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Daniel Bikle, MD, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address4150 Clement St
San Francisco CA 94121
Phone415-575-0557
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    Collapse Biography 
    Collapse Education and Training
    HarvardAB1965Harvard
    University of PennsylvaniaMD1969School of Medicine
    University of PennsylvaniaPhD1974Graduate School of Arts and Sciences

    Collapse Research 
    Collapse Research Activities and Funding
    Vitamin D and Calcium signaling in epidermal stem cell maintenance, activation, and function
    VA I01BX003814Jan 1, 2018 - Dec 31, 2021
    Role: Principal Investigator
    Mechanisms Underlying Hormonal Regulation of Fracture Repair
    VA IP1BX001599Jan 1, 2012 - Dec 31, 2015
    Role: Principal Investigator
    Role of vitamin D and calcium signaling in wound healing
    VA I01BX001066Apr 1, 2011 - Mar 31, 2015
    Role: Principal Investigator
    Role of IGF-I/integrin signaling in the periosteal response to load
    NIH/NIAMS R01AR055924Apr 1, 2008 - Jan 31, 2020
    Role: Principal Investigator
    Vitamin D Receptor Coactivators in Keratinocytes
    NIH/NIAMS R01AR050023Jul 1, 2003 - May 31, 2015
    Role: Principal Investigator
    IGF-1 Mediates the Anabolic Effects of PTH on Bone
    NIH/NIDDK R01DK054793Feb 15, 2001 - Aug 31, 2014
    Role: Principal Investigator
    ESTROGEN/CALCITRIOL IN THE ETIOLOGY OF BREAST CANCER
    NIH/NCI R03CA070572Sep 30, 1995 - Mar 31, 1999
    Role: Principal Investigator
    Relationship of Keratinocyte Function to Differentiation
    NIH/NIAMS P01AR039448Jul 15, 1988 - Jul 31, 2010
    Role: Principal Investigator
    VITAMIN D AND THE DIFFERENTIATION OF KERATINOCYTES
    NIH/NIAMS R01AR038386May 1, 1987 - Mar 31, 2005
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    REGULATION OF INTESTINAL CALCIUM TRANSPORT BY VITAMIN D
    NIH/NIDDK R01DK028116Apr 1, 1981 - Jun 30, 2004
    Role: Principal Investigator
    VITAMIN D STIMULATED INTESTINAL CALCIUM TRANSPORT
    NIH/NIADDK R01AM028116Apr 1, 1981 - Mar 31, 1987
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Schwartz JB, Gallagher C, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Holick M, Orwoll E, Nielson C, Kaufman M, Jones G, Bouillon R, Lai J, Verotta D, Bikle D. Determination of free 25(OH)D concentrations and their relationships to total 25(OH)D in multiple clinical populations. J Clin Endocrinol Metab. 2018 Jun 27. PMID: 29955795.
      View in: PubMed
    2. Xie Z, Tang Y, Man MQ, Shrestha C, Bikle DD. p120-catenin is required for regulating epidermal proliferation, differentiation, and barrier function. J Cell Physiol. 2018 Jun 19. PMID: 29923340.
      View in: PubMed
    3. Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, DeLuca HF, Jones G, Munns CF, Bilezikian JP, Giustina A, Binkley N. Vitamin D Assays and the Definition of Hypovitaminosis D: Results from the 1st International Conference on Controversies in Vitamin D. Br J Clin Pharmacol. 2018 May 31. PMID: 29851137.
      View in: PubMed
    4. Oda Y, Hu L, Nguyen T, Fong C, Zhang J, Guo P, Bikle DD. Vitamin D receptor is required for proliferation, migration and differentiation of epidermal stem cells and progeny during cutaneous wound repair. J Invest Dermatol. 2018 May 19. PMID: 29787748.
      View in: PubMed
    5. Bikle DD, Patzek S, Wang Y. Physiologic and pathophysiologic roles of extra renal CYP27b1: Case report and review. Bone Rep. 2018 Jun; 8:255-267. PMID: 29963603.
      View in: PubMed
    6. Bikle DD, Malmstroem S, Schwartz J. Current Controversies: Are Free Vitamin Metabolite Levels a More Accurate Assessment of Vitamin D Status than Total Levels? Endocrinol Metab Clin North Am. 2017 Dec; 46(4):901-918. PMID: 29080642.
      View in: PubMed
    7. Tian F, Wang Y, Bikle DD. IGF-1 signaling mediated cell-specific skeletal mechano-transduction. J Orthop Res. 2018 Feb; 36(2):576-583. PMID: 28980721.
      View in: PubMed
    8. Bikle DD. Vitamin D Prevents Sunburn: Tips for the Summer? J Invest Dermatol. 2017 Oct; 137(10):2045-2047. PMID: 28941472.
      View in: PubMed
    9. Gallagher JC, Bikle DD. Vitamin D: Mechanisms of Action and Clinical Applications. Endocrinol Metab Clin North Am. 2017 Dec; 46(4):xvii-xviii. PMID: 29080648.
      View in: PubMed
    10. Yoshizaki K, Hu L, Nguyen T, Sakai K, Ishikawa M, Takahashi I, Fukumoto S, DenBesten PK, Bikle DD, Oda Y, Yamada Y. Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene. J Biol Chem. 2017 08 18; 292(33):13531-13540. PMID: 28673966.
      View in: PubMed
    11. Oda Y, Hu L, Nguyen T, Fong C, Tu CL, Bikle DD. Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization. Endocrinology. 2017 06 01; 158(6):1929-1938. PMID: 28368538.
      View in: PubMed
    12. Malmstroem S, Rejnmark L, Imboden JB, Shoback DM, Bikle DD. Current Assays to Determine Free 25-Hydroxyvitamin D in Serum. J AOAC Int. 2017 Sep 01; 100(5):1323-1327. PMID: 28492133.
      View in: PubMed
    13. Jassil NK, Sharma A, Bikle D, Wang X. VITAMIN D BINDING PROTEIN AND 25-HYDROXYVITAMIN D LEVELS: EMERGING CLINICAL APPLICATIONS. Endocr Pract. 2017 May; 23(5):605-613. PMID: 28095044.
      View in: PubMed
    14. Bikle D, Bouillon R, Thadhani R, Schoenmakers I. Vitamin D metabolites in captivity? Should we measure free or total 25(OH)D to assess vitamin D status? J Steroid Biochem Mol Biol. 2017 10; 173:105-116. PMID: 28093353.
      View in: PubMed
    15. Xie Z, Yuan Y, Jiang Y, Shrestha C, Chen Y, Liao L, Ji S, Deng X, Liao E, Bikle DD. p120-Catenin Is Required for Dietary Calcium Suppression of Oral Carcinogenesis in Mice. J Cell Physiol. 2017 Jun; 232(6):1360-1367. PMID: 27682597.
      View in: PubMed
    16. Wang T, Zhang X, Bikle DD. Osteogenic Differentiation of Periosteal Cells During Fracture Healing. J Cell Physiol. 2017 May; 232(5):913-921. PMID: 27731505.
      View in: PubMed
    17. Elias PM, Williams ML, Bikle DD. The vitamin D hypothesis: Dead or alive?: Response to Dr. William Grant's "The UVB-vitamin D3-pigment hypothesis is alive and well-AJPA-2016-00237". Am J Phys Anthropol. 2016 Dec; 161(4):756-757. PMID: 27634223.
      View in: PubMed
    18. Bikle DD, Jiang Y, Nguyen T, Oda Y, Tu CL. Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. Front Physiol. 2016; 7:296. PMID: 27462278; PMCID: PMC4940389.
    19. Bikle DD. Extraskeletal actions of vitamin D. Ann N Y Acad Sci. 2016 07; 1376(1):29-52. PMID: 27649525.
      View in: PubMed
    20. Shrestha C, Tang Y, Fan H, Li L, Zeng Q, Pennypacker SD, Bikle DD, Xie Z. Phosphoprotein Phosphatase 1 Is Required for Extracellular Calcium-Induced Keratinocyte Differentiation. Biomed Res Int. 2016; 2016:3062765. PMID: 27340655; PMCID: PMC4909930.
    21. Bikle DD. The Endocrine Society Centennial: Extrarenal Production of 1,25 Dihyroxyvitamin D Is Now Proven. Endocrinology. 2016 05; 157(5):1717-8. PMID: 27014941.
      View in: PubMed
    22. Mady LJ, Ajibade DV, Hsaio C, Teichert A, Fong C, Wang Y, Christakos S, Bikle DD. The Transient Role for Calcium and Vitamin D during the Developmental Hair Follicle Cycle. J Invest Dermatol. 2016 07; 136(7):1337-1345. PMID: 26994969.
      View in: PubMed
    23. Tahimic CG, Long RK, Kubota T, Sun MY, Elalieh H, Fong C, Menendez AT, Wang Y, Vilardaga JP, Bikle DD. Regulation of Ligand and Shear Stress-induced Insulin-like Growth Factor 1 (IGF1) Signaling by the Integrin Pathway. J Biol Chem. 2016 Apr 08; 291(15):8140-9. PMID: 26865633; PMCID: PMC4825016 [Available on 04/08/17].
    24. Teske KA, Bogart JW, Sanchez LM, Yu OB, Preston JV, Cook JM, Silvaggi NR, Bikle DD, Arnold LA. Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites. Eur J Med Chem. 2016 Feb 15; 109:238-46. PMID: 26774929; PMCID: PMC4737989 [Available on 02/15/17].
    25. Schwartz JB, Kane L, Bikle D. Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial. J Am Geriatr Soc. 2016 Jan; 64(1):65-72. PMID: 26782853; PMCID: PMC4724876 [Available on 01/01/17].
    26. Bikle DD, Tahimic C, Chang W, Wang Y, Philippou A, Barton ER. Role of IGF-I signaling in muscle bone interactions. Bone. 2015 Nov; 80:79-88. PMID: 26453498; PMCID: PMC4600536 [Available on 11/01/16].
    27. Guthrie ML, Sidhu PS, Hill EK, Horan TC, Nandhikonda P, Teske KA, Yuan NY, Sidorko M, Rodali R, Cook JM, Han L, Silvaggi NR, Bikle DD, Moore RG, Singh RK, Arnold LA. Antitumor Activity of 3-Indolylmethanamines 31B and PS121912. Anticancer Res. 2015 Nov; 35(11):6001-7. PMID: 26504023; PMCID: PMC4633305.
    28. Bikle DD. Pregnane X receptor expression in skin: the good and the bad. Exp Dermatol. 2015 Nov; 24(11):829-30. PMID: 26269123.
      View in: PubMed
    29. Wang T, Wang Y, Menendez A, Fong C, Babey M, Tahimic CG, Cheng Z, Li A, Chang W, Bikle DD. Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing. J Bone Miner Res. 2015 Sep; 30(9):1572-84. PMID: 25801198.
      View in: PubMed
    30. Oda Y, Tu CL, Menendez A, Nguyen T, Bikle DD. Vitamin D and calcium regulation of epidermal wound healing. J Steroid Biochem Mol Biol. 2016 11; 164:379-385. PMID: 26282157.
      View in: PubMed
    31. Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC. A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting. Calcif Tissue Int. 2015 Dec; 97(6):634-9. PMID: 26253396; PMCID: PMC4861400 [Available on 12/01/16].
    32. Wang Y, Menendez A, Fong C, ElAlieh HZ, Kubota T, Long R, Bikle DD. IGF-I Signaling in Osterix-Expressing Cells Regulates Secondary Ossification Center Formation, Growth Plate Maturation, and Metaphyseal Formation During Postnatal Bone Development. J Bone Miner Res. 2015 Dec; 30(12):2239-48. PMID: 26011431.
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    33. Shah AD, Hsiao EC, O'Donnell B, Salmeen K, Nussbaum R, Krebs M, Baumgartner-Parzer S, Kaufmann M, Jones G, Bikle DD, Wang Y, Mathew AS, Shoback D, Block-Kurbisch I. Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations. J Clin Endocrinol Metab. 2015 Aug; 100(8):2832-6. PMID: 26097993; PMCID: PMC4524985.
    34. Babey M, Wang Y, Kubota T, Fong C, Menendez A, ElAlieh HZ, Bikle DD. Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts. J Bone Miner Res. 2015 Jun; 30(6):1064-76. PMID: 25502173.
      View in: PubMed
    35. Bourguignon LY, Bikle D. Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation. Front Immunol. 2015; 6:224. PMID: 26029210; PMCID: PMC4429634.
    36. Tiganescu A, Hupe M, Jiang YJ, Celli A, Uchida Y, Mauro TM, Bikle DD, Elias PM, Holleran WM. UVB induces epidermal 11ß-hydroxysteroid dehydrogenase type 1 activity in vivo. Exp Dermatol. 2015 May; 24(5):370-6. PMID: 25739654.
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    37. Lai JC, Bikle DD, Lizaola B, Hayssen H, Terrault NA, Schwartz JB. Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction. Liver Int. 2015 Oct; 35(10):2294-300. PMID: 25757956; PMCID: PMC4567539 [Available on 10/01/16].
    38. Welsh J, Bikle DD, Lips P. Highlights from the 17th workshop on vitamin D, Chicago, IL, June 17-21, 2014. J Steroid Biochem Mol Biol. 2015 Apr; 148:1-2. PMID: 25641118.
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    39. Bikle DD. Vitamin D receptor, a tumor suppressor in skin. Can J Physiol Pharmacol. 2015 May; 93(5):349-54. PMID: 25559384.
      View in: PubMed
    40. Bikle DD, Oda Y, Tu CL, Jiang Y. Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer. J Steroid Biochem Mol Biol. 2015 Apr; 148:47-51. PMID: 25445917; PMCID: PMC4361259.
    41. Thyssen JP, Bikle DD, Elias PM. Evidence That Loss-of-Function Filaggrin Gene Mutations Evolved in Northern Europeans to Favor Intracutaneous Vitamin D3 Production. Evol Biol. 2014 Sep 01; 41(3):388-396. PMID: 25506102.
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    42. Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle DD, Arnold LA. Anticancer activity of VDR-coregulator inhibitor PS121912. Cancer Chemother Pharmacol. 2014 Oct; 74(4):787-98. PMID: 25107568; PMCID: PMC4177010.
    43. Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle DD. Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation. J Bone Miner Res. 2014 Aug; 29(8):1900-13. PMID: 24677183; PMCID: PMC4108521.
    44. Yoshizaki K, Hu L, Nguyen T, Sakai K, He B, Fong C, Yamada Y, Bikle DD, Oda Y. Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair. PLoS One. 2014; 9(6):e99991. PMID: 24949995; PMCID: PMC4065011.
    45. Bikle DD, Mauro TM. Calcium, Orai1, and epidermal proliferation. J Invest Dermatol. 2014 Jun; 134(6):1506-1508. PMID: 24825060; PMCID: PMC4023905.
    46. Bikle D. Highlights from the 16th Vitamin D Workshop, San Francisco, CA, June 11-14, 2013. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:1-4. PMID: 24793579.
      View in: PubMed
    47. Jiang YJ, Bikle DD. LncRNA: a new player in 1a, 25(OH)(2) vitamin D(3) /VDR protection against skin cancer formation. Exp Dermatol. 2014 Mar; 23(3):147-50. PMID: 24499465; PMCID: PMC4103949.
    48. Hollis BW, Bikle DD. Vitamin D-binding protein and vitamin D in blacks and whites. N Engl J Med. 2014 02 27; 370(9):879-80. PMID: 24571766.
      View in: PubMed
    49. Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014 Mar 20; 21(3):319-29. PMID: 24529992; PMCID: PMC3968073.
    50. Sidhu PS, Nassif N, McCallum MM, Teske K, Feleke B, Yuan NY, Nandhikonda P, Cook JM, Singh RK, Bikle DD, Arnold LA. Development of novel Vitamin D Receptor-Coactivator Inhibitors. ACS Med Chem Lett. 2014 Feb 13; 5(2):199-204. PMID: 24799995.
      View in: PubMed
    51. Bikle DD. Vitamin D and cancer: the promise not yet fulfilled. Endocrine. 2014 May; 46(1):29-38. PMID: 24402695; PMCID: PMC3976762.
    52. Teske K, Nandhikonda P, Bogart JW, Feleke B, Sidhu P, Yuan N, Preston J, Goy R, Han L, Silvaggi NR, Singh RK, Bikle DD, Cook JM, Arnold LA. IDENTIFICATION OF VDR ANTAGONISTS AMONG NUCLEAR RECEPTOR LIGANDS USING VIRTUAL SCREENING. Nucl Receptor Res. 2014; 1. PMID: 25419525.
      View in: PubMed
    53. Bikle DD. The vitamin D receptor: a tumor suppressor in skin. Adv Exp Med Biol. 2014; 810:282-302. PMID: 25207372.
      View in: PubMed
    54. Jiang YJ, Bikle DD. LncRNA profiling reveals new mechanism for VDR protection against skin cancer formation. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:87-90. PMID: 24342142.
      View in: PubMed
    55. Hu L, Bikle DD, Oda Y. Reciprocal role of vitamin D receptor on ß-catenin regulated keratinocyte proliferation and differentiation. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:237-41. PMID: 24239508; PMCID: PMC4061268.
    56. Bikle DD, Jiang Y. The protective role of vitamin d signaling in non-melanoma skin cancer. Cancers (Basel). 2013 Nov 05; 5(4):1426-38. PMID: 24202452; PMCID: PMC3875946.
    57. Kubota T, Elalieh HZ, Saless N, Fong C, Wang Y, Babey M, Cheng Z, Bikle DD. Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading. Acta Astronaut. 2013 Nov; 92(1):73-78. PMID: 23976802.
      View in: PubMed
    58. Wang Y, Bikle DD, Chang W. Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development. Bone Res. 2013 Sep; 1(3):249-59. PMID: 26273506; PMCID: PMC4472106.
    59. Kane L, Moore K, Lütjohann D, Bikle D, Schwartz JB. Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships. J Clin Endocrinol Metab. 2013 Nov; 98(11):4400-9. PMID: 24030939; PMCID: PMC3816263.
    60. Norman AW, Bikle D, Bouillon R. Fifteenth vitamin D workshop. J Steroid Biochem Mol Biol. 2013 Jul; 136:1-2. PMID: 23768771; PMCID: PMC4102609.
    61. Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology. 2013 Sep; 154(9):3031-42. PMID: 23782944; PMCID: PMC3749485.
    62. Nandhikonda P, Yasgar A, Baranowski AM, Sidhu PS, McCallum MM, Pawlak AJ, Teske K, Feleke B, Yuan NY, Kevin C, Bikle DD, Ayers SD, Webb P, Rai G, Simeonov A, Jadhav A, Maloney D, Arnold LA. Peroxisome proliferation-activated receptor d agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor. Biochemistry. 2013 Jun 18; 52(24):4193-203. PMID: 23713684; PMCID: PMC3724348.
    63. Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD. Vitamin D: beyond bone. Ann N Y Acad Sci. 2013 May; 1287:45-58. PMID: 23682710; PMCID: PMC3717170.
    64. Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W. Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice. J Bone Miner Res. 2013 May; 28(5):1087-100. PMID: 23239173; PMCID: PMC3617088.
    65. Tu CL, Bikle DD. Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function. Best Pract Res Clin Endocrinol Metab. 2013 Jun; 27(3):415-27. PMID: 23856269; PMCID: PMC3713412.
    66. Tahimic CG, Wang Y, Bikle DD. Anabolic effects of IGF-1 signaling on the skeleton. Front Endocrinol (Lausanne). 2013; 4:6. PMID: 23382729; PMCID: PMC3563099.
    67. Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR. Ceramides stimulate caspase-14 expression in human keratinocytes. Exp Dermatol. 2013 Feb; 22(2):113-8. PMID: 23362869; PMCID: PMC4099380.
    68. Bikle DD. Protective actions of vitamin D in UVB induced skin cancer. Photochem Photobiol Sci. 2012 Dec; 11(12):1808-16. PMID: 22990497; PMCID: PMC3501582.
    69. Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM. Vitamin D in cutaneous carcinogenesis: part II. J Am Acad Dermatol. 2012 Nov; 67(5):817.e1-11; quiz 827-8. PMID: 23062904.
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    70. Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM. Vitamin D in cutaneous carcinogenesis: part I. J Am Acad Dermatol. 2012 Nov; 67(5):803.e1-12, quiz 815-6. PMID: 23062903.
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    71. Shahnazari M, Kurimoto P, Boudignon BM, Orwoll BE, Bikle DD, Halloran BP. Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice. Am J Physiol Endocrinol Metab. 2012 Dec 01; 303(11):E1354-62. PMID: 23047986; PMCID: PMC3774081.
    72. Bikle DD, Elalieh H, Welsh J, Oh D, Cleaver J, Teichert A. Protective role of vitamin D signaling in skin cancer formation. J Steroid Biochem Mol Biol. 2013 Jul; 136:271-9. PMID: 23059470; PMCID: PMC3596439.
    73. Jiang YJ, Teichert AE, Fong F, Oda Y, Bikle DD. 1a,25(OH)2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the ß-catenin pathway. J Steroid Biochem Mol Biol. 2013 Jul; 136:229-32. PMID: 23026511; PMCID: PMC4102608.
    74. Bikle DD, Xie Z, Tu CL. Calcium regulation of keratinocyte differentiation. Expert Rev Endocrinol Metab. 2012 Jul; 7(4):461-472. PMID: 23144648.
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    75. Bikle DD. Vitamin D and bone. Curr Osteoporos Rep. 2012 Jun; 10(2):151-9. PMID: 22544628; PMCID: PMC3688475.
    76. Bikle DD, Wang Y. Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormone. Curr Mol Pharmacol. 2012 Jun; 5(2):135-42. PMID: 21787292; PMCID: PMC3690777.
    77. Tu CL, Crumrine DA, Man MQ, Chang W, Elalieh H, You M, Elias PM, Bikle DD. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J Invest Dermatol. 2012 Oct; 132(10):2350-2359. PMID: 22622426; PMCID: PMC3434298.
    78. Muehleisen B, Bikle DD, Aguilera C, Burton DW, Sen GL, Deftos LJ, Gallo RL. PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection. Sci Transl Med. 2012 May 23; 4(135):135ra66. PMID: 22623742; PMCID: PMC3725981.
    79. Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev. 2012 Jun; 33(3):456-92. PMID: 22596255; PMCID: PMC3365859.
    80. Nandhikonda P, Lynt WZ, McCallum MM, Ara T, Baranowski AM, Yuan NY, Pearson D, Bikle DD, Guy RK, Arnold LA. Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators. J Med Chem. 2012 May 24; 55(10):4640-51. PMID: 22563729; PMCID: PMC3364162.
    81. Demetriou SK, Ona-Vu K, Teichert AE, Cleaver JE, Bikle DD, Oh DH. Vitamin D receptor mediates DNA repair and is UV inducible in intact epidermis but not in cultured keratinocytes. J Invest Dermatol. 2012 Aug; 132(8):2097-100. PMID: 22495177; PMCID: PMC3396713.
    82. Bikle DD. Vitamin D and the skin: Physiology and pathophysiology. Rev Endocr Metab Disord. 2012 Mar; 13(1):3-19. PMID: 21845365; PMCID: PMC3687803.
    83. Celli A, Mackenzie DS, Zhai Y, Tu CL, Bikle DD, Holleran WM, Uchida Y, Mauro TM. SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease. J Invest Dermatol. 2012 Apr; 132(4):1188-95. PMID: 22277942; PMCID: PMC3305850.
    84. Oda Y, Hu L, Bul V, Elalieh H, Reddy JK, Bikle DD. Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterations. J Invest Dermatol. 2012 Apr; 132(4):1075-83. PMID: 22189783; PMCID: PMC3400544.
    85. Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM. Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover. J Bone Miner Res. 2011 Dec; 26(12):2935-47. PMID: 21956637; PMCID: PMC3222747.
    86. Long RK, Nishida S, Kubota T, Wang Y, Sakata T, Elalieh HZ, Halloran BP, Bikle DD. Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling. J Bone Miner Res. 2011 Dec; 26(12):2948-58. PMID: 21932337; PMCID: PMC3222734.
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