Daniel Bikle, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
Phone415-750-2089
ORCID ORCID Icon0000-0002-1040-475x Additional info
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    Collapse Biography 
    Collapse Education and Training
    HarvardAB1965Harvard
    University of PennsylvaniaMD1969School of Medicine
    University of PennsylvaniaPhD1974Graduate School of Arts and Sciences
    Collapse Awards and Honors
    Harvard1965Henderson Memorial Prize in Biochemistry
    Harvard1965Magna Cum Laude
    University of Pennsylvania1966Baldwin Lucke Memorial Prize
    University of Pennsylvania1968alpha omega alpha
    University of Pennsylvania1969Horatio C Wood Prize in Pharmacology
    University of Pennsylvania1969Borden Research Award
    University of Pennsylvania1969Spencer Morris Prize
    American College of Physicians1982Fellow, American College of Physicians
    American Society of Clinical Investigation1985member American Society of Clinical Investigation
    Association of American Physicians1995member Association of American Physicians
    ASBMR2007Boy Frame Award for Clinical Excellence in Bone and Mineral Research
    International Workshop for Vitamin D2009Career Award in Vitamin D research
    ASBMR2016Louis V Avioli Founders Award
    ASBMR2019Fellowship, ASBMR

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Vitamin D and Calcium signaling in epidermal stem cell maintenance, activation, and function
    NIH I01BX003814Jan 1, 2018 - Dec 31, 2021
    Role: Principal Investigator
    Role of IGF-I/integrin signaling in the periosteal response to load
    NIH R01AR055924Apr 1, 2008 - Jan 31, 2021
    Role: Principal Investigator
    Vitamin D Receptor Coactivators in Keratinocytes
    NIH R01AR050023Jul 1, 2003 - May 31, 2016
    Role: Principal Investigator
    IGF-1 Mediates the Anabolic Effects of PTH on Bone
    NIH R01DK054793Feb 15, 2001 - Aug 31, 2015
    Role: Principal Investigator
    ESTROGEN/CALCITRIOL IN THE ETIOLOGY OF BREAST CANCER
    NIH R03CA070572Sep 30, 1995 - Mar 31, 1999
    Role: Principal Investigator
    Relationship of Keratinocyte Function to Differentiation
    NIH P01AR039448Jul 15, 1988 - Jul 31, 2010
    Role: Principal Investigator
    VITAMIN D AND THE DIFFERENTIATION OF KERATINOCYTES
    NIH R01AR038386May 1, 1987 - Mar 31, 2005
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    REGULATION OF INTESTINAL CALCIUM TRANSPORT BY VITAMIN D
    NIH R01DK028116Apr 1, 1981 - Jun 30, 2004
    Role: Principal Investigator
    VITAMIN D STIMULATED INTESTINAL CALCIUM TRANSPORT
    NIH R01AM028116Apr 1, 1981 - Mar 31, 1987
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Vitamin D regulation of and by long non coding RNAs. Mol Cell Endocrinol. 2021 May 17; 532:111317. Bikle DD. PMID: 34015414.
      View in: PubMed   Mentions:    Fields:    
    2. DECREASED CALCIUM SENSING RECEPTOR EXPRESSION CONTROLS CALCIUM SIGNALING AND CELL-TO-CELL ADHESION DEFECTS IN AGED SKIN. J Invest Dermatol. 2021 Apr 13. Celli A, Tu CL, Lee E, Bikle DD, Mauro TM. PMID: 33862069.
      View in: PubMed   Mentions:    Fields:    
    3. Introduction: Special Issue on Vitamin D Dedicated to the Memory of Anthony W Norman. JBMR Plus. 2021 Jan; 5(1):e10445. Bouillon R, Haussler M, Bikle D, Christakos S, Welsh J. PMID: 33553991.
      View in: PubMed   Mentions:
    4. Ablation of Ephrin B2 in Col2 Expressing Cells Delays Fracture Repair. Endocrinology. 2020 12 01; 161(12). Wang Y, Ling L, Tian F, Won Kim SH, Ho S, Bikle DD. PMID: 32987403.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Transcriptional Regulation of Dental Epithelial Cell Fate. Int J Mol Sci. 2020 Nov 25; 21(23). Yoshizaki K, Fukumoto S, Bikle DD, Oda Y. PMID: 33255698.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. The Free Hormone Hypothesis: When, Why, and How to Measure the Free Hormone Levels to Assess Vitamin D, Thyroid, Sex Hormone, and Cortisol Status. JBMR Plus. 2021 Jan; 5(1):e10418. Bikle DD. PMID: 33553985.
      View in: PubMed   Mentions:
    7. MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19. Eur J Endocrinol. 2020 Nov; 183(5):R133-R147. Bilezikian JP, Bikle D, Hewison M, Lazaretti-Castro M, Formenti AM, Gupta A, Madhavan MV, Nair N, Babalyan V, Hutchings N, Napoli N, Accili D, Binkley N, Landry DW, Giustina A. PMID: 32755992.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCellsPHPublic Health
    8. Deletion of Mediator 1 suppresses TGFß signaling leading to changes in epidermal lineages and regeneration. PLoS One. 2020; 15(8):e0238076. Oda Y, Nguyen T, Hata A, Meyer MB, Pike JW, Bikle DD. PMID: 32857768.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. Vitamin D and calcium signaling in epidermal stem cells and their regeneration. World J Stem Cells. 2020 Jul 26; 12(7):604-611. Oda Y, Bikle DD. PMID: 32843916.
      View in: PubMed   Mentions:
    10. p120-catenin suppresses proliferation and tumor growth of oral squamous cell carcinoma via inhibiting nuclear phospholipase C-?1 signaling. J Cell Physiol. 2020 12; 235(12):9399-9413. Li L, Ji S, Shrestha C, Jiang Y, Liao L, Xu F, Liu Z, Bikle DD, Xie Z. PMID: 32356317.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    11. Editorial: Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions. Front Endocrinol (Lausanne). 2020; 11:40. Xie Z, Wang X, Bikle DD. PMID: 32117066.
      View in: PubMed   Mentions:
    12. New aspects of vitamin D metabolism and action - addressing the skin as source and target. Nat Rev Endocrinol. 2020 04; 16(4):234-252. Bikle D, Christakos S. PMID: 32029884.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    13. Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level. J Endocr Soc. 2020 Feb 01; 4(2):bvz038. Bikle DD. PMID: 32051922.
      View in: PubMed   Mentions:
    14. The Vitamin D Receptor as Tumor Suppressor in Skin. Adv Exp Med Biol. 2020; 1268:285-306. Bikle DD. PMID: 32918224.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Vitamin D Metabolism Revised: Fall of Dogmas. J Bone Miner Res. 2019 11; 34(11):1985-1992. Bouillon R, Bikle D. PMID: 31589774.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    16. Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport. J Endocr Soc. 2019 Nov 01; 3(11):1993-2011. Munson S, Wang Y, Chang W, Bikle DD. PMID: 31620669.
      View in: PubMed   Mentions:
    17. Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions. Endocr Rev. 2019 08 01; 40(4):1109-1151. Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J. PMID: 30321335.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    18. New developments in our understanding of vitamin metabolism, action and treatment. Metabolism. 2019 09; 98:112-120. Christakos S, Li S, De La Cruz J, Bikle DD. PMID: 31226354.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    19. Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions. Front Endocrinol (Lausanne). 2019; 10:317. Bikle DD, Schwartz J. PMID: 31191450.
      View in: PubMed   Mentions:
    20. The Fracture Callus Is Formed by Progenitors of Different Skeletal Origins in a Site-Specific Manner. JBMR Plus. 2019 Sep; 3(9):e10193. Wang Y, Chen L, Kang M, Ling L, Tian F, Won-Kim SH, Ho S, Bikle DD. PMID: 31667451.
      View in: PubMed   Mentions:
    21. Rapid onset of hypercalcemia from high-grade lymphoma in the setting of HIV-related immune reconstitution inflammatory syndrome. Bone Rep. 2019 Jun; 10:100194. Kim SJ, Peluso MJ, Wang Y, Bikle D, Shoback D, Kim S. PMID: 30627599.
      View in: PubMed   Mentions:
    22. Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations. J Clin Endocrinol Metab. 2018 09 01; 103(9):3278-3288. Schwartz JB, Gallagher JC, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Holick M, Orwoll E, Nielson C, Kaufmann M, Jones G, Bouillon R, Lai J, Verotta D, Bikle D. PMID: 29955795.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    23. Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D. Br J Clin Pharmacol. 2018 10; 84(10):2194-2207. Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, DeLuca HF, Jones G, Munns CF, Bilezikian JP, Giustina A, Binkley N. PMID: 29851137.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    24. Vitamin D and bone and beyond. Bone Rep. 2018 Dec; 9:120-121. Bikle DD, Bouillon R. PMID: 30591929.
      View in: PubMed   Mentions:
    25. p120-catenin is required for regulating epidermal proliferation, differentiation, and barrier function. J Cell Physiol. 2018 01; 234(1):427-432. Xie Z, Tang Y, Man MQ, Shrestha C, Bikle DD. PMID: 29923340.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    26. Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny during Cutaneous Wound Repair. J Invest Dermatol. 2018 11; 138(11):2423-2431. Oda Y, Hu L, Nguyen T, Fong C, Zhang J, Guo P, Bikle DD. PMID: 29787748.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    27. Vitamin D Assays. Front Horm Res. 2018; 50:14-30. Bikle DD. PMID: 29597233.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    28. Physiologic and pathophysiologic roles of extra renal CYP27b1: Case report and review. Bone Rep. 2018 Jun; 8:255-267. Bikle DD, Patzek S, Wang Y. PMID: 29963603.
      View in: PubMed   Mentions:
    29. Current Controversies: Are Free Vitamin Metabolite Levels a More Accurate Assessment of Vitamin D Status than Total Levels? Endocrinol Metab Clin North Am. 2017 12; 46(4):901-918. Bikle DD, Malmstroem S, Schwartz J. PMID: 29080642.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    30. IGF-1 signaling mediated cell-specific skeletal mechano-transduction. J Orthop Res. 2018 02; 36(2):576-583. Tian F, Wang Y, Bikle DD. PMID: 28980721.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    31. Vitamin D Prevents Sunburn: Tips for the Summer? J Invest Dermatol. 2017 10; 137(10):2045-2047. Bikle DD. PMID: 28941472.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    32. Vitamin D: Mechanisms of Action and Clinical Applications. Endocrinol Metab Clin North Am. 2017 12; 46(4):xvii-xviii. Gallagher JC, Bikle DD. PMID: 29080648.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene. J Biol Chem. 2017 08 18; 292(33):13531-13540. Yoshizaki K, Hu L, Nguyen T, Sakai K, Ishikawa M, Takahashi I, Fukumoto S, DenBesten PK, Bikle DD, Oda Y, Yamada Y. PMID: 28673966.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    34. Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization. Endocrinology. 2017 06 01; 158(6):1929-1938. Oda Y, Hu L, Nguyen T, Fong C, Tu CL, Bikle DD. PMID: 28368538.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    35. Current Assays to Determine Free 25-Hydroxyvitamin D in Serum. J AOAC Int. 2017 Sep 01; 100(5):1323-1327. Malmstroem S, Rejnmark L, Imboden JB, Shoback DM, Bikle DD. PMID: 28492133.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    36. VITAMIN D BINDING PROTEIN AND 25-HYDROXYVITAMIN D LEVELS: EMERGING CLINICAL APPLICATIONS. Endocr Pract. 2017 May; 23(5):605-613. Jassil NK, Sharma A, Bikle D, Wang X. PMID: 28095044.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    37. Vitamin D metabolites in captivity? Should we measure free or total 25(OH)D to assess vitamin D status? J Steroid Biochem Mol Biol. 2017 10; 173:105-116. Bikle D, Bouillon R, Thadhani R, Schoenmakers I. PMID: 28093353.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    38. p120-Catenin Is Required for Dietary Calcium Suppression of Oral Carcinogenesis in Mice. J Cell Physiol. 2017 Jun; 232(6):1360-1367. Xie Z, Yuan Y, Jiang Y, Shrestha C, Chen Y, Liao L, Ji S, Deng X, Liao E, Bikle DD. PMID: 27682597.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    39. Osteogenic Differentiation of Periosteal Cells During Fracture Healing. J Cell Physiol. 2017 05; 232(5):913-921. Wang T, Zhang X, Bikle DD. PMID: 27731505.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    40. The vitamin D hypothesis: Dead or alive?: Response to Dr. William Grant's "The UVB-vitamin D3-pigment hypothesis is alive and well-AJPA-2016-00237". Am J Phys Anthropol. 2016 12; 161(4):756-757. Elias PM, Williams ML, Bikle DD. PMID: 27634223.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    41. Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. Front Physiol. 2016; 7:296. Bikle DD, Jiang Y, Nguyen T, Oda Y, Tu CL. PMID: 27462278.
      View in: PubMed   Mentions:
    42. Extraskeletal actions of vitamin D. Ann N Y Acad Sci. 2016 07; 1376(1):29-52. Bikle DD. PMID: 27649525.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    43. Phosphoprotein Phosphatase 1 Is Required for Extracellular Calcium-Induced Keratinocyte Differentiation. Biomed Res Int. 2016; 2016:3062765. Shrestha C, Tang Y, Fan H, Li L, Zeng Q, Pennypacker SD, Bikle DD, Xie Z. PMID: 27340655.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    44. The Endocrine Society Centennial: Extrarenal Production of 1,25 Dihyroxyvitamin D Is Now Proven. Endocrinology. 2016 05; 157(5):1717-8. Bikle DD. PMID: 27014941.
      View in: PubMed   Mentions: 1     Fields:    
    45. The Transient Role for Calcium and Vitamin D during the Developmental Hair Follicle Cycle. J Invest Dermatol. 2016 07; 136(7):1337-1345. Mady LJ, Ajibade DV, Hsaio C, Teichert A, Fong C, Wang Y, Christakos S, Bikle DD. PMID: 26994969.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    46. Regulation of Ligand and Shear Stress-induced Insulin-like Growth Factor 1 (IGF1) Signaling by the Integrin Pathway. J Biol Chem. 2016 Apr 08; 291(15):8140-9. Tahimic CG, Long RK, Kubota T, Sun MY, Elalieh H, Fong C, Menendez AT, Wang Y, Vilardaga JP, Bikle DD. PMID: 26865633.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    47. Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites. Eur J Med Chem. 2016 Feb 15; 109:238-46. Teske KA, Bogart JW, Sanchez LM, Yu OB, Preston JV, Cook JM, Silvaggi NR, Bikle DD, Arnold LA. PMID: 26774929.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    48. Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial. J Am Geriatr Soc. 2016 Jan; 64(1):65-72. Schwartz JB, Kane L, Bikle D. PMID: 26782853.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    49. Role of IGF-I signaling in muscle bone interactions. Bone. 2015 Nov; 80:79-88. Bikle DD, Tahimic C, Chang W, Wang Y, Philippou A, Barton ER. PMID: 26453498.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    50. Antitumor Activity of 3-Indolylmethanamines 31B and PS121912. Anticancer Res. 2015 Nov; 35(11):6001-7. Guthrie ML, Sidhu PS, Hill EK, Horan TC, Nandhikonda P, Teske KA, Yuan NY, Sidorko M, Rodali R, Cook JM, Han L, Silvaggi NR, Bikle DD, Moore RG, Singh RK, Arnold LA. PMID: 26504023.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    51. Pregnane X receptor expression in skin: the good and the bad. Exp Dermatol. 2015 Nov; 24(11):829-30. Bikle DD. PMID: 26269123.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    52. Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing. J Bone Miner Res. 2015 Sep; 30(9):1572-84. Wang T, Wang Y, Menendez A, Fong C, Babey M, Tahimic CG, Cheng Z, Li A, Chang W, Bikle DD. PMID: 25801198.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    53. Vitamin D and calcium regulation of epidermal wound healing. J Steroid Biochem Mol Biol. 2016 11; 164:379-385. Oda Y, Tu CL, Menendez A, Nguyen T, Bikle DD. PMID: 26282157.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    54. A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting. Calcif Tissue Int. 2015 Dec; 97(6):634-9. Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC. PMID: 26253396.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    55. IGF-I Signaling in Osterix-Expressing Cells Regulates Secondary Ossification Center Formation, Growth Plate Maturation, and Metaphyseal Formation During Postnatal Bone Development. J Bone Miner Res. 2015 Dec; 30(12):2239-48. Wang Y, Menendez A, Fong C, ElAlieh HZ, Kubota T, Long R, Bikle DD. PMID: 26011431.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    56. Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations. J Clin Endocrinol Metab. 2015 Aug; 100(8):2832-6. Shah AD, Hsiao EC, O'Donnell B, Salmeen K, Nussbaum R, Krebs M, Baumgartner-Parzer S, Kaufmann M, Jones G, Bikle DD, Wang Y, Mathew AS, Shoback D, Block-Kurbisch I. PMID: 26097993.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    57. Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts. J Bone Miner Res. 2015 Jun; 30(6):1064-76. Babey M, Wang Y, Kubota T, Fong C, Menendez A, ElAlieh HZ, Bikle DD. PMID: 25502173.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    58. Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation. Front Immunol. 2015; 6:224. Bourguignon LY, Bikle D. PMID: 26029210.
      View in: PubMed   Mentions: 7     Fields:    
    59. UVB induces epidermal 11ß-hydroxysteroid dehydrogenase type 1 activity in vivo. Exp Dermatol. 2015 May; 24(5):370-6. Tiganescu A, Hupe M, Jiang YJ, Celli A, Uchida Y, Mauro TM, Bikle DD, Elias PM, Holleran WM. PMID: 25739654.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    60. Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction. Liver Int. 2015 Oct; 35(10):2294-300. Lai JC, Bikle DD, Lizaola B, Hayssen H, Terrault NA, Schwartz JB. PMID: 25757956.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    61. Highlights from the 17th workshop on vitamin D, Chicago, IL, June 17-21, 2014. J Steroid Biochem Mol Biol. 2015 Apr; 148:1-2. Welsh J, Bikle DD, Lips P. PMID: 25641118.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    62. Vitamin D receptor, a tumor suppressor in skin. Can J Physiol Pharmacol. 2015 May; 93(5):349-54. Bikle DD. PMID: 25559384.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    63. Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer. J Steroid Biochem Mol Biol. 2015 Apr; 148:47-51. Bikle DD, Oda Y, Tu CL, Jiang Y. PMID: 25445917.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    64. Evidence That Loss-of-Function Filaggrin Gene Mutations Evolved in Northern Europeans to Favor Intracutaneous Vitamin D3 Production. Evol Biol. 2014 Sep 01; 41(3):388-396. Thyssen JP, Bikle DD, Elias PM. PMID: 25506102.
      View in: PubMed   Mentions:
    65. Anticancer activity of VDR-coregulator inhibitor PS121912. Cancer Chemother Pharmacol. 2014 Oct; 74(4):787-98. Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle DD, Arnold LA. PMID: 25107568.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    66. Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation. J Bone Miner Res. 2014 Aug; 29(8):1900-13. Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle DD. PMID: 24677183.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    67. Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair. PLoS One. 2014; 9(6):e99991. Yoshizaki K, Hu L, Nguyen T, Sakai K, He B, Fong C, Yamada Y, Bikle DD, Oda Y. PMID: 24949995.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    68. Calcium, Orai1, and epidermal proliferation. J Invest Dermatol. 2014 Jun; 134(6):1506-1508. Bikle DD, Mauro TM. PMID: 24825060.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    69. Highlights from the 16th Vitamin D Workshop, San Francisco, CA, June 11-14, 2013. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:1-4. Bikle D. PMID: 24793579.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    70. LncRNA: a new player in 1a, 25(OH)(2) vitamin D(3) /VDR protection against skin cancer formation. Exp Dermatol. 2014 Mar; 23(3):147-50. Jiang YJ, Bikle DD. PMID: 24499465.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    71. Vitamin D-binding protein and vitamin D in blacks and whites. N Engl J Med. 2014 02 27; 370(9):879-80. Hollis BW, Bikle DD. PMID: 24571766.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    72. Development of novel Vitamin D Receptor-Coactivator Inhibitors. ACS Med Chem Lett. 2014 Feb 13; 5(2):199-204. Sidhu PS, Nassif N, McCallum MM, Teske K, Feleke B, Yuan NY, Nandhikonda P, Cook JM, Singh RK, Bikle DD, Arnold LA. PMID: 24799995.
      View in: PubMed   Mentions:
    73. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014 Mar 20; 21(3):319-29. Bikle DD. PMID: 24529992.
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    84. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology. 2013 Sep; 154(9):3031-42. Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. PMID: 23782944.
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    85. Peroxisome proliferation-activated receptor d agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor. Biochemistry. 2013 Jun 18; 52(24):4193-203. Nandhikonda P, Yasgar A, Baranowski AM, Sidhu PS, McCallum MM, Pawlak AJ, Teske K, Feleke B, Yuan NY, Kevin C, Bikle DD, Ayers SD, Webb P, Rai G, Simeonov A, Jadhav A, Maloney D, Arnold LA. PMID: 23713684.
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    86. Vitamin D: beyond bone. Ann N Y Acad Sci. 2013 May; 1287:45-58. Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD. PMID: 23682710.
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    101. PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection. Sci Transl Med. 2012 May 23; 4(135):135ra66. Muehleisen B, Bikle DD, Aguilera C, Burton DW, Sen GL, Deftos LJ, Gallo RL. PMID: 22623742.
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    120. Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice. J Cell Physiol. 2010 Nov; 225(2):482-9. Teichert A, Elalieh H, Bikle D. PMID: 20458748.
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    122. Differential regulation of epidermal function by VDR coactivators. J Steroid Biochem Mol Biol. 2010 Jul; 121(1-2):308-13. Bikle DD, Teichert A, Arnold LA, Uchida Y, Elias PM, Oda Y. PMID: 20298785.
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    129. Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation. Mol Biol Cell. 2009 Mar; 20(6):1695-704. Xie Z, Chang SM, Pennypacker SD, Liao EY, Bikle DD. PMID: 19158393.
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    157. Vitamin D and skin cancer: a problem in gene regulation. J Steroid Biochem Mol Biol. 2005 Oct; 97(1-2):83-91. Bikle DD, Oda Y, Xie Z. PMID: 16039846.
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    158. Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1. Mol Biol Cell. 2005 Jul; 16(7):3236-46. Xie Z, Singleton PA, Bourguignon LY, Bikle DD. PMID: 15872086.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    159. Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes. J Invest Dermatol. 2005 Jan; 124(1):187-97. Tu CL, Chang W, Bikle DD. PMID: 15654973.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    160. Vitamin D and skin cancer. J Nutr. 2004 12; 134(12 Suppl):3472S-3478S. Bikle DD. PMID: 15570056.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    161. The effect of LXR activators on AP-1 proteins in keratinocytes. J Invest Dermatol. 2004 Jul; 123(1):41-8. Schmuth M, Elias PM, Hanley K, Lau P, Moser A, Willson TM, Bikle DD, Feingold KR. PMID: 15191540.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    162. Vitamin D regulated keratinocyte differentiation. J Cell Biochem. 2004 Jun 01; 92(3):436-44. Bikle DD. PMID: 15156556.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    163. Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in VDR transactivation during keratinocyte differentiation. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):273-6. Oda Y, Sihlbom C, Chalkley RJ, Huang L, Rachez C, Chang CP, Burlingame AL, Freedman LP, Bikle DD. PMID: 15225784.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    164. The role of the calcium-sensing receptor in epidermal differentiation. Cell Calcium. 2004 Mar; 35(3):265-73. Tu CL, Oda Y, Komuves L, Bikle DD. PMID: 15200150.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    165. Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways. J Bone Miner Res. 2004 Mar; 19(3):436-46. Sakata T, Wang Y, Halloran BP, Elalieh HZ, Cao J, Bikle DD. PMID: 15040832.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    166. PTH differentially regulates expression of RANKL and OPG. J Bone Miner Res. 2004 Feb; 19(2):235-44. Huang JC, Sakata T, Pfleger LL, Bencsik M, Halloran BP, Bikle DD, Nissenson RA. PMID: 14969393.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    167. Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores. J Invest Dermatol. 2003 Oct; 121(4):688-94. Behne MJ, Tu CL, Aronchik I, Epstein E, Bench G, Bikle DD, Pozzan T, Mauro TM. PMID: 14632183.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    168. Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiation. Mol Endocrinol. 2003 Nov; 17(11):2329-39. Oda Y, Sihlbom C, Chalkley RJ, Huang L, Rachez C, Chang CP, Burlingame AL, Freedman LP, Bikle DD. PMID: 12893881.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    169. The impact of skeletal unloading on bone formation. Gravit Space Biol Bull. 2003 Jun; 16(2):45-54. Bikle DD, Sakata T, Halloran BP. PMID: 12959131.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    170. Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma. J Cell Physiol. 2003 May; 195(2):249-59. Yang LC, Ng DC, Bikle DD. PMID: 12652652.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    171. Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. J Cell Biochem. 2003 Mar 01; 88(4):732-43. Dolezalova H, Shankar G, Huang MC, Bikle DD, Goetzl EJ. PMID: 12577307.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    172. Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why? Recent Results Cancer Res. 2003; 164:111-22. Bikle DD, Xie Z, Ng D, Tu CL, Oda Y. PMID: 12899516.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    173. The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3. J Invest Dermatol. 2002 Nov; 119(5):1109-13. Bikle DD, Ng D, Oda Y, Hanley K, Feingold K, Xie Z. PMID: 12445200.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    174. Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone. J Bone Miner Res. 2002 Sep; 17(9):1570-8. Bikle DD, Sakata T, Leary C, Elalieh H, Ginzinger D, Rosen CJ, Beamer W, Majumdar S, Halloran BP. PMID: 12211426.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    175. Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation. J Cell Physiol. 2002 Jul; 192(1):45-54. Komuves L, Oda Y, Tu CL, Chang WH, Ho-Pao CL, Mauro T, Bikle DD. PMID: 12115735.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    176. The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytes. J Biol Chem. 2002 Oct 04; 277(40):36987-90. Xie Z, Munson SJ, Huang N, Portale AA, Miller WL, Bikle DD. PMID: 11956203.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    177. Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. J Invest Dermatol. 2002 Jan; 118(1):11-6. Xie Z, Komuves L, Yu QC, Elalieh H, Ng DC, Leary C, Chang S, Crumrine D, Yoshizawa T, Kato S, Bikle DD. PMID: 11851870.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    178. Fluoride treatment of osteoporosis: a new look at an old drug. Ann Intern Med. 1983 Jun; 98(6):1013-5. Bikle DD. PMID: 6859684.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
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