David Castillo Azofeifa, PhD
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| Title(s) | Assistant Researcher, Orofacial Sciences |
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| School | School of Dentistry |
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| Address | 513 Parnassus Avenue, HSE
San Francisco CA 94143
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| Phone | -- |
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ORCID
.gif) | 0000-0001-9121-4829  |
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| vCard | Download vCard |
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Biography
| Universidad de Costa Rica | B.S. | 2006 | Biology |
| University of South Carolina | PSM | 2010 | Biological Sciences |
| University of Colorado Anschutz Medical Campus | Ph.D. | 2016 | Cell and Developmental Biology |
Overview
The scientific area to which I have devoted most of my work is stem cell research. I am interested in signaling circuits that might regulate the stem/progenitor cell pool(s) within epithelial tissues, which are responsible for homeostatic maintenance and regeneration after injury. Uncovering key signals for stem cell proliferation and differentiation will provide new insights useful for disease treatments and regenerative medicine.
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Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
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Tools and Concepts for Interrogating and Defining Cellular Identity. Cell Stem Cell. 2020 05 07; 26(5):632-656.
McKinley KL, Castillo-Azofeifa D, Klein OD. PMID: 32386555; PMCID: PMC7250495.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Lgr5+ telocytes are a signaling source at the intestinal villus tip. Nat Commun. 2020 04 22; 11(1):1936.
Bahar Halpern K, Massalha H, Zwick RK, Moor AE, Castillo-Azofeifa D, Rozenberg M, Farack L, Egozi A, Miller DR, Averbukh I, Harnik Y, Weinberg-Corem N, de Sauvage FJ, Amit I, Klein OD, Shoshkes-Carmel M, Itzkovitz S. PMID: 32321913; PMCID: PMC7176679.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage. Nat Cell Biol. 2019 09; 21(9):1102-1112.
Sharir A, Marangoni P, Zilionis R, Wan M, Wald T, Hu JK, Kawaguchi K, Castillo-Azofeifa D, Epstein L, Harrington K, Pagella P, Mitsiadis T, Siebel CW, Klein AM, Klein OD. PMID: 31481792; PMCID: PMC6935352.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Atoh1+ secretory progenitors possess renewal capacity independent of Lgr5+ cells during colonic regeneration. EMBO J. 2019 02 15; 38(4).
Castillo-Azofeifa D, Fazio EN, Nattiv R, Good HJ, Wald T, Pest MA, de Sauvage FJ, Klein OD, Asfaha S. PMID: 30635334; PMCID: PMC6376326.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis. Development. 2018 07 17; 145(14).
Castillo-Azofeifa D, Seidel K, Gross L, Golden EJ, Jacquez B, Klein OD, Barlow LA. PMID: 29945863; PMCID: PMC6078335.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. Elife. 2018 06 13; 7.
McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD. PMID: 29897330; PMCID: PMC6023609.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Rep. 2018 01 23; 22(4):1003-1015.
Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MK. PMID: 29386123; PMCID: PMC5798462.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Contribution of the two dsRBM motifs to the double-stranded RNA binding and protein interactions of PACT. J Cell Biochem. 2018 04; 119(4):3598-3607.
Chukwurah E, Willingham V, Singh M, Castillo-Azofeifa D, Patel RC. PMID: 29231267.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Sonic hedgehog from both nerves and epithelium is a key trophic factor for taste bud maintenance. Development. 2017 09 01; 144(17):3054-3065.
Castillo-Azofeifa D, Losacco JT, Salcedo E, Golden EJ, Finger TE, Barlow LA. PMID: 28743797; PMCID: PMC5611957.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium. Development. 2014 Aug; 141(15):2993-3002.
Castillo D, Seidel K, Salcedo E, Ahn C, de Sauvage FJ, Klein OD, Barlow LA. PMID: 24993944; PMCID: PMC4197660.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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Stress-induced phosphorylation of PACT reduces its interaction with TRBP and leads to PKR activation. Biochemistry. 2011 May 31; 50(21):4550-60.
Singh M, Castillo D, Patel CV, Patel RC. PMID: 21526770.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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| Year | Publications |
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| 2011 | 1 |
| 2014 | 1 |
| 2017 | 1 |
| 2018 | 4 |
| 2019 | 2 |
| 2020 | 2 |
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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