David Agard, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th St
San Francisco CA 94158
Phone415-476-5143
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    Other Positions
    Title(s)Howard Hughes Investigator


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division - Biochemistry

    Collapse Research 
    Collapse Research Activities and Funding
    Tau Metabolism in FTD: From Gene Mutations to Molecular Chaperones and Lysosomal Proteases
    NIH U54NS123985Sep 27, 2021 - Aug 31, 2026
    Role: Co-Principal Investigator
    Structure and Mechanism: Hsp90 proteostasis, cilia biogenesis and the jumbo phage ?nucleus?
    NIH R35GM118099Jun 1, 2016 - May 31, 2026
    Role: Principal Investigator
    The Yeast Centrosome - Structure Assembly & Function
    NIH P01GM105537Sep 1, 2014 - Aug 31, 2020
    Role: Co-Investigator
    Characterization of a bacteriophage tubulin involved in viral replication
    NIH R01GM104556Aug 1, 2013 - Apr 30, 2018
    Role: Principal Investigator
    Structural Basis of Protein Homeostasis
    NIH U01GM098254Sep 30, 2012 - Jul 31, 2016
    Role: Principal Investigator
    National Resource for Automated Molecular Microscopy
    NIH P41RR017573Sep 30, 2002 - Jul 31, 2012
    Role: Co-Investigator
    STRUCTURE AND DYNAMICS OF NUCLEAR RECEPTORS
    NIH P01DK058390Aug 15, 2000 - Jul 31, 2006
    Role: Co-Investigator
    FASEB CONFERENCE: PROTEIN FOLDING AND ASSEMBLY IN CELLS
    NIH R13GM061717Jul 1, 2000 - Jun 30, 2001
    Role: Principal Investigator
    GATAN IMAGING ENERGY FILTER WITH CCD CAMERA FOR IVEM
    NIH S10RR013926Feb 1, 2000 - Jan 31, 2001
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    BioCAT - Biophysics Collaborative Access Team
    NIH P41RR008630Sep 30, 1995 - Mar 31, 2012
    Role: Co-Investigator
    Molecular Biophysics Training Grant
    NIH T32GM008284Sep 30, 1988 - Jun 30, 2023
    Role: Principal Investigator
    National Biomedical NMR Resource at Madison
    NIH P41RR002301Jul 1, 1985 - Feb 28, 2015
    Role: Co-Investigator
    Macromolecular Diffraction Resource: MacCHESS
    NIH P41RR001646Sep 1, 1983 - Jun 30, 2013
    Role: Co-Investigator
    Centrosome structure and mechanism of MT nucleation by gamma-tubulin complexes
    NIH R01GM031627Mar 1, 1983 - Dec 31, 2016
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    A Synchroton Radiation Structural Biology Resource
    NIH P41RR001209Mar 1, 1980 - Feb 28, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. AreTomo: An integrated software package for automated marker-free, motion-corrected cryo-electron tomographic alignment and reconstruction. J Struct Biol X. 2022; 6:100068. Zheng S, Wolff G, Greenan G, Chen Z, Faas FGA, Bárcena M, Koster AJ, Cheng Y, Agard DA. PMID: 35601683; PMCID: PMC9117686.
      View in: PubMed   Mentions: 1  
    2. Author Correction: Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface. Nature. 2022 Feb; 602(7898):E26. Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N. PMID: 35132240.
      View in: PubMed   Mentions:    Fields:    
    3. Electron cryo-tomography structure of axonemal doublet microtubule from Tetrahymena thermophila. Life Sci Alliance. 2022 03; 5(3). Li S, Fernandez JJ, Fabritius AS, Agard DA, Winey M. PMID: 34969817; PMCID: PMC8742875.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism. Nature. 2022 01; 601(7893):460-464. Wang RY, Noddings CM, Kirschke E, Myasnikov AG, Johnson JL, Agard DA. PMID: 34937942; PMCID: PMC9179170.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    5. Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism. Nature. 2022 01; 601(7893):465-469. Noddings CM, Wang RY, Johnson JL, Agard DA. PMID: 34937936; PMCID: PMC8994517.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    6. Entropy-regularized deconvolution of cellular cryotransmission electron tomograms. Proc Natl Acad Sci U S A. 2021 12 14; 118(50). Croxford M, Elbaum M, Arigovindan M, Kam Z, Agard D, Villa E, Sedat J. PMID: 34876518; PMCID: PMC8685678.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface. Nature. 2021 12; 600(7888):339-343. Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N. PMID: 34759323; PMCID: PMC9298180.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    8. Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs. Mol Biol Cell. 2021 11 01; 32(21):br8. Fabritius AS, Bayless BA, Li S, Stoddard D, Heydeck W, Ebmeier CC, Anderson L, Gunnels T, Nachiappan C, Whittall JB, Old W, Agard DA, Nicastro D, Winey M. PMID: 34406789; PMCID: PMC8693976.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Res Sq. 2021 May 19. Verba K, Gupta M, Azumaya C, Moritz M, Pourmal S, Diallo A, Merz G, Jang G, Bouhaddou M, Fossati A, Brilot A, Diwanji D, Hernandez E, Herrera N, Kratochvil H, Lam V, Li F, Li Y, Nguyen H, Nowotny C, Owens T, Peters J, Rizo A, Schulze-Gahmen U, Smith A, Young I, Yu Z, Asarnow D, Billesbølle C, Campbell M, Chen J, Chen KH, Chio US, Dickinson M, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez K, Mancino A, Iii FM, Paul M, Pawar K, Pelin A, Pospiech T, Puchades C, Remesh S, Safari M, Schaefer K, Sun M, Tabios M, Thwin A, Titus E, Trenker R, Tse E, Tsui TKM, Feng F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, Agard D, Cheng Y, Fraser J, Jura N, Kortemme T, Manglik A, Southworth D, Stroud R, Swaney D, Krogan N, Frost A, Rosenberg O. PMID: 34031651; PMCID: PMC8142659.
      View in: PubMed   Mentions: 1  
    10. Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM. J Struct Biol. 2021 09; 213(3):107745. Sun M, Azumaya CM, Tse E, Bulkley DP, Harrington MB, Gilbert G, Frost A, Southworth D, Verba KA, Cheng Y, Agard DA. PMID: 33984504.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    11. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. bioRxiv. 2021 May 11. Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34013269; PMCID: PMC8132225.
      View in: PubMed   Mentions:
    12. CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation. Elife. 2021 05 05; 10. Brilot AF, Lyon AS, Zelter A, Viswanath S, Maxwell A, MacCoss MJ, Muller EG, Sali A, Davis TN, Agard DA. PMID: 33949948; PMCID: PMC8099430.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Microtubules form by progressively faster tubulin accretion, not by nucleation-elongation. J Cell Biol. 2021 05 03; 220(5). Rice LM, Moritz M, Agard DA. PMID: 33734292; PMCID: PMC7980253.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    14. Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism. J Biol Chem. 2021 Jan-Jun; 296:100613. Tao J, Berthet A, Citron YR, Tsiolaki PL, Stanley R, Gestwicki JE, Agard DA, McConlogue L. PMID: 33798554; PMCID: PMC8102405.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    15. [The basics of immobilisation]. Rev Infirm. 2021 Jan; 70(267):28-30. Rebours I, Agard D, Messager C, Cattelin C, Barbier O, Choufani C. PMID: 33455677.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. 2020 12 04; 370(6521). Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat KM, García-Sastre A, Rassen JA, Grosse R, et al. PMID: 33060197; PMCID: PMC7808408.
      View in: PubMed   Mentions: 208     Fields:    Translation:HumansCells
    17. General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM. Proc Natl Acad Sci U S A. 2020 09 29; 117(39):24269-24273. Wang F, Liu Y, Yu Z, Li S, Feng S, Cheng Y, Agard DA. PMID: 32913054; PMCID: PMC7533693.
      View in: PubMed   Mentions: 14     Fields:    
    18. A molecular pore spans the double membrane of the coronavirus replication organelle. Science. 2020 09 11; 369(6509):1395-1398. Wolff G, Limpens RWAL, Zevenhoven-Dobbe JC, Laugks U, Zheng S, de Jong AWM, Koning RI, Agard DA, Grünewald K, Koster AJ, Snijder EJ, Bárcena M. PMID: 32763915; PMCID: PMC7665310.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    19. XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions. Mol Biol Cell. 2020 09 15; 31(20):2187-2194. King BR, Moritz M, Kim H, Agard DA, Asbury CL, Davis TN. PMID: 32726183; PMCID: PMC7550701.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    20. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 07; 583(7816):459-468. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859; PMCID: PMC7431030.
      View in: PubMed   Mentions: 1575     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    21. Author Correction: Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. Nat Commun. 2020 Apr 15; 11(1):1862. Gopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith AH, Megraw TL, Nicastro D, Gygi SP, Agard DA, Avidor-Reiss T. PMID: 32296038; PMCID: PMC7160143.
      View in: PubMed   Mentions: 1     Fields:    
    22. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. 2020 Mar 22. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Naing ZZC, Zhou Y, Peng S, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Lin Y, Wankowicz SA, Bohn M, Trenker R, Young JM, Cavero D, Hiatt J, Roth T, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White KM, Miorin L, Agard D, Emerman M, Ruggero D, García-Sastre A, Jura N, von Zastrow M, Taunton J, Schwartz O, Vignuzzi M, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor S, Fraser JS, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet BK, Krogan NJ. PMID: 32511329; PMCID: PMC7239059.
      View in: PubMed   Mentions: 25  
    23. The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis. BMC Biol. 2020 01 27; 18(1):10. Joshi A, Dai L, Liu Y, Lee J, Ghahhari NM, Segala G, Beebe K, Jenkins LM, Lyons GC, Bernasconi L, Tsai FTF, Agard DA, Neckers L, Picard D. PMID: 31987035; PMCID: PMC6986101.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    24. Electron cryotomography of intact motile cilia defines the basal body to axoneme transition. J Cell Biol. 2020 01 06; 219(1). Greenan GA, Vale RD, Agard DA. PMID: 31874113; PMCID: PMC7039205.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    25. Amino and PEG-amino graphene oxide grids enrich and protect samples for high-resolution single particle cryo-electron microscopy. J Struct Biol. 2020 02 01; 209(2):107437. Wang F, Yu Z, Betegon M, Campbell MG, Aksel T, Zhao J, Li S, Douglas SM, Cheng Y, Agard DA. PMID: 31866389; PMCID: PMC7272056.
      View in: PubMed   Mentions: 9     Fields:    
    26. A bacteriophage nucleus-like compartment shields DNA from CRISPR nucleases. Nature. 2020 01; 577(7789):244-248. Mendoza SD, Nieweglowska ES, Govindarajan S, Leon LM, Berry JD, Tiwari A, Chaikeeratisak V, Pogliano J, Agard DA, Bondy-Denomy J. PMID: 31819262; PMCID: PMC6949375.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    27. Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions. Sci Rep. 2019 11 18; 9(1):16947. Tóth G, Neumann T, Berthet A, Masliah E, Spencer B, Tao J, Jobling MF, Gardai SJ, Bertoncini CW, Cremades N, Bova M, Ballaron S, Chen XH, Mao W, Nguyen P, Tabios MC, Tambe MA, Rochet JC, Junker HD, Schwizer D, Sekul R, Ott I, Anderson JP, Szoke B, Hoffman W, Christodoulou J, Yednock T, Agard DA, Schenk D, McConlogue L. PMID: 31740740; PMCID: PMC6861283.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    28. Mind the gap: Micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae. J Struct Biol. 2019 12 01; 208(3):107389. Wolff G, Limpens RWAL, Zheng S, Snijder EJ, Agard DA, Koster AJ, Bárcena M. PMID: 31536774.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    29. Viral Capsid Trafficking along Treadmilling Tubulin Filaments in Bacteria. Cell. 2019 06 13; 177(7):1771-1780.e12. Chaikeeratisak V, Khanna K, Nguyen KT, Sugie J, Egan ME, Erb ML, Vavilina A, Nonejuie P, Nieweglowska E, Pogliano K, Agard DA, Villa E, Pogliano J. PMID: 31199917; PMCID: PMC7301877.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    30. Electron cryo-tomography provides insight into procentriole architecture and assembly mechanism. Elife. 2019 02 11; 8. Li S, Fernandez JJ, Marshall WF, Agard DA. PMID: 30741631; PMCID: PMC6384029.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    31. Consideration of sample motion in cryo-tomography based on alignment residual interpolation. J Struct Biol. 2019 03 01; 205(3):1-6. Fernandez JJ, Li S, Agard DA. PMID: 30690142; PMCID: PMC6420838.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    32. Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau. Nat Commun. 2018 11 01; 9(1):4563. Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE. PMID: 30385828; PMCID: PMC6212398.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    33. Insights into centriole geometry revealed by cryotomography of doublet and triplet centrioles. Elife. 2018 08 06; 7. Greenan GA, Keszthelyi B, Vale RD, Agard DA. PMID: 30080137; PMCID: PMC6110610.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    34. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 2018 07 26; 174(3):505-520. Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. PMID: 30053424; PMCID: PMC6247911.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    35. A simple and robust procedure for preparing graphene-oxide cryo-EM grids. J Struct Biol. 2018 10; 204(1):80-84. Palovcak E, Wang F, Zheng SQ, Yu Z, Li S, Betegon M, Bulkley D, Agard DA, Cheng Y. PMID: 30017701; PMCID: PMC6119484.
      View in: PubMed   Mentions: 32     Fields:    
    36. Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity. J Biol Chem. 2018 08 31; 293(35):13717-13724. Elnatan D, Agard DA. PMID: 29991590; PMCID: PMC6120219.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    37. Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature. 2018 06; 558(7710):401-405. Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM, Frost A. PMID: 29899447; PMCID: PMC6120343.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    38. Cryo-tomography tilt-series alignment with consideration of the beam-induced sample motion. J Struct Biol. 2018 06; 202(3):200-209. Fernandez JJ, Li S, Bharat TAM, Agard DA. PMID: 29410148; PMCID: PMC5949096.
      View in: PubMed   Mentions: 16     Fields:    
    39. The Structural Asymmetry of Mitochondrial Hsp90 (Trap1) Determines Fine Tuning of Functional Dynamics. J Chem Theory Comput. 2018 Feb 13; 14(2):1033-1044. Moroni E, Agard DA, Colombo G. PMID: 29320629.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    40. The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles. PLoS One. 2018; 13(1):e0190530. Citron YR, Fagerstrom CJ, Keszthelyi B, Huang B, Rusan NM, Kelly MJS, Agard DA. PMID: 29315319; PMCID: PMC5760045.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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    197. Activation of a retroviral membrane fusion protein: soluble receptor-induced liposome binding of the ALSV envelope glycoprotein. J Cell Biol. 1997 Dec 15; 139(6):1455-64. Hernandez LD, Peters RJ, Delos SE, Young JA, Agard DA, White JM. PMID: 9396751; PMCID: PMC2132611.
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    198. Practical image restoration of thick biological specimens using multiple focus levels in transmission electron microscopy. J Struct Biol. 1997 Dec; 120(3):237-44. Han KF, Sedat JW, Agard DA. PMID: 9441929.
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    199. Interphase chromosomes undergo constrained diffusional motion in living cells. Curr Biol. 1997 Dec 01; 7(12):930-9. Marshall WF, Straight A, Marko JF, Swedlow J, Dernburg A, Belmont A, Murray AW, Agard DA, Sedat JW. PMID: 9382846.
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    200. Alterations in chemical shifts and exchange broadening upon peptide boronic acid inhibitor binding to alpha-lytic protease. J Biomol NMR. 1997 Jul; 10(1):21-7. Davis JH, Agard DA, Handel TM, Basus VJ. PMID: 9335113.
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    201. Conformational substates in enzyme mechanism: the 120 K structure of alpha-lytic protease at 1.5 A resolution. Protein Sci. 1997 Jul; 6(7):1375-86. Rader SD, Agard DA. PMID: 9232638; PMCID: PMC2143753.
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    202. Telomeres cluster de novo before the initiation of synapsis: a three-dimensional spatial analysis of telomere positions before and during meiotic prophase. J Cell Biol. 1997 Apr 07; 137(1):5-18. Bass HW, Marshall WF, Sedat JW, Agard DA, Cande WZ. PMID: 9105032; PMCID: PMC2139864.
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    203. Inhibition of alpha-lytic protease by pro region C-terminal steric occlusion of the active site. Biochemistry. 1997 Apr 01; 36(13):3894-902. Sohl JL, Shiau AK, Rader SD, Wilk BJ, Agard DA. PMID: 9092819.
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    204. Optimal strategies for imaging thick biological specimens: exit wavefront reconstruction and energy-filtered imaging. J Microsc. 1996 Aug; 183(Pt 2):124-32. Han KF, Gubbens AJ, Sedat JW, Agard DA. PMID: 8805824.
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    205. Perturbation of nuclear architecture by long-distance chromosome interactions. Cell. 1996 May 31; 85(5):745-59. Dernburg AF, Broman KW, Fung JC, Marshall WF, Philips J, Agard DA, Sedat JW. PMID: 8646782.
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    206. Specific interactions of chromatin with the nuclear envelope: positional determination within the nucleus in Drosophila melanogaster. Mol Biol Cell. 1996 May; 7(5):825-42. Marshall WF, Dernburg AF, Harmon B, Agard DA, Sedat JW. PMID: 8744953; PMCID: PMC275932.
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    207. Dispersion, aberration and deconvolution in multi-wavelength fluorescence images. J Microsc. 1996 Apr; 182(Pt 1):50-60. Scalettar BA, Swedlow JR, Sedat JW, Agard DA. PMID: 8632447.
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    208. Time-resolved, in vivo studies of mitotic spindle formation and nuclear lamina breakdown in Drosophila early embryos. J Cell Sci. 1996 Mar; 109 ( Pt 3):591-607. Paddy MR, Saumweber H, Agard DA, Sedat JW. PMID: 8907705.
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    209. IVE (Image Visualization Environment): a software platform for all three-dimensional microscopy applications. J Struct Biol. 1996 Jan-Feb; 116(1):56-60. Chen H, Hughes DD, Chan TA, Sedat JW, Agard DA. PMID: 8742723.
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    210. Toward fully automated high-resolution electron tomography. J Struct Biol. 1996 Jan-Feb; 116(1):181-9. Fung JC, Liu W, de Ruijter WJ, Chen H, Abbey CK, Sedat JW, Agard DA. PMID: 8742742.
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    211. Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity. J Mol Biol. 1995 Dec 08; 254(4):720-36. Mace JE, Agard DA. PMID: 7500345.
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    212. Microtubule nucleation by gamma-tubulin-containing rings in the centrosome. Nature. 1995 Dec 07; 378(6557):638-40. Moritz M, Braunfeld MB, Sedat JW, Alberts B, Agard DA. PMID: 8524401.
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    213. A three-dimensional structural dissection of Drosophila polytene chromosomes. J Cell Biol. 1995 Oct; 131(2):279-95. Urata Y, Parmelee SJ, Agard DA, Sedat JW. PMID: 7593159; PMCID: PMC2199990.
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    214. Three-dimensional structural characterization of centrosomes from early Drosophila embryos. J Cell Biol. 1995 Sep; 130(5):1149-59. Moritz M, Braunfeld MB, Fung JC, Sedat JW, Alberts BM, Agard DA. PMID: 7657699; PMCID: PMC2120545.
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    215. Functional linkage between the active site of alpha-lytic protease and distant regions of structure: scanning alanine mutagenesis of a surface loop affects activity and substrate specificity. J Mol Biol. 1995 Aug 04; 251(1):116-34. Mace JE, Wilk BJ, Agard DA. PMID: 7643381.
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    216. Mechanism of image formation for thick biological specimens: exit wavefront reconstruction and electron energy-loss spectroscopic imaging. J Microsc. 1995 May; 178(Pt 2):107-19. Han KF, Sedat JW, Agard DA. PMID: 7783184.
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    217. Influenza hemagglutinin: kinetic control of protein function. Structure. 1994 Oct 15; 2(10):907-10. Baker D, Agard DA. PMID: 7866741.
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    218. Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J Biol Chem. 1994 Sep 02; 269(35):22358-65. Dong LM, Wilson C, Wardell MR, Simmons T, Mahley RW, Weisgraber KH, Agard DA. PMID: 8071364.
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    219. Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein. Structure. 1994 Aug 15; 2(8):713-8. Wilson C, Mau T, Weisgraber KH, Wardell MR, Mahley RW, Agard DA. PMID: 7994571.
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    220. Kinetics versus thermodynamics in protein folding. Biochemistry. 1994 Jun 21; 33(24):7505-9. Baker D, Agard DA. PMID: 8011615.
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    221. Cryo automated electron tomography: towards high-resolution reconstructions of plastic-embedded structures. J Microsc. 1994 May; 174(Pt 2):75-84. Braunfeld MB, Koster AJ, Sedat JW, Agard DA. PMID: 8051698.
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    222. The three-dimensional architecture of chromatin in situ: electron tomography reveals fibers composed of a continuously variable zig-zag nucleosomal ribbon. J Cell Biol. 1994 Apr; 125(1):1-10. Horowitz RA, Agard DA, Sedat JW, Woodcock CL. PMID: 8138564; PMCID: PMC2120010.
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    223. Meiotic chromosome pairing in maize is associated with a novel chromatin organization. Cell. 1994 Mar 11; 76(5):901-12. Dawe RK, Sedat JW, Agard DA, Cande WZ. PMID: 8124724.
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    224. The role of pro regions in protein folding. Curr Opin Cell Biol. 1993 Dec; 5(6):966-70. Baker D, Shiau AK, Agard DA. PMID: 8129949.
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    225. PRISM: topologically constrained phased refinement for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr. 1993 Sep 01; 49(Pt 5):429-39. Baker D, Bystroff C, Fletterick RJ, Agard DA. PMID: 15299502.
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    226. PRISM: application to the solution of two protein structures. Acta Crystallogr D Biol Crystallogr. 1993 Sep 01; 49(Pt 5):440-8. Bystroff C, Baker D, Fletterick RJ, Agard DA. PMID: 15299503.
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    227. To fold or not to fold.... Science. 1993 Jun 25; 260(5116):1903-4. Agard DA. PMID: 8100365.
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    228. Chromosome structure inside the nucleus. Curr Opin Cell Biol. 1993 Jun; 5(3):412-6. Swedlow JR, Agard DA, Sedat JW. PMID: 8352957.
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    229. Multiple chromosomal populations of topoisomerase II detected in vivo by time-lapse, three-dimensional wide-field microscopy. Cell. 1993 Apr 09; 73(1):97-108. Swedlow JR, Sedat JW, Agard DA. PMID: 8384932.
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    230. Modeling side-chain conformation for homologous proteins using an energy-based rotamer search. J Mol Biol. 1993 Feb 20; 229(4):996-1006. Wilson C, Gregoret LM, Agard DA. PMID: 8445659.
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    231. The onset of homologous chromosome pairing during Drosophila melanogaster embryogenesis. J Cell Biol. 1993 Feb; 120(3):591-600. Hiraoka Y, Dernburg AF, Parmelee SJ, Rykowski MC, Agard DA, Sedat JW. PMID: 8425892; PMCID: PMC2119536.
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    232. Uniqueness and the ab initio phase problem in macromolecular crystallography. Acta Crystallogr D Biol Crystallogr. 1993 Jan 01; 49(Pt 1):186-92. Baker D, Krukowski AE, Agard DA. PMID: 15299560.
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    233. Automated microscopy for electron tomography. Ultramicroscopy. 1992 Oct; 46(1-4):207-27. Koster AJ, Chen H, Sedat JW, Agard DA. PMID: 1481272.
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    234. An extended view of nuclear lamin structure, function, and dynamics. Semin Cell Biol. 1992 Aug; 3(4):255-66. Paddy MR, Agard DA, Sedat JW. PMID: 1421171.
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    235. Correct folding of alpha-lytic protease is required for its extracellular secretion from Escherichia coli. J Cell Biol. 1992 Jul; 118(1):33-42. Fujishige A, Smith KR, Silen JL, Agard DA. PMID: 1618906; PMCID: PMC2289522.
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    236. Protease pro region required for folding is a potent inhibitor of the mature enzyme. Proteins. 1992 Apr; 12(4):339-44. Baker D, Silen JL, Agard DA. PMID: 1579568.
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    237. A protein-folding reaction under kinetic control. Nature. 1992 Mar 19; 356(6366):263-5. Baker D, Sohl JL, Agard DA. PMID: 1552947.
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    238. Structural basis for broad specificity in alpha-lytic protease mutants. Biochemistry. 1991 Oct 29; 30(43):10388-98. Bone R, Fujishige A, Kettner CA, Agard DA. PMID: 1931963.
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    239. Computational method for the design of enzymes with altered substrate specificity. J Mol Biol. 1991 Jul 20; 220(2):495-506. Wilson C, Mace JE, Agard DA. PMID: 1856870.
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    240. Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science. 1991 Jun 28; 252(5014):1817-22. Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA. PMID: 2063194.
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    241. Drosophila gastrulation: analysis of cell shape changes in living embryos by three-dimensional fluorescence microscopy. Development. 1991 Jun; 112(2):365-70. Kam Z, Minden JS, Agard DA, Sedat JW, Leptin M. PMID: 1794308.
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    242. Three-dimensional multiple-wavelength fluorescence microscopy for the structural analysis of biological phenomena. Semin Cell Biol. 1991 Jun; 2(3):153-65. Hiraoka Y, Swedlow JR, Paddy MR, Agard DA, Sedat JW. PMID: 1720334.
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    243. Crystal structures of alpha-lytic protease complexes with irreversibly bound phosphonate esters. Biochemistry. 1991 Feb 26; 30(8):2263-72. Bone R, Sampson NS, Bartlett PA, Agard DA. PMID: 1998685.
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    244. Free energy calculations on binding and catalysis by alpha-lytic protease: the role of substrate size in the P1 pocket. Proteins. 1991; 10(2):140-8. Caldwell JW, Agard DA, Kollman PA. PMID: 1896427.
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    245. Mutational remodeling of enzyme specificity. Methods Enzymol. 1991; 202:643-71. Bone R, Agard DA. PMID: 1784192.
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    246. Temporal and spatial coordination of chromosome movement, spindle formation, and nuclear envelope breakdown during prometaphase in Drosophila melanogaster embryos. J Cell Biol. 1990 Dec; 111(6 Pt 2):2815-28. Hiraoka Y, Agard DA, Sedat JW. PMID: 2125300; PMCID: PMC2116368.
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    247. Interphase nuclear envelope lamins form a discontinuous network that interacts with only a fraction of the chromatin in the nuclear periphery. Cell. 1990 Jul 13; 62(1):89-106. Paddy MR, Belmont AS, Saumweber H, Agard DA, Sedat JW. PMID: 2194675.
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    248. Determination of three-dimensional imaging properties of a light microscope system. Partial confocal behavior in epifluorescence microscopy. Biophys J. 1990 Feb; 57(2):325-33. Hiraoka Y, Sedat JW, Agard DA. PMID: 2317554; PMCID: PMC1280673.
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    249. Focal points for chromosome condensation and decondensation revealed by three-dimensional in vivo time-lapse microscopy. Nature. 1989 Nov 16; 342(6247):293-6. Hiraoka Y, Minden JS, Swedlow JR, Sedat JW, Agard DA. PMID: 2509947.
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    250. The alpha-lytic protease pro-region does not require a physical linkage to activate the protease domain in vivo. Nature. 1989 Oct 05; 341(6241):462-4. Silen JL, Agard DA. PMID: 2507926.
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    251. Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates. Biochemistry. 1989 Sep 19; 28(19):7600-9. Bone R, Frank D, Kettner CA, Agard DA. PMID: 2611204.
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    252. Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro. Chromosoma. 1989 Aug; 98(2):129-43. Belmont AS, Braunfeld MB, Sedat JW, Agard DA. PMID: 2476279.
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    253. Direct cell lineage analysis in Drosophila melanogaster by time-lapse, three-dimensional optical microscopy of living embryos. J Cell Biol. 1989 Aug; 109(2):505-16. Minden JS, Agard DA, Sedat JW, Alberts BM. PMID: 2503522; PMCID: PMC2115721.
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    254. Structural plasticity broadens the specificity of an engineered protease. Nature. 1989 May 18; 339(6221):191-5. Bone R, Silen JL, Agard DA. PMID: 2716847.
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    255. Analysis of prepro-alpha-lytic protease expression in Escherichia coli reveals that the pro region is required for activity. J Bacteriol. 1989 Mar; 171(3):1320-5. Silen JL, Frank D, Fujishige A, Bone R, Agard DA. PMID: 2646278; PMCID: PMC209748.
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    256. Solid-state imagers for microscopy. Methods Cell Biol. 1989; 29:291-313. Aikens RS, Agard DA, Sedat JW. PMID: 2643764.
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    257. Fluorescence microscopy in three dimensions. Methods Cell Biol. 1989; 30:353-77. Agard DA, Hiraoka Y, Shaw P, Sedat JW. PMID: 2494418.
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    258. Tilted view reconstruction in optical microscopy. Three-dimensional reconstruction of Drosophila melanogaster embryo nuclei. Biophys J. 1989 Jan; 55(1):101-10. Shaw PJ, Agard DA, Hiraoka Y, Sedat JW. PMID: 2495031; PMCID: PMC1330446.
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    259. Kinetic properties of the binding of alpha-lytic protease to peptide boronic acids. Biochemistry. 1988 Oct 04; 27(20):7682-8. Kettner CA, Bone R, Agard DA, Bachovchin WW. PMID: 3207699.
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    260. Molecular analysis of the gene encoding alpha-lytic protease: evidence for a preproenzyme. Gene. 1988 Sep 30; 69(2):237-44. Silen JL, McGrath CN, Smith KR, Agard DA. PMID: 3234766.
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    261. Precise determination of the molecular limits of a polytene chromosome band: regulatory sequences for the Notch gene are in the interband. Cell. 1988 Aug 12; 54(4):461-72. Rykowski MC, Parmelee SJ, Agard DA, Sedat JW. PMID: 3135939.
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    262. Crystallization and preliminary X-ray diffraction studies on the amino-terminal (receptor-binding) domain of human apolipoprotein E3 from serum very low density lipoproteins. J Mol Biol. 1988 Jul 05; 202(1):179-81. Aggerbeck LP, Wetterau JR, Weisgraber KH, Mahley RW, Agard DA. PMID: 3172212.
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    263. Three-dimensional light microscopy of diploid Drosophila chromosomes. Cell Motil Cytoskeleton. 1988; 10(1-2):18-27. Agard DA, Hiraoka Y, Sedat JW. PMID: 3141069.
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    264. Serine protease mechanism: structure of an inhibitory complex of alpha-lytic protease and a tightly bound peptide boronic acid. Biochemistry. 1987 Dec 01; 26(24):7609-14. Bone R, Shenvi AB, Kettner CA, Agard DA. PMID: 3122831.
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    265. The use of a charge-coupled device for quantitative optical microscopy of biological structures. Science. 1987 Oct 02; 238(4823):36-41. Hiraoka Y, Sedat JW, Agard DA. PMID: 3116667.
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    266. [Hepatonephritis caused by piroxicam]. Gastroenterol Clin Biol. 1987 Oct; 11(10):712-3. Marsepoil T, Levesque P, Agard D, Dubeaux P, Blin F. PMID: 3692097.
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    267. A three-dimensional approach to mitotic chromosome structure: evidence for a complex hierarchical organization. J Cell Biol. 1987 Jul; 105(1):77-92. Belmont AS, Sedat JW, Agard DA. PMID: 3112167; PMCID: PMC2114920.
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    268. Quantitative analysis of nucleic acids, proteins, and viruses by Raman band deconvolution. Biophys J. 1984 Dec; 46(6):763-8. Thomas GJ, Agard DA. PMID: 6083811; PMCID: PMC1435106.
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    269. [Anorectal manifestations of sexually transmissible diseases. Kaposi's sarcoma]. Ann Gastroenterol Hepatol (Paris). 1984 Oct-Nov; 20(5):265-70. Libeskind M, Malbran J, Agard D, Pannetier C, Lecouillard C, Ivanovic A. PMID: 6549375.
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    270. Optical sectioning microscopy: cellular architecture in three dimensions. Annu Rev Biophys Bioeng. 1984; 13:191-219. Agard DA. PMID: 6742801.
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    271. Spatial organization of the Drosophila nucleus: a three-dimensional cytogenetic study. J Cell Sci Suppl. 1984; 1:223-34. Gruenbaum Y, Hochstrasser M, Mathog D, Saumweber H, Agard DA, Sedat JW. PMID: 6442295.
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    272. A least-squares method for determining structure factors in three-dimensional tilted-view reconstructions. J Mol Biol. 1983 Jul 15; 167(4):849-52. Agard DA. PMID: 6876167.
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    273. Three-dimensional architecture of a polytene nucleus. Nature. 1983 Apr 21; 302(5910):676-81. Agard DA, Sedat JW. PMID: 6403872.
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    275. Linking regions between helices in bacteriorhodopsin revealed. Biophys J. 1982 Mar; 37(3):589-602. Agard DA, Stroud RM. PMID: 7074187; PMCID: PMC1328844.
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    276. Studies on the phosphorylation and synthesis of type I regulatory subunit of cyclic AMP-dependent protein kinase in intact S49 mouse lymphoma cells. J Biol Chem. 1981 Nov 10; 256(21):11356-64. Steinberg RA, Agard DA. PMID: 6270151.
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    283. [Secondary melanomas of the liver. Appropos of 3 cases with hepatic symptomatology]. Med Chir Dig. 1978; 7(4):315-8. Libeskind M, Redelsperger PY, Lugagne F, Malbran J, Agard D. PMID: 672278.
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    284. Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol. 1977 Nov; 116(4):635-59. Ross MJ, Klymkowsky MW, Agard DA, Stroud RM. PMID: 563472.
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