David Castillo Azofeifa * UCSF Profiles

David Castillo Azofeifa, PhD

Title(s)	Assistant Researcher, Orofacial Sciences
School	School of Dentistry
ORCID	0000-0001-9121-4829
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Biography

Education and Training

Universidad de Costa Rica	B.S.	2006	Biology
University of South Carolina	PSM	2010	Biological Sciences
University of Colorado Anschutz Medical Campus	Ph.D.	2016	Cell and Developmental Biology

Overview

The scientific area to which I have devoted most of my work is stem cell research. I am interested in signaling circuits that might regulate the stem/progenitor cell pool(s) within epithelial tissues, which are responsible for homeostatic maintenance and regeneration after injury. Uncovering key signals for stem cell proliferation and differentiation will provide new insights useful for disease treatments and regenerative medicine.

ORNG Applications

Websites

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

List All | Timeline

Sharir A, Marangoni P, Zilionis R, Wan M, Wald T, Hu JK, Kawaguchi K, Castillo-Azofeifa D, Epstein L, Harrington K, Pagella P, Mitsiadis T, Siebel CW, Klein AM, Klein OD. A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage. Nat Cell Biol. 2019 09; 21(9):1102-1112. PMID: 31481792.

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Castillo-Azofeifa D, Fazio EN, Nattiv R, Good HJ, Wald T, Pest MA, de Sauvage FJ, Klein OD, Asfaha S. Atoh1+ secretory progenitors possess renewal capacity independent of Lgr5+ cells during colonic regeneration. EMBO J. 2019 02 15; 38(4). PMID: 30635334.

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Castillo-Azofeifa D, Seidel K, Gross L, Golden EJ, Jacquez B, Klein OD, Barlow LA. SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis. Development. 2018 07 17; 145(14). PMID: 29945863.

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McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD. Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. Elife. 2018 06 13; 7. PMID: 29897330.

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Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MK. Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Rep. 2018 01 23; 22(4):1003-1015. PMID: 29386123.

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Chukwurah E, Willingham V, Singh M, Castillo-Azofeifa D, Patel RC. Contribution of the two dsRBM motifs to the double-stranded RNA binding and protein interactions of PACT. J Cell Biochem. 2018 04; 119(4):3598-3607. PMID: 29231267.

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Castillo-Azofeifa D, Losacco JT, Salcedo E, Golden EJ, Finger TE, Barlow LA. Sonic hedgehog from both nerves and epithelium is a key trophic factor for taste bud maintenance. Development. 2017 09 01; 144(17):3054-3065. PMID: 28743797.

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Castillo D, Seidel K, Salcedo E, Ahn C, de Sauvage FJ, Klein OD, Barlow LA. Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium. Development. 2014 Aug; 141(15):2993-3002. PMID: 24993944.

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Singh M, Castillo D, Patel CV, Patel RC. Stress-induced phosphorylation of PACT reduces its interaction with TRBP and leads to PKR activation. Biochemistry. 2011 May 31; 50(21):4550-60. PMID: 21526770.

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