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David Chu, PhD

Title(s)Postdoctoral Scholar, HDF Comprehensive Cancer Ctr
SchoolSchool of Medicine
Address1450 Third St
San Francisco CA 94158
Phone415-502-3579
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    Collapse Biography 
    Collapse Education and Training
    University of California Los Angeles, Los Angeles, CABSc2008Biochemistry
    Cedars-Sinai Medical Center, Los Angeles, CA2011Cancer Biology
    Johns Hopkins School of Medicine, Baltimore, MDPhD2017Cellular and Molecular Medicine

    Collapse Overview 

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation. J Clin Invest. 2019 08 08; 129(11):4708-4723. Dalton WB, Helmenstine E, Walsh N, Gondek LP, Kelkar DS, Read A, Natrajan R, Christenson ES, Roman B, Das S, Zhao L, Leone RD, Shinn D, Groginski T, Madugundu AK, Patil A, Zabransky DJ, Medford A, Lee J, Cole AJ, Rosen M, Thakar M, Ambinder A, Donaldson J, DeZern AE, Cravero K, Chu D, Madero-Marroquin R, Pandey A, Hurley PJ, Lauring J, Park BH. PMID: 31393856.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    2. Genetic Alterations Detected in Cell-Free DNA Are Associated With Enzalutamide and Abiraterone Resistance in Castration-Resistant Prostate Cancer. JCO Precis Oncol. 2019; 3. Torquato S, Pallavajjala A, Goldstein A, Toro PV, Silberstein JL, Lee J, Nakazawa M, Waters I, Chu D, Shinn D, Groginski T, Hughes RM, Simons BW, Khan H, Feng Z, Carducci MA, Paller CJ, Denmeade SR, Kressel B, Eisenberger MA, Antonarakis ES, Trock BJ, Park BH, Hurley PJ. PMID: 31131348.
      View in: PubMed   Mentions:
    3. The estrogen receptor-alpha S118P variant does not affect breast cancer incidence or response to endocrine therapies. Breast Cancer Res Treat. 2019 Apr; 174(2):401-412. Button B, Croessmann S, Chu D, Rosen DM, Zabransky DJ, Dalton WB, Cravero K, Kyker-Snowman K, Waters I, Karthikeyan S, Christenson ES, Donaldson J, Hunter T, Dennison L, Ramin C, May B, Roden R, Petry D, Armstrong DK, Visvanathan K, Park BH. PMID: 30560461.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Biotinylated amplicon sequencing: A method for preserving DNA samples of limited quantity. Pract Lab Med. 2018 Nov; 12:e00108. Cravero K, Medford A, Pallavajjala A, Canzoniero J, Hunter N, Chu D, Cochran RL, Waters I, Christenson ES, Kyker-Snowman K, Button B, Cole AJ, Park BH. PMID: 30140723.
      View in: PubMed   Mentions:
    5. Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells. Endocrinology. 2018 01 01; 159(1):285-296. Li Z, Levine KM, Bahreini A, Wang P, Chu D, Park BH, Oesterreich S, Lee AV. PMID: 29029116.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. Comprehensive Mutation and Copy Number Profiling in Archived Circulating Breast Cancer Tumor Cells Documents Heterogeneous Resistance Mechanisms. Cancer Res. 2018 02 15; 78(4):1110-1122. Paoletti C, Cani AK, Larios JM, Hovelson DH, Aung K, Darga EP, Cannell EM, Baratta PJ, Liu CJ, Chu D, Yazdani M, Blevins AR, Sero V, Tokudome N, Thomas DG, Gersch C, Schott AF, Wu YM, Lonigro R, Robinson DR, Chinnaiyan AM, Bischoff FZ, Johnson MD, Park BH, Hayes DF, Rae JM, Tomlins SA. PMID: 29233927.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    7. Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors. Cancer Res. 2017 10 15; 77(20):5602-5613. Zhao Y, Laws MJ, Guillen VS, Ziegler Y, Min J, Sharma A, Kim SH, Chu D, Park BH, Oesterreich S, Mao C, Shapiro DJ, Nettles KW, Katzenellenbogen JA, Katzenellenbogen BS. PMID: 28904064.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    8. Single-Nucleotide Polymorphism Leading to False Allelic Fraction by Droplet Digital PCR. Clin Chem. 2017 Aug; 63(8):1370-1376. Christenson ES, Dalton WB, Chu D, Waters I, Cravero K, Zabransky DJ, DeZern AE, Park BH. PMID: 28615231.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models. Breast Cancer Res. 2017 05 23; 19(1):60. Bahreini A, Li Z, Wang P, Levine KM, Tasdemir N, Cao L, Weir HM, Puhalla SL, Davidson NE, Stern AM, Chu D, Park BH, Lee AV, Oesterreich S. PMID: 28535794.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    10. Liquid biopsy: unlocking the potentials of cell-free DNA. Virchows Arch. 2017 Aug; 471(2):147-154. Chu D, Park BH. PMID: 28466157.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    11. Whole-Exome Sequencing of Metaplastic Breast Carcinoma Indicates Monoclonality with Associated Ductal Carcinoma Component. Clin Cancer Res. 2017 Aug 15; 23(16):4875-4884. Avigdor BE, Beierl K, Gocke CD, Zabransky DJ, Cravero K, Kyker-Snowman K, Button B, Chu D, Croessmann S, Cochran RL, Connolly RM, Park BH, Wheelan SJ, Cimino-Mathews A. PMID: 28424200.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    12. Detection fidelity of AR mutations in plasma derived cell-free DNA. Oncotarget. 2017 Feb 28; 8(9):15651-15662. Goldstein A, Toro PV, Lee J, Silberstein JL, Nakazawa M, Waters I, Cravero K, Chu D, Cochran RL, Kim M, Shinn D, Torquato S, Hughes RM, Pallavajjala A, Carducci MA, Paller CJ, Denmeade SR, Kressel B, Trock BJ, Eisenberger MA, Antonarakis ES, Park BH, Hurley PJ. PMID: 28152506.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    13. PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity. Breast Cancer Res Treat. 2017 04; 162(3):451-464. Croessmann S, Wong HY, Zabransky DJ, Chu D, Rosen DM, Cidado J, Cochran RL, Dalton WB, Erlanger B, Cravero K, Button B, Kyker-Snowman K, Hurley PJ, Lauring J, Park BH. PMID: 28190247.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. A Polycythemia Vera JAK2 Mutation Masquerading as a Duodenal Cancer Mutation. J Natl Compr Canc Netw. 2016 12; 14(12):1495-1498. Lee J, Axilbund J, Dalton WB, Laheru D, Watkins S, Chu D, Cravero K, Button B, Kyker-Snowman K, Waters I, Gocke CD, Lauring J, Park BH. PMID: 27956534.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    15. ERpS294 is a biomarker of ligand or mutational ERa activation and a breast cancer target for CDK2 inhibition. Oncotarget. 2017 Oct 13; 8(48):83432-83445. Scott GK, Chu D, Kaur R, Malato J, Rothschild DE, Frazier K, Eppenberger-Castori S, Hann B, Park BH, Benz CC. PMID: 29137354.
      View in: PubMed   Mentions: 4     Fields:    
    16. Adalimumab in Patients with Active Noninfectious Uveitis. N Engl J Med. 2016 Sep 08; 375(10):932-43. Jaffe GJ, Dick AD, Brézin AP, Nguyen QD, Thorne JE, Kestelyn P, Barisani-Asenbauer T, Franco P, Heiligenhaus A, Scales D, Chu DS, Camez A, Kwatra NV, Song AP, Kron M, Tari S, Suhler EB. PMID: 27602665.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCTClinical Trials
    17. Individualized Molecular Analyses Guide Efforts (IMAGE): A Prospective Study of Molecular Profiling of Tissue and Blood in Metastatic Triple-Negative Breast Cancer. Clin Cancer Res. 2017 Jan 15; 23(2):379-386. Parsons HA, Beaver JA, Cimino-Mathews A, Ali SM, Axilbund J, Chu D, Connolly RM, Cochran RL, Croessmann S, Clark TA, Gocke CD, Jeter SC, Kennedy MR, Lauring J, Lee J, Lipson D, Miller VA, Otto GA, Rosner GL, Ross JS, Slater S, Stephens PJ, VanDenBerg DA, Wolff AC, Young LE, Zabransky DJ, Zhang Z, Zorzi J, Stearns V, Park BH. PMID: 27489289.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    18. Highly personalized detection of minimal Ewing sarcoma disease burden from plasma tumor DNA. Cancer. 2016 10; 122(19):3015-23. Hayashi M, Chu D, Meyer CF, Llosa NJ, McCarty G, Morris CD, Levin AS, Wolinsky JP, Albert CM, Steppan DA, Park BH, Loeb DM. PMID: 27351911.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    19. Ki-67 is required for maintenance of cancer stem cells but not cell proliferation. Oncotarget. 2016 Feb 02; 7(5):6281-93. Cidado J, Wong HY, Rosen DM, Cimino-Mathews A, Garay JP, Fessler AG, Rasheed ZA, Hicks J, Cochran RL, Croessmann S, Zabransky DJ, Mohseni M, Beaver JA, Chu D, Cravero K, Christenson ES, Medford A, Mattox A, De Marzo AM, Argani P, Chawla A, Hurley PJ, Lauring J, Park BH. PMID: 26823390.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    20. TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer. Oncotarget. 2015 Dec 29; 6(42):44927-40. Wong HY, Wang GM, Croessmann S, Zabransky DJ, Chu D, Garay JP, Cidado J, Cochran RL, Beaver JA, Aggarwal A, Liu ML, Argani P, Meeker A, Hurley PJ, Lauring J, Park BH. PMID: 26702755.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    21. HER2 missense mutations have distinct effects on oncogenic signaling and migration. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):E6205-14. Zabransky DJ, Yankaskas CL, Cochran RL, Wong HY, Croessmann S, Chu D, Kavuri SM, Red Brewer M, Rosen DM, Dalton WB, Cimino-Mathews A, Cravero K, Button B, Kyker-Snowman K, Cidado J, Erlanger B, Parsons HA, Manto KM, Bose R, Lauring J, Arteaga CL, Konstantopoulos K, Park BH. PMID: 26508629.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    22. Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes. Oncotarget. 2015 Sep 22; 6(28):25240-51. Cochran RL, Cidado J, Kim M, Zabransky DJ, Croessmann S, Chu D, Wong HY, Beaver JA, Cravero K, Erlanger B, Parsons H, Heaphy CM, Meeker AK, Lauring J, Park BH. PMID: 26246475.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    23. NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability. Proc Natl Acad Sci U S A. 2015 Sep 15; 112(37):11583-8. Croessmann S, Wong HY, Zabransky DJ, Chu D, Mendonca J, Sharma A, Mohseni M, Rosen DM, Scharpf RB, Cidado J, Cochran RL, Parsons HA, Dalton WB, Erlanger B, Button B, Cravero K, Kyker-Snowman K, Beaver JA, Kachhap S, Hurley PJ, Lauring J, Park BH. PMID: 26324937.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    24. ESR1 Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients. Clin Cancer Res. 2016 Feb 15; 22(4):993-9. Chu D, Paoletti C, Gersch C, VanDenBerg DA, Zabransky DJ, Cochran RL, Wong HY, Toro PV, Cidado J, Croessmann S, Erlanger B, Cravero K, Kyker-Snowman K, Button B, Parsons HA, Dalton WB, Gillani R, Medford A, Aung K, Tokudome N, Chinnaiyan AM, Schott A, Robinson D, Jacks KS, Lauring J, Hurley PJ, Hayes DF, Rae JM, Park BH. PMID: 26261103.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    25. Comparison of cell stabilizing blood collection tubes for circulating plasma tumor DNA. Clin Biochem. 2015 Oct; 48(15):993-8. Toro PV, Erlanger B, Beaver JA, Cochran RL, VanDenBerg DA, Yakim E, Cravero K, Chu D, Zabransky DJ, Wong HY, Croessmann S, Parsons H, Hurley PJ, Lauring J, Park BH. PMID: 26234639.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    26. Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature. Semin Ophthalmol. 2016; 31(6):526-31. Tu Y, Gonzalez-Gronow M, Kolomeyer AM, Cohen A, Pruzon J, Milman T, Chu DS. PMID: 25674820.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. A phosphoproteomic screen demonstrates differential dependence on HER3 for MAP kinase pathway activation by distinct PIK3CA mutations. Proteomics. 2015 Jan; 15(2-3):318-26. Blair BG, Wu X, Zahari MS, Mohseni M, Cidado J, Wong HY, Beaver JA, Cochran RL, Zabransky DJ, Croessmann S, Chu D, Toro PV, Cravero K, Pandey A, Park BH. PMID: 25367220.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    28. Analysis of BRCA2 loss of heterozygosity in tumor tissue using droplet digital polymerase chain reaction. Hum Pathol. 2014 Jul; 45(7):1546-1550. Cochran RL, Cravero K, Chu D, Erlanger B, Toro PV, Beaver JA, Zabransky DJ, Wong HY, Cidado J, Croessmann S, Parsons H, Kim M, Wheelan SJ, Argani P, Ho Park B. PMID: 24824029.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    29. Detection of cancer DNA in plasma of patients with early-stage breast cancer. Clin Cancer Res. 2014 May 15; 20(10):2643-2650. Beaver JA, Jelovac D, Balukrishna S, Cochran R, Croessmann S, Zabransky DJ, Wong HY, Toro PV, Cidado J, Blair BG, Chu D, Burns T, Higgins MJ, Stearns V, Jacobs L, Habibi M, Lange J, Hurley PJ, Lauring J, VanDenBerg D, Kessler J, Jeter S, Samuels ML, Maar D, Cope L, Cimino-Mathews A, Argani P, Wolff AC, Park BH. PMID: 24504125.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    30. Cysteines in the stalk of the nipah virus G glycoprotein are located in a distinct subdomain critical for fusion activation. J Virol. 2012 Jun; 86(12):6632-42. Maar D, Harmon B, Chu D, Schulz B, Aguilar HC, Lee B, Negrete OA. PMID: 22496210.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    31. Malignant biliary tract obstruction: evaluation and therapy. J Natl Compr Canc Netw. 2010 Sep; 8(9):1033-44. Chu D, Adler DG. PMID: 20876543.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    32. Improved survival with adjuvant external-beam radiation therapy in lymph node-negative pancreatic cancer: a United States population-based assessment. Cancer. 2008 Sep 01; 113(5):1110-1; author reply 1111-2. Chu DZ. PMID: 18623375.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. Mutational spectra of p53 in geographically localized esophageal squamous cell carcinoma groups in China. Cancer. 2004 Aug 15; 101(4):834-44. Cao W, Chen X, Dai H, Wang H, Shen B, Chu D, McAfee T, Zhang ZF. PMID: 15305417.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    34. Pilot trial evaluating an 123I-labeled 80-kilodalton engineered anticarcinoembryonic antigen antibody fragment (cT84.66 minibody) in patients with colorectal cancer. Clin Cancer Res. 2004 Aug 01; 10(15):5014-21. Wong JY, Chu DZ, Williams LE, Yamauchi DM, Ikle DN, Kwok CS, Liu A, Wilczynski S, Colcher D, Yazaki PJ, Shively JE, Wu AM, Raubitschek AA. PMID: 15297402.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    35. A Phase I trial of 90Y-anti-carcinoembryonic antigen chimeric T84.66 radioimmunotherapy with 5-fluorouracil in patients with metastatic colorectal cancer. Clin Cancer Res. 2003 Dec 01; 9(16 Pt 1):5842-52. Wong JY, Shibata S, Williams LE, Kwok CS, Liu A, Chu DZ, Yamauchi DM, Wilczynski S, Ikle DN, Wu AM, Yazaki PJ, Shively JE, Doroshow JH, Raubitschek AA. PMID: 14676105.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCTClinical Trials
    36. The surgical treatment of cancer: a comparison of resource utilization following procedures performed with a curative and palliative intent. Cancer. 2003 Nov 15; 98(10):2266-73. Cullinane CA, Borneman T, Smith DD, Chu DZ, Ferrell BR, Wagman LD. PMID: 14601098.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. Quality of life in patients with colorectal metastasis and intrahepatic chemotherapy. Ann Surg Oncol. 2003 Mar; 10(2):144-9. Blair SL, Grant M, Chu DZ, Cullinane C, Dean G, Schwarz RE, Wagman L. PMID: 12620909.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    38. Impact of intraoperative radiation on postoperative and disease-specific outcome after pancreatoduodenectomy for adenocarcinoma: a propensity score analysis. Am J Clin Oncol. 2003 Feb; 26(1):16-21. Schwarz RE, Smith DD, Keny H, Iklé DN, Shibata SI, Chu DZ, Pezner RD. PMID: 12576918.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    39. Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes. Cancer Res. 2002 Feb 15; 62(4):1213-21. Chen X, Shen B, Xia L, Khaletzkiy A, Chu D, Wong JY, Li JJ. PMID: 11861406.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
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