alpha,25-dihydroxyvitamin D(3) regulated keratinocyte differentiation. Steroids. 2001 Mar-May; 66(3-5):339-45. Xie Z, Bikle DD. PMID: 11179742.
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    213. Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D. J Lipid Res. 2001 Mar; 42(3):390-8. Hanley K, Wood L, Ng DC, He SS, Lau P, Moser A, Elias PM, Bikle DD, Williams ML, Feingold KR. PMID: 11254751.
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    214. Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo. J Invest Dermatol. 2000 Sep; 115(3):353-60. Kömüves LG, Hanley K, Lefebvre AM, Man MQ, Ng DC, Bikle DD, Williams ML, Elias PM, Auwerx J, Feingold KR. PMID: 10951268.
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    215. Requirement of an AP-1 site in the calcium response region of the involucrin promoter. J Biol Chem. 2000 Aug 04; 275(31):24080-8. Ng DC, Shafaee S, Lee D, Bikle DD. PMID: 10816578.
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    216. Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha. J Biol Chem. 2000 Apr 14; 275(15):11484-91. Hanley K, Kömüves LG, Ng DC, Schoonjans K, He SS, Lau P, Bikle DD, Williams ML, Elias PM, Auwerx J, Feingold KR. PMID: 10753967.
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    217. Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. J Invest Dermatol. 2000 Mar; 114(3):545-53. Hanley K, Ng DC, He SS, Lau P, Min K, Elias PM, Bikle DD, Mangelsdorf DJ, Williams ML, Feingold KR. PMID: 10692116.
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    218. The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation. J Biol Chem. 2000 Jan 14; 275(2):1183-90. Oda Y, Tu CL, Chang W, Crumrine D, Kömüves L, Mauro T, Elias PM, Bikle DD. PMID: 10625662.
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    219. Effects of a calcium receptor activator on the cellular response to calcium in human keratinocytes. J Invest Dermatol. 1999 Sep; 113(3):340-5. Tu CL, Oda Y, Bikle DD. PMID: 10469331.
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    220. Phospholipase C-gamma1 is required for calcium-induced keratinocyte differentiation. J Biol Chem. 1999 Jul 16; 274(29):20421-4. Xie Z, Bikle DD. PMID: 10400667.
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    221. Differences in calcium metabolism between black and white men and women. Miner Electrolyte Metab. 1999 May-Jun; 25(3):178-84. Bikle DD, Ettinger B, Sidney S, Tekawa IS, Tolan K. PMID: 10436403.
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    222. 1,25 dihydroxyvitamin D3 enhances the calcium response of keratinocytes. J Cell Physiol. 1999 Feb; 178(2):188-96. Ratnam AV, Bikle DD, Cho JK. PMID: 10048583.
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    223. Six putative IQ motifs of the recombinant chicken intestinal brush border myosin I are involved in calmodulin binding. Arch Biochem Biophys. 1999 Jan 01; 361(1):94-100. Khoroshev MI, Munson SJ, Bikle DD. PMID: 9882432.
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    224. Bone and hormonal changes induced by skeletal unloading in the mature male rat. Am J Physiol. 1999 Jan; 276(1 Pt 1):E62-9. Dehority W, Halloran BP, Bikle DD, Curren T, Kostenuik PJ, Wronski TJ, Shen Y, Rabkin B, Bouraoui A, Morey-Holton E. PMID: 9886951.
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    225. The response of bone to unloading. J Bone Miner Metab. 1999; 17(4):233-44. Bikle DD, Halloran BP. PMID: 10575587.
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    226. Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I. J Bone Miner Res. 1999 Jan; 14(1):21-31. Kostenuik PJ, Harris J, Halloran BP, Turner RT, Morey-Holton ER, Bikle DD. PMID: 9893062.
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    227. The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation. J Biol Chem. 1998 Sep 04; 273(36):23344-52. Oda Y, Tu CL, Pillai S, Bikle DD. PMID: 9722568.
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    228. Differential regulation of vitamin D responsive elements in normal and transformed keratinocytes. J Invest Dermatol. 1998 May; 110(5):730-3. Xie Z, Bikle DD. PMID: 9579536.
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    229. Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARalpha. J Invest Dermatol. 1998 Apr; 110(4):368-75. Hanley K, Jiang Y, He SS, Friedman M, Elias PM, Bikle DD, Williams ML, Feingold KR. PMID: 9540977.
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    230. All-trans retinoic acid blocks the antiproliferative prodifferentiating actions of 1,25-dihydroxyvitamin D3 in normal human keratinocytes. J Cell Physiol. 1998 Jan; 174(1):1-8. Gibson DF, Bikle DD, Harris J. PMID: 9397150.
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    231. Skeletal unloading inhibits the in vitro proliferation and differentiation of rat osteoprogenitor cells. Am J Physiol. 1997 Dec; 273(6 Pt 1):E1133-9. Kostenuik PJ, Halloran BP, Morey-Holton ER, Bikle DD. PMID: 9435529.
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    232. Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Mol Endocrinol. 1997 Dec; 11(13):1961-70. Fu GK, Lin D, Zhang MY, Bikle DD, Shackleton CH, Miller WL, Portale AA. PMID: 9415400.
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    233. Biochemical markers in the assessment of bone disease. Am J Med. 1997 Nov; 103(5):427-36. Bikle DD. PMID: 9375712.
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    234. Vitamin D: a calciotropic hormone regulating calcium-induced keratinocyte differentiation. J Am Acad Dermatol. 1997 Sep; 37(3 Pt 2):S42-52. Bikle DD. PMID: 9344184.
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    235. Decrease of Ca(2+)-ATPase activity in human keratinocytes during calcium-induced differentiation. J Cell Physiol. 1997 Aug; 172(2):146-54. Cho JK, Bikle DD. PMID: 9258336.
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    236. The expression of the gap junctional protein Cx43 is restricted to proliferating and non differentiated normal and transformed keratinocytes. Exp Dermatol. 1997 Aug; 6(4):167-74. Gibson DF, Bikle DD, Harris J, Goldberg GS. PMID: 9293388.
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    237. Regional responsiveness of the tibia to intermittent administration of parathyroid hormone as affected by skeletal unloading. J Bone Miner Res. 1997 Jul; 12(7):1068-74. Halloran BP, Bikle DD, Harris J, Tanner S, Curren T, Morey-Holton E. PMID: 9200006.
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    238. Spaceflight and the skeleton: lessons for the earthbound. Gravit Space Biol Bull. 1997 Jun; 10(2):119-35. Bikle DD, Halloran BP, Morey-Holton E. PMID: 11540113.
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    239. Cloning of the human phospholipase C-gamma1 promoter and identification of a DR6-type vitamin D-responsive element. J Biol Chem. 1997 Mar 07; 272(10):6573-7. Xie Z, Bikle DD. PMID: 9045685.
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    240. Racial differences in bone density between young adult black and white subjects persist after adjustment for anthropometric, lifestyle, and biochemical differences. J Clin Endocrinol Metab. 1997 Feb; 82(2):429-34. Ettinger B, Sidney S, Cummings SR, Libanati C, Bikle DD, Tekawa IS, Tolan K, Steiger P. PMID: 9024231.
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    241. Space flight and the skeleton: lessons for the earthbound. Endocrinologist. 1997 Jan-Feb; 7(1):10-22. Bikle DD, Halloran BP, Morey-Holton E. PMID: 11540416.
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    242. Antiestrogen potentiation of antiproliferative effects of vitamin D3 analogues in breast cancer cells. Cancer Res. 1996 Jun 15; 56(12):2789-94. Love-Schimenti CD, Gibson DF, Ratnam AV, Bikle DD. PMID: 8665515.
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    243. Zipper protein, a B-G protein with the ability to regulate actin/myosin 1 interactions in the intestinal brush border. J Biol Chem. 1996 Apr 12; 271(15):9075-83. Bikle DD, Munson S, Komuves L. PMID: 8621557.
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    244. 1,25(OH)2D3-modulated calcium induced keratinocyte differentiation. J Investig Dermatol Symp Proc. 1996 Apr; 1(1):22-7. Bikle DD. PMID: 9627687.
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    245. Squamous carcinoma cell lines fail to respond to 1,25-Dihydroxyvitamin D despite normal levels of the vitamin D receptor. J Invest Dermatol. 1996 Mar; 106(3):522-5. Ratnam AV, Bikle DD, Su MJ, Pillai S. PMID: 8648187.
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    246. Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor. J Clin Invest. 1996 Feb 15; 97(4):1085-93. Bikle DD, Ratnam A, Mauro T, Harris J, Pillai S. PMID: 8613532; PMCID: PMC507156.
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    247. Evidence for separate control mechanisms at the message, protein, and enzyme activation levels for transglutaminase during calcium-induced differentiation of normal and transformed human keratinocytes. J Invest Dermatol. 1996 Jan; 106(1):154-61. Gibson DF, Ratnam AV, Bikle DD. PMID: 8592067.
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    248. Regulation of involucrin gene expression by calcium in normal human keratinocytes. Front Biosci. 1996 Jan 01; 1:a16-24. Ng DC, Su MJ, Kim R, Bikle DD. PMID: 9159190.
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    249. 22-Oxa calcitriol is a less potent regulator of keratinocyte proliferation and differentiation due to decreased cellular uptake and enhanced catabolism. J Invest Dermatol. 1995 Nov; 105(5):693-8. Bikle DD, Abe-Hashimoto J, Su MJ, Felt S, Gibson DF, Pillai S. PMID: 7594646.
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    250. Skeletal unloading induces selective resistance to the anabolic actions of growth hormone on bone. J Bone Miner Res. 1995 Aug; 10(8):1168-76. Halloran BP, Bikle DD, Harris J, Autry CP, Currier PA, Tanner S, Patterson-Buckendahl P, Morey-Holton E. PMID: 8585419.
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    251. 1,25-Dihydroxyvitamin D3 upregulates the phosphatidylinositol signaling pathway in human keratinocytes by increasing phospholipase C levels. J Clin Invest. 1995 Jul; 96(1):602-9. Pillai S, Bikle DD, Su MJ, Ratnam A, Abe J. PMID: 7615834; PMCID: PMC185235.
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    252. 1,25(OH)2D3-regulated human keratinocyte proliferation and differentiation: basic studies and their clinical application. J Nutr. 1995 06; 125(6 Suppl):1709S-1714S. Bikle DD. PMID: 7782932.
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    253. The molecular response of bone to growth hormone during skeletal unloading: regional differences. Endocrinology. 1995 May; 136(5):2099-109. Bikle DD, Harris J, Halloran BP, Currier PA, Tanner S, Morey-Holton E. PMID: 7720659.
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    254. Serum levels of free 1,25-dihydroxyvitamin D in vitamin D toxicity. Ann Intern Med. 1995 Apr 01; 122(7):511-3. Pettifor JM, Bikle DD, Cavaleros M, Zachen D, Kamdar MC, Ross FP. PMID: 7872586.
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    255. Altered skeletal pattern of gene expression in response to spaceflight and hindlimb elevation. Am J Physiol. 1994 Dec; 267(6 Pt 1):E822-7. Bikle DD, Harris J, Halloran BP, Morey-Holton E. PMID: 7810622.
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    256. Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage. J Bone Miner Res. 1994 Nov; 9(11):1777-87. Bikle DD, Morey-Holton ER, Doty SB, Currier PA, Tanner SJ, Halloran BP. PMID: 7863829.
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    257. Skeletal unloading induces resistance to insulin-like growth factor I. J Bone Miner Res. 1994 Nov; 9(11):1789-96. Bikle DD, Harris J, Halloran BP, Morey-Holton ER. PMID: 7532347.
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    258. Expression of the genes for insulin-like growth factors and their receptors in bone during skeletal growth. Am J Physiol. 1994 Aug; 267(2 Pt 1):E278-86. Bikle DD, Harris J, Halloran BP, Roberts CT, Leroith D, Morey-Holton E. PMID: 8074208.
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    259. Role of vitamin D, its metabolites, and analogs in the management of osteoporosis. Rheum Dis Clin North Am. 1994 Aug; 20(3):759-75. Bikle DD. PMID: 7984788.
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    260. Impact of skeletal unloading on bone formation: role of systemic and local factors. Acta Astronaut. 1994 Jul; 33:119-29. Bikle DD, Halloran BP, Morey-Holton E. PMID: 11539511.
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    261. 1,25-Dihydroxyvitamin D3 potentiates the keratinocyte response to calcium. J Biol Chem. 1994 May 20; 269(20):14723-9. Su MJ, Bikle DD, Mancianti ML, Pillai S. PMID: 7910167.
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    262. Production of 1,25 dihydroxyvitamin D3 by perfused pig skin. J Invest Dermatol. 1994 May; 102(5):796-8. Bikle DD, Halloran BP, Riviere JE. PMID: 8176265.
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    263. Regulation of calmodulin binding to the ATP extractable 110 kDa protein (myosin I) from chicken duodenal brush border by 1,25-(OH)2D3. Biochim Biophys Acta. 1994 Mar 23; 1190(2):329-36. Kaune R, Munson S, Bikle DD. PMID: 8142433.
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    264. Regulation of keratinocyte growth, differentiation, and vitamin D metabolism by analogs of 1,25-dihydroxyvitamin D. J Invest Dermatol. 1993 Nov; 101(5):713-8. Bikle DD, Gee E, Pillai S. PMID: 8228333.
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    265. Alcohol-induced bone disease: relationship to age and parathyroid hormone levels. Alcohol Clin Exp Res. 1993 Jun; 17(3):690-5. Bikle DD, Stesin A, Halloran B, Steinbach L, Recker R. PMID: 8333602.
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    266. Skeletal unloading decreases production of 1,25-dihydroxyvitamin D. Am J Physiol. 1993 May; 264(5 Pt 1):E712-6. Halloran BP, Bikle DD, Harris J, Foskett HC, Morey-Holton E. PMID: 8498493.
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    267. Elevated 1,25-dihydroxyvitamin D levels in patients with chronic obstructive pulmonary disease treated with prednisone. J Clin Endocrinol Metab. 1993 Feb; 76(2):456-61. Bikle DD, Halloran B, Fong L, Steinbach L, Shellito J. PMID: 8432789.
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    268. Vitamin D, calcium, and epidermal differentiation. Endocr Rev. 1993 Feb; 14(1):3-19. Bikle DD, Pillai S. PMID: 8491153.
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    269. Zipper protein, a newly described tropomyosin-like protein of the intestinal brush border. J Biol Chem. 1993 Jan 05; 268(1):620-6. Bikle DD, Munson S, Morrison N, Eisman J. PMID: 7678004.
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    270. Localization and quantitation of calcium pools and calcium binding sites in cultured human keratinocytes. J Cell Physiol. 1993 Jan; 154(1):101-12. Pillai S, Menon GK, Bikle DD, Elias PM. PMID: 8419397.
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    271. Alcohol-induced bone disease. World Rev Nutr Diet. 1993; 73:53-79. Bikle DD. PMID: 8367983.
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    272. Metabolic acidosis reverses the increase in serum 1,25(OH)2D in phosphorus-restricted normal men. Am J Physiol. 1992 12; 263(6):E1164-70. Portale AA, Halloran BP, Harris ST, Bikle DD, Morris RC. PMID: 1476189.
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    273. Clinical counterpoint: vitamin D: new actions, new analogs, new therapeutic potential. Endocr Rev. 1992 Nov; 13(4):765-84. Bikle DD. PMID: 1459048.
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    274. Progestin antagonism of estrogen stimulated 1,25-dihydroxyvitamin D levels. J Clin Endocrinol Metab. 1992 Aug; 75(2):519-23. Bikle DD, Halloran BP, Harris ST, Portale AA. PMID: 1639954.
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    275. Effects of dietary protein deficiency on mineral metabolism and bone mineral density. Am J Clin Nutr. 1992 Aug; 56(2):314-9. Orwoll E, Ware M, Stribrska L, Bikle D, Sanchez T, Andon M, Li H. PMID: 1636610.
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    276. Adenosine triphosphate stimulates phosphoinositide metabolism, mobilizes intracellular calcium, and inhibits terminal differentiation of human epidermal keratinocytes. J Clin Invest. 1992 Jul; 90(1):42-51. Pillai S, Bikle DD. PMID: 1321844; PMCID: PMC443061.
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    277. Lanthanum influx into cultured human keratinocytes: effect on calcium flux and terminal differentiation. J Cell Physiol. 1992 Jun; 151(3):623-9. Pillai S, Bikle DD. PMID: 1363554.
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    278. Squamous carcinoma cell lines produce 1,25 dihydroxyvitamin D, but fail to respond to its prodifferentiating effect. J Invest Dermatol. 1991 Sep; 97(3):435-41. Bikle DD, Pillai S, Gee E. PMID: 1875043.
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    279. Tumor necrosis factor-alpha regulation of 1,25-dihydroxyvitamin D production by human keratinocytes. Endocrinology. 1991 Jul; 129(1):33-8. Bikle DD, Pillai S, Gee E, Hincenbergs M. PMID: 1675987.
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    280. Limited tissue distribution of the intestinal brush border myosin I protein. Gastroenterology. 1991 Feb; 100(2):395-402. Bikle DD, Munson S, Mancianti ML. PMID: 1985037.
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    281. Uncoupling of the calcium-sensing mechanism and differentiation in squamous carcinoma cell lines. Exp Cell Res. 1991 Feb; 192(2):567-73. Pillai S, Bikle DD, Mancianti ML, Hincenbergs M. PMID: 1988295.
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    282. Role of intracellular-free calcium in the cornified envelope formation of keratinocytes: differences in the mode of action of extracellular calcium and 1,25 dihydroxyvitamin D3. J Cell Physiol. 1991 Jan; 146(1):94-100. Pillai S, Bikle DD. PMID: 1990023.
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    283. Epidermal vitamin D metabolism, function, and regulation. Adv Lipid Res. 1991; 24:321-41. Pillai S, Bikle DD. PMID: 1763717.
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    284. Different responses of trabecular and cortical bone to 1,25(OH)2D3 infusion. Am J Physiol. 1990 Nov; 259(5 Pt 1):E715-22. Bikle DD, Halloran BP, McGalliard-Cone C, Morey-Holton E. PMID: 2240210.
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    285. Calcium regulation of growth and differentiation of normal human keratinocytes: modulation of differentiation competence by stages of growth and extracellular calcium. J Cell Physiol. 1990 May; 143(2):294-302. Pillai S, Bikle DD, Mancianti ML, Cline P, Hincenbergs M. PMID: 1970572.
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    286. Serum vitamin D metabolites are not responsible for low turnover osteoporosis in chronic liver disease. J Clin Endocrinol Metab. 1989 Dec; 69(6):1234-9. Diamond T, Stiel D, Mason R, Lissner D, Bikle D, Wilson S, Posen S. PMID: 2584358.
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    287. Effects of simulated weightlessness on rat osteocalcin and bone calcium. Am J Physiol. 1989 Nov; 257(5 Pt 2):R1103-9. Patterson-Buckendahl P, Globus RK, Bikle DD, Cann CE, Morey-Holton E. PMID: 2589536.
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    288. Bone response to normal weight bearing after a period of skeletal unloading. Am J Physiol. 1989 Oct; 257(4 Pt 1):E606-10. Sessions ND, Halloran BP, Bikle DD, Wronski TJ, Cone CM, Morey-Holton E. PMID: 2801939.
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    289. Transpleural gradient of 1,25-dihydroxyvitamin D in tuberculous pleuritis. J Clin Invest. 1989 May; 83(5):1527-32. Barnes PF, Modlin RL, Bikle DD, Adams JS. PMID: 2540219; PMCID: PMC303857.
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    290. Binding and biological effects of tumor necrosis factor alpha on cultured human neonatal foreskin keratinocytes. J Clin Invest. 1989 Mar; 83(3):816-21. Pillai S, Bikle DD, Eessalu TE, Aggarwal BB, Elias PM. PMID: 2466051; PMCID: PMC303753.
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    291. Isotopic labeling affects 1,25-dihydroxyvitamin D metabolism. Biochemistry. 1989 Feb 07; 28(3):1278-81. Halloran BP, Bikle DD, Castro ME, Gee E. PMID: 2713363.
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    292. Free, and not total, 1,25-dihydroxyvitamin D regulates 25-hydroxyvitamin D metabolism by keratinocytes. Endocrinology. 1989 Feb; 124(2):649-54. Bikle DD, Gee E. PMID: 2463902.
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    293. Regulation of 1,25-dihydroxyvitamin D production in human keratinocytes by interferon-gamma. Endocrinology. 1989 Feb; 124(2):655-60. Bikle DD, Pillai S, Gee E, Hincenbergs M. PMID: 2463903.
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    294. Calmodulin binding to the intestinal brush-border membrane: comparison to other calcium-binding proteins. Biochim Biophys Acta. 1989 Jan 17; 1010(1):122-7. Bikle D, Munson S, Christakos S, Kumar R, Buckendahl P. PMID: 2909247.
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    295. Glucocorticoids and inhibition of bone formation induced by skeletal unloading. Am J Physiol. 1988 Dec; 255(6 Pt 1):E875-9. Halloran BP, Bikle DD, Cone CM, Morey-Holton E. PMID: 3202163.
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    296. Serum dihydrotachysterol levels and biological action in normal man. J Clin Endocrinol Metab. 1988 Jul; 67(1):198-202. Taylor A, Bikle DD, Norman ME. PMID: 3379133.
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    297. 1,25-Dihydroxyvitamin D production and receptor binding in human keratinocytes varies with differentiation. J Biol Chem. 1988 Apr 15; 263(11):5390-5. Pillai S, Bikle DD, Elias PM. PMID: 2451669.
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    298. Biochemical and morphological characterization of growth and differentiation of normal human neonatal keratinocytes in a serum-free medium. J Cell Physiol. 1988 Feb; 134(2):229-37. Pillai S, Bikle DD, Hincenbergs M, Elias PM. PMID: 2450102.
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    299. Effects of alcohol abuse on bone. Compr Ther. 1988 Feb; 14(2):16-20. Bikle DD. PMID: 3278834.
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    300. Vitamin D and epidermal differentiation: evidence for a role of endogenously produced vitamin D metabolites in keratinocyte differentiation. Skin Pharmacol. 1988; 1(3):149-60. Pillai S, Bikle DD, Elias PM. PMID: 3078531.
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    301. Vitamin D metabolite production and function in keratinocytes. Ann N Y Acad Sci. 1988; 548:27-44. Bikle DD, Pillai S. PMID: 2470300.
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    302. The effect of vitamin D status on cutaneous sterologenesis in vivo and in vitro. Biochim Biophys Acta. 1987 Sep 14; 930(2):193-200. Feingold KR, Williams ML, Pillai S, Menon GK, Halloran BP, Bikle DD, Elias PM. PMID: 3040120.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    303. Effect of dietary acid and calcium on 25-hydroxyvitamin D metabolism by chick kidney. J Bone Miner Res. 1987 Aug; 2(4):289-96. Cunningham J, Bikle DD, Avioli LV. PMID: 3455615.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    304. The effects of simulated weightlessness on bone maturation. Endocrinology. 1987 Feb; 120(2):678-84. Bikle DD, Halloran BP, Cone CM, Globus RK, Morey-Holton E. PMID: 3803298.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    305. Stimulation by 1,25-dihydroxyvitamin D3 of adenylate cyclase along the villus of chick duodenum. Endocrinology. 1986 Dec; 119(6):2568-73. Long RG, Bikle DD, Munson SJ. PMID: 3780539.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    306. Chronic administration of 1,25-dihydroxyvitamin D3: increased bone but impaired mineralization. Endocrinology. 1986 Dec; 119(6):2580-5. Wronski TJ, Halloran BP, Bikle DD, Globus RK, Morey-Holton ER. PMID: 3780540.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    307. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab. 1986 Oct; 63(4):954-9. Bikle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG. PMID: 3745408.
      View in: PubMed   Mentions: 264     Fields:    Translation:HumansCells
    308. Effect of ethanol on intestinal calcium transport in chicks. Gastroenterology. 1986 Oct; 91(4):870-6. Bikle DD, Gee EA, Munson SJ. PMID: 3743964.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    309. Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels. J Clin Invest. 1986 Sep; 78(3):748-52. Bikle DD, Halloran BP, Gee E, Ryzen E, Haddad JG. PMID: 3745436; PMCID: PMC423667.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    310. Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate. J Clin Invest. 1986 Sep; 78(3):622-8. Halloran BP, Bikle DD, Levens MJ, Castro ME, Globus RK, Holton E. PMID: 3489007; PMCID: PMC423635.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    311. 1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation. J Clin Invest. 1986 Aug; 78(2):557-66. Bikle DD, Nemanic MK, Gee E, Elias P. PMID: 2426308; PMCID: PMC423594.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    312. Neonatal human foreskin keratinocytes produce 1,25-dihydroxyvitamin D3. Biochemistry. 1986 Apr 08; 25(7):1545-8. Bikle DD, Nemanic MK, Whitney JO, Elias PW. PMID: 2423114.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    313. Skeletal response to dietary calcium in a rat model simulating weightlessness. J Bone Miner Res. 1986 Apr; 1(2):191-7. Globus RK, Bikle DD, Halloran B, Morey-Holton E. PMID: 3503537.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    314. The role of 1,25-dihydroxyvitamin D in the inhibition of bone formation induced by skeletal unloading. Endocrinology. 1986 Mar; 118(3):948-54. Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E. PMID: 3485043.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    315. The villus gradient of brush border membrane calmodulin and the calcium-independent calmodulin-binding protein parallels that of calcium-accumulating ability. Endocrinology. 1986 Feb; 118(2):727-32. Bikle DD, Munson S. PMID: 3753677.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    316. The temporal response of bone to unloading. Endocrinology. 1986 Feb; 118(2):733-42. Globus RK, Bikle DD, Morey-Holton E. PMID: 3943489.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    317. 1,25-Dihydroxyvitamin D increases calmodulin binding to specific proteins in the chick duodenal brush border membrane. J Clin Invest. 1985 Dec; 76(6):2312-6. Bikle DD, Munson S. PMID: 3841129; PMCID: PMC424356.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    318. Effect of simulated weightlessness and chronic 1,25-dihydroxyvitamin D administration on bone metabolism. Physiologist. 1985 Dec; 28(6 Suppl):S127-8. Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E. PMID: 3841737.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    319. Bone loss during simulated weightlessness: is it glucocorticoid mediated? Physiologist. 1985 Dec; 28(6 Suppl):S123-4. Bikle DD, Halloran BP, Cone CM, Morey-Holton E. PMID: 3834430.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    320. Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels. J Clin Endocrinol Metab. 1985 Nov; 61(5):969-75. Bikle DD, Siiteri PK, Ryzen E, Haddad JG. PMID: 3840175.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    321. Bone disease in alcohol abuse. Ann Intern Med. 1985 Jul; 103(1):42-8. Bikle DD, Genant HK, Cann C, Recker RR, Halloran BP, Strewler GJ. PMID: 2988390.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    322. Measurement of 25,26-dihydroxyvitamin D: importance of the configuration of the C-25 hydroxyl group. Biochemistry. 1984 Dec 18; 23(26):6920-5. Bikle DD, Halloran BP, Whitney JO, Hollis BW. PMID: 6543324.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    323. Differential response of duodenal epithelial cells to 1,25-dihydroxyvitamin D3 according to position on the villus: a comparison of calcium uptake, calcium-binding protein, and alkaline phosphatase activity. Endocrinology. 1984 Dec; 115(6):2077-84. Bikle DD, Zolock DT, Munson S. PMID: 6548695.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    324. Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J Clin Invest. 1984 Dec; 74(6):1966-71. Bikle DD, Gee E, Halloran B, Haddad JG. PMID: 6549014; PMCID: PMC425383.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    325. Separation of isotopically labeled vitamin D metabolites by high-performance liquid chromatography. J Chromatogr. 1984 Oct 26; 303(1):229-33. Halloran BP, Bikle DD, Whitney JO. PMID: 6511833.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    326. Calmodulin may mediate 1,25-dihydroxyvitamin D-stimulated intestinal calcium transport. FEBS Lett. 1984 Aug 20; 174(1):30-3. Bikle DD, Munson S, Chafouleas J. PMID: 6547914.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    327. Effects of simulated weightlessness on bone mineral metabolism. Endocrinology. 1984 Jun; 114(6):2264-70. Globus RK, Bikle DD, Morey-Holton E. PMID: 6723581.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    328. Acute, but not chronic, metabolic acidosis disturbs 25-hydroxyvitamin D3 metabolism. Kidney Int. 1984 Jan; 25(1):47-52. Cunningham J, Bikle DD, Avioli LV. PMID: 6610073.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    329. The relationship of membrane fluidity to calcium flux in chick intestinal brush border membranes. Endocrinology. 1984 Jan; 114(1):260-7. Bikle DD, Whitney J, Munson S. PMID: 6546306.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    330. The role of calmodulin in 1,25-dihydroxyvitamin D regulation of calcium transport across the intestinal brush border membrane. Prog Clin Biol Res. 1984; 168:193-8. Bikle DD, Munson S, Chafouleas JG. PMID: 6549067.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    331. Calcium flux across chick duodenal brush border membrane vesicles: regulation by 1,25-dihydroxyvitamin D. Endocrinology. 1983 Dec; 113(6):2072-80. Bikle DD, Munson S, Zolock DT. PMID: 6416812.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    332. Simulating certain aspects of hypogravity: effects on bone maturation in the non-weight bearing skeleton. Aviat Space Environ Med. 1983 Dec; 54(12 Pt 1):1080-4. Simmons DJ, Grazman B, Russell JE, Walker WV, Bikle DD, Morey ER. PMID: 6661121.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    333. Fluoride treatment of osteoporosis: a new look at an old drug. Ann Intern Med. 1983 Jun; 98(6):1013-5. Bikle DD. PMID: 6859684.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    334. Calcium absorption and vitamin D metabolism. Clin Gastroenterol. 1983 May; 12(2):379-94. Bikle DD. PMID: 6347462.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    335. Adaptive response of humans to changes in dietary calcium: relationship between vitamin D regulated intestinal function and serum 1,25-dihydroxyvitamin D levels. Gastroenterology. 1983 Feb; 84(2):314-23. Bikle DD, Herman RH, Hull S, Hagler L, Harris D, Halloran B. PMID: 6687358.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    336. Calcium potentiates the cyclic nucleotide and phosphaturic response to parathyroid hormone infusion. J Clin Endocrinol Metab. 1983 Jan; 56(1):11-7. Bikle DD, Herman RH. PMID: 6292254.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    337. Pharmacokinetics and pharmacodynamics of 1,25-dihydroxyvitamin D3 in the chick. Endocrinology. 1982 Sep; 111(3):939-46. Bikle DD, Peck CC, Holford NH, Zolock DT, Morrissey RL. PMID: 6896685.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    338. The vitamin D endocrine system. Adv Intern Med. 1982; 27:45-71. Bikle DD. PMID: 7041549.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    339. In vitro stimulation of 25-hydroxycholecalciferol 1 alpha-hydroxylation by parathyroid hormone in chick kidney slices: evidence for a role for adenosine 3',5'-monophosphate. Endocrinology. 1981 Mar; 108(3):1002-6. Rost CR, Bikle DD, Kaplan RA. PMID: 6257493.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    340. The intestinal response to vitamin D. Rev Physiol Biochem Pharmacol. 1981; 89:63-142. Bikle DD, Morrissey RL, Zolock DT, Rasmussen H. PMID: 7015459.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    341. Action of vitamin D on intestinal calcium transport. Ann N Y Acad Sci. 1981; 372:481-501. Bikle DD, Zolock DT, Morrissey RL. PMID: 6951425.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    342. Studies of the chick renal mitochondrial 25-hydroxyvitamin D-3 24-hydroxylase. Biochim Biophys Acta. 1980 Sep 09; 615(1):208-22. Bikle DD. PMID: 6775702.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    343. Prolactin but not growth hormone stimulates 1,25-dihydroxyvitamin D3 production by chick renal preparations in vitro. Endocrinology. 1980 Jul; 107(1):81-4. Bikle DD, Spencer EM, Burke WH, Rost CR. PMID: 6892897.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    344. Calcium accumulation by chick intestinal mitochondria. Regulation by vitamin D-3 and 1,25-dihydroxyvitamin D-3. Biochim Biophys Acta. 1980 Jun 06; 598(3):561-74. Bikle DD, Askew EW, Zolock DT, Morrissey RL, Herman RH. PMID: 6155944.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    345. Effects of 1 alpha-hydroxy vitamin D3 on the rachitic chick intestine: a comparison to the effects of 1,25-dihydroxyvitamin D3. Calcif Tissue Int. 1980; 32(1):9-17. Bikle DD, Empson RN, Morrissey RL, Zolock DT, Bucci TJ, Herman RH, Pechet MM. PMID: 6775785.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    346. The mechanism of action of vitamin D in the intestine. Am J Clin Nutr. 1979 Nov; 32(11):2322-8. Bikle DD, Morrissey RL, Zolock DT. PMID: 158978.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    347. Stimulation of chick gut alkaline phosphatase activity by actinomycin D and 1,25-dihydroxyvitamin D3: evidence for independent mechanisms. J Lab Clin Med. 1979 Jul; 94(1):88-94. Bikle DD, Morrissey RL, Zolock DT, Herman RH. PMID: 313969.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    348. Work-induced muscle hypertrophy in vitamin D-deficient rats. Am J Clin Nutr. 1979 Mar; 32(3):515-6. Bikle DD, Hagler L, Lollini LO, Hull SF, Herman RH. PMID: 420144.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    349. Independence of 1,25-dihydroxyvitamin D3-mediated calcium transport from de novo RNA and protein synthesis. J Biol Chem. 1978 Jan 25; 253(2):484-8. Bikle DD, Zolock DT, Morrissey RL, Herman RH. PMID: 618881.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    350. Intestinal response to 1 alpha, 25-dihydroxycholecalciferol. I. RNA polymerase, alkaline phosphatase, calcium and phosphorus uptake in vitro, and in vivo calcium transport and accumulation. Biochim Biophys Acta. 1978 Jan 03; 538(1):23-33. Morrissey RL, Zolock DT, Bikle DD, Empson RN, Bucci TJ. PMID: 620061.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    351. Intestinal response to 1alpha,25-dihydroxycholecalciferol. II. A timed study of the intracellular localization of calcium binding protein. Biochim Biophys Acta. 1978 Jan 03; 538(1):34-41. Morrissey RL, Empson RN, Zolock DT, Bikle DD, Bucci TJ. PMID: 620062.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    352. Ionic control of 1,25-dihydroxy vitamin D-3 production by isolated chick renal mitochondria. Influence of anions and sucrose. Biochim Biophys Acta. 1978 Jan 03; 538(1):127-38. Bikle DD, Rasmussen H. PMID: 413585.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    353. The effect of 1,25-dihydroxyvitamin D-3 on the distribution of alkaline phosphatase activity along the chick intestinal villus. Biochim Biophys Acta. 1977 Aug 25; 499(1):61-6. Bikle DD, Empson RN, Herman RH, Morrissey RL, Zolock DR. PMID: 889896.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    354. The ionic control of 1,25-dihydroxyvitamin D3 production in isolated chick renal tubules. J Clin Invest. 1975 Feb; 55(2):292-8. Bikle DD, Rasmussen H. PMID: 236326; PMCID: PMC301747.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    355. The ionic control of 1,25-dihydroxyvitamin D3 synthesis in isolated chick renal mitochondria. The role of calcium as influenced by inorganic phosphate and hydrogen-ion. J Clin Invest. 1975 Feb; 55(2):299-304. Bikle DD, Murphy EW, Rasmussen H. PMID: 236327; PMCID: PMC301748.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    356. The metabolism of 25-hydroxycholecalciferol by isolated renal tubules in vitro as studied by a new chromatographic technique. Biochim Biophys Acta. 1974 Oct 08; 362(3):425-38. Bikle DD, Rasmussen H. PMID: 4370485.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    357. A comparison of the metabolism of 25-hydroxyvitamin D3 by chick renal tubules, homogenates and mitochondria. Biochim Biophys Acta. 1974 Oct 08; 362(3):439-47. Bikle DD, Rasmussen H. PMID: 4411605.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    358. Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. J Clin Invest. 1972 Sep; 51(9):2502-4. Rasmussen H, Wong M, Bikle D, Goodman DB. PMID: 4344734; PMCID: PMC292420.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
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