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David Chu, PhD

TitlePostdoctoral Scholar
InstitutionUniversity of California San Francisco
DepartmentHDF Comprehensive Cancer Ctr
AddressLocation Required
Varies CA 00000
Phone415-502-3579
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    Collapse Biography 
    Collapse Education and Training
    University of California Los Angeles, Los Angeles, CABSc2008Biochemistry
    Cedars-Sinai Medical Center, Los Angeles, CA2011Cancer Biology
    Johns Hopkins School of Medicine, Baltimore, MDPhD2017Cellular and Molecular Medicine

    Collapse Overview 

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cravero K, Medford A, Pallavajjala A, Canzoniero J, Hunter N, Chu D, Cochran RL, Waters I, Christenson ES, Kyker-Snowman K, Button B, Cole AJ, Park BH. Biotinylated amplicon sequencing: A method for preserving DNA samples of limited quantity. Pract Lab Med. 2018 Nov; 12:e00108. PMID: 30140723.
      View in: PubMed
    2. Li Z, Levine KM, Bahreini A, Wang P, Chu D, Park BH, Oesterreich S, Lee AV. Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells. Endocrinology. 2018 01 01; 159(1):285-296. PMID: 29029116.
      View in: PubMed
    3. Paoletti C, Cani AK, Larios JM, Hovelson DH, Aung K, Darga EP, Cannell EM, Baratta PJ, Liu CJ, Chu D, Yazdani M, Blevins AR, Sero V, Tokudome N, Thomas DG, Gersch C, Schott AF, Wu YM, Lonigro R, Robinson DR, Chinnaiyan AM, Bischoff FZ, Johnson MD, Park BH, Hayes DF, Rae JM, Tomlins SA. Comprehensive Mutation and Copy Number Profiling in Archived Circulating Breast Cancer Tumor Cells Documents Heterogeneous Resistance Mechanisms. Cancer Res. 2018 Feb 15; 78(4):1110-1122. PMID: 29233927.
      View in: PubMed
    4. Zhao Y, Laws MJ, Guillen VS, Ziegler Y, Min J, Sharma A, Kim SH, Chu D, Park BH, Oesterreich S, Mao C, Shapiro DJ, Nettles KW, Katzenellenbogen JA, Katzenellenbogen BS. Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors. Cancer Res. 2017 10 15; 77(20):5602-5613. PMID: 28904064.
      View in: PubMed
    5. Christenson ES, Dalton WB, Chu D, Waters I, Cravero K, Zabransky DJ, DeZern AE, Park BH. Single-Nucleotide Polymorphism Leading to False Allelic Fraction by Droplet Digital PCR. Clin Chem. 2017 Aug; 63(8):1370-1376. PMID: 28615231.
      View in: PubMed
    6. Bahreini A, Li Z, Wang P, Levine KM, Tasdemir N, Cao L, Weir HM, Puhalla SL, Davidson NE, Stern AM, Chu D, Park BH, Lee AV, Oesterreich S. Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models. Breast Cancer Res. 2017 May 23; 19(1):60. PMID: 28535794.
      View in: PubMed
    7. Chu D, Park BH. Liquid biopsy: unlocking the potentials of cell-free DNA. Virchows Arch. 2017 Aug; 471(2):147-154. PMID: 28466157.
      View in: PubMed
    8. Avigdor BE, Beierl K, Gocke CD, Zabransky DJ, Cravero K, Kyker-Snowman K, Button B, Chu D, Croessmann S, Cochran RL, Connolly RM, Park BH, Wheelan SJ, Cimino-Mathews A. Whole-Exome Sequencing of Metaplastic Breast Carcinoma Indicates Monoclonality with Associated Ductal Carcinoma Component. Clin Cancer Res. 2017 Aug 15; 23(16):4875-4884. PMID: 28424200.
      View in: PubMed
    9. Goldstein A, Toro PV, Lee J, Silberstein JL, Nakazawa M, Waters I, Cravero K, Chu D, Cochran RL, Kim M, Shinn D, Torquato S, Hughes RM, Pallavajjala A, Carducci MA, Paller CJ, Denmeade SR, Kressel B, Trock BJ, Eisenberger MA, Antonarakis ES, Park BH, Hurley PJ. Detection fidelity of AR mutations in plasma derived cell-free DNA. Oncotarget. 2017 Feb 28; 8(9):15651-15662. PMID: 28152506.
      View in: PubMed
    10. Croessmann S, Wong HY, Zabransky DJ, Chu D, Rosen DM, Cidado J, Cochran RL, Dalton WB, Erlanger B, Cravero K, Button B, Kyker-Snowman K, Hurley PJ, Lauring J, Park BH. PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity. Breast Cancer Res Treat. 2017 04; 162(3):451-464. PMID: 28190247.
      View in: PubMed
    11. Lee J, Axilbund J, Dalton WB, Laheru D, Watkins S, Chu D, Cravero K, Button B, Kyker-Snowman K, Waters I, Gocke CD, Lauring J, Park BH. A Polycythemia Vera JAK2 Mutation Masquerading as a Duodenal Cancer Mutation. J Natl Compr Canc Netw. 2016 12; 14(12):1495-1498. PMID: 27956534.
      View in: PubMed
    12. Scott GK, Chu D, Kaur R, Malato J, Rothschild DE, Frazier K, Eppenberger-Castori S, Hann B, Park BH, Benz CC. ERpS294 is a biomarker of ligand or mutational ERα activation and a breast cancer target for CDK2 inhibition. Oncotarget. 2017 Oct 13; 8(48):83432-83445. PMID: 29137354.
      View in: PubMed
    13. Jaffe GJ, Dick AD, Brézin AP, Nguyen QD, Thorne JE, Kestelyn P, Barisani-Asenbauer T, Franco P, Heiligenhaus A, Scales D, Chu DS, Camez A, Kwatra NV, Song AP, Kron M, Tari S, Suhler EB. Adalimumab in Patients with Active Noninfectious Uveitis. N Engl J Med. 2016 Sep 08; 375(10):932-43. PMID: 27602665.
      View in: PubMed
    14. Parsons HA, Beaver JA, Cimino-Mathews A, Ali SM, Axilbund J, Chu D, Connolly RM, Cochran RL, Croessmann S, Clark TA, Gocke CD, Jeter SC, Kennedy MR, Lauring J, Lee J, Lipson D, Miller VA, Otto GA, Rosner GL, Ross JS, Slater S, Stephens PJ, VanDenBerg DA, Wolff AC, Young LE, Zabransky DJ, Zhang Z, Zorzi J, Stearns V, Park BH. Individualized Molecular Analyses Guide Efforts (IMAGE): A Prospective Study of Molecular Profiling of Tissue and Blood in Metastatic Triple-Negative Breast Cancer. Clin Cancer Res. 2017 Jan 15; 23(2):379-386. PMID: 27489289.
      View in: PubMed
    15. Hayashi M, Chu D, Meyer CF, Llosa NJ, McCarty G, Morris CD, Levin AS, Wolinsky JP, Albert CM, Steppan DA, Park BH, Loeb DM. Highly personalized detection of minimal Ewing sarcoma disease burden from plasma tumor DNA. Cancer. 2016 10; 122(19):3015-23. PMID: 27351911.
      View in: PubMed
    16. Cidado J, Wong HY, Rosen DM, Cimino-Mathews A, Garay JP, Fessler AG, Rasheed ZA, Hicks J, Cochran RL, Croessmann S, Zabransky DJ, Mohseni M, Beaver JA, Chu D, Cravero K, Christenson ES, Medford A, Mattox A, De Marzo AM, Argani P, Chawla A, Hurley PJ, Lauring J, Park BH. Ki-67 is required for maintenance of cancer stem cells but not cell proliferation. Oncotarget. 2016 Feb 02; 7(5):6281-93. PMID: 26823390.
      View in: PubMed
    17. Wong HY, Wang GM, Croessmann S, Zabransky DJ, Chu D, Garay JP, Cidado J, Cochran RL, Beaver JA, Aggarwal A, Liu ML, Argani P, Meeker A, Hurley PJ, Lauring J, Park BH. TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer. Oncotarget. 2015 Dec 29; 6(42):44927-40. PMID: 26702755.
      View in: PubMed
    18. Zabransky DJ, Yankaskas CL, Cochran RL, Wong HY, Croessmann S, Chu D, Kavuri SM, Red Brewer M, Rosen DM, Dalton WB, Cimino-Mathews A, Cravero K, Button B, Kyker-Snowman K, Cidado J, Erlanger B, Parsons HA, Manto KM, Bose R, Lauring J, Arteaga CL, Konstantopoulos K, Park BH. HER2 missense mutations have distinct effects on oncogenic signaling and migration. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):E6205-14. PMID: 26508629.
      View in: PubMed
    19. Cochran RL, Cidado J, Kim M, Zabransky DJ, Croessmann S, Chu D, Wong HY, Beaver JA, Cravero K, Erlanger B, Parsons H, Heaphy CM, Meeker AK, Lauring J, Park BH. Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes. Oncotarget. 2015 Sep 22; 6(28):25240-51. PMID: 26246475.
      View in: PubMed
    20. Croessmann S, Wong HY, Zabransky DJ, Chu D, Mendonca J, Sharma A, Mohseni M, Rosen DM, Scharpf RB, Cidado J, Cochran RL, Parsons HA, Dalton WB, Erlanger B, Button B, Cravero K, Kyker-Snowman K, Beaver JA, Kachhap S, Hurley PJ, Lauring J, Park BH. NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability. Proc Natl Acad Sci U S A. 2015 Sep 15; 112(37):11583-8. PMID: 26324937.
      View in: PubMed
    21. Chu D, Paoletti C, Gersch C, VanDenBerg DA, Zabransky DJ, Cochran RL, Wong HY, Toro PV, Cidado J, Croessmann S, Erlanger B, Cravero K, Kyker-Snowman K, Button B, Parsons HA, Dalton WB, Gillani R, Medford A, Aung K, Tokudome N, Chinnaiyan AM, Schott A, Robinson D, Jacks KS, Lauring J, Hurley PJ, Hayes DF, Rae JM, Park BH. ESR1 Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients. Clin Cancer Res. 2016 Feb 15; 22(4):993-9. PMID: 26261103.
      View in: PubMed
    22. Toro PV, Erlanger B, Beaver JA, Cochran RL, VanDenBerg DA, Yakim E, Cravero K, Chu D, Zabransky DJ, Wong HY, Croessmann S, Parsons H, Hurley PJ, Lauring J, Park BH. Comparison of cell stabilizing blood collection tubes for circulating plasma tumor DNA. Clin Biochem. 2015 Oct; 48(15):993-8. PMID: 26234639.
      View in: PubMed
    23. Tu Y, Gonzalez-Gronow M, Kolomeyer AM, Cohen A, Pruzon J, Milman T, Chu DS. Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature. Semin Ophthalmol. 2016; 31(6):526-31. PMID: 25674820.
      View in: PubMed
    24. Blair BG, Wu X, Zahari MS, Mohseni M, Cidado J, Wong HY, Beaver JA, Cochran RL, Zabransky DJ, Croessmann S, Chu D, Toro PV, Cravero K, Pandey A, Park BH. A phosphoproteomic screen demonstrates differential dependence on HER3 for MAP kinase pathway activation by distinct PIK3CA mutations. Proteomics. 2015 Jan; 15(2-3):318-26. PMID: 25367220; PMCID: PMC4352327.
    25. Cochran RL, Cravero K, Chu D, Erlanger B, Toro PV, Beaver JA, Zabransky DJ, Wong HY, Cidado J, Croessmann S, Parsons H, Kim M, Wheelan SJ, Argani P, Ho Park B. Analysis of BRCA2 loss of heterozygosity in tumor tissue using droplet digital polymerase chain reaction. Hum Pathol. 2014 Jul; 45(7):1546-1550. PMID: 24824029; PMCID: PMC4065621.
    26. Beaver JA, Jelovac D, Balukrishna S, Cochran R, Croessmann S, Zabransky DJ, Wong HY, Toro PV, Cidado J, Blair BG, Chu D, Burns T, Higgins MJ, Stearns V, Jacobs L, Habibi M, Lange J, Hurley PJ, Lauring J, VanDenBerg D, Kessler J, Jeter S, Samuels ML, Maar D, Cope L, Cimino-Mathews A, Argani P, Wolff AC, Park BH. Detection of cancer DNA in plasma of patients with early-stage breast cancer. Clin Cancer Res. 2014 May 15; 20(10):2643-2650. PMID: 24504125.
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    27. Maar D, Harmon B, Chu D, Schulz B, Aguilar HC, Lee B, Negrete OA. Cysteines in the stalk of the nipah virus G glycoprotein are located in a distinct subdomain critical for fusion activation. J Virol. 2012 Jun; 86(12):6632-42. PMID: 22496210; PMCID: PMC3393546.
    28. Chu D, Adler DG. Malignant biliary tract obstruction: evaluation and therapy. J Natl Compr Canc Netw. 2010 Sep; 8(9):1033-44. PMID: 20876543.
      View in: PubMed
    29. Chu DZ. Improved survival with adjuvant external-beam radiation therapy in lymph node-negative pancreatic cancer: a United States population-based assessment. Cancer. 2008 Sep 01; 113(5):1110-1; author reply 1111-2. PMID: 18623375.
      View in: PubMed
    30. Cao W, Chen X, Dai H, Wang H, Shen B, Chu D, McAfee T, Zhang ZF. Mutational spectra of p53 in geographically localized esophageal squamous cell carcinoma groups in China. Cancer. 2004 Aug 15; 101(4):834-44. PMID: 15305417.
      View in: PubMed
    31. Wong JY, Chu DZ, Williams LE, Yamauchi DM, Ikle DN, Kwok CS, Liu A, Wilczynski S, Colcher D, Yazaki PJ, Shively JE, Wu AM, Raubitschek AA. Pilot trial evaluating an 123I-labeled 80-kilodalton engineered anticarcinoembryonic antigen antibody fragment (cT84.66 minibody) in patients with colorectal cancer. Clin Cancer Res. 2004 Aug 01; 10(15):5014-21. PMID: 15297402.
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    32. Wong JY, Shibata S, Williams LE, Kwok CS, Liu A, Chu DZ, Yamauchi DM, Wilczynski S, Ikle DN, Wu AM, Yazaki PJ, Shively JE, Doroshow JH, Raubitschek AA. A Phase I trial of 90Y-anti-carcinoembryonic antigen chimeric T84.66 radioimmunotherapy with 5-fluorouracil in patients with metastatic colorectal cancer. Clin Cancer Res. 2003 Dec 01; 9(16 Pt 1):5842-52. PMID: 14676105.
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    33. Cullinane CA, Borneman T, Smith DD, Chu DZ, Ferrell BR, Wagman LD. The surgical treatment of cancer: a comparison of resource utilization following procedures performed with a curative and palliative intent. Cancer. 2003 Nov 15; 98(10):2266-73. PMID: 14601098.
      View in: PubMed
    34. Blair SL, Grant M, Chu DZ, Cullinane C, Dean G, Schwarz RE, Wagman L. Quality of life in patients with colorectal metastasis and intrahepatic chemotherapy. Ann Surg Oncol. 2003 Mar; 10(2):144-9. PMID: 12620909.
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    35. Schwarz RE, Smith DD, Keny H, Iklé DN, Shibata SI, Chu DZ, Pezner RD. Impact of intraoperative radiation on postoperative and disease-specific outcome after pancreatoduodenectomy for adenocarcinoma: a propensity score analysis. Am J Clin Oncol. 2003 Feb; 26(1):16-21. PMID: 12576918.
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    36. Chen X, Shen B, Xia L, Khaletzkiy A, Chu D, Wong JY, Li JJ. Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes. Cancer Res. 2002 Feb 15; 62(4):1213-21. PMID: 11861406.
      View in: PubMed
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