David Booth, PhD

Title(s)Assistant Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th Street, #001
San Francisco CA 94158
Phone415-921-9772
PronounsHe/Him/His
ORCID ORCID Icon0000-0002-4724-4702 Additional info
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    Collapse Biography 
    Collapse education and training
    The Colorado CollegeBA05/2007Biochemistry
    University of California, San FranciscoPhD09/2014Biophysics
    University of California, BerkeleyPostdoc02/2020Molecular and Cell Biology

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    Propelling choanoflagellate genome engineering to discover the origins of animal cell differentiation
    Program for Breakthrough Biomedical Research Jan 15, 2021 - Jan 15, 2022
    Role: Principle Investigator
    Structural requirements for the nuclear export of HIV RNA
    NIH F31GM095350Jun 1, 2011 - May 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cell differentiation controls iron assimilation in the choanoflagellate Salpingoeca rosetta. mSphere. 2025 Mar 25; 10(3):e0091724. Leon F, Espinoza-Esparza JM, Deng V, Coyle MC, Espinoza S, Booth DS. PMID: 40008892; PMCID: PMC11934334.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Cell differentiation controls iron assimilation in a choanoflagellate. bioRxiv. 2024 Sep 16. Leon F, Espinoza-Esparza JM, Deng V, Coyle MC, Espinoza S, Booth DS. PMID: 39345370; PMCID: PMC11429873.
      View in: PubMed   Mentions:
    3. Chromatin profiling identifies putative dual roles for H3K27me3 in regulating transposons and cell type-specific genes in choanoflagellates. bioRxiv. 2024 May 30. Gahan JM, Helfrich LW, Wetzel LA, Bhanu NV, Yuan ZF, Garcia BA, Klose R, Booth DS. PMID: 38854040; PMCID: PMC11160669.
      View in: PubMed   Mentions:
    4. A red algal polysaccharide influences the multicellular development of the choanoflagellate Salpingoeca rosetta. bioRxiv. 2024 May 15. Perotti O, Esparza GV, Booth DS. PMID: 38798503; PMCID: PMC11118467.
      View in: PubMed   Mentions:
    5. An RFX transcription factor regulates ciliogenesis in the closest living relatives of animals. Curr Biol. 2023 09 11; 33(17):3747-3758.e9. Coyle MC, Tajima AM, Leon F, Choksi SP, Yang A, Espinoza S, Hughes TR, Reiter JF, Booth DS, King N. PMID: 37552984; PMCID: PMC10530576.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. Cell polarity in the protist-to-animal transition. Curr Top Dev Biol. 2023; 154:1-36. Brunet T, Booth DS. PMID: 37100515.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    7. The history of Salpingoeca rosetta as a model for reconstructing animal origins. Curr Top Dev Biol. 2022; 147:73-91. Booth DS, King N. PMID: 35337467.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    8. Rapid deployment of SARS-CoV-2 testing: The CLIAHUB. PLoS Pathog. 2020 10; 16(10):e1008966. Crawford ED, Acosta I, Ahyong V, Anderson EC, Arevalo S, Asarnow D, Axelrod S, Ayscue P, Azimi CS, Azumaya CM, Bachl S, Bachmutsky I, Bhaduri A, Brown JB, Batson J, Behnert A, Boileau RM, Bollam SR, Bonny AR, Booth D, Borja MJB, Brown D, Buie B, Burnett CE, Byrnes LE, Cabral KA, Cabrera JP, Caldera S, Canales G, Castañeda GR, Chan AP, Chang CR, Charles-Orszag A, Cheung C, Chio U, Chow ED, Citron YR, Cohen A, Cohn LB, Chiu C, Cole MA, Conrad DN, Constantino A, Cote A, Crayton-Hall T, Darmanis S, Detweiler AM, Dial RL, Dong S, Duarte EM, Dynerman D, Egger R, Fanton A, Frumm SM, Fu BXH, Garcia VE, Garcia J, Gladkova C, Goldman M, Gomez-Sjoberg R, Gordon MG, Grove JCR, Gupta S, Haddjeri-Hopkins A, Hadley P, Haliburton J, Hao SL, Hartoularos G, Herrera N, Hilberg M, Ho KYE, Hoppe N, Hosseinzadeh S, Howard CJ, Hussmann JA, Hwang E, Ingebrigtsen D, Jackson JR, Jowhar ZM, Kain D, Kim JYS, Kistler A, Kreutzfeld O, Kulsuptrakul J, Kung AF, Langelier C, Laurie MT, Lee L, Leng K, Leon KE, Leonetti MD, Levan SR, Li S, Li AW, Liu J, Lubin HS, Lyden A, Mann J, Mann S, Margulis G, Marquez DM, Marsh BP, Martyn C, McCarthy EE, McGeever A, Merriman AF, Meyer LK, Miller S, Moore MK, Mowery CT, Mukhtar T, Mwakibete LL, Narez N, Neff NF, Osso LA, Oviedo D, Peng S, Phelps M, Phong K, Picard P, Pieper LM, Pincha N, Pisco AO, Pogson A, Pourmal S, Puccinelli RR, Puschnik AS, Rackaityte E, Raghavan P, Raghavan M, Reese J, Replogle JM, Retallack H, Reyes H, Rose D, Rosenberg MF, Sanchez-Guerrero E, Sattler SM, Savy L, See SK, Sellers KK, Serpa PH, Sheehy M, Sheu J, Silas S, Streithorst JA, Strickland J, Stryke D, Sunshine S, Suslow P, Sutanto R, Tamura S, Tan M, Tan J, Tang A, Tato CM, Taylor JC, Tenvooren I, Thompson EM, Thornborrow EC, Tse E, Tung T, Turner ML, Turner VS, Turnham RE, Turocy MJ, Vaidyanathan TV, Vainchtein ID, Vanaerschot M, Vazquez SE, Wandler AM, Wapniarski A, Webber JT, Weinberg ZY, Westbrook A, Wong AW, Wong E, Worthington G, Xie F, Xu A, Yamamoto T, Yang Y, Yarza F, Zaltsman Y, Zheng T, DeRisi JL. PMID: 33112933; PMCID: PMC7592773.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCellsPHPublic Health
    9. Genome editing enables reverse genetics of multicellular development in the choanoflagellate Salpingoeca rosetta. Elife. 2020 06 04; 9. Booth DS, King N. PMID: 32496191; PMCID: PMC7314544.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    10. Genetic tool development in marine protists: emerging model organisms for experimental cell biology. Nat Methods. 2020 05; 17(5):481-494. Faktorová D, Nisbet RER, Fernández Robledo JA, Casacuberta E, Sudek L, Allen AE, Ares M, Aresté C, Balestreri C, Barbrook AC, Beardslee P, Bender S, Booth DS, Bouget FY, Bowler C, Breglia SA, Brownlee C, Burger G, Cerutti H, Cesaroni R, Chiurillo MA, Clemente T, Coles DB, Collier JL, Cooney EC, Coyne K, Docampo R, Dupont CL, Edgcomb V, Einarsson E, Elustondo PA, Federici F, Freire-Beneitez V, Freyria NJ, Fukuda K, García PA, Girguis PR, Gomaa F, Gornik SG, Guo J, Hampl V, Hanawa Y, Haro-Contreras ER, Hehenberger E, Highfield A, Hirakawa Y, Hopes A, Howe CJ, Hu I, Ibañez J, Irwin NAT, Ishii Y, Janowicz NE, Jones AC, Kachale A, Fujimura-Kamada K, Kaur B, Kaye JZ, Kazana E, Keeling PJ, King N, Klobutcher LA, Lander N, Lassadi I, Li Z, Lin S, Lozano JC, Luan F, Maruyama S, Matute T, Miceli C, Minagawa J, Moosburner M, Najle SR, Nanjappa D, Nimmo IC, Noble L, Novák Vanclová AMG, Nowacki M, Nuñez I, Pain A, Piersanti A, Pucciarelli S, Pyrih J, Rest JS, Rius M, Robertson D, Ruaud A, Ruiz-Trillo I, Sigg MA, Silver PA, Slamovits CH, Jason Smith G, Sprecher BN, Stern R, Swart EC, Tsaousis AD, Tsypin L, Turkewitz A, Turnšek J, Valach M, Vergé V, von Dassow P, von der Haar T, Waller RF, Wang L, Wen X, Wheeler G, Woods A, Zhang H, Mock T, Worden AZ, Lukeš J. PMID: 32251396; PMCID: PMC7200600.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    11. Predicted glycosyltransferases promote development and prevent spurious cell clumping in the choanoflagellate S. rosetta. Elife. 2018 12 17; 7. Wetzel LA, Levin TC, Hulett RE, Chan D, King GA, Aldayafleh R, Booth DS, Sigg MA, King N. PMID: 30556809; PMCID: PMC6322860.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    12. Transfection of choanoflagellates illuminates their cell biology and the ancestry of animal septins. Mol Biol Cell. 2018 12 01; 29(25):3026-3038. Booth DS, Szmidt-Middleton H, King N. PMID: 30281390; PMCID: PMC6333174.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    13. Evolution: Gene regulation in transition. Nature. 2016 06 23; 534(7608):482-3. Booth DS, King N. PMID: 27309804.
      View in: PubMed   Mentions: 1     Fields:    
    14. A structurally plastic ribonucleoprotein complex mediates post-transcriptional gene regulation in HIV-1. Wiley Interdiscip Rev RNA. 2016 07; 7(4):470-86. Fernandes JD, Booth DS, Frankel AD. PMID: 26929078; PMCID: PMC5026123.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    15. The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA. Elife. 2014 Dec 08; 3:e04121. Booth DS, Cheng Y, Frankel AD. PMID: 25486595; PMCID: PMC4360530.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    16. Transition step during assembly of HIV Tat:P-TEFb transcription complexes and transfer to TAR RNA. Mol Cell Biol. 2012 Dec; 32(23):4780-93. D'Orso I, Jang GM, Pastuszak AW, Faust TB, Quezada E, Booth DS, Frankel AD. PMID: 23007159; PMCID: PMC3497596.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    17. Fabs enable single particle cryoEM studies of small proteins. Structure. 2012 Apr 04; 20(4):582-92. Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y. PMID: 22483106; PMCID: PMC3322386.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    18. Visualizing proteins and macromolecular complexes by negative stain EM: from grid preparation to image acquisition. J Vis Exp. 2011 Dec 22; (58). Booth DS, Avila-Sakar A, Cheng Y. PMID: 22215030; PMCID: PMC3369646.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    19. HIV Rev response element (RRE) directs assembly of the Rev homooligomer into discrete asymmetric complexes. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12481-6. Daugherty MD, Booth DS, Jayaraman B, Cheng Y, Frankel AD. PMID: 20616058; PMCID: PMC2906596.
      View in: PubMed   Mentions: 56     Fields:    
    20. Signal sequences activate the catalytic switch of SRP RNA. Science. 2009 Jan 02; 323(5910):127-30. Bradshaw N, Neher SB, Booth DS, Walter P. PMID: 19119234; PMCID: PMC2767340.
      View in: PubMed   Mentions: 45     Fields:    
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