Daniel Mordes, MD, PhD

Title(s)Assistant Professor, Institute for Neurodegenerative Diseases
SchoolSchool of Medicine
Address675 Nelson Rising Lane, #314C
San Francisco CA 94158
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Harvard University PostdoctoralStem Cell & Regenerative Biology
    Massachusetts General HospitalFellowshipNeuropathology
    Massachusetts General HospitalResidencyAnatomic Pathology
    Vanderbilt University School of MedicineMDMedicine
    Vanderbilt University School of MedicinePhDBiochemistry
    Duke UniversityBSEBiomedical Engineering
    Collapse Awards and Honors
    UCSF2023Stuart Lindsay Professorship in Experimental Pathology IV
    The Association for Frontotemporal Degeneration (AFTD)2022Pathways for Hope Pilot Grant
    2021Frick Foundation for ALS Research Award
    2021MSA Coalition Grant
    NINDS2019  - 2024Mentored Clinical-Scientist Research Career Development Award (K08)
    ADRC2017  - 2018Massachusetts Alzheimer’s Disease Center, Pilot Project Award
    ALS Association2015Investigator-Initiated Starter Grant
    National Academy of Sciences2015Cozzarelli Prize (with Prusiner lab) for top biomedical sciences publication in PNAS
    Vanderbilt University2010Dean’s Award for Research
    Vanderbilt University2009Alpha Omega Alpha
    2008Young Investigator Award, International Ataxia-Telangiectasia Workshop
    2008Leon W. Cunningham Graduate Biochemistry Award

    Collapse Overview 
    Collapse Overview
    Dr. Daniel Mordes is a neuropathologist focused on understanding neurodegenerative diseases, including ALS, frontotemporal dementia, and Parkinson's disease. He is the Stuart Lindsay Professor in Experimental Pathology IV in the Department of Pathology and an Assistant Professor in the Institute for Neurodegenerative Diseases (IND) at UCSF. His research group integrates human stem cell-derived neuronal models and patient brain samples to study neurodegeneration at the Mission Bay campus. Currently, his research support includes the NINDS, Target ALS, The Frick Foundation for ALS Research, The Association for Frontotemporal Degeneration, and the Weill Neurohub Alliance for Therapies in Neuroscience. Dr. Mordes completed clinical training in neuropathology at Massachusetts General Hospital and post-doctoral training in stem cell biology and neuroscience with Kevin Eggan at Harvard University and the Broad Institute, and served as a neuropathologist for the Harvard Brain Tissue Resource Center (Brain Bank).

    Collapse Research 
    Collapse Research Activities and Funding
    Novel pathways in C9ORF72-associated ALS and dementia
    NIH K08NS104270Aug 15, 2019 - May 31, 2024
    Role: Principal Investigator
    Defining TBK1-associated autophagy networks in neurons
    NIH/NIA 1R01AG089849
    Targeting selective autophagy mechanisms in ALS
    Target ALS Collaborative Consortia
    Role: PI
    Cellular Dissection of MSA
    The Multiple System Atrophy Coalition Pilot Award
    Role: PI

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cryo-EM structure of a novel a-synuclein filament subtype from multiple system atrophy. FEBS Lett. 2024 Nov 07. Yan NL, Candido F, Tse E, Melo AA, Prusiner SB, Mordes DA, Southworth DR, Paras NA, Merz GE. PMID: 39511911.
      View in: PubMed   Mentions:    Fields:    
    2. Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP. Nat Commun. 2024 Sep 12; 15(1):7972. Nadel CM, Pokhrel S, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE. PMID: 39266525; PMCID: PMC11393453.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs. bioRxiv. 2024 Sep 02. Carroll EC, Yang H, Jones JG, Oehler A, Charvat AF, Montgomery KM, Yung A, Millbern Z, Vinueza NR, DeGrado WF, Mordes DA, Condello C, Gestwicki JE. PMID: 39282355; PMCID: PMC11398390.
      View in: PubMed   Mentions:
    4. Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic neurons sensitive to degeneration in ALS. Nat Aging. 2024 Jul; 4(7):984-997. Limone F, Mordes DA, Couto A, Joseph BJ, Mitchell JM, Therrien M, Ghosh SD, Meyer D, Zhang Y, Goldman M, Bortolin L, Cobos I, Stevens B, McCarroll SA, Kadiu I, Burberry A, Pietiläinen O, Eggan K. PMID: 38907103; PMCID: PMC11257952.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    5. Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP. bioRxiv. 2023 Aug 16. Nadel CM, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE. PMID: 37645969; PMCID: PMC10462110.
      View in: PubMed   Mentions:
    6. Running up that pill for amyotrophic lateral sclerosis. Brain. 2023 01 05; 146(1):4-5. Smeyers J, Mordes DA. PMID: 36329511.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. The E46K mutation modulates α-synuclein prion replication in transgenic mice. PLoS Pathog. 2022 12; 18(12):e1010956. Holec SAM, Lee J, Oehler A, Batia L, Wiggins-Gamble A, Lau J, Ooi FK, Merz GE, Wang M, Mordes DA, Olson SH, Woerman AL. PMID: 36454879; PMCID: PMC9714912.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    8. Pluripotent stem cell strategies for rebuilding the human brain. Front Aging Neurosci. 2022; 14:1017299. Limone F, Klim JR, Mordes DA. PMID: 36408113; PMCID: PMC9667068.
      View in: PubMed   Mentions: 4  
    9. Multiple system atrophy prions transmit neurological disease to mice expressing wild-type human α-synuclein. Acta Neuropathol. 2022 10; 144(4):677-690. Holec SAM, Lee J, Oehler A, Ooi FK, Mordes DA, Olson SH, Prusiner SB, Woerman AL. PMID: 36018376; PMCID: PMC9636591.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    10. Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC Mice. Neuron. 2020 11 25; 108(4):775-783.e4. Mordes DA, Morrison BM, Ament XH, Cantrell C, Mok J, Eggan P, Xue C, Wang JY, Eggan K, Rothstein JD. PMID: 33022228.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    11. Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy. PLoS Pathog. 2020 02; 16(2):e1008222. Woerman AL, Patel S, Kazmi SA, Oehler A, Lee J, Mordes DA, Olson SH, Prusiner SB. PMID: 32017806; PMCID: PMC6999861.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    12. Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nat Neurosci. 2020 Feb; 23(2):295. Farhan SMK, Howrigan DP, Abbott LE, Klim JR, Topp SD, Byrnes AE, Churchhouse C, Phatnani H, Smith BN, Rampersaud E, Wu G, Wuu J, Shatunov A, Iacoangeli A, Khleifat AA, Mordes DA, Ghosh S, ALSGENS Consortium, FALS Consortium, Project MinE Consortium, CReATe Consortium, Eggan K, Rademakers R, McCauley JL, Schüle R, Züchner S, Benatar M, Taylor JP, Nalls M, Gotkine M, Shaw PJ, Morrison KE, Al-Chalabi A, Traynor B, Shaw CE, Goldstein DB, Harms MB, Daly MJ, Neale BM. PMID: 31857710.
      View in: PubMed   Mentions: 4     Fields:    
    13. Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nat Neurosci. 2019 12; 22(12):1966-1974. Farhan SMK, Howrigan DP, Abbott LE, Klim JR, Topp SD, Byrnes AE, Churchhouse C, Phatnani H, Smith BN, Rampersaud E, Wu G, Wuu J, Shatunov A, Iacoangeli A, Al Khleifat A, Mordes DA, Ghosh S, ALSGENS Consortium, FALS Consortium, Project MinE Consortium, CReATe Consortium, Eggan K, Rademakers R, McCauley JL, Schüle R, Züchner S, Benatar M, Taylor JP, Nalls M, Gotkine M, Shaw PJ, Morrison KE, Al-Chalabi A, Traynor B, Shaw CE, Goldstein DB, Harms MB, Daly MJ, Neale BM. PMID: 31768050; PMCID: PMC6919277.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    14. Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines. Acta Neuropathol. 2019 03; 137(3):437-454. Woerman AL, Oehler A, Kazmi SA, Lee J, Halliday GM, Middleton LT, Gentleman SM, Mordes DA, Spina S, Grinberg LT, Olson SH, Prusiner SB. PMID: 30690664; PMCID: PMC6454887.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    15. ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair. Nat Neurosci. 2019 02; 22(2):167-179. Klim JR, Williams LA, Limone F, Guerra San Juan I, Davis-Dusenbery BN, Mordes DA, Burberry A, Steinbaugh MJ, Gamage KK, Kirchner R, Moccia R, Cassel SH, Chen K, Wainger BJ, Woolf CJ, Eggan K. PMID: 30643292; PMCID: PMC7153761.
      View in: PubMed   Mentions: 244     Fields:    Translation:HumansCells
    16. Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta Neuropathol Commun. 2018 07 04; 6(1):55. Mordes DA, Prudencio M, Goodman LD, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K. PMID: 29973287; PMCID: PMC6031111.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    17. The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis. Genes Dev. 2018 07 01; 32(13-14):929-943. Zhang Y, Burberry A, Wang JY, Sandoe J, Ghosh S, Udeshi ND, Svinkina T, Mordes DA, Mok J, Charlton M, Li QZ, Carr SA, Eggan K. PMID: 29950492; PMCID: PMC6075033.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    18. Familial Parkinson's point mutation abolishes multiple system atrophy prion replication. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):409-414. Woerman AL, Kazmi SA, Patel S, Aoyagi A, Oehler A, Widjaja K, Mordes DA, Olson SH, Prusiner SB. PMID: 29279394; PMCID: PMC5777081.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    19. MSA prions exhibit remarkable stability and resistance to inactivation. Acta Neuropathol. 2018 01; 135(1):49-63. Woerman AL, Kazmi SA, Patel S, Freyman Y, Oehler A, Aoyagi A, Mordes DA, Halliday GM, Middleton LT, Gentleman SM, Olson SH, Prusiner SB. PMID: 28849371; PMCID: PMC5756500.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    20. Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage. Proc Natl Acad Sci U S A. 2016 11 29; 113(48):E7701-E7709. Hill SJ, Mordes DA, Cameron LA, Neuberg DS, Landini S, Eggan K, Livingston DM. PMID: 27849576; PMCID: PMC5137757.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    21. Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging. Nat Commun. 2016 10 31; 7:13283. Tian F, Yang W, Mordes DA, Wang JY, Salameh JS, Mok J, Chew J, Sharma A, Leno-Duran E, Suzuki-Uematsu S, Suzuki N, Han SS, Lu FK, Ji M, Zhang R, Liu Y, Strominger J, Shneider NA, Petrucelli L, Xie XS, Eggan K. PMID: 27796305; PMCID: PMC5095598.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    22. Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Sci Transl Med. 2016 07 13; 8(347):347ra93. Burberry A, Suzuki N, Wang JY, Moccia R, Mordes DA, Stewart MH, Suzuki-Uematsu S, Ghosh S, Singh A, Merkle FT, Koszka K, Li QZ, Zon L, Rossi DJ, Trowbridge JJ, Notarangelo LD, Eggan K. PMID: 27412785; PMCID: PMC5024536.
      View in: PubMed   Mentions: 139     Fields:    Translation:Animals
    23. A 34-Year-Old Male with An Intracranial Mass. Brain Pathol. 2016 Mar; 26(2):289-90. LaBuzetta JN, Mordes D, Arrillaga I, Chi A, Dietrich J. PMID: 27000488; PMCID: PMC8029394.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Pigmented Lesions of the Nervous System and the Neural Crest: Lessons From Embryology. Neurosurgery. 2016 Jan; 78(1):142-55. Agarwalla PK, Koch MJ, Mordes DA, Codd PJ, Coumans JV. PMID: 26355366.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    25. Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening. Sci Rep. 2015 Nov 13; 5:16622. Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. PMID: 26564777; PMCID: PMC4643219.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    26. Case Records of the Massachusetts General Hospital. Case 30-2015: A 50-Year-Old Man with Cardiogenic Shock. N Engl J Med. 2015 Sep 24; 373(13):1251-61. Wheeler TM, Baker JN, Chad DA, Zilinski JL, Verzosa S, Mordes DA. PMID: 26398074.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):E5308-17. Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K. PMID: 26324905; PMCID: PMC4586853.
      View in: PubMed   Mentions: 369     Fields:    Translation:HumansAnimalsCells
    28. Propagation of prions causing synucleinopathies in cultured cells. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):E4949-58. Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K, Prusiner SB. PMID: 26286986; PMCID: PMC4568231.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    29. Case records of the Massachusetts General Hospital. Case 12-2015. A newborn boy with respiratory distress, lethargy, and hypernatremia. N Engl J Med. 2015 Apr 16; 372(16):1550-62. Lin TY, Ebb DH, Boepple PA, Thiele EA, Rincon SP, Mordes DA. PMID: 25875261.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. VE1 antibody immunoreactivity in normal anterior pituitary and adrenal cortex without detectable BRAF V600E mutations. Am J Clin Pathol. 2014 Jun; 141(6):811-5. Mordes DA, Lynch K, Campbell S, Dias-Santagata D, Nose V, Louis DN, Hoang MP. PMID: 24838325.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    31. Intracranial organizing hematoma with papillary endothelial hyperplasia features after resection and involved field radiotherapy for cerebellar juvenile pilocytic astrocytoma. Clin Imaging. 2014 May-Jun; 38(3):322-5. Ginat DT, Walcott BP, Mordes D, Schaefer PW, Nahed B. PMID: 24456989.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. Glioblastoma mimicking an arteriovenous malformation. Front Neurol. 2013; 4:144. Khanna A, Venteicher AS, Walcott BP, Kahle KT, Mordes DA, William CM, Ghogawala Z, Ogilvy CS. PMID: 24137154; PMCID: PMC3786388.
      View in: PubMed   Mentions: 8  
    33. Cytopathology of subacute thyroiditis. Diagn Cytopathol. 2012 May; 40(5):433-4. Mordes DA, Brachtel EF. PMID: 22045514.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    34. A workshop on leadership for MD/PhD students. Med Educ Online. 2011; 16. Ciampa EJ, Hunt AA, Arneson KO, Mordes DA, Oldham WM, Vin Woo K, Owens DA, Cannon MD, Dermody TS. PMID: 21841905; PMCID: PMC3154680.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    35. In vitro fluid dynamics of the Ahmed glaucoma valve modified with expanded polytetrafluoroethylene. Curr Eye Res. 2011 Feb; 36(2):112-7. DeCroos FC, Kondo Y, Mordes D, Lee MR, Ahmad S, Asrani S, Allingham RR, Olbrich KC, Klitzman B. PMID: 21281065.
      View in: PubMed   Mentions: 5     Fields:    
    36. Expanded polytetrafluoroethylene membrane alters tissue response to implanted Ahmed glaucoma valve. Curr Eye Res. 2009 Jul; 34(7):562-7. DeCroos FC, Ahmad S, Kondo Y, Chow J, Mordes D, Lee MR, Asrani S, Allingham RR, Olbrich KC, Klitzman B. PMID: 19899969.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    37. Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A. 2008 Dec 02; 105(48):18730-4. Mordes DA, Nam EA, Cortez D. PMID: 19028869; PMCID: PMC2596233.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    38. The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling. Mol Cell Biol. 2008 Dec; 28(24):7345-53. Xu X, Vaithiyalingam S, Glick GG, Mordes DA, Chazin WJ, Cortez D. PMID: 18936170; PMCID: PMC2593429.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    39. Activation of ATR and related PIKKs. Cell Cycle. 2008 Sep 15; 7(18):2809-12. Mordes DA, Cortez D. PMID: 18769153; PMCID: PMC2672405.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    40. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev. 2008 Jun 01; 22(11):1478-89. Mordes DA, Glick GG, Zhao R, Cortez D. PMID: 18519640; PMCID: PMC2418584.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansAnimalsCells
    41. Identification of photoreceptor genes affected by PRPF31 mutations associated with autosomal dominant retinitis pigmentosa. Neurobiol Dis. 2007 May; 26(2):291-300. Mordes D, Yuan L, Xu L, Kawada M, Molday RS, Wu JY. PMID: 17350276; PMCID: PMC2014719.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    42. Function of a conserved checkpoint recruitment domain in ATRIP proteins. Mol Cell Biol. 2007 May; 27(9):3367-77. Ball HL, Ehrhardt MR, Mordes DA, Glick GG, Chazin WJ, Cortez D. PMID: 17339343; PMCID: PMC1899971.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    43. Pre-mRNA splicing and retinitis pigmentosa. Mol Vis. 2006 Oct 26; 12:1259-71. Mordes D, Luo X, Kar A, Kuo D, Xu L, Fushimi K, Yu G, Sternberg P, Wu JY. PMID: 17110909; PMCID: PMC2683577.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    Daniel's Networks
    Concepts (270)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (21)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCSF Profiles is managed by the UCSF Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH).

    We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use. This site is running Profiles RNS version UCSF-v3.1.0-6-g69de2244 on PROFILES-PWEB03.

    Copyright © The Regents of the University of California.